Association between obesity and psychiatric disorders in the US adult population.
paper
Cited
Public
Unavailable
- Authors
- Simon, Gregory E; Von Korff, Michael; Saunders, Kathleen; Miglioretti, Diana L; Crane, Paul K; van Belle, Gerald; Kessler, Ronald C
- Year
- 2006
- Journal
- Archives of general psychiatry
- PMID
- 16818872
- DOI
- 10.1001/archpsyc.63.7.824
- PMCID
- PMC1913935
BACKGROUND: Epidemiologic data suggest an association between obesity and depression, but findings vary across studies and suggest a stronger relationship in women than men. OBJECTIVE: To evaluate the relationship between obesity and a range of mood, anxiety, and substance use disorders in the US general population. DESIGN: Cross-sectional epidemiologic survey. SETTING: Nationally representative sample of US adults. PARTICIPANTS: A total of 9125 respondents who provided complete data on psychiatric disorder, height, and weight. Response rate was 70.9%. MAIN OUTCOME MEASURES: Participants completed an in-person interview, including assessment of a range of mental disorders (assessed using the World Health Organization Composite International Diagnostic Interview) and height and weight (by self-report). RESULTS: Obesity (defined as body mass index [calculated as weight in kilograms divided by the square of height in meters] of > or =30) was associated with significant increases in lifetime diagnosis of major depression (odds ratio [OR], 1.21; 95% confidence interval [CI], 1.09-1.35), bipolar disorder (OR, 1.47; 95% CI, 1.12-1.93), and panic disorder or agoraphobia (OR, 1.27; 95% CI, 1.01-1.60). Obesity was associated with significantly lower lifetime risk of substance use disorder (OR, 0.78; 95% CI, 0.65-0.93). Subgroup analyses found no difference in these associations between men and women, but the association between obesity and mood disorder was strongest in non-Hispanic whites (OR, 1.38; 95% CI, 1.20-1.59) and college graduates (OR, 1.44; 95% CI, 1.14-1.81). CONCLUSIONS: Obesity is associated with an approximately 25% increase in odds of mood and anxiety disorders and an approximately 25% decrease in odds of substance use disorders. Variation across demographic groups suggests that social or cultural factors may moderate or mediate the association between obesity and mood disorder.
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| Risk factors for psychiatric disorders in infertile women and men undergoing in vitro fertilization treatment. | Volgsten H et al. | — | 2010 | → |
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| The association between obesity and anxiety disorders in the population: a systematic review and meta-analysis. | Gariepy G et al. | — | 2010 | → |
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| The emerging link between alcoholism risk and obesity in the United States. | Grucza RA et al. | — | 2010 | → |
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| Toward a cancer-specific model of psychological distress: population data from the 2003-2005 National Health Interview Surveys. | Kaiser NC et al. | — | 2010 | → |
| Very low calorie diet (VLCD) followed by a randomized trial of corset treatment for obesity in primary care. | Wikstrand I et al. | — | 2010 | → |
| Adding cognitive behavioural treatment to either low-carbohydrate or low-fat diets: differential short-term effects. | Rodriguez-Hernandez H et al. | — | 2009 | → |
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| Relation of body mass index, periodontitis and Tannerella forsythia. | Haffajee AD et al. | — | 2009 | → |
| Role of depressive symptoms in explaining socioeconomic status disparities in dietary quality and central adiposity among US adults: a structural equation modeling approach. | Beydoun MA et al. | — | 2009 | → |
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| Elevated prevalence of obesity, metabolic syndrome, and cardiovascular risk factors in bipolar disorder. | Fiedorowicz JG et al. | — | 2008 | → |
| Exposure to elevated levels of dietary fat attenuates psychostimulant reward and mesolimbic dopamine turnover in the rat. | Davis JF et al. | — | 2008 | → |
| Gender differences in associations between body mass index and DSM-IV mood and anxiety disorders: results from the National Epidemiologic Survey on Alcohol and Related Conditions. | Barry D et al. | — | 2008 | → |
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| Increased rates of obesity in first-presentation adults with mood disorders over the course of four-year follow-up. | Taylor V et al. | — | 2008 | → |
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| Modification of cardiometabolic risk through cannabinoid type-1 receptor antagonism. | Andrikopoulos GK et al. | — | 2008 | → |
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| Selective 5-HT6 receptor ligands: progress in the development of a novel pharmacological approach to the treatment of obesity and related metabolic disorders. | Heal DJ et al. | — | 2008 | → |
| Shared psychopathology in obese subjects with and without binge-eating disorder. | Ramacciotti CE et al. | — | 2008 | → |
| Socioeconomic status, negative affect, and modifiable cancer risk factors in African-American smokers. | Kendzor DE et al. | — | 2008 | → |
| The association of depression and anxiety with obesity and unhealthy behaviors among community-dwelling US adults. | Strine TW et al. | — | 2008 | → |
| The influence of multi-morbidity and self-reported socio-economic standing on the prevalence of depression in an elderly Hong Kong population. | Wong SY et al. | — | 2008 | → |
| The relation between body mass index, mental health, and functional disability: a European population perspective. | Bruffaerts R et al. | — | 2008 | → |
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| Association of major depression and binge eating disorder with weight loss in a clinical setting. | Pagoto S et al. | — | 2007 | → |
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| Factors influencing glycemic control in type 2 diabetes during acute- and maintenance-phase treatment of major depressive disorder with bupropion. | Lustman PJ et al. | — | 2007 | → |
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| Highly palatable diet consumption increases protein oxidation in rat frontal cortex and anxiety-like behavior. | Souza CG et al. | — | 2007 | → |
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| Urban-rural differences in BMI, overweight and obesity in Norway (1990 and 2001). | Svensson E et al. | — | 2007 | → |
| Vagus nerve stimulation and emotional responses to food among depressed patients. | Bodenlos JS et al. | — | 2007 | → |