Co-occurring mental and substance use disorders: the neurobiological effects of chronic stress.
paper
Cited
Public
Unavailable
- Authors
- Brady, Kathleen T; Sinha, Rajita
- Year
- 2005
- Journal
- The American journal of psychiatry
- PMID
- 16055769
- DOI
- 10.1176/appi.ajp.162.8.1483
The high rate of co-occurrence of substance use disorders and other psychiatric disorders is well established. The population of people with co-occurring disorders is heterogeneous, and the prevalence of comorbidity differs by diagnostic group. One of the overarching issues in the area of comorbidity is the nature of the connection between psychiatric disorders and substance use disorders. The rapid development of technical advances in the neurosciences has led to a better understanding of the molecular biology, neurotransmitter systems, and neural circuitry involved in mental illness and substance use disorders. The authors discuss the neurobiological interface between substance use disorders and other psychiatric disorders with an emphasis on emerging data concerning four psychiatric disorders that commonly co-occur with substance use disorders: depression/mood disorders, posttraumatic stress disorder, attention deficit hyperactivity disorder, and schizophrenia. Better understanding of the connection between substance use disorders and psychiatric disorders could have a profound effect on prevention and treatment.
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| A test of adolescent internalizing and externalizing symptoms as prospective predictors of type of trauma exposure and posttraumatic stress disorder. | Haller M et al. | β | 2012 | β |
| Blockade of dopamine d4 receptors attenuates reinstatement of extinguished nicotine-seeking behavior in rats. | Yan Y et al. | β | 2012 | β |
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| Effect of cannabidiol on sleep disruption induced by the repeated combination tests consisting of open field and elevated plus-maze in rats. | Hsiao YT et al. | β | 2012 | β |
| Exploring age of onset as a causal link between major depression and nonmedical use of prescription medications. | Schepis TS et al. | β | 2012 | β |
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| Neuroimmunological effects of physical exercise in depression. | Eyre H et al. | β | 2012 | β |
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| Resilience to meet the challenge of addiction: psychobiology and clinical considerations. | Alim TN et al. | β | 2012 | β |
| Review of biological mechanisms and pharmacological treatments of comorbid PTSD and substance use disorder. | Norman SB et al. | β | 2012 | β |
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| A Heuristic for Developing Transdiagnostic Models of Psychopathology: Explaining Multifinality and Divergent Trajectories. | Nolen-Hoeksema S et al. | β | 2011 | β |
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| A perfect platform: combining contingency management with medications for drug abuse. | Carroll KM et al. | β | 2007 | β |
| Contested conclusions: claims that can (and cannot) be made from the current research on gay, lesbian, and bisexual teen suicide attempts. | Saewyc EM | β | 2007 | β |
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| Factors associated with discontinuation of antiretroviral therapy in HIV-infected patients with alcohol problems. | Kim TW et al. | β | 2007 | β |
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| In their own words: trauma and substance abuse in the lives of formerly homeless women with serious mental illness. | Padgett DK et al. | β | 2006 | β |
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