Opposite modulation of cocaine-seeking behavior by D1- and D2-like dopamine receptor agonists.
paper
Cited
Public
Unavailable
- Authors
- Self, D W; Barnhart, W J; Lehman, D A; Nestler, E J
- Year
- 1996
- Journal
- Science (New York, N.Y.)
- PMID
- 8599115
- DOI
- 10.1126/science.271.5255.1586
Activation of the mesolimbic dopamine system is known to trigger relapse in animal models of cocaine-seeking behavior. We found that this "priming" effect was selectively induced by D2-like, and not by D1-like, dopamine receptor agonists in rats. Moreover, D1-like receptor agonists prevented cocaine-seeking behavior induced by cocaine itself, whereas D2-like receptor agonists enhanced this behavior. These results demonstrate an important dissociation between D1- and D2-like receptor processes in cocaine-seeking behavior and support further evaluation of D1-like receptor agonists as a possible pharmacotherapy for cocaine addiction.
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