Gene coexpression networks in human brain identify epigenetic modifications in alcohol dependence.
paper
Cited
Public
Unavailable
- Authors
- Ponomarev, Igor; Wang, Shi; Zhang, Lingling; Harris, R Adron; Mayfield, R Dayne
- Year
- 2012
- Journal
- The Journal of neuroscience : the official journal of the Society for Neuroscience
- PMID
- 22302827
- DOI
- 10.1523/JNEUROSCI.3136-11.2012
- PMCID
- PMC3564514
Alcohol abuse causes widespread changes in gene expression in human brain, some of which contribute to alcohol dependence. Previous microarray studies identified individual genes as candidates for alcohol phenotypes, but efforts to generate an integrated view of molecular and cellular changes underlying alcohol addiction are lacking. Here, we applied a novel systems approach to transcriptome profiling in postmortem human brains and generated a systemic view of brain alterations associated with alcohol abuse. We identified critical cellular components and previously unrecognized epigenetic determinants of gene coexpression relationships and discovered novel markers of chromatin modifications in alcoholic brain. Higher expression levels of endogenous retroviruses and genes with high GC content in alcoholics were associated with DNA hypomethylation and increased histone H3K4 trimethylation, suggesting a critical role of epigenetic mechanisms in alcohol addiction. Analysis of cell-type-specific transcriptomes revealed remarkable consistency between molecular profiles and cellular abnormalities in alcoholic brain. Based on evidence from this study and others, we generated a systems hypothesis for the central role of chromatin modifications in alcohol dependence that integrates epigenetic regulation of gene expression with pathophysiological and neuroadaptive changes in alcoholic brain. Our results offer implications for epigenetic therapeutics in alcohol and drug addiction.
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|---|---|---|---|---|
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| Central amygdala single-nucleus atlas reveals chromatin and gene transcription dynamics in human alcohol use disorder. | Lee CY et al. | β | 2026 | β |
| Chronic alcohol consumption sex-dependently affects IL-6 modulation of GABAergic synapses in the central amygdala of rhesus macaques. | Bajo M et al. | β | 2026 | β |
| Cortical reactive microglia activate astrocytes, increasing neurodegeneration in human alcohol use disorder. | Crews FT et al. | β | 2026 | β |
| Integrative Genomics Approach Identifies Glial Transcriptomic Dysregulation and Risk in the Cortex of Individuals With Alcohol Use Disorder. | Warden AS et al. | β | 2026 | β |
| Alcohol Use Disorder and the Gut-Brain Axis: A Narrative Review of the Role of Gut Microbiota and Implications for Treatment. | Shukla S et al. | β | 2025 | β |
| A systematic review and meta-analysis on the transcriptomic signatures in alcohol use disorder. | Friske MM et al. | β | 2025 | β |
| Cell-type specific epigenetic and transcriptional mechanisms in substance use disorder. | Wang B et al. | β | 2025 | β |
| Drug-Induced Epigenetic Alterations: A Set of Forensic Toxicological Fingerprints?-A Systematic Review. | Grassi S et al. | β | 2025 | β |
| Effects of innate immune activation by Toll-like receptor agonists on ethanol consumption and preference in FVB/NJ x C57BL/6J hybrid mice | Kisby BR et al. | β | 2025 | β |
| Epigenetic Insights into Substance Use Disorder and Associated Psychiatric Conditions. | Ngo AL et al. | β | 2025 | β |
| Functional Consequences Paternal Preconceptual Alcohol Consumption. | Hussain S et al. | β | 2025 | β |
| Gene expression differences associated with alcohol use disorder in human brain. | Willis C et al. | β | 2025 | β |
| piRNA/PIWI pathways and epigenetic crosstalk in human diseases: Molecular insights into HIV-1 infection and drugs of abuse. | Chennakesavan K et al. | β | 2025 | β |
| Sex differences in nucleus accumbens circuitry engaged with binge-like ethanol drinking. | Chan AE et al. | β | 2025 | β |
| Systematic screening and dynamic profiling of germline regulatory pathways and spermatogonial surface markers in a bivalve mollusc. | Liu L et al. | β | 2025 | β |
| Targeting IL-6 as a novel therapeutic approach for alcohol abstinence - related mechanical allodynia. | Borgonetti V et al. | β | 2025 | β |
| Transcriptome characterization of three main ganglia in Patinopecten yessoensis provides novel insights into a monophyletic origin of the bilaterian central nervous system. | Ning X et al. | β | 2025 | β |
| Adaptations in glutathione-based redox protein signaling pathways and alcohol drinking across species. | Womersley JS et al. | β | 2024 | β |
| Adolescent binge ethanol impacts H3K9me3-occupancy at synaptic genes and the regulation of oligodendrocyte development. | Brocato ER et al. | β | 2024 | β |
| Alcohol: Epigenome alteration and inter/transgenerational effect. | Heidari N et al. | β | 2024 | β |
| Calling the question: what is mammalian transgenerational epigenetic inheritance? | Khatib H et al. | β | 2024 | β |
| Epigenetic drugs and psychedelics as emerging therapies for alcohol use disorder: insights from preclinical studies. | Hilal FF et al. | β | 2024 | β |
| Human genetics and epigenetics of alcohol use disorder. | Zhou H et al. | β | 2024 | β |
| Identification of novel genetic loci and candidate genes for progressive ethanol consumption in diversity outbred mice. | Mignogna KM et al. | β | 2024 | β |
