Alcohol reduces cross-frequency theta-phase gamma-amplitude coupling in resting electroencephalography.
- Authors
- Lee, Jaewon; Yun, Kyongsik
- Year
- 2014
- Journal
- Alcoholism, clinical and experimental research
- PMID
- 24255944
- DOI
- 10.1111/acer.12310
BACKGROUND: The electrophysiological inhibitory mechanism of cognitive control for alcohol remains largely unknown. The purpose of the study was to compare electroencephalogram (EEG) power spectra and cross-frequency phase-amplitude coupling (CFPAC) at rest and during a simple subtraction task after acute alcohol ingestion. METHODS: Twenty-one healthy subjects participated in this study. Two experiments were performed 1 week apart, and the order of the experiments was randomly assigned to each subject. During the experiments, each subject was provided with orange juice containing alcohol or orange juice only. We recorded EEG activity and analyzed power spectra and CFPAC data. RESULTS: The results showed prominent theta-phase gamma-amplitude coupling at the frontal and parietal electrodes at rest. This effect was significantly reduced after alcohol ingestion. CONCLUSIONS: Our findings suggest that theta-phase gamma-amplitude coupling is deficiently synchronized at rest after alcohol ingestion. Therefore, cross-frequency coupling could be a useful tool for studying the effects of alcohol on the brain and investigating alcohol addiction.
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External
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|---|---|---|---|---|
| Alcohol use disorder is associated with altered frontomedial phase-amplitude coupling strength during resting state. | Richard CD et al. | — | 2026 | → |
| Abnormal Exploratory Tendencies in Risk Decision-Making in Gambling Disorder: Evidence from the Balloon Analogue Risk Task. | Zhong G et al. | — | 2025 | → |
| Alcohol use disorder is associated with altered frontomedial phase-amplitude coupling strength during resting state | Richard C et al. | — | 2025 | — |
| A Systematic Review of the Balloon Analogue Risk Task (BART) in Alcohol Research. | Canning JR et al. | — | 2022 | → |
| Acute Low Alcohol Disrupts Hippocampus-Striatum Neural Correlate of Learning Strategy by Inhibition of PKA/CREB Pathway in Rats. | Sun W et al. | — | 2018 | → |
| Beta-frequency EEG activity increased during transcranial direct current stimulation. | Song M et al. | — | 2014 | → |