Evaluating coverage of genome-wide association studies.
paper
Cited
Public
Unavailable
- Authors
- Barrett, Jeffrey C; Cardon, Lon R
- Year
- 2006
- Journal
- Nature genetics
- PMID
- 16715099
- DOI
- 10.1038/ng1801
Genome-wide association studies involving hundreds of thousands of SNPs in thousands of cases and controls are now underway. The first of many analytical challenges in these studies involves the choice of SNPs to genotype. It is not practical to construct a different panel of tag SNPs for each study, so the first generation of genome-wide scans will use predefined, commercially available marker panels, which will in part dictate their success or failure. We compare different approaches in use today, and show that although many of them provide substantial coverage of common variation in non-African populations, the precise extent is strongly dependent on the frequencies of alleles of interest and on specific considerations of study design. Overall, despite substantial differences in genotyping technologies, marker selection strategies and number of markers assayed, the first-generation high-throughput platforms all offer similar levels of genome coverage.
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| Imputation-Aware Tag SNP Selection To Improve Power for Large-Scale, Multi-ethnic Association Studies. | Wojcik GL et al. | — | 2018 | → |
| Rare-Variant Studies to Complement Genome-Wide Association Studies. | Sazonovs A et al. | — | 2018 | → |
| Genetics of common complex diseases: a view from Iceland. | Arnar DO et al. | — | 2017 | → |
| Genome-wide association study identifies novel type II diabetes risk loci in Jordan subpopulations. | Dajani R et al. | — | 2017 | → |
| Genome-wide linkage and association study implicates the 10q26 region as a major genetic contributor to primary nonsyndromic vesicoureteric reflux. | Darlow JM et al. | — | 2017 | → |
| Imputation aware tag SNP selection to improve power for multi-ethnic association studies | Wojcik GL et al. | — | 2017 | — |
| KIF3A genetic variation is associated with pediatric asthma in the presence of eczema independent of allergic rhinitis. | Johansson E et al. | — | 2017 | → |
| Response to interferon-beta treatment in multiple sclerosis patients: a genome-wide association study. | Mahurkar S et al. | — | 2017 | → |
| Analysis of Heritability Using Genome-Wide Data. | Hall JB et al. | — | 2016 | → |
| Evaluation of power of the Illumina HumanOmni5M-4v1 BeadChip to detect risk variants for human complex diseases. | Xing C et al. | — | 2016 | → |
| Exome genotyping arrays to identify rare and low frequency variants associated with epithelial ovarian cancer risk. | Permuth JB et al. | — | 2016 | → |
| The rate of meiotic gene conversion varies by sex and age. | Halldorsson BV et al. | — | 2016 | → |
| Vitamin D Receptor Gene Polymorphisms Are Associated with Abdominal Visceral Adipose Tissue Volume and Serum Adipokine Concentrations but Not with Body Mass Index or Waist Circumference in African Americans: The Jackson Heart Study. | Khan RJ et al. | — | 2016 | → |
| Discovery and Fine-Mapping of Glycaemic and Obesity-Related Trait Loci Using High-Density Imputation. | Horikoshi M et al. | — | 2015 | → |
| ESPRESSO: taking into account assessment errors on outcome and exposures in power analysis for association studies. | Gaye A et al. | — | 2015 | → |
| Progress and promise in understanding the genetic basis of common diseases. | Price AL et al. | — | 2015 | → |
| QTL mapping using high-throughput sequencing. | Jamann TM et al. | — | 2015 | → |
| Understanding inflammatory bowel disease via immunogenetics. | de Lange KM et al. | — | 2015 | → |
| Accounting for linkage disequilibrium in association analysis of diverse populations. | Charles BA et al. | — | 2014 | → |
| A systematic review of cancer GWAS and candidate gene meta-analyses reveals limited overlap but similar effect sizes. | Chang CQ et al. | — | 2014 | → |
| Bioinformatics challenges in genome-wide association studies (GWAS). | De R et al. | — | 2014 | → |
| Coverage and efficiency in current SNP chips. | Ha NT et al. | — | 2014 | → |
| Epigenetic heredity of human height. | Simeone P et al. | — | 2014 | → |
| Fine mapping of type 2 diabetes susceptibility loci. | Morris AP | — | 2014 | → |