| The Impact of Alcohol-Induced Epigenetic Modifications in the Treatment of Alcohol use Disorders. | Fanfarillo F et al. | β | 2024 | β |
| Adaptor protein complex 2 in the orbitofrontal cortex predicts alcohol use disorder. | Mulholland PJ et al. | β | 2023 | β |
| Adolescent binge ethanol impacts H3K36me3 regulation of synaptic genes. | Brocato ER et al. | β | 2023 | β |
| Analysis of the brain transcriptome for substance-associated genes: An update on large-scale genome-wide association studies. | Zhao Y et al. | β | 2023 | β |
| A study of differential microRNA expression profile in migraine: the microMIG exploratory study. | Gallardo VJ et al. | β | 2023 | β |
| Chemical Genetic Identification of PKC Epsilon Substrates in Mouse Brain. | Dugan MP et al. | β | 2023 | β |
| Chronic Voluntary Alcohol Consumption Alters Promoter Methylation and Expression of <i>Fgf-2</i> and <i>Fgfr1</i>. | Herburg L et al. | β | 2023 | β |
| Comparing DRD2 Promoter Methylation Between Blood and Brain in Alcohol Dependence. | Arfmann W et al. | β | 2023 | β |
| Gene network analyses of larvae under different egg-protecting behaviors provide novel insights into immune response mechanisms of Amphioctopus fangsiao. | Li Z et al. | β | 2023 | β |
| Gene network analyses of Sepia esculenta larvae exposed to copper and cadmium: A comprehensive investigation of oxidative stress, immune response, and toxicological mechanisms. | Li Z et al. | β | 2023 | β |
| IL-18 Signaling in the Rat Central Amygdala Is Disrupted in a Comorbid Model of Post-Traumatic Stress and Alcohol Use Disorder. | Borgonetti V et al. | β | 2023 | β |
| Integrative Analysis of Proteome-wide Association Studies and Functional Enrichment Analysis to Identify Genes and Chemicals Associated with Alcohol Dependence. | Zhang J et al. | β | 2023 | β |
| Investigation of Gene Networks in Three Components of Immune System Provides Novel Insights into Immune Response Mechanisms against <i>Edwardsiella tarda</i> Infection in <i>Paralichthys olivaceus</i>. | Liu X et al. | β | 2023 | β |
| Maternal Immune Activation and Enriched Environments Impact B2 SINE Expression in Stress Sensitive Brain Regions of Rodent Offspring. | Richter TA et al. | β | 2023 | β |
| Molecular mechanisms of alcohol's effects on the human body: A review and update. | Renu K et al. | β | 2023 | β |
| Sex-dependent factors of alcohol and neuroimmune mechanisms. | Cruz B et al. | β | 2023 | β |
| Targeted Therapy for Orofacial Pain: A Novel Perspective for Precision Medicine. | Raman S et al. | β | 2023 | β |
| Transcriptional and epigenetic regulation of microglia in substance use disorders. | Vilca SJ et al. | β | 2023 | β |
| Alcohol-Associated Tissue Injury: Current Views on Pathophysiological Mechanisms. | Simon L et al. | β | 2022 | β |
| An Overview of Epigenetics in Obesity: The Role of Lifestyle and Therapeutic Interventions. | Mahmoud AM | β | 2022 | β |
| Blood and brain gene expression signatures of chronic intermittent ethanol consumption in mice. | Ferguson LB et al. | β | 2022 | β |
| Chloride intracellular channel 4 (CLIC4) expression profile in the mouse medial prefrontal cortex and its regulation by ethanol. | Bogenpohl JW et al. | β | 2022 | β |
| DNA Epigenetics in Addiction Susceptibility. | Kaplan G et al. | β | 2022 | β |
| Dynamic transcriptome analysis reveals the gene network of gonadal development from the early history life stages in dwarf surfclam Mulinia lateralis. | Li Y et al. | β | 2022 | β |
| FACTORS CONTRIBUTING TO THE ESCALATION OF ALCOHOL CONSUMPTION. | Bowen MT et al. | β | 2022 | β |
| GeneCup: mining PubMed and GWAS catalog for gene-keyword relationships. | Gunturkun MH et al. | β | 2022 | β |
| Genome-wide association mapping of ethanol sensitivity in the Diversity Outbred mouse population. | Parker CC et al. | β | 2022 | β |
| Inhibitors of DNA Methylation. | Lopez M et al. | β | 2022 | β |
| L1 Retrotransposons: A Potential Endogenous Regulator for Schizophrenia. | Jahangir M et al. | β | 2022 | β |
| Multi-omics signatures of alcohol use disorder in the dorsal and ventral striatum. | Zillich L et al. | β | 2022 | β |
| Multiple Myeloma: Challenges Encountered and Future Options for Better Treatment. | Das S et al. | β | 2022 | β |
| Prenatal and adolescent alcohol exposure programs immunity across the lifespan: CNS-mediated regulation. | Deak T et al. | β | 2022 | β |
| Sex differences in stress-induced alcohol intake: a review of preclinical studies focused on amygdala and inflammatory pathways. | Mineur YS et al. | β | 2022 | β |
| Sleep, sleep homeostasis and arousal disturbances in alcoholism. | Sharma R et al. | β | 2022 | β |
| The Role of Transposable Elements of the Human Genome in Neuronal Function and Pathology. | Chesnokova E et al. | β | 2022 | β |
| Unraveling the epigenomic and transcriptomic interplay during alcohol-induced anxiolysis. | Krishnan HR et al. | β | 2022 | β |
| Alcohol Dependence in Rats Is Associated with Global Changes in Gene Expression in the Central Amygdala. | Kisby BR et al. | β | 2021 | β |
| Alcohol-induced aggression in Drosophila. | Park A et al. | β | 2021 | β |
| Changes in DNA methylation persist over time in males with severe alcohol use disorder-A longitudinal follow-up study. | Soundararajan S et al. | β | 2021 | β |
| Chronic Alcohol Use Induces Molecular Genetic Changes in the Dorsomedial Thalamus of People with Alcohol-Related Disorders. | Hade AC et al. | β | 2021 | β |
