New brain networks are active after right MCA stroke when moving the ipsilesional arm.
- Authors
- Hanlon, Colleen A; Buffington, Angela L H; McKeown, Martin J
- Year
- 2005
- Journal
- Neurology
- PMID
- 15642913
- DOI
- 10.1212/01.WNL.0000148726.45458.A9
OBJECTIVE: To determine whether, like the paretic arm, movement of the ipsilesional arm after middle cerebral artery (MCA) stroke is associated with widespread neural activation changes in areas anatomically and functionally connected to the lesion. METHODS: In this fMRI experiment, seven patients with right MCA stroke and seven healthy control subjects performed a series of movements with their (nonparetic) right hand. Subjects either mimicked a visual display (visually guided) or generated the same motor task after a visual start signal (self-monitored). A multivariate linear discriminant analysis was used to determine the combinations of brain regions of interest (ROIs) that demonstrated maximum differences in activation between healthy and stroke subjects. The analysis was repeated within subject groups to differentiate self-monitored and visually guided movement. RESULTS: There was a significantly different network of neural regions recruited for movement with the nonparetic, ipsilesional arm in patients with stroke vs healthy control subjects. The anterior cingulate cortex was significantly more active when patients execute self-monitored movement than visually guided movement, suggesting changes in attentional processing required for the two tasks. The lesioned hemisphere was significantly more active in patients with stroke using the nonparetic arm than in control subjects during visually guided movement. CONCLUSIONS: These results support a model of widespread bihemispheric reorganization in the motor system after a focal right hemisphere lesion. Attentional demands of self-monitored movement may be much greater than visually guided movement in patients, possibly impacting rehabilitation protocols for these patients.
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In this knowledge base
| Title | Year | PMID |
|---|---|---|
| Advances in Electrophysiological Research. | 2015 | 26259089 |
External
| Title | Authors | Journal | Year | Link |
|---|---|---|---|---|
| Poststroke Ipsilesional Motor Performance: Microstructural Biomarkers and Their Associations With Executive Function. | Kim Y et al. | — | 2025 | → |
| Connecting the dots: Motor and default mode network crossroads in post-stroke motor learning deficits. | Dahms C et al. | — | 2024 | → |
| Differentiated Effects of Robot Hand Training With and Without Neural Guidance on Neuroplasticity Patterns in Chronic Stroke. | Wang X et al. | — | 2018 | → |
| A comprehensive study of sensorimotor cortex excitability in chronic cocaine users: Integrating TMS and functional MRI data. | Hanlon CA et al. | — | 2015 | → |
| Advances in Electrophysiological Research. | Kamarajan C et al. | — | 2015 | → |
| A Randomized Controlled Trial of the Effect of Early Upper-Limb Training on Stroke Recovery and Brain Activation. | Hubbard IJ et al. | — | 2015 | → |
| A Review of Transcranial Magnetic Stimulation and Multimodal Neuroimaging to Characterize Post-Stroke Neuroplasticity. | Auriat AM et al. | — | 2015 | → |
| Neuroplastic changes in resting-state functional connectivity after stroke rehabilitation. | Fan YT et al. | — | 2015 | → |
| Resting state changes in functional connectivity correlate with movement recovery for BCI and robot-assisted upper-extremity training after stroke. | Várkuti B et al. | — | 2013 | → |
| Patients with severe poststroke fatigue show a psychosocial profile comparable to patients with other chronic disease: implications for diagnosis and treatment. | Zedlitz AM et al. | — | 2011 | → |
| Greater activation of secondary motor areas is related to less arm use after stroke. | Kokotilo KJ et al. | — | 2010 | → |
| Identification of critical areas for motor function recovery in chronic stroke subjects using voxel-based lesion symptom mapping. | Lo R et al. | — | 2010 | → |
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