Neuropeptide Y (NPY) in alcohol intake and dependence.
paper
Cited
Public
Unavailable
- Authors
- Thorsell, Annika
- Year
- 2007
- Journal
- Peptides
- PMID
- 17239487
- DOI
- 10.1016/j.peptides.2006.11.017
Neuropeptide Y has a role in alcohol intake and dependence. NPY's effect on alcohol intake appears to be in part dependent on the individual's history of alcohol dependence. In models of high intake such as alcohol-preferring, selectively bred rat lines (e.g., the P-line and the HAD line), as well as in ethanol-vapor-exposed subjects, NPY modulates alcohol intake while leaving it unaffected during baseline conditions. The primary receptor subtype mediating NPY's effect on ethanol intake remains in question. The Y2-antagonist BIIE0246 significantly suppresses ethanol intake in an operant paradigm with a sensitization to the effect of BIIE0246 in vapor-exposed subjects. We propose the NPY system to be one of the most interesting target systems for the development of treatments for alcohol abuse and dependence.
No figures extracted from this document.
No chunks — full text not yet ingested.
No entities extracted from this document yet.
No uploaded files.
Not in any collection.
No citations found.
In this knowledge base
| Title | Year | PMID |
|---|---|---|
| Neuropeptide Y receptor genes are associated with alcohol dependence, alcohol withdrawal phenotypes, and cocaine dependence. | 2008 | 18828811 |
External
| Title | Authors | Journal | Year | Link |
|---|---|---|---|---|
| The neuropeptide Y single-nucleotide polymorphism <i>rs16147:T</i>><i>C</i> moderates the effect of alcohol dependence on depression in male Chinese Han population. | Wei X et al. | — | 2022 | → |
| Meta-Analysis on the Association of Neuropeptide Y rs16139 Variant With the Risk of Alcoholism. | Chen B et al. | — | 2021 | → |
| Nerve Growth Factor in Alcohol Use Disorders. | Ceci FM et al. | — | 2021 | → |
| Medications development for the treatment of alcohol use disorder: insights into the predictive value of animal and human laboratory models. | Yardley MM et al. | — | 2017 | → |
| Effects of chronic alcohol consumption, withdrawal and nerve growth factor on neuropeptide Y expression and cholinergic innervation of the rat dentate hilus. | Pereira PA et al. | — | 2016 | → |
| Effects of drugs of abuse on the central neuropeptide Y system. | Gonçalves J et al. | — | 2016 | → |
| Neuropeptide Y (NPY) and posttraumatic stress disorder (PTSD): A translational update. | Schmeltzer SN et al. | — | 2016 | → |
| The glucagon-like peptide 1 receptor agonist liraglutide attenuates the reinforcing properties of alcohol in rodents. | Vallöf D et al. | — | 2016 | → |
| Genetics and genomics of alcohol sensitivity. | Morozova TV et al. | — | 2014 | → |
| Ligands of the neuropeptide Y Y2 receptor. | Mittapalli GK et al. | — | 2014 | → |
| Mechanisms underlying sleep-wake disturbances in alcoholism: focus on the cholinergic pedunculopontine tegmentum. | Knapp CM et al. | — | 2014 | → |
| Nematodes feel a craving--using Caenorhabditis elegans as a model to study alcohol addiction. | Zhu G et al. | — | 2014 | → |
| Neurochemical mechanisms of alcohol withdrawal. | Becker HC et al. | — | 2014 | → |
| Association between neuropeptide Y gene polymorphisms and alcohol dependence: a case-control study in two independent populations. | Bhaskar LV et al. | — | 2013 | → |
| Neuropeptide Y and posttraumatic stress disorder. | Sah R et al. | — | 2013 | → |
| Resilience to meet the challenge of addiction: psychobiology and clinical considerations. | Alim TN et al. | — | 2012 | → |
| Sexual deprivation increases ethanol intake in Drosophila. | Shohat-Ophir G et al. | — | 2012 | → |
| The genetic basis of alcoholism: multiple phenotypes, many genes, complex networks. | Morozova TV et al. | — | 2012 | → |
| Treatment of alcohol dependence with drug antagonists of the stress response. | Higley AE et al. | — | 2012 | → |
| Central functions of neuropeptide Y in mood and anxiety disorders. | Wu G et al. | — | 2011 | → |
| Effects of a selective Y2R antagonist, JNJ-31020028, on nicotine abstinence-related social anxiety-like behavior, neuropeptide Y and corticotropin releasing factor mRNA levels in the novelty-seeking phenotype. | Aydin C et al. | — | 2011 | → |
| Neuropeptide Y receptors: ligand binding and trafficking suggest novel approaches in drug development. | Walther C et al. | — | 2011 | → |
| Prolonged chronic ethanol exposure alters neuropeptide Y and corticotropin-releasing factor levels in the brain of adult Wistar rats. | Criado JR et al. | — | 2011 | → |
| Role of feeding-related pathways in alcohol dependence: A focus on sweet preference, NPY, and ghrelin. | Leggio L et al. | — | 2011 | → |
| A differential role for neuropeptides in acute and chronic adaptive responses to alcohol: behavioural and genetic analysis in Caenorhabditis elegans. | Mitchell P et al. | — | 2010 | → |
| Neuropeptide Y (NPY) suppresses yohimbine-induced reinstatement of alcohol seeking. | Cippitelli A et al. | — | 2010 | → |
| New horizons for therapeutics in drug and alcohol abuse. | Jupp B et al. | — | 2010 | → |
| Analysis of single nucleotide polymorphisms and haplotypes in the neuropeptide Y gene: no evidence for association with alcoholism in a German population sample. | Zill P et al. | — | 2008 | → |
| Communication networks in the brain: neurons, receptors, neurotransmitters, and alcohol. | Lovinger DM | — | 2008 | → |
| Neuropeptide Y receptor genes are associated with alcohol dependence, alcohol withdrawal phenotypes, and cocaine dependence. | Wetherill L et al. | — | 2008 | → |
| Neuropeptide Y Y2 receptor in health and disease. | Parker SL et al. | — | 2008 | → |