Genome-wide association of major depression: description of samples for the GAIN Major Depressive Disorder Study: NTR and NESDA biobank projects.
paper
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- Authors
- Boomsma, Dorret I; Willemsen, Gonneke; Sullivan, Patrick F; Heutink, Peter; Meijer, Piet; Sondervan, David; Kluft, Cornelis; Smit, Guus; Nolen, Willem A; Zitman, Frans G; Smit, Johannes H; Hoogendijk, Witte J; van Dyck, Richard; de Geus, Eco J C; Penninx, Brenda W J H
- Year
- 2008
- Journal
- European journal of human genetics : EJHG
- PMID
- 18197199
- DOI
- 10.1038/sj.ejhg.5201979
To identify the genomic regions that confer risk and protection for major depressive disorder (MDD) in humans, large-scale studies are needed. Such studies should collect multiple phenotypes, DNA, and ideally, biological material that allows gene expression analysis, transcriptomic, proteomic, and metabolomic studies. In this paper, we briefly review linkage studies of MDD and then describe the large-scale nationwide biological sample collection in Dutch twin families from the Netherlands Twin Register (NTR) and in participants in the Netherlands Study of Depression and Anxiety (NESDA). Within these studies, 1,862 participants with a diagnosis of MDD and 1,857 controls at low liability for MDD have been selected for genome-wide genotyping by the US Foundation for the National Institutes of Health Genetic Association Information Network. Stage 1 genome-wide association results are scheduled to be accessible before the end of 2007. Genome-wide association results are open-access and can be viewed at the dbGAP web portal (http://www.ncbi.nlm.nih.gov). Approved users can download the genotype and phenotype data, which have been made available as of 9 October 2007.
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|---|---|---|---|---|
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| A statistical method for image-mediated association studies discovers genes and pathways associated with four brain disorders. | He J et al. | β | 2024 | β |
| Genome-wide association study meta-analysis of dizygotic twinning illuminates genetic regulation of female fecundity. | Mbarek H et al. | β | 2024 | β |
| A statistical method for image-mediated association studies discovers genes and pathways associated with four brain disorders | He J et al. | β | 2023 | β |
| Depressive symptoms predict longitudinal changes of chronic inflammation at the transition to adulthood. | Zhai S et al. | β | 2022 | β |
| Exploring the role of biologics in depression. | Rani T et al. | β | 2022 | β |
| Methylome-wide association study of antidepressant use in Generation Scotland and the Netherlands Twin Register implicates the innate immune system. | Barbu MC et al. | β | 2022 | β |
| TNF-Ξ± Mediates the Association between Dietary Inflammatory Index and Depressive Symptoms in Breast Cancer. | Chen Y et al. | β | 2022 | β |
| DNA methylation of the KLK8 gene in depression symptomatology. | Starnawska A et al. | β | 2021 | β |
| Obesity and atypical depression symptoms: findings from Mendelian randomization in two European cohorts. | Pistis G et al. | β | 2021 | β |
| The type 2 diabetes mellitus susceptibility gene CDKAL1 polymorphism is associated with depressive symptom in first-episode drug-naive schizophrenic patients. | Yin XY et al. | β | 2021 | β |
| Embracing study heterogeneity for finding genetic interactions in large-scale research consortia. | Liu Y et al. | β | 2020 | β |
| Methylome-wide association findings for major depressive disorder overlap in blood and brain and replicate in independent brain samples. | Aberg KA et al. | β | 2020 | β |
| Effect of selective serotonin reuptake inhibitor on prefrontal-striatal connectivity is dependent on the level of TNF-Ξ± in patients with major depressive disorder. | Liu K et al. | β | 2019 | β |