| Genetic studies of Crohn's disease: past, present and future. | Liu JZ et al. | — | 2014 | → |
| Imputation without doing imputation: a new method for the detection of non-genotyped causal variants. | Howey R et al. | — | 2014 | → |
| Inferring population structure and relationship using minimal independent evolutionary markers in Y-chromosome: a hybrid approach of recursive feature selection for hierarchical clustering. | Srivastava AK et al. | — | 2014 | → |
| Methodology for the analysis of rare genetic variation in genome-wide association and re-sequencing studies of complex human traits. | Moutsianas L et al. | — | 2014 | → |
| Morphological and population genomic evidence that human faces have evolved to signal individual identity. | Sheehan MJ et al. | — | 2014 | → |
| Pharmacogenomics of interferon beta and glatiramer acetate response: a review of the literature. | Mahurkar S et al. | — | 2014 | → |
| RING finger protein RNF207, a novel regulator of cardiac excitation. | Roder K et al. | — | 2014 | → |
| The genetic epidemiology of prostate cancer and its clinical implications. | Eeles R et al. | — | 2014 | → |
| The immunopathology of ANCA-associated vasculitis. | McKinney EF et al. | — | 2014 | → |
| Comparison of the performance of two commercial genome-wide association study genotyping platforms in Han Chinese samples. | Jiang L et al. | — | 2013 | → |
| Decoding retinitis pigmentosa. | Natarajan S | — | 2013 | → |
| Evaluating coverage of exons by HapMap SNPs. | Dong X et al. | — | 2013 | → |
| Genome-Wide Association Study Reveals Host Genetic Factors for Liver Diseases. | Nishida N et al. | — | 2013 | → |
| GWAS in autoimmune thyroid disease: redefining our understanding of pathogenesis. | Simmonds MJ | — | 2013 | → |
| Haplotype kernel association test as a powerful method to identify chromosomal regions harboring uncommon causal variants. | Lin WY et al. | — | 2013 | → |
| Imputation-based genomic coverage assessments of current human genotyping arrays. | Nelson SC et al. | — | 2013 | → |
| Inference of kinship coefficients from Korean SNP genotyping data. | Park SJ et al. | — | 2013 | → |
| Insights from genome-wide association studies of drug response. | Zhou K et al. | — | 2013 | → |
| Molecular genetics and subjective well-being. | Rietveld CA et al. | — | 2013 | → |
| Novel SNPs in the bovine ADIPOQ and PPARGC1A genes are associated with carcass traits in Hanwoo (Korean cattle). | Shin S et al. | — | 2013 | → |
| The geometric increase in meta-analyses from China in the genomic era. | Ioannidis JP et al. | — | 2013 | → |
| ABCB1 and ABCC3 gene polymorphisms are associated with first-year response to methotrexate in juvenile idiopathic arthritis. | de Rotte MC et al. | — | 2012 | → |
| A genome wide association study of pulmonary tuberculosis susceptibility in Indonesians. | Png E et al. | — | 2012 | → |
| Clinical review: Genome-wide association studies of skeletal phenotypes: what we have learned and where we are headed. | Hsu YH et al. | — | 2012 | → |
| Efficiency and power as a function of sequence coverage, SNP array density, and imputation. | Flannick J et al. | — | 2012 | → |
| Epi4K: gene discovery in 4,000 genomes. | Epi4K Consortium | — | 2012 | → |
| Evaluating the effective numbers of independent tests and significant p-value thresholds in commercial genotyping arrays and public imputation reference datasets. | Li MX et al. | — | 2012 | → |
| Evaluation of the imputation performance of the program IMPUTE in an admixed sample from Mexico City using several model designs. | Krithika S et al. | — | 2012 | → |
| Examining markers in 8q24 to explain differences in evidence for association with cleft lip with/without cleft palate between Asians and Europeans. | Murray T et al. | — | 2012 | → |
| Exome sequencing followed by large-scale genotyping suggests a limited role for moderately rare risk factors of strong effect in schizophrenia. | Need AC et al. | — | 2012 | → |
| Genome-wide association analysis of imputed rare variants: application to seven common complex diseases. | Mägi R et al. | — | 2012 | → |
| Genome-wide evaluation of genetic diversity and linkage disequilibrium in winter and spring triticale (x Triticosecale Wittmack). | Alheit KV et al. | — | 2012 | → |
| Genomic profiling: cDNA arrays and oligoarrays. | Gorreta F et al. | — | 2012 | → |
