Ethanol stimulates gamma-aminobutyric acid receptor-mediated chloride transport in rat brain synaptoneurosomes.
paper
Cited
Public
Unavailable
- Authors
- Suzdak, P D; Schwartz, R D; Skolnick, P; Paul, S M
- Year
- 1986
- Journal
- Proceedings of the National Academy of Sciences of the United States of America
- PMID
- 2424017
- DOI
- 10.1073/pnas.83.11.4071
- PMCID
- PMC323668
The effects of ethanol on Cl- uptake were studied using a cell-free subcellular preparation from brain that contains a gamma-aminobutyric acid (GABA)/barbiturate receptor-sensitive Cl- transport system. In isolated vesicles prepared from rat cerebral cortex, ethanol, at concentrations that are present during acute intoxication (20-50 mM), stimulated 36Cl- uptake in a concentration-dependent and biphasic manner. The ethanol-stimulated uptake of 36Cl- was markedly inhibited by the GABA antagonists picrotoxin and bicuculline but not by a variety of other neurotransmitter receptor antagonists. The effects of ethanol in stimulating 36Cl- uptake in isolated brain vesicles were qualitatively and quantitatively similar to that of pentobarbital. Ethanol also markedly potentiated both muscimol- and pentobarbital-stimulated 36Cl- uptake at concentrations below those that directly stimulate 36Cl- uptake. Under our incubation conditions, ethanol did not release GABA, suggesting that it interacts with the postsynaptic GABA/barbiturate receptor complex. The ability of ethanol to stimulate GABA/barbiturate receptor-mediated Cl- transport may explain many of its pharmacological properties and provides a mechanism for the common psychopharmacological actions of ethanol, barbiturates, and benzodiazepines.
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| Ethanol reduces norepinephrine-stimulated melatonin synthesis in rat pinealocytes. | Chik CL et al. | β | 1992 | β |
| GABA agonists and antagonists. | Kerr DI et al. | β | 1992 | β |
| GABA and nucleus accumbens glutamate neurotransmission modulate ethanol self-administration in rats. | Rassnick S et al. | β | 1992 | β |
| Involvement of gamma-aminobutyric acid and N-methyl-D-aspartate receptors in the inhibitory effect of ethanol on pentylenetetrazole-induced c-fos expression in rat brain. | Le F et al. | β | 1992 | β |
| Neonatal administration of a GABA-T inhibitor alters central GABAA receptor mechanisms and alcohol drinking in adult rats. | TΓ‘ira T et al. | β | 1992 | β |
| Neural mechanisms of drug reinforcement. | Koob GF | β | 1992 | β |
| Neuropharmacology of cocaine and ethanol dependence. | Koob GF et al. | β | 1992 | β |
| NMDA receptors: role in ethanol withdrawal seizures. | Hoffman PL et al. | β | 1992 | β |
| Perinatal protein deprivation enhances the anticonflict effect measured after chronic ethanol administration in adult rats. | CΓ³rdoba NE et al. | β | 1992 | β |
| PET analysis of alcohol interaction with the brain disposition of [11C]flumazenil. | Pauli S et al. | β | 1992 | β |
| Potentiation of gamma-aminobutyric acid-mediated chloride flux by pentobarbital and diazepam but not ethanol. | Mihic SJ et al. | β | 1992 | β |
| Response to diazepam in sons of alcoholics. | Cowley DS et al. | β | 1992 | β |
| Allosteric actions of central nervous system depressants including anesthetics on subtypes of the inhibitory gamma-aminobutyric acidA receptor-chloride channel complex. | Olsen RW et al. | β | 1991 | β |
| Effect of ethanol and DSIP on the 36Cl-flux in synaptosomal vesicles. | Yukhananov R et al. | β | 1991 | β |
| Effect of ethanol on gamma-aminobutyric acid and glycine receptor-coupled Cl- fluxes in rat brain synaptoneurosomes. | Engblom AC et al. | β | 1991 | β |
| Effects of alcohols on ion channels of cultured neurons. | Narahashi T et al. | β | 1991 | β |