| Contribution of TSPO imaging in the understanding of the state of gliosis in substance use disorders. | Leroy C et al. | β | 2021 | β |
| Cortical astrocytes regulate ethanol consumption and intoxication in mice. | Erickson EK et al. | β | 2021 | β |
| Detection of altered methylation of MB-COMT promotor and DRD2 gene in cannabinoid or synthetic cannabinoid use disorder regarding gene variants and clinical parameters. | Oyaci Y et al. | β | 2021 | β |
| Differential regulation of alcohol consumption and reward by the transcriptional cofactor LMO4. | Maiya R et al. | β | 2021 | β |
| Dysregulation of the histone demethylase KDM6B in alcohol dependence is associated with epigenetic regulation of inflammatory signaling pathways. | Johnstone AL et al. | β | 2021 | β |
| Effect of chronic ethanol consumption in rhesus macaques on the nucleus accumbens core transcriptome. | Walter N et al. | β | 2021 | β |
| Epigenetic landscape of stress surfeit disorders: Key role for DNA methylation dynamics. | Gatta E et al. | β | 2021 | β |
| Epigenetic modification in alcohol use disorder and alcoholic cardiomyopathy: From pathophysiology to therapeutic opportunities. | Wu L et al. | β | 2021 | β |
| Exploration of the Role of Serine Proteinase Inhibitor A3 in Alcohol Dependence Using Gene Expression Omnibus Database. | Zhang B et al. | β | 2021 | β |
| Factors Regulating the Activity of LINE1 Retrotransposons. | Protasova MS et al. | β | 2021 | β |
| Gene Expression Differences Between Young Adults Based on Trauma History and Post-traumatic Stress Disorder. | Bountress KE et al. | β | 2021 | β |
| Gene expression signatures differentiating major depressive disorder from subsyndromal symptomatic depression. | Hu G et al. | β | 2021 | β |
| Genome-wide admixture mapping of DSM-IV alcohol dependence, criterion count, and the self-rating of the effects of ethanol in African American populations. | Lai D et al. | β | 2021 | β |
| Genome-wide methylation in alcohol use disorder subjects: implications for an epigenetic regulation of the cortico-limbic glucocorticoid receptors (NR3C1). | Gatta E et al. | β | 2021 | β |
| Global and glucocorticoid receptor gene-specific (NR3C1) DNA methylation analysis in patients with cannabinoid or synthetic cannabinoid use disorder. | Pehlivan S et al. | β | 2021 | β |
| Histone Methylation Regulation in Neurodegenerative Disorders. | Basavarajappa BS et al. | β | 2021 | β |
| Histone modifications, DNA methylation, and the epigenetic code of alcohol use disorder. | Bohnsack JP et al. | β | 2021 | β |
| IL-10 normalizes aberrant amygdala GABA transmission and reverses anxiety-like behavior and dependence-induced escalation of alcohol intake. | Patel RR et al. | β | 2021 | β |
| Increased transcription of TSPO, HDAC2, and HDAC6 in the amygdala of males with alcohol use disorder. | De Carvalho LM et al. | β | 2021 | β |
| Microglia depletion and alcohol: Transcriptome and behavioral profiles. | Warden AS et al. | β | 2021 | β |
| Social isolation-related depression accelerates ethanol intake via microglia-derived neuroinflammation. | Lee JS et al. | β | 2021 | β |
| Targeting Epigenetic Mechanisms to Treat Alcohol Use Disorders (AUD). | Rodriguez FD | β | 2021 | β |
| The Molecular Basis of Alcohol Use Disorder (AUD). Genetics, Epigenetics, and Nutrition in AUD: An Amazing Triangle. | Siomek-Gorecka A et al. | β | 2021 | β |
| Acetylcholine Muscarinic M<sub>4</sub> Receptors as a Therapeutic Target for Alcohol Use Disorder: Converging Evidence From Humans and Rodents. | Walker LC et al. | β | 2020 | β |
| Advances in Nutritional Epigenetics-A Fresh Perspective for an Old Idea. Lessons Learned, Limitations, and Future Directions. | Sedley L | β | 2020 | β |
| Assessing the Role of Long Noncoding RNA in Nucleus Accumbens in Subjects With Alcohol Dependence. | Drake J et al. | β | 2020 | β |
| Bioinformatics identification and pharmacological validation of Kcnn3/K<sub>Ca</sub>2 channels as a mediator of negative affective behaviors and excessive alcohol drinking in mice. | Padula AE et al. | β | 2020 | β |
| Brain regional gene expression network analysis identifies unique interactions between chronic ethanol exposure and consumption. | Smith ML et al. | β | 2020 | β |
| Differential Responses of LINE-1 in the Dentate Gyrus, Striatum and Prefrontal Cortex to Chronic Neurotoxic Methamphetamine: A Study in Rat Brain. | Moszczynska A | β | 2020 | β |
| Effects of chronic intermittent ethanol exposure and withdrawal on neuroblastoma cell transcriptome. | McClintick JN et al. | β | 2020 | β |
| Effects of Tacrolimus and Other Immune Targeting Compounds on Binge-Like Ethanol Drinking in High Drinking in the Dark Mice. | Grigsby KB et al. | β | 2020 | β |
| Epigenetic mechanisms underlying pathobiology of alcohol use disorder. | Dulman RS et al. | β | 2020 | β |
| Ethanol-Induced Changes in Brain of Transgenic Mice Overexpressing DYRK1A. | Fructuoso M et al. | β | 2020 | β |
| Flying Together: <i>Drosophila</i> as a Tool to Understand the Genetics of Human Alcoholism. | Lathen DR et al. | β | 2020 | β |
| Further evidence for the involvement of the PPARΞ³ system on alcohol intake and sensitivity in rodents. | Domi E et al. | β | 2020 | β |
| Gene network analysis reveals a core set of genes involved in the immune response of Japanese flounder (Paralichthys olivaceus) against Vibrio anguillarum infection. | Ning X et al. | β | 2020 | β |
| Genetic Architecture and Molecular Neuropathology of Human Cocaine Addiction. | Huggett SB et al. | β | 2020 | β |