| Genotype imputation for African Americans using data from HapMap phase II versus 1000 genomes projects. | Sung YJ et al. | — | 2012 | → |
| Haplotype-based methods for detecting uncommon causal variants with common SNPs. | Lin WY et al. | — | 2012 | → |
| Low-frequency variants in HMGA1 are not associated with type 2 diabetes risk. | Marquez M et al. | — | 2012 | → |
| Mapping of the UGT1A locus identifies an uncommon coding variant that affects mRNA expression and protects from bladder cancer. | Tang W et al. | — | 2012 | → |
| Methods for meta-analyses of genome-wide association studies: critical assessment of empirical evidence. | Gögele M et al. | — | 2012 | → |
| Pooled sample-based GWAS: a cost-effective alternative for identifying colorectal and prostate cancer risk variants in the Polish population. | Gaj P et al. | — | 2012 | → |
| The Genetic Diversity and Structure of Linkage Disequilibrium of the MTHFR Gene in Populations of Northern Eurasia. | Trifonova EA et al. | — | 2012 | → |
| Using multiple genetic variants as instrumental variables for modifiable risk factors. | Palmer TM et al. | — | 2012 | → |
| What should the genome-wide significance threshold be? Empirical replication of borderline genetic associations. | Panagiotou OA et al. | — | 2012 | → |
| Alzheimer's disease genetics: current knowledge and future challenges. | Hollingworth P et al. | — | 2011 | → |
| Analysis of genome-wide association study data using the protein knowledge base. | Ballouz S et al. | — | 2011 | → |
| An empirical evaluation of imputation accuracy for association statistics reveals increased type-I error rates in genome-wide associations. | Almeida MA et al. | — | 2011 | → |
| Assessing the impact of missing genotype data in rare variant association analysis. | Mägi R et al. | — | 2011 | → |
| Assessment of the functionality of genome-wide canine SNP arrays and implications for canine disease association studies. | Ke X et al. | — | 2011 | → |
| Current status of genome-wide association studies in cancer. | Chung CC et al. | — | 2011 | → |
| Data integration workflow for search of disease driving genes and genetic variants. | Karinen S et al. | — | 2011 | → |
| Extent and genome-wide distribution of linkage disequilibrium in commercial maize germplasm. | Van Inghelandt D et al. | — | 2011 | → |
| Genetics and epigenetics of obesity. | Herrera BM et al. | — | 2011 | → |
| Genetics in psychiatry: are the promises met? | Bondy B | — | 2011 | → |
| Genetics of bipolar disorder. | Wendland JR et al. | — | 2011 | → |
| Genome-wide association mapping of agronomic traits in sugar beet. | Würschum T et al. | — | 2011 | → |
| Genome-wide population-based association study of extremely overweight young adults--the GOYA study. | Paternoster L et al. | — | 2011 | → |
| Human genetics and genomics a decade after the release of the draft sequence of the human genome. | Naidoo N et al. | — | 2011 | → |
| Immunogenetic mechanisms leading to thyroid autoimmunity: recent advances in identifying susceptibility genes and regions. | Brand OJ et al. | — | 2011 | → |
| Implication of next-generation sequencing on association studies. | Siu H et al. | — | 2011 | → |
| Imputation of low-frequency variants using the HapMap3 benefits from large, diverse reference sets. | Jostins L et al. | — | 2011 | → |
| Liver fibrogenesis and genetic factors. | Boursier J et al. | — | 2011 | → |
| Methods for testing association between uncertain genotypes and quantitative traits. | Kutalik Z et al. | — | 2011 | → |
| Molecular basis of obesity: current status and future prospects. | Choquet H et al. | — | 2011 | → |
| Technological issues and experimental design of gene association studies. | Distefano JK et al. | — | 2011 | → |
| The effect of genome-wide association scan quality control on imputation outcome for common variants. | Southam L et al. | — | 2011 | → |
| The search for the genetic contribution to autoimmune thyroid disease: the never ending story? | Simmonds MJ et al. | — | 2011 | → |
| The use of imputed values in the meta-analysis of genome-wide association studies. | Jiao S et al. | — | 2011 | → |
| Using Ascertainment for Targeted Resequencing to Increase Power to Identify Causal Variants. | Swartz MD et al. | — | 2011 | → |