| Ethanol-induced changes in chloride flux are mediated by both GABA(A) and GABA(B) receptors. | Allan AM et al. | β | 1991 | β |
| Ethanol interactions at the gamma-aminobutyric acid receptor complex. | Ticku MK | β | 1991 | β |
| Evidence that genetic differences in habituation and GABAergic mechanisms may be related to sensitivity to ethanol and development of ethanol tolerance in mice. | Liljequist S | β | 1991 | β |
| GABAA receptor function and expression following chronic ethanol and barbiturate administration. | Morrow AL et al. | β | 1991 | β |
| gamma-Aminobutyric acid-activated chloride channels in rats selectively bred for differential acute sensitivity to alcohol. | Allan AM et al. | β | 1991 | β |
| "In vivo" inhibition of GABAergic transmission increases 35S-TBPS binding in the rat brain. | Biggio G et al. | β | 1991 | β |
| Lack of effects of handling habituation and swimming stress on ethanol-induced motor impairment and GABAA receptor function. | Tuominen K et al. | β | 1991 | β |
| Neuroadaptive responses to chronic ethanol. | Buck KJ et al. | β | 1991 | β |
| Protection against ethanol-induced gastric damage by drugs acting at the GABA-benzodiazepine receptor complex. | Najim RA et al. | β | 1991 | β |
| Response of three hormones to diazepam challenge in sons of alcoholics and controls. | Schuckit MA et al. | β | 1991 | β |
| Selective effects of sedative/hypnotic drugs on excitatory amino acid receptors in brain. | Tabakoff B et al. | β | 1991 | β |
| Sensitivity of N-methyl-D-aspartate (NMDA) and nicotinic acetylcholine receptors to ethanol and pyrazole. | Aracava Y et al. | β | 1991 | β |
| Specific alterations in the cerebellar GABA(A) receptors of an alcohol-sensitive ANT rat line. | Uusi-Oukari M et al. | β | 1991 | β |
| t-[35S]butylbicyclophosphorothionate binding under equilibrium and nonequilibrium conditions: differential effects of barbiturates and gamma-aminobutyric acid in the long-sleep and short-sleep selected mouse lines. | McIntyre T et al. | β | 1991 | β |
| The molecular biology of addictive drugs. | Mackler SA et al. | β | 1991 | β |
| Transmitter-activated ion channels as the target of chemical agents. | Narahashi T | β | 1991 | β |
| Alcohol and GABA-benzodiazepine receptor function. | Ticku MK | β | 1990 | β |
| Diazepam sensitivity of the binding of an imidazobenzodiazepine, [3H]Ro 15-4513, in cerebellar membranes from two rat lines developed for high and low alcohol sensitivity. | Uusi-Oukari M et al. | β | 1990 | β |
| Electrophysiological effects of ethanol on monoaminergic neurons: an in vivo and in vitro study. | Verbanck P et al. | β | 1990 | β |
| Ethanol inhibition of baroreflex bradycardia: role of brainstem GABA receptors. | Varga K et al. | β | 1990 | β |
| Ethanol inhibition of neuronal glutamate receptor function. | Lovinger DM et al. | β | 1990 | β |
| Ethanol inhibits thrombin-induced secretion by human platelets at a site distinct from phospholipase C or protein kinase C. | Benistant C et al. | β | 1990 | β |
| GABAergic mechanisms in the electrophysiological actions of ethanol on cerebellar neurons. | Palmer MR et al. | β | 1990 | β |
| Genetic differences in the ethanol sensitivity of GABAA receptors expressed in Xenopus oocytes. | Wafford KA et al. | β | 1990 | β |
| Heterotropic cooperativity between putative recognition sites for progesterone metabolites and the atypical benzodiazepine Ro 5-4864. | Belelli D et al. | β | 1990 | β |
| Increased number of GABAergic terminals in the nucleus accumbens is associated with alcohol preference in rats. | Hwang BH et al. | β | 1990 | β |
| In vivo administration of ethanol enhances the function of the gamma-aminobutyric acid-dependent chloride channel in the rat cerebral cortex. | Sanna E et al. | β | 1990 | β |
| Modification of chloride flux across brain membranes by inhibitory amino acids in developing and adult mice. | Oja SS et al. | β | 1990 | β |