| Genome-wide Burden of Rare Short Deletions Is Enriched in Major Depressive Disorder in Four Cohorts. | Zhang X et al. | β | 2019 | β |
| Network Analysis of Depression-Related Transcriptomic Profiles. | Miao X et al. | β | 2019 | β |
| Quantifying between-cohort and between-sex genetic heterogeneity in major depressive disorder. | Trzaskowski M et al. | β | 2019 | β |
| Characterizing the Relation Between Expression QTLs and Complex Traits: Exploring the Role of Tissue Specificity. | Ip HF et al. | β | 2018 | β |
| Convergence of evidence from a methylome-wide CpG-SNP association study and GWAS of major depressive disorder. | Aberg KA et al. | β | 2018 | β |
| Epigenetic Aging in Major Depressive Disorder. | Han LKM et al. | β | 2018 | β |
| 2SNP heritability and effects of genetic variants for neutrophil-to-lymphocyte and platelet-to-lymphocyte ratio. | Lin BD et al. | β | 2017 | β |
| Conditional eQTL analysis reveals allelic heterogeneity of gene expression. | Jansen R et al. | β | 2017 | β |
| Copy number variation meta-analysis reveals a novel duplication at 9p24 associated with multiple neurodevelopmental disorders. | Glessner JT et al. | β | 2017 | β |
| Disease variants alter transcription factor levels and methylation of their binding sites. | Bonder MJ et al. | β | 2017 | β |
| Genome-Wide Significance for PCLO as a Gene for Major Depressive Disorder. | Mbarek H et al. | β | 2017 | β |
| Heritability and GWAS Studies for Monocyte-Lymphocyte Ratio. | Lin BD et al. | β | 2017 | β |
| HPA Axis Genes, and Their Interaction with Childhood Maltreatment, are Related to Cortisol Levels and Stress-Related Phenotypes. | Gerritsen L et al. | β | 2017 | β |
| Immunometabolic dysregulation is associated with reduced cortical thickness of the anterior cingulate cortex. | van Velzen LS et al. | β | 2017 | β |
| The association of childhood maltreatment with depression and anxiety is not moderated by the oxytocin receptor gene. | Tollenaar MS et al. | β | 2017 | β |
| Using a multivariate model to assess the interactive effects of demographics and lifestyle on the hematological profile. | McArtor DB et al. | β | 2017 | β |
| Using Clinical Characteristics to Identify Which Patients With Major Depressive Disorder Have a Higher Genetic Load for Three Psychiatric Disorders. | Verduijn J et al. | β | 2017 | β |
| Validity of LIDAS (LIfetime Depression Assessment Self-report): a self-report online assessment of lifetime major depressive disorder. | Bot M et al. | β | 2017 | β |
| Assessment and characterization of phenotypic heterogeneity of anxiety disorders across five large cohorts. | Lee M et al. | β | 2016 | β |
| Does refining the phenotype improve replication rates? A review and replication of candidate gene studies on Major Depressive Disorder and Chronic Major Depressive Disorder. | Luo X et al. | β | 2016 | β |
| Effect of childhood maltreatment and brain-derived neurotrophic factor on brain morphology. | van Velzen LS et al. | β | 2016 | β |
| Gene expression in major depressive disorder. | Jansen R et al. | β | 2016 | β |
| Meta-analysis of the COMT Val158Met polymorphism in major depressive disorder: the role of gender. | Klein M et al. | β | 2016 | β |
| Multimarker analysis suggests the involvement of BDNF signaling and microRNA biosynthesis in suicidal behavior. | Pulay AJ et al. | β | 2016 | β |
| Pathogenetic and Therapeutic Applications of Tumor Necrosis Factor-Ξ± (TNF-Ξ±) in Major Depressive Disorder: A Systematic Review. | Ma K et al. | β | 2016 | β |
| Polygenic dissection of major depression clinical heterogeneity. | Milaneschi Y et al. | β | 2016 | β |
| The brain-derived neurotrophic factor pathway, life stress, and chronic multi-site musculoskeletal pain. | Generaal E et al. | β | 2016 | β |
| Association between smoking, nicotine dependence, and BDNF Val66Met polymorphism with BDNF concentrations in serum. | Jamal M et al. | β | 2015 | β |
| Educational attainment influences levels of homozygosity through migration and assortative mating. | Abdellaoui A et al. | β | 2015 | β |