| Validation in genetic association studies. | König IR | — | 2011 | → |
| Variation in human recombination rates and its genetic determinants. | Fledel-Alon A et al. | — | 2011 | → |
| Where in the genome are significant single nucleotide polymorphisms from genome-wide association studies located? | Günther T et al. | — | 2011 | → |
| You've gotta be lucky: Coverage and the elusive gene-gene interaction. | Reimherr M et al. | — | 2011 | → |
| Advances in genomic analysis of stroke: what have we learned and where are we headed? | Lanktree MB et al. | — | 2010 | → |
| Association of three polymorphisms selected from a genome-wide association study with coronary heart disease in the Tunisian population. | Ghazouani L et al. | — | 2010 | → |
| Evaluation of candidate genes in a genome-wide association study of childhood asthma in Mexicans. | Wu H et al. | — | 2010 | → |
| Fine-mapping quantitative trait loci for twinning rate on Bos taurus chromosome 14 in North American Holsteins. | Bierman CD et al. | — | 2010 | → |
| Genome-wide association studies in cancer--current and future directions. | Chung CC et al. | — | 2010 | → |
| Genome-wide association studies in diverse populations. | Rosenberg NA et al. | — | 2010 | → |
| Genome-wide association studies of hypertension: have they been fruitful? | Rafiq S et al. | — | 2010 | → |
| Genome-wide association study of recurrent major depressive disorder in two European case-control cohorts. | Muglia P et al. | — | 2010 | → |
| Genome-wide significant associations for variants with minor allele frequency of 5% or less--an overview: A HuGE review. | Panagiotou OA et al. | — | 2010 | → |
| HLA has strongest association with IgA nephropathy in genome-wide analysis. | Feehally J et al. | — | 2010 | → |
| Identifying candidate causal variants via trans-population fine-mapping. | Teo YY et al. | — | 2010 | → |
| Integrative systems biology for data-driven knowledge discovery. | Greene CS et al. | — | 2010 | → |
| MaCH: using sequence and genotype data to estimate haplotypes and unobserved genotypes. | Li Y et al. | — | 2010 | → |
| Methodological challenges of genome-wide association analysis in Africa. | Teo YY et al. | — | 2010 | → |
| Methods: genetic epidemiology. | Benke KS et al. | — | 2010 | → |
| New technologies in the genetic approach to sudden cardiac death in the young. | Brion M et al. | — | 2010 | → |
| Optimizing the power of genome-wide association studies by using publicly available reference samples to expand the control group. | Zhuang JJ et al. | — | 2010 | → |
| Patterns of linkage disequilibrium in different populations: implications and opportunities for lipid-associated loci identified from genome-wide association studies. | Teo YY et al. | — | 2010 | → |
| Practical considerations for imputation of untyped markers in admixed populations. | Shriner D et al. | — | 2010 | → |
| Quality control and quality assurance in genotypic data for genome-wide association studies. | Laurie CC et al. | — | 2010 | → |
| Rapid genomic characterization of the genus vitis. | Myles S et al. | — | 2010 | → |
| Replication of past candidate loci for common diseases and phenotypes in 100 genome-wide association studies. | Siontis KC et al. | — | 2010 | → |
| Search for cancer risk factors with microarray-based genome-wide association studies. | Zhang L et al. | — | 2010 | → |
| Systems biology and heart failure: concepts, methods, and potential research applications. | Adams KF | — | 2010 | → |
| The discovery of human genetic variations and their use as disease markers: past, present and future. | Ku CS et al. | — | 2010 | → |
| The genetics of NOD-like receptors in Crohn's disease. | Cummings JR et al. | — | 2010 | → |
| The genetics of obesity. | Herrera BM et al. | — | 2010 | → |
| The pursuit of genome-wide association studies: where are we now? | Ku CS et al. | — | 2010 | → |
| Validation of whole genome linkage-linkage disequilibrium and association results, and identification of markers to predict genetic merit for twinning. | Bierman CD et al. | — | 2010 | → |
| Whole-genome linkage and association scan in primary, nonsyndromic vesicoureteric reflux. | Cordell HJ et al. | — | 2010 | → |
| Accuracy of genome-wide imputation of untyped markers and impacts on statistical power for association studies. | Hao K et al. | — | 2009 | → |