| Interplay between Metabolism, Nutrition and Epigenetics in Shaping Brain DNA Methylation, Neural Function and Behavior. | Pizzorusso T et al. | β | 2020 | β |
| Microglia Control Escalation of Drinking in Alcohol-Dependent Mice: Genomic and Synaptic Drivers. | Warden AS et al. | β | 2020 | β |
| Suicide and suicide behaviors: A review of transcriptomics and multiomics studies in psychiatric disorders. | Zhou Y et al. | β | 2020 | β |
| Systems genetics analysis of the LXS recombinant inbred mouse strains:Genetic and molecular insights into acute ethanol tolerance. | Radcliffe RA et al. | β | 2020 | β |
| Altered amygdala DNA methylation mechanisms after adolescent alcohol exposure contribute to adult anxiety and alcohol drinking. | Sakharkar AJ et al. | β | 2019 | β |
| A Pathway-Based Genomic Approach to Identify Medications: Application to Alcohol Use Disorder. | Ferguson LB et al. | β | 2019 | β |
| Chronic heavy drinking drives distinct transcriptional and epigenetic changes in splenic macrophages. | Sureshchandra S et al. | β | 2019 | β |
| Chronic Intermittent Ethanol Exposure Induces Upregulation of Matrix Metalloproteinase-9 in the Rat Medial Prefrontal Cortex and Hippocampus. | Yin L et al. | β | 2019 | β |
| Cross-Species Co-analysis of Prefrontal Cortex Chronic Ethanol Transcriptome Responses in Mice and Monkeys. | Bogenpohl JW et al. | β | 2019 | β |
| Dissecting Brain Networks Underlying Alcohol Binge Drinking Using a Systems Genomics Approach. | Ferguson LB et al. | β | 2019 | β |
| DNA methylation correlates of PTSD: Recent findings and technical challenges. | Morrison FG et al. | β | 2019 | β |
| Dose-dependent effects of chronic alcohol drinking on peripheral immune responses. | Sureshchandra S et al. | β | 2019 | β |
| Early life exposures, neurodevelopmental disorders, and transposable elements. | Lapp HE et al. | β | 2019 | β |
| Environmental stressors and alcoholism development: Focus on molecular targets and their epigenetic regulation. | Pucci M et al. | β | 2019 | β |
| Epigenetic regulation of motivated behaviors by histone deacetylase inhibitors. | Elvir L et al. | β | 2019 | β |
| Ethanol activates immune response in lymphoblastoid cells. | McClintick JN et al. | β | 2019 | β |
| Gene Saturation: An Approach to Assess Exploration Stage of Gene Interaction Networks. | Yin Z et al. | β | 2019 | β |
| Glial gene networks associated with alcohol dependence. | Erickson EK et al. | β | 2019 | β |
| How alcohol drinking affects our genes: an epigenetic point of view. | CiafrΓ¨ S et al. | β | 2019 | β |
| Intergenerational Effects of Alcohol: A Review of Paternal Preconception Ethanol Exposure Studies and Epigenetic Mechanisms in the Male Germline. | Rompala GR et al. | β | 2019 | β |
| Neuroimmune signaling in alcohol use disorder. | Erickson EK et al. | β | 2019 | β |
| Optimal pathways involved in the treatment of sevoflurane or propofol for patients undergoing coronary artery bypass graft surgery. | Pan ZG et al. | β | 2019 | β |
| Shared Molecular Neuropathology Across Major Psychiatric Disorders Parallels Polygenic Overlap. | Gandal MJ et al. | β | 2019 | β |
| Studying alcohol use disorder using Drosophila melanogaster in the era of 'Big Data'. | Engel GL et al. | β | 2019 | β |
| Systemic Administration of the Cyclin-Dependent Kinase Inhibitor (S)-CR8 Selectively Reduces Escalated Ethanol Intake in Dependent Rats. | Goulding SP et al. | β | 2019 | β |
| The Neuroscience of Drug Reward and Addiction. | Volkow ND et al. | β | 2019 | β |
| Toll-like receptor 3 activation increases voluntary alcohol intake in C57BL/6J male mice. | Warden AS et al. | β | 2019 | β |
| Toll-like receptor 3 dynamics in female C57BL/6J mice: Regulation of alcohol intake. | Warden AS et al. | β | 2019 | β |
| Transcription of human endogenous retroviruses in human brain by RNA-seq analysis. | Li F et al. | β | 2019 | β |
| Transcriptomic Profiling Provides Insights into Inbreeding Depression in Yesso Scallop Patinopecten yessoensis. | Zhao L et al. | β | 2019 | β |
| Transposable Elements. | Guffanti G et al. | β | 2019 | β |
| Alcohol exposure promotes DNA methyltransferase DNMT3A upregulation through reactive oxygen species-dependent mechanisms. | Miozzo F et al. | β | 2018 | β |
| Astrocyte-specific transcriptome responses to chronic ethanol consumption. | Erickson EK et al. | β | 2018 | β |
| A support vector machine and a random forest classifier indicates a 15-miRNA set related to osteosarcoma recurrence. | He Y et al. | β | 2018 | β |
| Chronic Alcohol, Intrinsic Excitability, and Potassium Channels: Neuroadaptations and Drinking Behavior. | Cannady R et al. | β | 2018 | β |
| CIS-Acting Allele-Specific Expression Differences Induced by Alcohol and Impacted by Sex as Well as Parental Genotype of Origin. | Lo CL et al. | β | 2018 | β |
| DNA methylation of methylation complex genes in relation to stress and genome-wide methylation in mother-newborn dyads. | Clukay CJ et al. | β | 2018 | β |
| DNA methylation signatures: Biomarkers of drug and alcohol abuse. | Mahna D et al. | β | 2018 | β |
| Elementary screening of lymph node metastatic-related genes in gastric cancer based on the co-expression network of messenger RNA, microRNA and long non-coding RNA. | Song Z et al. | β | 2018 | β |
| Epigenetic Mechanisms of Alcohol Neuroadaptation: Insights from <i>Drosophila</i>. | Ramirez-Roman ME et al. | β | 2018 | β |
