Non-coding RNA in alcohol use disorder by affecting synaptic plasticity.
- Authors
- Zhu, Shuang; Wu, Jiaming; Hu, Jian
- Year
- 2022
- Journal
- Experimental brain research
- PMID
- 35028694
- DOI
- 10.1007/s00221-022-06305-x
Alcohol use disorder (AUD) is one of the most serious public health problems worldwide. AUD is a complex disorder, and there is ample evidence that genetic predisposition is critical to its development. Recent studies have shown that genetic predisposition leads to the onset of AUD, and alcohol metabolism can affect epigenetic inheritance, which in turn affects synaptic plasticity, alters brain function, and leads to more severe addictive behaviors. Non-coding RNAs (ncRNAs), especially microRNAs (miRNAs) and long non-coding RNAs (lncRNAs), play an important role in alcohol addiction. This paper reviews the regulatory role of ncRNAs. ncRNAs are involved in enzyme and neurotransmitter reaction systems during alcohol use disorder. Alcohol consumption regulates the expression of ncRNAs that mediate epigenetic modification and synaptic plasticity, which play an important role in the development of chronic AUD. ncRNAs may be used not only as predictors of therapeutic responses but also as therapeutic targets of AUD. Chronic alcoholism is more likely to lead to neuroimmune disorders, including permanent brain dysfunction. AUD induced by long-term alcoholism greatly alters the expression of genes in the human genome, especially the expression of ncRNAs. Alcohol can cause a series of pathological changes by interfering with gene expression, such as through disordered miRNA-mRNA expression networks, epigenetic modifications, disordered metabolism, and even synaptic remodeling. ncRNAs are involved in the transition from moderate drinking to alcohol dependence.
No figures extracted from this document.
No chunks — full text not yet ingested.
No entities extracted from this document yet.
No uploaded files.
No citations found.
In this knowledge base
| Title | Year | PMID |
|---|---|---|
| Alcohol reverses the effects of KCNJ6 (GIRK2) noncoding variants on excitability of human glutamatergic neurons. | 2023 | 36207584 |
External
| Title | Authors | Journal | Year | Link |
|---|---|---|---|---|
| Integrative Genomics Approach Identifies Glial Transcriptomic Dysregulation and Risk in the Cortex of Individuals With Alcohol Use Disorder. | Warden AS et al. | — | 2026 | → |
| Chronic Alcohol Use and Accelerated Brain Aging: Shared Mechanisms with Alzheimer's Disease Pathophysiology. | Singh N et al. | — | 2025 | → |
| Circulating microRNA profiling identifies microRNAs linked to prediabetes associated with alcohol dependence syndrome. | Ramaswamy P et al. | — | 2025 | → |
| m6A-modified lncRNA GAS5 promotes M1-polarization of microglia in alcohol use disorder. | Zhu S et al. | — | 2025 | → |
| Recent Advances in the Role of Non-coding RNAs in Fetal Alcohol Spectrum Disorders. | Pritha AN et al. | — | 2025 | → |
| Brain lncRNA-mRNA co-expression regulatory networks and alcohol use disorder. | Besong OTO et al. | — | 2024 | → |
| Alcohol reverses the effects of KCNJ6 (GIRK2) noncoding variants on excitability of human glutamatergic neurons. | Popova D et al. | — | 2023 | → |
| Functional roles, regulatory mechanisms and theranostics applications of ncRNAs in alcohol use disorder. | Wang JQ et al. | — | 2023 | → |
| Is DNA methylation in the brain a mechanism of alcohol use disorder? | Jarczak J et al. | — | 2023 | → |
| Polygenic influences on the behavioral effects of alcohol withdrawal in a mixed-ancestry population from the collaborative study on the genetics of alcoholism (COGA). | Benca-Bachman CE et al. | — | 2023 | → |
| Integrating nutriepigenomics in Parkinson's disease management: New promising strategy in the omics era. | Razali K et al. | — | 2022 | → |
| Long Non-Coding RNAs: The New Frontier into Understanding the Etiology of Alcohol Use Disorder. | Denham AN et al. | — | 2022 | → |
| MicroRNA Regulation of the Environmental Impact on Adolescent Neurobehavioral Development: A Systematic Review. | Vázquez-Ágredos A et al. | — | 2022 | → |