| Advances in the genetics of schizophrenia: will high-risk copy number variants be useful in clinical genetics or diagnostics? | Collier DA et al. | — | 2009 | → |
| A genome-wide association study primer for clinicians. | Wang TH et al. | — | 2009 | → |
| A genome-wide investigation of SNPs and CNVs in schizophrenia. | Need AC et al. | — | 2009 | → |
| A genome-wide study of common SNPs and CNVs in cognitive performance in the CANTAB. | Need AC et al. | — | 2009 | → |
| A neurologist's guide to genome-wide association studies. | Mullen SA et al. | — | 2009 | → |
| Assessing the reproducibility of asthma candidate gene associations, using genome-wide data. | Rogers AJ et al. | — | 2009 | → |
| Common variants in the region around Osterix are associated with bone mineral density and growth in childhood. | Timpson NJ et al. | — | 2009 | → |
| Designing genome-wide association studies: sample size, power, imputation, and the choice of genotyping chip. | Spencer CC et al. | — | 2009 | → |
| Finding common susceptibility variants for complex disease: past, present and future. | Panoutsopoulou K et al. | — | 2009 | → |
| Flexible designs for genomewide association studies. | Scherag A et al. | — | 2009 | → |
| Genetics: unraveling the genetics of autoimmune disease. | Vyse TJ | — | 2009 | → |
| Genome-wide and fine-resolution association analysis of malaria in West Africa. | Jallow M et al. | — | 2009 | → |
| Genome-wide association database developed in the Japanese Integrated Database Project. | Koike A et al. | — | 2009 | → |
| Genome-wide association studies and the genetic dissection of complex traits. | Sebastiani P et al. | — | 2009 | → |
| Genome-wide association studies in Alzheimer's disease. | Bertram L et al. | — | 2009 | → |
| Genome-wide association study in humans. | Smith JG et al. | — | 2009 | → |
| Genome-wide association study in premature ovarian failure patients suggests ADAMTS19 as a possible candidate gene. | Knauff EA et al. | — | 2009 | → |
| Genome-wide association study of smoking initiation and current smoking. | Vink JM et al. | — | 2009 | → |
| Genome-wide scan for bovine twinning rate QTL using linkage disequilibrium. | Kim ES et al. | — | 2009 | → |
| Genotyping technologies for genetic research. | Ragoussis J | — | 2009 | → |
| Haploview: Visualization and analysis of SNP genotype data. | Barrett JC | — | 2009 | → |
| HapMap scanning of novel human minor histocompatibility antigens. | Kamei M et al. | — | 2009 | → |
| Human genetic variation and its contribution to complex traits. | Frazer KA et al. | — | 2009 | → |
| Is there still a need for candidate gene approaches in the era of genome-wide association studies? | Wilkening S et al. | — | 2009 | → |
| Linkage disequilibrium in the North American Holstein population. | Kim ES et al. | — | 2009 | → |
| Marker selection for genetic case-control association studies. | Pettersson FH et al. | — | 2009 | → |
| Meta-analysis in genome-wide association studies. | Zeggini E et al. | — | 2009 | → |
| Methodological Issues in Multistage Genome-wide Association Studies. | Thomas DC et al. | — | 2009 | → |
| Multi-criteria decision making approaches for quality control of genome-wide association studies. | Malovini A et al. | — | 2009 | → |
| Next generation disparities in human genomics: concerns and remedies. | Need AC et al. | — | 2009 | → |
| On quality control measures in genome-wide association studies: a test to assess the genotyping quality of individual probands in family-based association studies and an application to the HapMap data. | Fardo DW et al. | — | 2009 | → |
| Power consequences of linkage disequilibrium variation between populations. | Teo YY et al. | — | 2009 | → |
| Refined mapping of twinning-rate quantitative trait loci on bovine chromosome 5 and analysis of insulin-like growth factor-1 as a positional candidate gene. | Kim ES et al. | — | 2009 | → |
| Role of in silico tools in gene discovery. | Yu B | — | 2009 | → |
| Searching genetic risk factors for schizophrenia and bipolar disorder: learn from the past and back to the future. | Alaerts M et al. | — | 2009 | → |
| Size matters: just how big is BIG?: Quantifying realistic sample size requirements for human genome epidemiology. | Burton PR et al. | — | 2009 | → |
