The function and expansion of the Patched- and Hedgehog-related homologs in C. elegans.
paper
Cited
Public
Unavailable
- Authors
- Zugasti, Olivier; Rajan, Jeena; Kuwabara, Patricia E
- Year
- 2005
- Journal
- Genome research
- PMID
- 16204193
- DOI
- 10.1101/gr.3935405
- PMCID
- PMC1240083
The Hedgehog (Hh) signaling pathway promotes pattern formation and cell proliferation in Drosophila and vertebrates. Hh is a ligand that binds and represses the Patched (Ptc) receptor and thereby releases the latent activity of the multipass membrane protein Smoothened (Smo), which is essential for transducing the Hh signal. In Caenorhabditis elegans, the Hh signaling pathway has undergone considerable divergence. Surprisingly, obvious Smo and Hh homologs are absent whereas PTC, PTC-related (PTR), and a large family of nematode Hh-related (Hh-r) proteins are present. We find that the number of PTC-related and Hh-r proteins has expanded in C. elegans, and that this expansion occurred early in Nematoda. Moreover, the function of these proteins appears to be conserved in Caenorhabditis briggsae. Given our present understanding of the Hh signaling pathway, the absence of Hh and Smo raises many questions about the evolution and the function of the PTC, PTR, and Hh-r proteins in C. elegans. To gain insights into their roles, we performed a global survey of the phenotypes produced by RNA-mediated interference (RNAi). Our study reveals that these genes do not require Smo for activity and that they function in multiple aspects of C. elegans development, including molting, cytokinesis, growth, and pattern formation. Moreover, a subset of the PTC, PTR, and Hh-r proteins have the same RNAi phenotypes, indicating that they have the potential to participate in the same processes.
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External
| Title | Authors | Journal | Year | Link |
|---|---|---|---|---|
| <i>Caenorhabditis elegans</i> as a model to explore the genetic underpinnings of human pain-related processes: cannabinoid and opioid neuropharmacology as an example. | Ernest-Hoar G et al. | β | 2026 | β |
| Early life starvation and Hedgehog-related signaling activate innate immunity downstream of daf-18/PTEN and lin-35/Rb causing developmental pathology in adult C. elegans. | Falsztyn IB et al. | β | 2025 | β |
| Non-cell-autonomous regulation of mTORC2 by Hedgehog signaling maintains lipid homeostasis. | VanDerMolen KR et al. | β | 2025 | β |
| Activated hedgehog and insulin ligands by decreased transcriptional factor DAF-16 mediate transgenerational nanoplastic toxicity in Caenorhabditis elegans. | Wu J et al. | β | 2024 | β |
| Caenorhabditis elegans Hedgehog-related proteins are tissue- and substructure-specific components of the cuticle and precuticle. | Serra ND et al. | β | 2024 | β |
| Stage-specific exposure of Caenorhabditis elegans to cadmium identifies unique transcriptomic response cascades and an uncharacterized cadmium responsive transcript. | Almutairi N et al. | β | 2024 | β |
| The Caenorhabditis elegans cuticle and precuticle: a model for studying dynamic apical extracellular matrices in vivo. | Sundaram MV et al. | β | 2024 | β |
| The <i>Caenorhabditis elegans</i> Dispatched ortholog, CHE-14, is dispensable for apical secretion of the Hedgehog-related proteins GRL-2 and WRT-10. | Serra ND et al. | β | 2024 | β |
| Tissue-specific RNA-seq defines genes governing male tail tip morphogenesis in C. elegans. | Kiontke KC et al. | β | 2024 | β |
| A DEAD-box helicase drives the partitioning of a pro-differentiation NAB protein into nuclear foci. | Doi A et al. | β | 2023 | β |
| A germline-targeted genetic screen for xrn-2 suppressors identifies a novel gene C34C12.2 in Caenorhabditis elegans. | AygΓΌn I et al. | β | 2023 | β |
| EAT-2 attenuates C. elegans development via metabolic remodeling in a chemically defined food environment. | Cao X et al. | β | 2023 | β |