| Effect of variation in BDNF Val(66)Met polymorphism, smoking, and nicotine dependence on symptom severity of depressive and anxiety disorders. | Jamal M et al. | β | 2015 | β |
| Heritability of liver enzyme levels estimated from genome-wide SNP data. | van Beek JH et al. | β | 2015 | β |
| In Silico Post Genome-Wide Association Studies Analysis of C-Reactive Protein Loci Suggests an Important Role for Interferons. | Vaez A et al. | β | 2015 | β |
| Prioritizing Approaches to Engage Community Members and Build Trust in Biobanks: A Survey of Attitudes and Opinions of Adults within Outpatient Practices at the University of Maryland. | Overby CL et al. | β | 2015 | β |
| ReMo-SNPs: a new software tool for identification of polymorphisms in regions and motifs genome-wide. | Graae L et al. | β | 2015 | β |
| Syndromes of Self-Reported Psychopathology for Ages 18-59 in 29 Societies. | Ivanova MY et al. | β | 2015 | β |
| The similarity of the structure of DSM-IV criteria for major depression in depressed women from China, the United States and Europe. | Kendler KS et al. | β | 2015 | β |
| Applying polygenic risk scores to postpartum depression. | Byrne EM et al. | β | 2014 | β |
| Bipolar polygenic loading and bipolar spectrum features in major depressive disorder. | Wiste A et al. | β | 2014 | β |
| Effect of polygenic risk scores on depression in childhood trauma. | Peyrot WJ et al. | β | 2014 | β |
| Further confirmation of the association between anxiety and CTNND2: replication in humans. | Nivard MG et al. | β | 2014 | β |
| Genetic risk score analysis indicates migraine with and without comorbid depression are genetically different disorders. | Ligthart L et al. | β | 2014 | β |
| Genome-wide pathway analysis in attention-deficit/hyperactivity disorder. | Lee YH et al. | β | 2014 | β |
| Heritability and genomics of gene expression in peripheral blood. | Wright FA et al. | β | 2014 | β |
| Identifying genetic variants for heart rate variability in the acetylcholine pathway. | Riese H et al. | β | 2014 | β |
| Meta-analysis on blood transcriptomic studies identifies consistently coexpressed protein-protein interaction modules as robust markers of human aging. | van den Akker EB et al. | β | 2014 | β |
| Principal component analysis characterizes shared pathogenetics from genome-wide association studies. | Chang D et al. | β | 2014 | β |
| Role of nicotine dependence in the association between the dopamine receptor gene DRD3 and major depressive disorder. | Korhonen T et al. | β | 2014 | β |
| Sex differences in the human peripheral blood transcriptome. | Jansen R et al. | β | 2014 | β |
| The contribution of the functional IL6R polymorphism rs2228145, eQTLs and other genome-wide SNPs to the heritability of plasma sIL-6R levels. | van Dongen J et al. | β | 2014 | β |
| The genetic interacting landscape of 63 candidate genes in Major Depressive Disorder: an explorative study. | Lekman M et al. | β | 2014 | β |
| ABCB1 gene variants influence tolerance to selective serotonin reuptake inhibitors in a large sample of Dutch cases with major depressive disorder. | de Klerk OL et al. | β | 2013 | β |
| A new regulatory variant in the interleukin-6 receptor gene associates with asthma risk. | Revez JA et al. | β | 2013 | β |
| Association between autozygosity and major depression: stratification due to religious assortment. | Abdellaoui A et al. | β | 2013 | β |
| Developmental aspects of mood disorders. | Lau JY | β | 2013 | β |
| FMR1, circadian genes and depression: suggestive associations or false discovery? | Kripke DF et al. | β | 2013 | β |
| Genetic and environmental stability in attention problems across the lifespan: evidence from the Netherlands twin register. | Kan KJ et al. | β | 2013 | β |
| Genome-wide pathway analysis in major depressive disorder. | Song GG et al. | β | 2013 | β |
