Genes, time to first cigarette and nicotine dependence in a general population sample of young adults.
- Authors
- Haberstick, Brett C; Timberlake, David; Ehringer, Marissa A; Lessem, Jeffrey M; Hopfer, Christian J; Smolen, Andrew; Hewitt, John K
- Year
- 2007
- Journal
- Addiction (Abingdon, England)
- PMID
- 17309537
- DOI
- 10.1111/j.1360-0443.2007.01746.x
AIM: To examine variation in nicotine dependence scores and covariation between different dependence symptoms. DESIGN: A 12-year, nationally representative, probability-based survey of adolescent health-related behaviors and their outcomes during young adulthood in the United States. The genetic contribution to nicotine dependence was evaluated in the sibling-pairs sample of the US National Longitudinal Study of Adolescent Health. MEASUREMENTS: Nicotine dependence (ND) was assessed using the Fagerström Test for Nicotine Dependence (FTND) and Heaviness of Smoking Index (HSI) in 1154 young adults, between the ages of 18 and 25 years, who were from twin, full sibling and half-sibling pairs. FINDINGS: Dependence in this sample was common and varied in degree. Total HSI scores evidenced moderate to large heritable contributions (61%, 95% confidence interval (CI): 0.46-0.72), as did the quantity of cigarettes smoked (52%, 95% CI: 0.39-0.63) and urgency to smoke (55%, 95% CI: 0.38-0.68). Multivariate modeling identified a highly heritable underlying factor (76%, 95% CI: 0.56-0.91) that influenced the covariation of dependence symptoms and loaded most heavily on how soon after waking a smoker uses his or her first cigarette. The quantity of cigarettes smoked per day also evidenced residual genetic influences that were not common to other dependence-related behaviors. CONCLUSIONS: In this sample of young adults from the general population, both genes and individual-specific environments are important etiological factors in ND. The urgency to smoke, as measured by the time to first cigarette, may be the most informative measure on the FTND for genetic studies of nicotine dependence.
No figures extracted from this document.
No chunks — full text not yet ingested.
No entities extracted from this document yet.
No uploaded files.
No citations found.
In this knowledge base
| Title | Year | PMID |
|---|---|---|
| CYP2A6 metabolism in the development of smoking behaviors in young adults. | 2018 | 28032407 |
External
| Title | Authors | Journal | Year | Link |
|---|---|---|---|---|
| A mixed-method analysis of counterfactual thinking, negative event themes, and the transtheoretical model in a community sample of smokers. | Arthur KM et al. | — | 2023 | → |
| A study on the prevalence of smoking habits among the student community in Aseer Region, Saudi Arabia. | Kandasamy G et al. | — | 2023 | → |
| Biochemical and genetic biomarkers associated with nicotine dependence in Mexican smokers. | Borrego-Soto G et al. | — | 2023 | → |
| Genetic architecture of four smoking behaviors using partitioned SNP heritability. | Evans LM et al. | — | 2021 | → |
| Expanding the genetic architecture of nicotine dependence and its shared genetics with multiple traits. | Quach BC et al. | — | 2020 | → |
| Genetic architecture of four smoking behaviors using partitioned <i>h</i><sup><i>2</i></sup><sub><i>SNP</i></sub> | Evans LM et al. | — | 2020 | — |
| The Intersection between Spliff Usage, Tobacco Smoking, and Having the First Joint after Waking. | Kumar N et al. | — | 2020 | → |
| A mixed-effects location scale model for time-to-event data: A smoking behavior application. | Courvoisier D et al. | — | 2019 | → |
| Time to First Cigarette and Self-Reported Health Among US Adult Smokers. | Sung B | — | 2019 | → |
| Adult interest in using a hypothetical modified risk tobacco product: findings from wave 1 of the Population Assessment of Tobacco and Health Study (2013-14). | Pearson JL et al. | — | 2018 | → |
| CYP2A6 metabolism in the development of smoking behaviors in young adults. | Olfson E et al. | — | 2018 | → |
| Earlier smoking after waking and the risk of asthma: a cross-sectional study using NHANES data. | Selya AS et al. | — | 2018 | → |
| Income as a moderator of psychological stress and nicotine dependence among adult smokers. | Hobkirk AL et al. | — | 2018 | → |
| Item Response Theory analysis of Fagerström Test for Cigarette Dependence. | Svicher A et al. | — | 2018 | → |
| Nicotine dependence is associated with functional variation in FMO3, an enzyme that metabolizes nicotine in the brain. | Teitelbaum AM et al. | — | 2018 | → |
| Examination of the Involvement of Cholinergic-Associated Genes in Nicotine Behaviors in European and African Americans. | Melroy-Greif WE et al. | — | 2017 | → |