| Ethanol actions on the ventral tegmental area: novel potential targets on reward pathway neurons. | You C et al. | β | 2018 | β |
| Ethanol and Cytokines in the Central Nervous System. | Roberto M et al. | β | 2018 | β |
| Exploration of gene functions for esophageal squamous cell carcinoma using network-based guilt by association principle. | Wu W et al. | β | 2018 | β |
| Exploring Potential Biomarkers Underlying Pathogenesis of Alzheimer's Disease by Differential Co-expression Analysis. | Izadi F et al. | β | 2018 | β |
| Integrating Genetic and Gene Co-expression Analysis Identifies Gene Networks Involved in Alcohol and Stress Responses. | Luo J et al. | β | 2018 | β |
| Investigational drugs for alcohol use disorders: a review of preclinical data. | Ch'Ng SS et al. | β | 2018 | β |
| Molecular Neuropathology of Astrocytes and Oligodendrocytes in Alcohol Use Disorders. | Miguel-Hidalgo JJ | β | 2018 | β |
| Neuroepigenetics and addiction. | Walker DM et al. | β | 2018 | β |
| Noncoding RNAs: Stress, Glucocorticoids, and Posttraumatic Stress Disorder. | Daskalakis NP et al. | β | 2018 | β |
| On the relationships in rhesus macaques between chronic ethanol consumption and the brain transcriptome. | Iancu OD et al. | β | 2018 | β |
| Overexpression of LINE-1 Retrotransposons in Autism Brain. | Shpyleva S et al. | β | 2018 | β |
| Peroxisome Proliferator Activated Receptor Agonists Modulate Transposable Element Expression in Brain and Liver. | Ferguson LB et al. | β | 2018 | β |
| Shared molecular neuropathology across major psychiatric disorders parallels polygenic overlap. | Gandal MJ et al. | β | 2018 | β |
| Stable Histone Methylation Changes at Proteoglycan Network Genes Following Ethanol Exposure. | Gavin DP et al. | β | 2018 | β |
| The Role of DNA Methylation in Drug Addiction: Implications for Diagnostic and Therapeutics. | Lax E et al. | β | 2018 | β |
| Transcriptional Regulators as Targets for Alcohol Pharmacotherapies. | Savarese AM et al. | β | 2018 | β |
| Alcohol effects on the epigenome in the germline: Role in the inheritance of alcohol-related pathology. | Chastain LG et al. | β | 2017 | β |
| Alcohol-Induced Behaviors Require a Subset of Drosophila JmjC-Domain Histone Demethylases in the Nervous System. | PinzΓ³n JH et al. | β | 2017 | β |
| Behavioral Deficits Following Withdrawal from Chronic Ethanol Are Influenced by SLO Channel Function in <i>Caenorhabditis elegans</i>. | Scott LL et al. | β | 2017 | β |
| Bioinformatics Tools for Genome-Wide Epigenetic Research. | Angarica VE et al. | β | 2017 | β |
| Chronic Alcohol Exposure Differentially Alters One-Carbon Metabolism in Rat Liver and Brain. | Auta J et al. | β | 2017 | β |
| Differential potassium channel gene regulation in BXD mice reveals novel targets for pharmacogenetic therapies to reduce heavy alcohol drinking. | Rinker JA et al. | β | 2017 | β |
| Disconnect between alcohol-induced alterations in chromatin structure and gene transcription in a mouse embryonic stem cell model of exposure. | Veazey KJ et al. | β | 2017 | β |
| DNA modifications in models of alcohol use disorders. | Tulisiak CT et al. | β | 2017 | β |
| Drug Addiction and DNA Modifications. | Brown AN et al. | β | 2017 | β |
| Emerging Role of Epigenetic Mechanisms in Alcohol Addiction. | Berkel TD et al. | β | 2017 | β |
| Emerging Role of One-Carbon Metabolism and DNA Methylation Enrichment on Ξ΄-Containing GABAA Receptor Expression in the Cerebellum of Subjects with Alcohol Use Disorders (AUD). | Gatta E et al. | β | 2017 | β |
| Epigenetic Interactions between Alcohol and Cannabinergic Effects: Focus on Histone Modification and DNA Methylation. | Parira T et al. | β | 2017 | β |
| Epigenetic mechanisms of alcoholism and stress-related disorders. | Palmisano M et al. | β | 2017 | β |
| Epigenetic mediators and consequences of excessive alcohol consumption. | Mahnke AH et al. | β | 2017 | β |
| Epigenetics: a link between addiction and social environment. | Ajonijebu DC et al. | β | 2017 | β |
| Ethanol affects limbic and striatal presynaptic glutamatergic and DNA methylation gene expression in outbred rats exposed to early-life stress. | Vrettou M et al. | β | 2017 | β |
| Ethanol Exposure Regulates <i>Gabra1</i> Expression via Histone Deacetylation at the Promoter in Cultured Cortical Neurons. | Bohnsack JP et al. | β | 2017 | β |
| Gene expression profiling in the human alcoholic brain. | Warden AS et al. | β | 2017 | β |
| Genetic divergence in the transcriptional engram of chronic alcohol abuse: A laser-capture RNA-seq study of the mouse mesocorticolimbic system. | Mulligan MK et al. | β | 2017 | β |
| Genetic studies of alcohol dependence in the context of the addiction cycle. | Reilly MT et al. | β | 2017 | β |
| Genetic variation in the exome: Associations with alcohol and tobacco co-use. | Otto JM et al. | β | 2017 | β |
| Genome to Phenome: A Systems Biology Approach to PTSD Using an Animal Model. | Chakraborty N et al. | β | 2017 | β |
| L1 retrotransposition alters the hippocampal genomic landscape enabling memory formation. | Bachiller S et al. | β | 2017 | β |
| Mechanistic insights into epigenetic modulation of ethanol consumption. | Ponomarev I et al. | β | 2017 | β |
| Pharmacoepigenomics of opiates and methadone maintenance treatment: current data and perspectives. | Marie-Claire C et al. | β | 2017 | β |
| Prediction of optimal gene functions for osteosarcoma using network-based- guilt by association method based on gene oncology and microarray profile. | Chen X | β | 2017 | β |