| Effectors of anterior morphogenesis in C. elegans embryos. | Balasubramaniam B et al. | β | 2023 | β |
| GRD-1/PTR-11, the C. elegans hedgehog/patched-like morphogen-receptor pair, modulates developmental rate. | Emans SW et al. | β | 2023 | β |
| Hedgehog receptors exert immune-surveillance roles in the epidermis across species. | Wang Q et al. | β | 2023 | β |
| Isolation and molecular identification of nematode surface mutants with resistance to bacterial pathogens. | O'Rourke D et al. | β | 2023 | β |
| A DEAD-box helicase drives the partitioning of a pro-differentiation NAB protein into nuclear foci | Doi A et al. | β | 2022 | β |
| A patched1 gene homologue participates in female differentiation of Cynoglossus semilaevis. | Qi Q et al. | β | 2022 | β |
| Differential regulation of degradation and immune pathways underlies adaptation of the ectosymbiotic nematode Laxus oneistus to oxic-anoxic interfaces. | Paredes GF et al. | β | 2022 | β |
| Meta-Analysis of <i>Caenorhabditis elegans</i> Transcriptomics Implicates Hedgehog-Like Signaling in Host-Microbe Interactions. | ZΓ‘rate-Potes A et al. | β | 2022 | β |
| Patched-Related Is Required for Proper Development of Embryonic <i>Drosophila</i> Nervous System. | Bolatto C et al. | β | 2022 | β |
| Sterol regulation of developmental and oncogenic Hedgehog signaling. | Daggubati V et al. | β | 2022 | β |
| A Patched-Like Protein PsPTL Is Not Essential for the Growth and Response to Various Stresses in <i>Phytophthora sojae</i>. | Xue Z et al. | β | 2021 | β |
| Caenorhabditis elegans PTR/PTCHD PTR-18 promotes the clearance of extracellular hedgehog-related protein via endocytosis. | Chiyoda H et al. | β | 2021 | β |
| Extensive non-redundancy in a recently duplicated developmental gene family. | Baker EA et al. | β | 2021 | β |
| Patched regulates lipid homeostasis by controlling cellular cholesterol levels. | Cadena Del Castillo CE et al. | β | 2021 | β |
| Single worm transcriptomics identifies a developmental core network of oscillating genes with deep conservation across nematodes. | Sun S et al. | β | 2021 | β |
| The Caenorhabditis elegans Patched domain protein PTR-4Β is required for proper organization of the precuticular apical extracellular matrix. | Cohen JD et al. | β | 2021 | β |
| ARL13B regulates Sonic hedgehog signaling from outside primary cilia. | Gigante ED et al. | β | 2020 | β |
| Bacterial diets differentially alter lifespan and healthspan trajectories in C. elegans. | Stuhr NL et al. | β | 2020 | β |
| CREB Non-autonomously Controls Reproductive Aging through Hedgehog/Patched Signaling. | Templeman NM et al. | β | 2020 | β |
| How Weird is The Worm? Evolution of the Developmental Gene Toolkit in <i>Caenorhabditis elegans</i>. | Baker EA et al. | β | 2019 | β |
| Nematode Autotomy Requires Molting and Entails Tissue Healing without Obvious Regeneration. | Hodgkin J | β | 2019 | β |
| Functional Interactions Between <i>rsks-1</i>/S6K, <i>glp-1</i>/Notch, and Regulators of <i>Caenorhabditis elegans</i> Fertility and Germline Stem Cell Maintenance. | Roy D et al. | β | 2018 | β |
| PRY-1/Axin signaling regulates lipid metabolism in Caenorhabditis elegans. | Ranawade A et al. | β | 2018 | β |
| Conserved Ankyrin Repeat Proteins and Their NIMA Kinase Partners Regulate Extracellular Matrix Remodeling and Intracellular Trafficking in Caenorhabditis elegans. | LaΕΎetiΔ V et al. | β | 2017 | β |
| Control of signaling molecule range during developmental patterning. | Wilcockson SG et al. | β | 2017 | β |
| JMJD-1.2/PHF8 controls axon guidance by regulating Hedgehog-like signaling. | Riveiro AR et al. | β | 2017 | β |
| Mechanisms and functions of extracellular vesicle release in vivo-What we can learn from flies and worms. | Beer KB et al. | β | 2017 | β |
