Ethanol enhances gamma-aminobutyric acid responses in a subpopulation of nucleus accumbens neurons: role of metabotropic glutamate receptors.
- Authors
- Nie, Z; Madamba, S G; Siggins, G R
- Year
- 2000
- Journal
- The Journal of pharmacology and experimental therapeutics
- PMID
- 10773041
The nucleus accumbens (NAcc) may be a key area in the rewarding effects of abused drugs. We previously showed that low ethanol concentrations decreased both N-methyl-D-aspartate (NMDA)-induced and kainate-induced currents in NAcc core neurons. To explore the effects of ethanol on gamma-aminobutyric acid (GABA) responses in NAcc, we used intracellular voltage-clamp recordings and locally applied GABA in a slice preparation containing the NAcc. Ethanol (11-200 mM) had no effect on resting membrane properties, but 11, 22, 44, 100, and 200 mM ethanol increased GABA currents in 17, 33, 45, 50, and 22% of cells, respectively. Superfusion of low glutamate concentrations that had no direct effect on membrane properties enhanced ethanol potentiation of GABA currents in more than half the NAcc cells. Neither alpha-amino-3-hydroxy-5-methylisoxazole-4-propionic acid/kainate receptor nor NMDA receptor antagonists affected the percentage of cells showing ethanol enhancement of GABA responses or the degree of ethanol enhancement of GABA currents in NAcc neurons. However, in ethanol-sensitive cells, the metabotropic receptor antagonist alpha-methyl-4-carboxyphenylglycine (MCPG) blocked the ethanol enhancement of GABA currents. In addition, the metabotropic receptor agonist trans-1-aminocyclopentane-1,3-dicarboxylic acid enhanced GABA responses in 50% of cells tested, an effect blocked by MCPG. These data suggest that NAcc core neurons possess both ethanol-sensitive and -insensitive GABA receptors and that glutamate can mimic and enhance the ethanol potentiation of GABA currents in many of these neurons. Furthermore, the ethanol potentiation of GABA currents may involve metabotropic glutamate receptors, perhaps via a phosphorylation mechanism that regulates ethanol sensitivity of GABA receptors in some NAcc neurons.
No figures extracted from this document.
No chunks β full text not yet ingested.
No entities extracted from this document yet.
No uploaded files.
No citations found.
In this knowledge base
External
| Title | Authors | Journal | Year | Link |
|---|---|---|---|---|
| Synaptic Effects Induced by Alcohol. | Lovinger DM et al. | β | 2025 | β |
| Acute Ethanol Modulates Synaptic Inhibition in the Basolateral Amygdala via Rapid NLRP3 Inflammasome Activation and Regulates Anxiety-Like Behavior in Rats. | Munshi S et al. | β | 2023 | β |
| Medication overuse headache and substance use disorder: A comparison based on basic research and neuroimaging. | Li C et al. | β | 2023 | β |
| Modulation of neuronal excitability by binge alcohol drinking. | Gimenez-Gomez P et al. | β | 2023 | β |
| The Role of the Central Amygdala in Alcohol Dependence. | Roberto M et al. | β | 2021 | β |
| Differential sensitivity of human neurons carrying ΞΌ opioid receptor (MOR) N40D variants in response to ethanol. | Scarnati MS et al. | β | 2020 | β |
| Using human stem cells as a model system to understand the neural mechanisms of alcohol use disorders: Current status and outlook. | Scarnati MS et al. | β | 2019 | β |
| Cross-Species Translational Findings in the Discriminative Stimulus Effects of Ethanol. | Allen DC et al. | β | 2018 | β |
| Examining the effects of alcohol on GABA<sub>A</sub> receptor mRNA expression and function in neural cultures generated from control and alcohol dependent donor induced pluripotent stem cells. | Lieberman R et al. | β | 2018 | β |
| GABA and Glutamate Synaptic Coadaptations to Chronic Ethanol in the Striatum. | Cuzon Carlson VC | β | 2018 | β |