| Prefrontal cortex expression of chromatin modifier genes in male WSP and WSR mice changes across ethanol dependence, withdrawal, and abstinence. | Hashimoto JG et al. | β | 2017 | β |
| Promising pharmacogenetic targets for treating alcohol use disorder: evidence from preclinical models. | Rinker JA et al. | β | 2017 | β |
| Small RNA Pathways That Protect the Somatic Genome. | Hyun S | β | 2017 | β |
| Synaptic targets: Chronic alcohol actions. | Roberto M et al. | β | 2017 | β |
| The recent progress in animal models of depression. | Wang Q et al. | β | 2017 | β |
| Tobacco and alcohol use during adolescence: Interactive mechanisms in animal models. | Abreu-VillaΓ§a Y et al. | β | 2017 | β |
| Transcriptomic profiling of the human brain reveals that altered synaptic gene expression is associated with chronological aging. | Dillman AA et al. | β | 2017 | β |
| Uncovering robust patterns of microRNA co-expression across cancers using Bayesian Relevance Networks. | Ramachandran P et al. | β | 2017 | β |
| A Genetic Animal Model of Alcoholism for Screening Medications to Treat Addiction. | Bell RL et al. | β | 2016 | β |
| Alcohol consumption induces global gene expression changes in VTA dopaminergic neurons. | Marballi K et al. | β | 2016 | β |
| Alcohol Induces Parallel Changes in Hippocampal Histone H3 Phosphorylation and c-Fos Protein Expression in Male Rats. | McClain JA et al. | β | 2016 | β |
| Alcohol resistance in Drosophila is modulated by the Toll innate immune pathway. | Troutwine BR et al. | β | 2016 | β |
| Altered expression of mRNA profiles in blood of early-onset schizophrenia. | Xu Y et al. | β | 2016 | β |
| An Exploratory Association Study of Alcohol Use Disorder and DNA Methylation. | Hagerty SL et al. | β | 2016 | β |
| A Systems Approach Implicates a Brain Mitochondrial Oxidative Homeostasis Co-expression Network in Genetic Vulnerability to Alcohol Withdrawal. | Walter NA et al. | β | 2016 | β |
| Chromothripsis and epigenomics complete causality criteria for cannabis- and addiction-connected carcinogenicity, congenital toxicity and heritable genotoxicity. | Reece AS et al. | β | 2016 | β |
| Chronic Intermittent Ethanol Exposure Enhances the Excitability and Synaptic Plasticity of Lateral Orbitofrontal Cortex Neurons and Induces a Tolerance to the Acute Inhibitory Actions of Ethanol. | Nimitvilai S et al. | β | 2016 | β |
| Downregulation of ARHGDIA contributes to human glioma progression through activation of Rho GTPase signaling pathway. | Lu W et al. | β | 2016 | β |
| Epigenetic Modifications, Alcoholic Brain and Potential Drug Targets. | Jangra A et al. | β | 2016 | β |
| Epigenetic regulation of nociceptin/orphanin FQ and corticotropin-releasing factor system genes in frustration stress-induced binge-like palatable food consumption. | Pucci M et al. | β | 2016 | β |
| Epigenetics of Stress, Addiction, and Resilience: Therapeutic Implications. | Cadet JL | β | 2016 | β |
| Exploring Transcription Factors-microRNAs Co-regulation Networks in Schizophrenia. | Xu Y et al. | β | 2016 | β |
| From genetic studies to precision medicine in alcohol dependence. | Sun Y et al. | β | 2016 | β |
| Functional Genomic Analyses Identify Pathways Dysregulated in Animal Model of Autism. | Huang JY et al. | β | 2016 | β |
| Genes and Alcohol Consumption: Studies with Mutant Mice. | Mayfield J et al. | β | 2016 | β |
| Inverse changes in L1 retrotransposons between blood and brain in major depressive disorder. | Liu S et al. | β | 2016 | β |
| Involvement of TLR4 in the long-term epigenetic changes, rewarding and anxiety effects induced by intermittent ethanol treatment in adolescence. | Montesinos J et al. | β | 2016 | β |
| Localization of PPAR isotypes in the adult mouse and human brain. | Warden A et al. | β | 2016 | β |
| Modular reorganization of the global network of gene regulatory interactions during perinatal human brain development. | MonzΓ³n-Sandoval J et al. | β | 2016 | β |
| Molecular mechanisms underlying alcohol-drinking behaviours. | Ron D et al. | β | 2016 | β |
| Profiling ethanol-targeted transcription factors in human carcinoma cell-derived embryoid bodies. | Mandal C et al. | β | 2016 | β |
| Rescuing prefrontal cAMP-CREB pathway reverses working memory deficits during withdrawal from prolonged alcohol exposure. | Dominguez G et al. | β | 2016 | β |
| RNA Sequencing Reveals the Alteration of the Expression of Novel Genes in Ethanol-Treated Embryoid Bodies. | Mandal C et al. | β | 2016 | β |
| Role of Growth Arrest and DNA Damage-Inducible, Beta in Alcohol-Drinking Behaviors. | Gavin DP et al. | β | 2016 | β |
| Synaptic microRNAs Coordinately Regulate Synaptic mRNAs: Perturbation by Chronic Alcohol Consumption. | Most D et al. | β | 2016 | β |
| The association of HTR3A mRNA expression and craving in Han Chinese alcohol-dependent patients: a preliminary study. | Xu YH et al. | β | 2016 | β |
| The developmental transcriptome atlas of the biofuel crop Camelina sativa. | Kagale S et al. | β | 2016 | β |
| The dynamic genome: transposons and environmental adaptation in the nervous system. | Lapp HE et al. | β | 2016 | β |
| The neuroimmune transcriptome and alcohol dependence: potential for targeted therapies. | Warden A et al. | β | 2016 | β |
| Time-Course Analysis of Brain Regional Expression Network Responses to Chronic Intermittent Ethanol and Withdrawal: Implications for Mechanisms Underlying Excessive Ethanol Consumption. | Smith ML et al. | β | 2016 | β |