| Inference of the genetic architecture underlying BMI and height with the use of 20,240 sibling pairs. | Hemani G et al. | β | 2013 | β |
| Rare ADH variant constellations are specific for alcohol dependence. | Zuo L et al. | β | 2013 | β |
| Resequencing three candidate genes for major depressive disorder in a Dutch cohort. | Verbeek EC et al. | β | 2013 | β |
| Strong effects of environmental factors on prevalence and course of major depressive disorder are not moderated by 5-HTTLPR polymorphisms in a large Dutch sample. | Peyrot WJ et al. | β | 2013 | β |
| The Adult Netherlands Twin Register: twenty-five years of survey and biological data collection. | Willemsen G et al. | β | 2013 | β |
| The protective effect of the obesity-associated rs9939609 A variant in fat mass- and obesity-associated gene on depression. | Samaan Z et al. | β | 2013 | β |
| TMPRSS9 and GRIN2B are associated with neuroticism: a genome-wide association study in a European sample. | Aragam N et al. | β | 2013 | β |
| Venlafaxine inhibits the upregulation of plasma tumor necrosis factor-alpha (TNF-Ξ±) in the Chinese patients with major depressive disorder: a prospective longitudinal study. | Li Z et al. | β | 2013 | β |
| A fine-mapping study of 7 top scoring genes from a GWAS for major depressive disorder. | Verbeek EC et al. | β | 2012 | β |
| BDNF val66met affects hippocampal volume and emotion-related hippocampal memory activity. | Molendijk ML et al. | β | 2012 | β |
| Different gene sets contribute to different symptom dimensions of depression and anxiety. | van Veen T et al. | β | 2012 | β |
| Effectiveness of a web-based protocol for the screening and phenotyping of individuals with Tourette syndrome for genetic studies. | Egan CA et al. | β | 2012 | β |
| Enriched pathways for major depressive disorder identified from a genome-wide association study. | Kao CF et al. | β | 2012 | β |
| Genome-wide association study of major depressive disorder: new results, meta-analysis, and lessons learned. | Wray NR et al. | β | 2012 | β |
| Loci affecting gamma-glutamyl transferase in adults and adolescents show age Γ SNP interaction and cardiometabolic disease associations. | Middelberg RP et al. | β | 2012 | β |
| Meta-analysis of genome-wide association studies for personality. | de Moor MH et al. | β | 2012 | β |
| Piccolo genotype modulates neural correlates of emotion processing but not executive functioning. | Woudstra S et al. | β | 2012 | β |
| Significant association of estrogen receptor binding site variation with bipolar disorder in females. | Graae L et al. | β | 2012 | β |
| Twins, tissue, and time: an assessment of SNPs and CNVs. | Scheet P et al. | β | 2012 | β |
| A 3p26-3p25 genetic linkage finding for DSM-IV major depression in heavy smoking families. | Pergadia ML et al. | β | 2011 | β |
| A genome-wide significant linkage for severe depression on chromosome 3: the depression network study. | Breen G et al. | β | 2011 | β |
| Association study in eating disorders: TPH2 associates with anorexia nervosa and self-induced vomiting. | Slof-Op 't Landt MC et al. | β | 2011 | β |
| Common functional mineralocorticoid receptor polymorphisms modulate the cortisol awakening response: Interaction with SSRIs. | Klok MD et al. | β | 2011 | β |
| Genetic risk profiles for depression and anxiety in adult and elderly cohorts. | Demirkan A et al. | β | 2011 | β |
| Genome-wide association analysis of gender differences in major depressive disorder in the Netherlands NESDA and NTR population-based samples. | Aragam N et al. | β | 2011 | β |
| Genome-wide association study identifies a single major locus contributing to survival into old age; the APOE locus revisited. | Deelen J et al. | β | 2011 | β |
| Glutamate cysteine ligase (GCL) and self reported depression: an association study from the HUNT. | Berk M et al. | β | 2011 | β |
| Heritability of insomnia symptoms in youth and their relationship to depression and anxiety. | Gehrman PR et al. | β | 2011 | β |