| The Cerebellar GABA<sub>A</sub>R System as a Potential Target for Treating Alcohol Use Disorder. | Rossi DJ et al. | β | 2018 | β |
| Synaptic targets: Chronic alcohol actions. | Roberto M et al. | β | 2017 | β |
| The reinforcing effects of ethanol within the nucleus accumbens shell involve activation of local GABA and serotonin receptors. | Ding ZM et al. | β | 2015 | β |
| Ethanol inhibits excitatory neurotransmission in the nucleus accumbens of adolescent mice through GABAA and GABAB receptors. | Mishra D et al. | β | 2013 | β |
| Opposite actions of alcohol on tonic GABA(A) receptor currents mediated by nNOS and PKC activity. | Kaplan JS et al. | β | 2013 | β |
| Primate cerebellar granule cells exhibit a tonic GABAAR conductance that is not affected by alcohol: a possible cellular substrate of the low level of response phenotype. | Mohr C et al. | β | 2013 | β |
| Synaptic effects induced by alcohol. | Lovinger DM et al. | β | 2013 | β |
| Alcohol dependence as a chronic pain disorder. | Egli M et al. | β | 2012 | β |
| Corticotropin-releasing factor (CRF) and neuropeptide Y (NPY): effects on inhibitory transmission in central amygdala, and anxiety- & alcohol-related behaviors. | Gilpin NW | β | 2012 | β |
| Effects of alcohol on the membrane excitability and synaptic transmission of medium spiny neurons in the nucleus accumbens. | Marty VN et al. | β | 2012 | β |
| Effects of ethanol on GABA(A) receptors in GABAergic and glutamatergic presynaptic nerve terminals. | Wakita M et al. | β | 2012 | β |
| Neuropeptide modulation of central amygdala neuroplasticity is a key mediator of alcohol dependence. | Gilpin NW et al. | β | 2012 | β |
| The central amygdala and alcohol: role of Ξ³-aminobutyric acid, glutamate, and neuropeptides. | Roberto M et al. | β | 2012 | β |
| Alcohol, cocaine, and brain stimulation-reward in C57Bl6/J and DBA2/J mice. | Fish EW et al. | β | 2010 | β |
| Suicidal behavior and alcohol abuse. | Pompili M et al. | β | 2010 | β |
| Cellular and behavioral interactions of gabapentin with alcohol dependence. | Roberto M et al. | β | 2008 | β |
| Ethanol modulates synaptic and extrasynaptic GABAA receptors in the thalamus. | Jia F et al. | β | 2008 | β |
| Basis of the gabamimetic profile of ethanol. | Breese GR et al. | β | 2006 | β |
| Ethanol modulation of GABAergic transmission: the view from the slice. | Weiner JL et al. | β | 2006 | β |
| A conceptualization of integrated actions of ethanol contributing to its GABAmimetic profile: a commentary. | Criswell HE et al. | β | 2005 | β |
| The tipsy terminal: presynaptic effects of ethanol. | Siggins GR et al. | β | 2005 | β |
| Ethanol augments GABAergic transmission in the central amygdala via CRF1 receptors. | Nie Z et al. | β | 2004 | β |
| Increased GABA release in the central amygdala of ethanol-dependent rats. | Roberto M et al. | β | 2004 | β |
| Ethanol differentially enhances hippocampal GABA A receptor-mediated responses in protein kinase C gamma (PKC gamma) and PKC epsilon null mice. | Proctor WR et al. | β | 2003 | β |
| Ethanol enhances alpha 4 beta 3 delta and alpha 6 beta 3 delta gamma-aminobutyric acid type A receptors at low concentrations known to affect humans. | Wallner M et al. | β | 2003 | β |
| Ethanol increases GABAergic transmission at both pre- and postsynaptic sites in rat central amygdala neurons. | Roberto M et al. | β | 2003 | β |
| Ethanol modulation of excitatory and inhibitory synaptic transmission in rat and monkey dentate granule neurons. | Ariwodola OJ et al. | β | 2003 | β |
| Interaction of the hypocretins with neurotransmitters in the nucleus accumbens. | Martin G et al. | β | 2002 | β |
| Long-lasting potentiation of GABAergic synapses in dopamine neurons after a single in vivo ethanol exposure. | Melis M et al. | β | 2002 | β |