| "Boomerang Neuropathology" of Late-Onset Alzheimer's Disease is Shrouded in Harmful "BDDS": Breathing, Diet, Drinking, and Sleep During Aging. | Daulatzai MA | β | 2015 | β |
| Brain plasticity and cognitive functions after ethanol consumption in C57BL/6J mice. | Stragier E et al. | β | 2015 | β |
| Canonical genetic signatures of the adult human brain. | Hawrylycz M et al. | β | 2015 | β |
| Chronic ethanol exposure produces time- and brain region-dependent changes in gene coexpression networks. | Osterndorff-Kahanek EA et al. | β | 2015 | β |
| Current and Future Prospects for Epigenetic Biomarkers of Substance Use Disorders. | Andersen AM et al. | β | 2015 | β |
| Dose-dependent alcohol-induced alterations in chromatin structure persist beyond the window of exposure and correlate with fetal alcohol syndrome birth defects. | Veazey KJ et al. | β | 2015 | β |
| Downregulation of Gabra4 expression during alcohol withdrawal is mediated by specific microRNAs in cultured mouse cortical neurons. | Bekdash RA et al. | β | 2015 | β |
| Dynamic expression of long noncoding RNAs and repeat elements in synaptic plasticity. | Maag JL et al. | β | 2015 | β |
| Epigenetic modulation of brain gene networks for cocaine and alcohol abuse. | Farris SP et al. | β | 2015 | β |
| Ethanol-induced epigenetic regulations at the Bdnf gene in C57BL/6J mice. | Stragier E et al. | β | 2015 | β |
| Gene expression profile analysis of rat cerebellum under acute alcohol intoxication. | Zhang Y et al. | β | 2015 | β |
| Increased Basolateral Amygdala Pyramidal Cell Excitability May Contribute to the Anxiogenic Phenotype Induced by Chronic Early-Life Stress. | Rau AR et al. | β | 2015 | β |
| Integrating mRNA and miRNA Weighted Gene Co-Expression Networks with eQTLs in the Nucleus Accumbens of Subjects with Alcohol Dependence. | Mamdani M et al. | β | 2015 | β |
| KCNN Genes that Encode Small-Conductance Ca2+-Activated K+ Channels Influence Alcohol and Drug Addiction. | Padula AE et al. | β | 2015 | β |
| Mechanisms of stress in the brain. | McEwen BS et al. | β | 2015 | β |
| Microglia recapitulate a hematopoietic master regulator network inΒ the aging human frontal cortex. | Wehrspaun CC et al. | β | 2015 | β |
| MicroRNA-30a-5p in the prefrontal cortex controls the transition from moderate to excessive alcohol consumption. | Darcq E et al. | β | 2015 | β |
| Multigenerational and transgenerational inheritance of drug exposure: The effects of alcohol, opiates, cocaine, marijuana, and nicotine. | Yohn NL et al. | β | 2015 | β |
| Neurotoxic Methamphetamine Doses Increase LINE-1 Expression in the Neurogenic Zones of the Adult Rat Brain. | Moszczynska A et al. | β | 2015 | β |
| Peroxisome proliferator-activated receptors Ξ± and Ξ³ are linked with alcohol consumption in mice and withdrawal and dependence in humans. | Blednov YA et al. | β | 2015 | β |
| Quantitative trait locus mapping of acute functional tolerance in the LXS recombinant inbred strains. | Bennett B et al. | β | 2015 | β |
| Repeated vapor ethanol exposure induces transient histone modifications in the brain that are modified by genotype and brain region. | Finegersh A et al. | β | 2015 | β |
| Stress and the dynamic genome: Steroids, epigenetics, and the transposome. | Hunter RG et al. | β | 2015 | β |
| The histone deacetylase inhibitor sodium butyrate decreases excessive ethanol intake in dependent animals. | Simon-O'Brien E et al. | β | 2015 | β |
| The synaptoneurosome transcriptome: a model for profiling the emolecular effects of alcohol. | Most D et al. | β | 2015 | β |
| Transcriptome organization for chronic alcohol abuse in human brain. | Farris SP et al. | β | 2015 | β |
| Acute ethanol alters multiple histone modifications at model gene promoters in the cerebral cortex. | Finegersh A et al. | β | 2014 | β |
| Alcohol dependence: molecular and behavioral evidence. | Trudell JR et al. | β | 2014 | β |
| Altered gamma-aminobutyric acid type B receptor subunit 1 splicing in alcoholics. | Lee C et al. | β | 2014 | β |
| Antidepressant-like effect of sodium butyrate is associated with an increase in TET1 and in 5-hydroxymethylation levels in the Bdnf gene. | Wei Y et al. | β | 2014 | β |
| Beyond modules and hubs: the potential of gene coexpression networks for investigating molecular mechanisms of complex brain disorders. | Gaiteri C et al. | β | 2014 | β |
| Comorbidities, confounders, and the white matter transcriptome in chronic alcoholism. | Sutherland GT et al. | β | 2014 | β |
| Comprehensive interrogation of CpG island methylation in the gene encoding COMT, a key estrogen and catecholamine regulator. | Swift-Scanlan T et al. | β | 2014 | β |
| Differentially co-expressed genes in postmortem prefrontal cortex of individuals with alcohol use disorders: influence on alcohol metabolism-related pathways. | Zhang H et al. | β | 2014 | β |
| Epigenetic mechanisms of drug addiction. | Nestler EJ | β | 2014 | β |
| Epigenetic signaling in psychiatric disorders. | PeΓ±a CJ et al. | β | 2014 | β |
| Expression of specific ionotropic glutamate and GABA-A receptor subunits is decreased in central amygdala of alcoholics. | Jin Z et al. | β | 2014 | β |
| Fetal alcohol programming of hypothalamic proopiomelanocortin system by epigenetic mechanisms and later life vulnerability to stress. | Bekdash R et al. | β | 2014 | β |
| Gene expression in the addicted brain. | Zhou Z et al. | β | 2014 | β |