| Poor replication of candidate genes for major depressive disorder using genome-wide association data. | Bosker FJ et al. | β | 2011 | β |
| Replication of association of 3p21.1 with susceptibility to bipolar disorder but not major depression. | Breen G et al. | β | 2011 | β |
| The genetic association between personality and major depression or bipolar disorder. A polygenic score analysis using genome-wide association data. | Middeldorp CM et al. | β | 2011 | β |
| The impact of childhood abuse and recent stress on serum brain-derived neurotrophic factor and the moderating role of BDNF Val66Met. | Elzinga BM et al. | β | 2011 | β |
| The relationship of deiodinase 1 genotype and thyroid function to lifetime history of major depression in three independent populations. | Philibert RA et al. | β | 2011 | β |
| A genomewide association study of nicotine and alcohol dependence in Australian and Dutch populations. | Lind PA et al. | β | 2010 | β |
| Allelic based gene-gene interaction in case-control studies. | Jung J et al. | β | 2010 | β |
| Associations between ADH gene variants and alcohol phenotypes in Dutch adults. | van Beek JH et al. | β | 2010 | β |
| Duplication of the SLIT3 locus on 5q35.1 predisposes to major depressive disorder. | Glessner JT et al. | β | 2010 | β |
| Genetic epidemiology of attention deficit hyperactivity disorder (ADHD index) in adults. | Boomsma DI et al. | β | 2010 | β |
| Genome-wide association-, replication-, and neuroimaging study implicates HOMER1 in the etiology of major depression. | Rietschel M et al. | β | 2010 | β |
| Genome-wide association study (GWAS)-identified disease risk alleles do not compromise human longevity. | Beekman M et al. | β | 2010 | β |
| Meta-analysis of genome-wide association data identifies a risk locus for major mood disorders on 3p21.1. | McMahon FJ et al. | β | 2010 | β |
| Methylation at SLC6A4 is linked to family history of child abuse: an examination of the Iowa Adoptee sample. | Beach SRH et al. | β | 2010 | β |
| Stimulated gene expression profiles as a blood marker of major depressive disorder. | Spijker S et al. | β | 2010 | β |
| The genetics of mood disorders. | Lau JY et al. | β | 2010 | β |
| The Netherlands Twin Register biobank: a resource for genetic epidemiological studies. | Willemsen G et al. | β | 2010 | β |
| Variation, patterns, and temporal stability of DNA methylation: considerations for epigenetic epidemiology. | Talens RP et al. | β | 2010 | β |
| Application of pharmacogenomics to clinical problems in depression. | Oestergaard S et al. | β | 2009 | β |
| Common variants in TMPRSS6 are associated with iron status and erythrocyte volume. | Benyamin B et al. | β | 2009 | β |
| Delineation of two genetic pathways to major depression. | Kendler KS et al. | β | 2009 | β |
| Genome-wide association for major depressive disorder: a possible role for the presynaptic protein piccolo. | Sullivan PF et al. | β | 2009 | β |
| Genome-wide association study of exercise behavior in Dutch and American adults. | De Moor MH et al. | β | 2009 | β |
| Genome-wide association study of smoking initiation and current smoking. | Vink JM et al. | β | 2009 | β |
| Global similarity with local differences in linkage disequilibrium between the Dutch and HapMap-CEU populations. | Pardo L et al. | β | 2009 | β |
| Loci influencing lipid levels and coronary heart disease risk in 16 European population cohorts. | Aulchenko YS et al. | β | 2009 | β |
| Sequence variants in three loci influence monocyte counts and erythrocyte volume. | Ferreira MA et al. | β | 2009 | β |
| The BDNF Val66Met polymorphism impacts parahippocampal and amygdala volume in healthy humans: incremental support for a genetic risk factor for depression. | Montag C et al. | β | 2009 | β |
| The Netherlands Study of Depression and Anxiety (NESDA): rationale, objectives and methods. | Penninx BW et al. | β | 2008 | β |