Global functional coupling of resting EEG rhythms is related to white-matter lesions along the cholinergic tracts in subjects with amnesic mild cognitive impairment.
paper
Cited
Public
Unavailable
- Authors
- Babiloni, Claudio; Frisoni, Giovanni B; Vecchio, Fabrizio; Pievani, Michela; Geroldi, Cristina; De Carli, Charles; Ferri, Raffaele; Vernieri, Fabrizio; Lizio, Roberta; Rossini, Paolo M
- Year
- 2010
- Journal
- Journal of Alzheimer's disease : JAD
- PMID
- 20157242
- DOI
- 10.3233/JAD-2010-1290
We tested the hypothesis that global functional coupling of resting cortical electroencephalographic (EEG) rhythms is abnormal in amnesic mild cognitive impairment (MCI) patients with remarkable lesions along the cholinergic white-matter tracts. We used the eyes-closed resting EEG data (10-20 montage) of the same groups of 28 healthy elderly (Nold) and 57 MCI subjects of a previous reference study. The estimation of the cholinergic lesion was performed with a validated semi-automatic algorithm based on fluid-attenuated inversion recovery sequences on MRI. The MCI patients were divided into groups of high (MCI+; n=28) and low (MCI-; n=29) cholinergic damage. EEG rhythms of interest were delta (2-4 Hz), theta (4-8 Hz), alpha1 (8-10.5 Hz), alpha2 (10.5-13 Hz), beta1 (13-20 Hz), beta2 (20-30 Hz), and gamma (30- 40 Hz). The global functional coupling of the EEG rhythms was indexed computing the spectral coherence between each electrode and the other 18 electrodes ("electrode" coherence) and then averaging the "electrode" coherence of all 19 electrodes (total coherence). Total coherence of alpha1 rhythms was highest in the Nold, intermediate in the MCI-, and lowest in the MCI+ groups. Furthermore, the alpha1 total coherence was negatively correlated to (moderate to high) cholinergic lesion across the MCI subjects. In conclusion, damage to the cholinergic system is associated with alterations of the functional global coupling of resting alpha rhythms.
No figures extracted from this document.
No chunks β full text not yet ingested.
No entities extracted from this document yet.
No uploaded files.
Not in any collection.
No citations found.
In this knowledge base
| Title | Year | PMID |
|---|---|---|
| Association of Polygenic Liability for Alcohol Dependence and EEG Connectivity in Adolescence and Young Adulthood. | 2019 | 31627376 |
| Advances in Electrophysiological Research. | 2015 | 26259089 |
External
| Title | Authors | Journal | Year | Link |
|---|---|---|---|---|
| Association of a DASH diet and magnetoencephalography in dementia-free adults with different risk levels of Alzheimer's disease. | Trabado-FernΓ‘ndez A et al. | β | 2025 | β |
| Cortical Functional Connectivity Changes in the Body-First and Brain-First Subtypes of Parkinson's Disease. | Conti M et al. | β | 2025 | β |
| From data to decisions: AI and functional connectivity for diagnosis, prognosis, and recovery prediction in stroke. | Cacciotti A et al. | β | 2025 | β |
| [EEG changes in patients with Alzheimer's disease]. | Burd SG et al. | β | 2024 | β |
| The oscillatory features of visual processing are altered in healthy aging. | LΓ©vesque M et al. | β | 2024 | β |
| A Real-Time Neurophysiologic Stress Test for the Aging Brain: Novel Perioperative and ICU Applications of EEG in Older Surgical Patients. | Berger M et al. | β | 2023 | β |
| Band-Specific Altered Cortical Connectivity in Early Parkinson's Disease and its Clinical Correlates. | Conti M et al. | β | 2023 | β |
| Determinants of approved acetylcholinesterase inhibitor response outcomes in Alzheimer's disease: relevance for precision medicine in neurodegenerative diseases. | Lista S et al. | β | 2023 | β |
| Patients with Alzheimer's disease dementia show partially preserved parietal 'hubs' modeled from resting-state alpha electroencephalographic rhythms. | Lopez S et al. | β | 2023 | β |
| Early dementia diagnosis, MCI-to-dementia risk prediction, and the role of machine learning methods for feature extraction from integrated biomarkers, in particular for EEG signal analysis. | Rossini PM et al. | β | 2022 | β |
| Measures of resting state EEG rhythms for clinical trials in Alzheimer's disease: Recommendations of an expert panel. | Babiloni C et al. | β | 2021 | β |
| Resting state EEG biomarkers of cognitive decline associated with Alzheimer's disease and mild cognitive impairment. | Meghdadi AH et al. | β | 2021 | β |
| Resting-state electroencephalographic delta rhythms may reflect global cortical arousal in healthy old seniors and patients with Alzheimer's disease dementia. | Babiloni C et al. | β | 2020 | β |
| Tau pathology in early Alzheimer's disease is linked to selective disruptions in neurophysiological network dynamics. | Kocagoncu E et al. | β | 2020 | β |
| Abnormalities of functional cortical source connectivity of resting-state electroencephalographic alpha rhythms are similar in patients with mild cognitive impairment due to Alzheimer's and Lewy body diseases. | Babiloni C et al. | β | 2019 | β |
| An Electrophysiological Biomarker That May Predict Treatment Response to ECT. | Scangos KW et al. | β | 2019 | β |
| Association of Polygenic Liability for Alcohol Dependence and EEG Connectivity in Adolescence and Young Adulthood. | Meyers JL et al. | β | 2019 | β |