| Genetics and genomics of alcohol sensitivity. | Morozova TV et al. | β | 2014 | β |
| Genome-wide association study of alcohol dependence:significant findings in African- and European-Americans including novel risk loci. | Gelernter J et al. | β | 2014 | β |
| Identification of a QTL in Mus musculus for alcohol preference, withdrawal, and Ap3m2 expression using integrative functional genomics and precision genetics. | Bubier JA et al. | β | 2014 | β |
| MicroRNAs and ethanol toxicity. | Miranda RC | β | 2014 | β |
| MiR-153 targets the nuclear factor-1 family and protects against teratogenic effects of ethanol exposure in fetal neural stem cells. | Tsai PC et al. | β | 2014 | β |
| Mobile DNA elements in the generation of diversity and complexity in the brain. | Erwin JA et al. | β | 2014 | β |
| Molecular and neurologic responses to chronic alcohol use. | Costin BN et al. | β | 2014 | β |
| Molecular basis of alcoholism. | Most D et al. | β | 2014 | β |
| Neurobiological disease etiology and inheritance: an epigenetic perspective. | Saab BJ et al. | β | 2014 | β |
| Neuroimmune pathways in alcohol consumption: evidence from behavioral and genetic studies in rodents and humans. | Robinson G et al. | β | 2014 | β |
| Neuropathology of alcoholism. | Sutherland GT et al. | β | 2014 | β |
| PPAR agonists regulate brain gene expression: relationship to their effects on ethanol consumption. | Ferguson LB et al. | β | 2014 | β |
| Proteomic approaches and identification of novel therapeutic targets for alcoholism. | Gorini G et al. | β | 2014 | β |
| RNA-Seq reveals novel transcriptional reorganization in human alcoholic brain. | Farris SP et al. | β | 2014 | β |
| Selective increases of AMPA, NMDA, and kainate receptor subunit mRNAs in the hippocampus and orbitofrontal cortex but not in prefrontal cortex of human alcoholics. | Jin Z et al. | β | 2014 | β |
| Sequencing-based gene network analysis provides a core set of gene resource for understanding thermal adaptation in Zhikong scallop Chlamys farreri. | Fu X et al. | β | 2014 | β |
| The epigenetic landscape of alcoholism. | Krishnan HR et al. | β | 2014 | β |
| Transcriptional coexpression network reveals the involvement of varying stem cell features with different dysregulations in different gastric cancer subtypes. | Kalamohan K et al. | β | 2014 | β |
| Understanding the addiction cycle: a complex biology with distinct contributions of genotype vs. sex at each stage. | Wilhelm CJ et al. | β | 2014 | β |
| Using autopsy brain tissue to study alcohol-related brain damage in the genomic age. | Sutherland GT et al. | β | 2014 | β |
| Alcohol and the methylome: design and analysis considerations for research using human samples. | Harlaar N et al. | β | 2013 | β |
| Alcohol-induced epigenetic alterations to developmentally crucial genes regulating neural stemness and differentiation. | Veazey KJ et al. | β | 2013 | β |
| A system biology approach to identify regulatory pathways underlying the neuroendocrine control of female puberty in rats and nonhuman primates. | Lomniczi A et al. | β | 2013 | β |
| Cellular basis of memory for addiction. | Nestler EJ | β | 2013 | β |
| Chromatin remodeling: a new landscape to treat harmful alcohol-use disorders. | Warnault V et al. | β | 2013 | β |
| Chromatin remodeling--a novel strategy to control excessive alcohol drinking. | Warnault V et al. | β | 2013 | β |
| DNA methylation/demethylation network expression in psychotic patients with a history of alcohol abuse. | Guidotti A et al. | β | 2013 | β |
| Epigenetic control of gene expression in the alcoholic brain. | Ponomarev I | β | 2013 | β |
| Epigenetic inheritance of disease and disease risk. | Bohacek J et al. | β | 2013 | β |
| Gene expression in brain and liver produced by three different regimens of alcohol consumption in mice: comparison with immune activation. | Osterndorff-Kahanek E et al. | β | 2013 | β |
| HSF1 transcriptional activity mediates alcohol induction of Vamp2 expression and GABA release. | Varodayan FP et al. | β | 2013 | β |
| Integration of miRNA and protein profiling reveals coordinated neuroadaptations in the alcohol-dependent mouse brain. | Gorini G et al. | β | 2013 | β |
| Molecular and genetic determinants of alcohol dependence. | Awofala AA | β | 2013 | β |
| Neurobiological signatures of alcohol dependence revealed by protein profiling. | Gorini G et al. | β | 2013 | β |
| Neuroimmune signaling: a key component of alcohol abuse. | Mayfield J et al. | β | 2013 | β |
| Positively correlated miRNA-mRNA regulatory networks in mouse frontal cortex during early stages of alcohol dependence. | Nunez YO et al. | β | 2013 | β |
| The role of transposable elements in health and diseases of the central nervous system. | Reilly MT et al. | β | 2013 | β |
| Corticosteroid-dependent plasticity mediates compulsive alcohol drinking in rats. | Vendruscolo LF et al. | β | 2012 | β |
| Current perspectives on the neurobiology of drug addiction: a focus on genetics and factors regulating gene expression. | Duncan JR | β | 2012 | β |
| Gene Expression Under the Influence: Transcriptional Profiling of Ethanol in the Brain. | Contet C | β | 2012 | β |
| Network analysis of oyster transcriptome revealed a cascade of cellular responses during recovery after heat shock. | Zhang L et al. | β | 2012 | β |
| Using genome-wide expression profiling to define gene networks relevant to the study of complex traits: from RNA integrity to network topology. | O'Brien MA et al. | β | 2012 | β |