| Supplementing high-density SNP microarrays for additional coverage of disease-related genes: addiction as a paradigm. | Saccone SF et al. | — | 2009 | → |
| TagSNP transferability and relative loss of variability prediction from HapMap to an admixed population. | Lins TC et al. | — | 2009 | → |
| The role of genomics in the neonatal ICU. | Maresso K et al. | — | 2009 | → |
| The SNPMaP package for R: a framework for genome-wide association using DNA pooling on microarrays. | Davis OS et al. | — | 2009 | → |
| Association of candidate genes with antisocial drug dependence in adolescents. | Corley RP et al. | — | 2008 | → |
| A susceptibility locus for lung cancer maps to nicotinic acetylcholine receptor subunit genes on 15q25. | Hung RJ et al. | — | 2008 | → |
| A variant associated with nicotine dependence, lung cancer and peripheral arterial disease. | Thorgeirsson TE et al. | — | 2008 | → |
| Calibrating the performance of SNP arrays for whole-genome association studies. | Hao K et al. | — | 2008 | → |
| Calibration of credibility of agnostic genome-wide associations. | Ioannidis JP | — | 2008 | → |
| Characterization of LD structures and the utility of HapMap in genetic association studies. | Gu CC et al. | — | 2008 | → |
| Common genetic variation and human disease. | Orr N et al. | — | 2008 | → |
| Common statistical issues in genome-wide association studies: a review on power, data quality control, genotype calling and population structure. | Teo YY | — | 2008 | → |
| Common variants on 1p36 and 1q42 are associated with cutaneous basal cell carcinoma but not with melanoma or pigmentation traits. | Stacey SN et al. | — | 2008 | → |
| Efficient whole-genome association mapping using local phylogenies for unphased genotype data. | Ding Z et al. | — | 2008 | → |
| Estimating coverage and power for genetic association studies using near-complete variation data. | Bhangale TR et al. | — | 2008 | → |
| Estimation of significance thresholds for genomewide association scans. | Dudbridge F et al. | — | 2008 | → |
| Estimation of the multiple testing burden for genomewide association studies of nearly all common variants. | Pe'er I et al. | — | 2008 | → |
| Evaluating cost efficiency of SNP chips in genome-wide association studies. | Li C et al. | — | 2008 | → |
| Evaluating the effects of imputation on the power, coverage, and cost efficiency of genome-wide SNP platforms. | Anderson CA et al. | — | 2008 | → |
| Evaluating the performance of Affymetrix SNP Array 6.0 platform with 400 Japanese individuals. | Nishida N et al. | — | 2008 | → |
| Evaluation of coverage variation of SNP chips for genome-wide association studies. | Li M et al. | — | 2008 | → |
| Examining the statistical properties of fine-scale mapping in large-scale association studies. | Wiltshire S et al. | — | 2008 | → |
| Genetic association studies. | Lunetta KL | — | 2008 | → |
| Genetics of sudden cardiac arrest. | Prutkin JM et al. | — | 2008 | → |
| Genetics of type 2 diabetes mellitus and obesity--a review. | Jafar-Mohammadi B et al. | — | 2008 | → |
| Genetic susceptibility loci for breast cancer by estrogen receptor status. | Garcia-Closas M et al. | — | 2008 | → |
| Genomewide association for schizophrenia in the CATIE study: results of stage 1. | Sullivan PF et al. | — | 2008 | → |
| Genome-wide association studies for complex traits: consensus, uncertainty and challenges. | McCarthy MI et al. | — | 2008 | → |
| Genome-wide association studies in psychiatry: lessons from early studies of non-psychiatric and psychiatric phenotypes. | Craddock N et al. | — | 2008 | → |
| Genotyping platforms for mass-throughput genotyping with SNPs, including human genome-wide scans. | Maresso K et al. | — | 2008 | → |
| HapMap and mapping genes for cardiovascular disease. | Musunuru K et al. | — | 2008 | → |
| Inherited predisposition to chronic lymphocytic leukemia. | Brown JR | — | 2008 | → |
| Many sequence variants affecting diversity of adult human height. | Gudbjartsson DF et al. | — | 2008 | → |
| Mechanisms of disease: genetic insights into the etiology of type 2 diabetes and obesity. | Lindgren CM et al. | — | 2008 | → |
| Meta-analysis for ranked discovery datasets: theoretical framework and empirical demonstration for microarrays. | Zintzaras E et al. | — | 2008 | → |