| Neuropharmacological and clinical aspects of alcohol withdrawal. | Nutt DJ et al. | β | 1990 | β |
| Overexcitement and disinhibition. Dynamic neurotransmitter interactions in alcohol withdrawal. | Glue P et al. | β | 1990 | β |
| Rat cerebral cortical synaptoneurosomal membranes. Structure and interactions with imidazobenzodiazepine and 1,4-dihydropyridine calcium channel drugs. | Moring J et al. | β | 1990 | β |
| Site-specific enhancement of gamma-aminobutyric acid-mediated inhibition of neural activity by ethanol in the rat medial septal area. | Givens BS et al. | β | 1990 | β |
| Benzodiazepines in the treatment of alcoholism. | Nutt D et al. | β | 1989 | β |
| Cerebellar GABAA receptor binding and function in vitro in two rat lines developed for high and low alcohol sensitivity. | Uusi-Oukari M et al. | β | 1989 | β |
| Ethanol and the benzodiazepine-GABA receptor-ionophore complex. | Ticku MK | β | 1989 | β |
| Ethanol and the nervous system. | Charness ME et al. | β | 1989 | β |
| Ethanol-induced hydrolysis of brain sialoglycoconjugates in the rat: effect of sialic acid in antagonizing ethanol intoxication. | Cherian L et al. | β | 1989 | β |
| Ethanol inhibits NMDA-activated ion current in hippocampal neurons. | Lovinger DM et al. | β | 1989 | β |
| Ethanol potentiates and blocks NMDA-activated single-channel currents in rat hippocampal pyramidal cells. | Lima-Landman MT et al. | β | 1989 | β |
| Modification of ethanol effects by bicuculline: genotype-dependent responses and inheritance. | Phillips TJ et al. | β | 1989 | β |
| New medical review series--4. Alcohol intoxication and physical dependence: a molecular mystery tour. | Littleton J | β | 1989 | β |
| N-methyl-D-aspartate receptors and ethanol: inhibition of calcium flux and cyclic GMP production. | Hoffman PL et al. | β | 1989 | β |
| Selected mouse lines, alcohol and behavior. | Phillips TJ et al. | β | 1989 | β |
| Sensitivity to ethanol hypnosis and modulation of chloride channels does not cosegregate with pentobarbital sensitivity in HS mice. | Allan AM et al. | β | 1989 | β |
| The effect of ethanol on 35S-TBPS binding to mouse brain membranes in the presence of chloride. | Liljequist S et al. | β | 1989 | β |
| Acute ethanol poisoning and the ethanol withdrawal syndrome. | Adinoff B et al. | β | 1988 | β |
| Alcohol-induced stimulation of phospholipase C in human platelets requires G-protein activation. | Rubin R et al. | β | 1988 | β |
| Benzodiazepine enhancement of gamma-aminobutyric acid-mediated chloride ion flux in rat brain synaptoneurosomes. | Morrow AL et al. | β | 1988 | β |
| Biology of anxiety. | Teicher MH | β | 1988 | β |
| Effect of ethanol on [3H]dopamine release in rat nucleus accumbens and striatal slices. | Russell VA et al. | β | 1988 | β |
| Effect of ethanol on GABA uptake and release from hypothalamic fragments. | Seilicovich A et al. | β | 1988 | β |
| Effects of an endogenous anxiolytic adrenal steroid, alpha-THDOC, on non-opioid defeat analgesia in male mice: interaction with Ro15-1788. | Rodgers RJ et al. | β | 1988 | β |
| Modulation of the benzodiazepine/gamma-aminobutyric acid receptor chloride channel complex by inhalation anesthetics. | Moody EJ et al. | β | 1988 | β |
| Benzodiazepine receptor binding of triazolobenzodiazepines in vivo: increased receptor number with low-dose alprazolam. | Miller LG et al. | β | 1987 | β |
| GABA-drug interactions. | Olsen RW | β | 1987 | β |
| Protection against the lethal effects of pentobarbital in mice by a benzodiazepine receptor inverse agonist, 6,7-dimethoxy-4-ethyl-3-carbomethoxy-beta-carboline. | Havoundjian H et al. | β | 1987 | β |
| A selective imidazobenzodiazepine antagonist of ethanol in the rat. | Suzdak PD et al. | β | 1986 | β |