| Oscillatory connectivity as a diagnostic marker of dementia due to Alzheimer's disease. | Musaeus CS et al. | β | 2019 | β |
| Tau pathology in early Alzheimerβs disease disrupts selective neurophysiological network dynamics | Kocagoncu E et al. | β | 2019 | β |
| Abnormalities of resting-state functional cortical connectivity in patients with dementia due to Alzheimer's and Lewy body diseases: an EEG study. | Babiloni C et al. | β | 2018 | β |
| Functional cortical source connectivity of resting state electroencephalographic alpha rhythms shows similar abnormalities in patients with mild cognitive impairment due to Alzheimer's and Parkinson's diseases. | Babiloni C et al. | β | 2018 | β |
| Revolution of Alzheimer Precision Neurology. Passageway of Systems Biology and Neurophysiology. | Hampel H et al. | β | 2018 | β |
| Abnormalities of cortical neural synchronization mechanisms in patients with dementia due to Alzheimer's and Lewy body diseases: an EEG study. | Babiloni C et al. | β | 2017 | β |
| Changes of Functional and Directed Resting-State Connectivity Are Associated with Neuronal Oscillations, ApoE Genotype and Amyloid Deposition in Mild Cognitive Impairment. | Michels L et al. | β | 2017 | β |
| Systemic and Disease-Specific Risk Factors in Vascular Dementia: Diagnosis and Prevention. | Jaul E et al. | β | 2017 | β |
| Antiretroviral therapy affects the z-score index of deviant cortical EEG rhythms in naΓ―ve HIV individuals. | Babiloni C et al. | β | 2016 | β |
| Atrophy of amygdala and abnormal memory-related alpha oscillations over posterior cingulate predict conversion to Alzheimer's disease. | Prieto Del Val L et al. | β | 2016 | β |
| Brain neural synchronization and functional coupling in Alzheimer's disease as revealed by resting state EEG rhythms. | Babiloni C et al. | β | 2016 | β |
| Classification of Healthy Subjects and Alzheimer's Disease Patients with Dementia from Cortical Sources of Resting State EEG Rhythms: A Study Using Artificial Neural Networks. | Triggiani AI et al. | β | 2016 | β |
| Classification of Single Normal and Alzheimer's Disease Individuals from Cortical Sources of Resting State EEG Rhythms. | Babiloni C et al. | β | 2016 | β |
| Cortical sources of resting state EEG rhythms are related to brain hypometabolism in subjects with Alzheimer's disease: an EEG-PET study. | Babiloni C et al. | β | 2016 | β |
| Effects of transcranial direct current stimulation on the functional coupling of the sensorimotor cortical network. | Vecchio F et al. | β | 2016 | β |
| Pathoconnectomics of cognitive impairment in small vessel disease: AΒ systematic review. | Dey AK et al. | β | 2016 | β |
| Resting state Rolandic mu rhythms are related to activity of sympathetic component of autonomic nervous system in healthy humans. | Triggiani AI et al. | β | 2016 | β |
| A critical review: coupling and synchronization analysis methods of EEG signal with mild cognitive impairment. | Wen D et al. | β | 2015 | β |
| Advances in Electrophysiological Research. | Kamarajan C et al. | β | 2015 | β |
| Cortical sources of resting state electroencephalographic alpha rhythms deteriorate across time in subjects with amnesic mild cognitive impairment. | Babiloni C et al. | β | 2014 | β |
| Hypercapnia affects the functional coupling of resting state electroencephalographic rhythms and cerebral haemodynamics in healthy elderly subjects and in patients with amnestic mild cognitive impairment. | Babiloni C et al. | β | 2014 | β |
| Back propagation artificial neural network for community Alzheimer's disease screening in China. | Tang J et al. | β | 2013 | β |
| Brain imaging and human nutrition: which measures to use in intervention studies? | Sizonenko SV et al. | β | 2013 | β |
| Effects of acetylcholinesterase inhibitors and memantine on resting-state electroencephalographic rhythms in Alzheimer's disease patients. | Babiloni C et al. | β | 2013 | β |
| Peak individual alpha frequency qualifies as a stable neurophysiological trait marker in healthy younger and older adults. | Grandy TH et al. | β | 2013 | β |
| Resting state cortical electroencephalographic rhythms are related to gray matter volume in subjects with mild cognitive impairment and Alzheimer's disease. | Babiloni C et al. | β | 2013 | β |
| Brain excitability and connectivity of neuronal assemblies in Alzheimer's disease: from animal models to human findings. | D'Amelio M et al. | β | 2012 | β |
| Coherence, phase differences, phase shift, and phase lock in EEG/ERP analyses. | Thatcher RW | β | 2012 | β |
| Differential contribution of right and left parietal cortex to the control of spatial attention: a simultaneous EEG-rTMS study. | Capotosto P et al. | β | 2012 | β |
| EEG correlates of haptic feedback in a visuomotor tracking task. | Lin CL et al. | β | 2012 | β |
| Functional coupling of parietal Ξ± rhythms is enhanced in athletes before visuomotor performance: a coherence electroencephalographic study. | Del Percio C et al. | β | 2011 | β |
| Intra-hemispheric functional coupling of alpha rhythms is related to golfer's performance: a coherence EEG study. | Babiloni C et al. | β | 2011 | β |