| New links to the pathogenesis of Crohn disease provided by genome-wide association scans. | Mathew CG | — | 2008 | → |
| On transferability of genome-wide tagSNPs. | Gu CC et al. | — | 2008 | → |
| Power and SNP tagging in whole mitochondrial genome association studies. | McRae AF et al. | — | 2008 | → |
| Practical aspects of imputation-driven meta-analysis of genome-wide association studies. | de Bakker PI et al. | — | 2008 | → |
| Quantification and correction of bias in tagging SNPs caused by insufficient sample size and marker density by means of haplotype-dropping. | Iles MM | — | 2008 | → |
| Singleton SNPs in the human genome and implications for genome-wide association studies. | Ke X et al. | — | 2008 | → |
| SNPFile--a software library and file format for large scale association mapping and population genetics studies. | Nielsen J et al. | — | 2008 | → |
| Strong association of common variants in the CDKN2A/CDKN2B region with type 2 diabetes in French Europids. | Duesing K et al. | — | 2008 | → |
| Study designs for genome-wide association studies. | Kraft P et al. | — | 2008 | → |
| The environmental genome project: reference polymorphisms for drug metabolism genes and genome-wide association studies. | Rieder MJ et al. | — | 2008 | → |
| The expanding universe of inflammatory bowel disease genetics. | Achkar JP et al. | — | 2008 | → |
| The positives, protocols, and perils of genome-wide association. | Neale BM et al. | — | 2008 | → |
| The success of the genome-wide association approach: a brief story of a long struggle. | Seng KC et al. | — | 2008 | → |
| To what extent do scans of non-synonymous SNPs complement denser genome-wide association studies? | Evans DM et al. | — | 2008 | → |
| Type 2 diabetes: new genes, new understanding. | Prokopenko I et al. | — | 2008 | → |
| Universal false discovery rate estimation methodology for genome-wide association studies. | Forner K et al. | — | 2008 | → |
| Using the longest significance run to estimate region-specific p-values in genetic association mapping studies. | Lian IeB et al. | — | 2008 | → |
| Validation of the performance of a comprehensive genotyping assay panel of single nucleotide polymorphisms in drug metabolism enzyme genes. | Welch RA et al. | — | 2008 | → |
| What will whole genome searches for susceptibility genes for common complex disease offer to clinical practice? | Lango H et al. | — | 2008 | → |
| A genetic risk factor for periodic limb movements in sleep. | Stefansson H et al. | — | 2007 | → |
| A new era for Type 2 diabetes genetics. | Zeggini E | — | 2007 | → |
| Applicability of DNA pools on 500 K SNP microarrays for cost-effective initial screens in genomewide association studies. | Docherty SJ et al. | — | 2007 | → |
| A second generation human haplotype map of over 3.1 million SNPs. | International HapMap Consortium et al. | — | 2007 | → |
| Common pathways in Crohn's disease and other inflammatory diseases revealed by genomics. | Massey D et al. | — | 2007 | → |
| Common variants on chromosomes 2q35 and 16q12 confer susceptibility to estrogen receptor-positive breast cancer. | Stacey SN et al. | — | 2007 | → |
| Contribution of the novel inflammatory bowel disease gene IL23R to disease susceptibility and phenotype. | Cummings JR et al. | — | 2007 | → |
| Designing candidate gene and genome-wide case-control association studies. | Zondervan KT et al. | — | 2007 | → |
| Differential dropout among SNP genotypes and impacts on association tests. | Hao K et al. | — | 2007 | → |
| Effects of environment, genetics and data analysis pitfalls in an esophageal cancer genome-wide association study. | Statnikov A et al. | — | 2007 | → |
| Evaluating the performance of commercial whole-genome marker sets for capturing common genetic variation. | Mägi R et al. | — | 2007 | → |
| Evaluation of genome-wide power of genetic association studies based on empirical data from the HapMap project. | Nannya Y et al. | — | 2007 | → |
| Family-based association tests for genomewide association scans. | Chen WM et al. | — | 2007 | → |
| Fine mapping of disease genes using tagging SNPs. | Sjölander A et al. | — | 2007 | → |
| Gene-centric characteristics of genome-wide association studies. | Dong C et al. | — | 2007 | → |