| Relationship between Personality Traits and Nicotine Dependence in Male and Female Smokers of African-American and European-American Samples. | Choi JS et al. | — | 2017 | → |
| Developmental Changes in Genetic and Shared Environmental Contributions to Smoking Initiation and Subsequent Smoking Quantity in Adolescence and Young Adulthood. | Bares CB et al. | — | 2015 | → |
| Predictors of the Nicotine Dependence Behavior Time to the First Cigarette in a Multiracial Cohort. | Branstetter SA et al. | — | 2015 | → |
| Strain-dependent performance in nicotine-induced conditioned place preference. | Kutlu MG et al. | — | 2015 | → |
| How smokers may react to cigarette taxes and price increases in Brazil: data from a national survey. | Gigliotti A et al. | — | 2014 | → |
| Nicotine dependence and biochemical exposure measures in the second trimester of pregnancy. | Kwok TC et al. | — | 2014 | → |
| Varenicline, low dose naltrexone, and their combination for heavy-drinking smokers: human laboratory findings. | Ray LA et al. | — | 2014 | → |
| The prevalence, predictors and associated health outcomes of high nicotine dependence using three measures among US smokers. | Schnoll RA et al. | — | 2013 | → |
| Time to first cigarette and lung cancer risk in Japan. | Ito H et al. | — | 2013 | → |
| Time to first cigarette and serum cotinine levels in adolescent smokers: National Health and Nutrition Examination Survey, 2007-2010. | Branstetter SA et al. | — | 2013 | → |
| Alpha-5 and -3 nicotinic receptor gene variants predict nicotine dependence but not cessation: findings from the COMMIT cohort. | Bousman CA et al. | — | 2012 | → |
| A systematic review of the A118G (Asn40Asp) variant of OPRM1 in relation to smoking initiation, nicotine dependence and smoking cessation. | Verhagen M et al. | — | 2012 | → |
| Development and reliability of the lifetime interview on smoking trajectories. | Colby SM et al. | — | 2012 | → |
| Psychosocial factors in adolescent nicotine dependence symptoms: a sample of high school juniors who smoke daily. | Bricker JB et al. | — | 2012 | → |
| Strain-dependent effects of acute, chronic, and withdrawal from chronic nicotine on fear conditioning. | Portugal GS et al. | — | 2012 | → |
| The genetic correlation between cigarette smoking and alcohol drinking among Chinese adult male twins: an ordinal bivariate genetic analysis. | Zhang T et al. | — | 2012 | → |
| A latent class analysis of DSM-IV and Fagerström (FTND) criteria for nicotine dependence. | Agrawal A et al. | — | 2011 | → |
| Biomarkers to optimize the treatment of nicotine dependence. | Schnoll RA et al. | — | 2011 | → |
| Changes in smokers' attitudes toward intended cessation attempts in Japan. | Goto R et al. | — | 2011 | → |
| Dizziness and the genetic influences on subjective experiences to initial cigarette use. | Haberstick BC et al. | — | 2011 | → |
| Heritability of smoking, alcohol use, and psychological characteristics among adolescent twins in Qingdao, China. | Unger JB et al. | — | 2011 | → |
| Major depression is a risk factor for shorter time to first cigarette irrespective of the number of cigarettes smoked per day: evidence from a National Population Health Survey. | Khaled SM et al. | — | 2011 | → |
| Nicotine dependence phenotype, time to first cigarette, and risk of head and neck cancer. | Muscat JE et al. | — | 2011 | → |
| The galanin receptor 1 gene associates with tobacco craving in smokers seeking cessation treatment. | Lori A et al. | — | 2011 | → |
| Does breath carbon monoxide measure nicotine dependence? | Kapusta ND et al. | — | 2010 | → |
| A testable prognostic model of nicotine dependence. | Ramoni RB et al. | — | 2009 | → |
| Differential item functioning of the English and Chinese versions of the Fagerstrom Test for Nicotine Dependence. | Yamada H et al. | — | 2009 | → |
| Do smokers know what we're talking about? The construct validity of nicotine dependence questionnaire measures. | Japuntich SJ et al. | — | 2009 | → |
| Do smokers of specialty and conventional cigarettes differ in their dependence on nicotine? | Huh J et al. | — | 2009 | → |
| The effect of smoking prevalence at worksites on individual cessation behavior. | Nishiura C et al. | — | 2009 | → |
| Time to first cigarette after waking predicts cotinine levels. | Muscat JE et al. | — | 2009 | → |
| Are there genetic influences on addiction: evidence from family, adoption and twin studies. | Agrawal A et al. | — | 2008 | → |
| Genetics of nicotine dependence and pharmacotherapy. | Lessov-Schlaggar CN et al. | — | 2008 | → |
| Genetics and smoking behavior. | Schnoll RA et al. | — | 2007 | → |
| Time to first cigarette in the morning as an index of ability to quit smoking: implications for nicotine dependence. | Transdisciplinary Tobacco Use Research Center (TTURC) Tobacco Dependence et al. | — | 2007 | → |