| Genome-wide association study identifies a second prostate cancer susceptibility variant at 8q24. | Gudmundsson J et al. | — | 2007 | → |
| Genome-wide association study of 14,000 cases of seven common diseases and 3,000 shared controls. | Wellcome Trust Case Control Consortium | — | 2007 | → |
| Genome-wide selection of tag SNPs using multiple-marker correlation. | Hao K | — | 2007 | → |
| Genomic DNA pooling for whole-genome association scans in complex disease: empirical demonstration of efficacy in rheumatoid arthritis. | Steer S et al. | — | 2007 | → |
| IL23R variation determines susceptibility but not disease phenotype in inflammatory bowel disease. | Tremelling M et al. | — | 2007 | → |
| Information capture using SNPs from HapMap and whole-genome chips differs in a sample of inflammatory and cardiovascular gene-centric regions from genome-wide estimates. | Wallace C et al. | — | 2007 | → |
| Meta-analysis in genome-wide association datasets: strategies and application in Parkinson disease. | Evangelou E et al. | — | 2007 | → |
| Mining the genome for susceptibility to diabetic nephropathy: the role of large-scale studies and consortia. | Iyengar SK et al. | — | 2007 | → |
| Non-replication and inconsistency in the genome-wide association setting. | Ioannidis JP | — | 2007 | → |
| On the synthesis and interpretation of consistent but weak gene-disease associations in the era of genome-wide association studies. | Khoury MJ et al. | — | 2007 | → |
| Platelet genomics and the risk of atherothrombosis. | Ouwehand WH et al. | — | 2007 | → |
| Power analysis for genome-wide association studies. | Klein RJ | — | 2007 | → |
| Power to detect risk alleles using genome-wide tag SNP panels. | Eberle MA et al. | — | 2007 | → |
| Prediction of individual genetic risk to disease from genome-wide association studies. | Wray NR et al. | — | 2007 | → |
| Rapid and accurate haplotype phasing and missing-data inference for whole-genome association studies by use of localized haplotype clustering. | Browning SR et al. | — | 2007 | → |
| Scanning the genome. | Vogan K | — | 2007 | → |
| Simulating association studies: a data-based resampling method for candidate regions or whole genome scans. | Wright FA et al. | — | 2007 | → |
| Systematic association mapping identifies NELL1 as a novel IBD disease gene. | Franke A et al. | — | 2007 | → |
| Tag SNPs chosen from HapMap perform well in several population isolates. | Service S et al. | — | 2007 | → |
| Tag SNP selection for candidate gene association studies using HapMap and gene resequencing data. | Xu Z et al. | — | 2007 | → |
| The application of the HapMap to diabetic nephropathy and other causes of chronic renal failure. | Iyengar SK et al. | — | 2007 | → |
| The search for peripheral disease markers in psychiatry by genomic and proteomic approaches. | Domenici E et al. | — | 2007 | → |
| Whole genome amplification of DNA extracted from hair samples: potential for use in molecular epidemiologic studies. | Leanza SM et al. | — | 2007 | → |
| Whole genome genotyping technologies on the BeadArray platform. | Steemers FJ et al. | — | 2007 | → |
| A gene-centric approach to genome-wide association studies. | Jorgenson E et al. | — | 2006 | → |
| Agnosticism and equity in genome-wide association studies. | Carlson CS | — | 2006 | → |
| A high-resolution survey of deletion polymorphism in the human genome. | Conrad DF et al. | — | 2006 | → |
| Application of genome-wide single nucleotide polymorphism typing: simple association and beyond. | Gibbs JR et al. | — | 2006 | → |
| Aspects of genetic susceptibility to human infectious diseases. | Hill AV | — | 2006 | → |
| A worldwide survey of haplotype variation and linkage disequilibrium in the human genome. | Conrad DF et al. | — | 2006 | → |
| Common genetic variants for breast cancer: 32 largely refuted candidates and larger prospects. | Ioannidis JP | — | 2006 | → |
| Functional genomics and its implications for molecular medicine. | Broeckel U et al. | — | 2006 | → |
| Genomics meets HIV-1. | Telenti A et al. | — | 2006 | → |
| Lack of replication of thirteen single-nucleotide polymorphisms implicated in Parkinson's disease: a large-scale international study. | Elbaz A et al. | — | 2006 | → |
| Whole genome association mapping by incompatibilities and local perfect phylogenies. | Mailund T et al. | — | 2006 | → |