| Molting in <i>C. elegans</i>. | LaΕΎetiΔ V et al. | β | 2017 | β |
| BLIMP-1/BLMP-1 and Metastasis-Associated Protein Regulate Stress Resistant Development in Caenorhabditis elegans. | Hyun M et al. | β | 2016 | β |
| Comparative transcriptomics of the nematode gut identifies global shifts in feeding mode and pathogen susceptibility. | Lightfoot JW et al. | β | 2016 | β |
| Maintenance of Membrane Integrity and Permeability Depends on a Patched-Related Protein in Caenorhabditis elegans. | Choi MK et al. | β | 2016 | β |
| Overlapping cell population expression profiling and regulatory inference in C. elegans. | Burdick J et al. | β | 2016 | β |
| rBmΞ±TX14 Increases the Life Span and Promotes the Locomotion of Caenorhabditis Elegans. | Chen L et al. | β | 2016 | β |
| C. elegans NIMA-related kinases NEKL-2 and NEKL-3 are required for the completion of molting. | Yochem J et al. | β | 2015 | β |
| Identification of Wnt Pathway Target Genes Regulating the Division and Differentiation of Larval Seam Cells and Vulval Precursor Cells in Caenorhabditis elegans. | Gorrepati L et al. | β | 2015 | β |
| Spatial and temporal distribution of Patched-related protein in the Drosophila embryo. | Bolatto C et al. | β | 2015 | β |
| Tissue-specific transcriptomics and proteomics of a filarial nematode and its Wolbachia endosymbiont. | Luck AN et al. | β | 2015 | β |
| C. elegans as a model for membrane traffic. | Sato K et al. | β | 2014 | β |
| Extensive oscillatory gene expression during C. elegans larval development. | Hendriks GJ et al. | β | 2014 | β |
| Sex differences in body composition, fat storage, and gene expression profile in Caenorhabditis elegans in response to dietary restriction. | Miersch C et al. | β | 2013 | β |
| TGF-Ξ² signaling in C. elegans. | Gumienny TL et al. | β | 2013 | β |
| Parasite neuropeptide biology: Seeding rational drug target selection? | McVeigh P et al. | β | 2012 | β |
| Some, but not all, retromer components promote morphogenesis of C. elegans sensory compartments. | Oikonomou G et al. | β | 2012 | β |
| The Caenorhabditis elegans epidermis as a model skin. II: differentiation and physiological roles. | Chisholm AD et al. | β | 2012 | β |
| Caenorhabditis elegans Heterochromatin protein 1 (HPL-2) links developmental plasticity, longevity and lipid metabolism. | Meister P et al. | β | 2011 | β |
| C. elegans patched-3 is an essential gene implicated in osmoregulation and requiring an intact permease transporter domain. | Soloviev A et al. | β | 2011 | β |
| Gene expression profiling of oxidative stress response of C. elegans aging defective AMPK mutants using massively parallel transcriptome sequencing. | Shin H et al. | β | 2011 | β |
| NHR-23 dependent collagen and hedgehog-related genes required for molting. | Kouns NA et al. | β | 2011 | β |
| The Caenorhabditis elegans mucin-like protein OSM-8 negatively regulates osmosensitive physiology via the transmembrane protein PTR-23. | Rohlfing AK et al. | β | 2011 | β |
| Disruption at the PTCHD1 Locus on Xp22.11 in Autism spectrum disorder and intellectual disability. | Noor A et al. | β | 2010 | β |
| MLT-10 defines a family of DUF644 and proline-rich repeat proteins involved in the molting cycle of Caenorhabditis elegans. | Meli VS et al. | β | 2010 | β |
| Regulation of genes affecting body size and innate immunity by the DBL-1/BMP-like pathway in Caenorhabditis elegans. | Roberts AF et al. | β | 2010 | β |
| Hedgehog signalling: emerging evidence for non-canonical pathways. | Jenkins D | β | 2009 | β |
| Loss of the insulator protein CTCF during nematode evolution. | Heger P et al. | β | 2009 | β |
| Secretion of Hedgehog-related peptides and WNT during Caenorhabditis elegans development. | Kolotuev I et al. | β | 2009 | β |
| A hedgehog homolog is involved in muscle formation and organization of Sepia officinalis (mollusca) mantle. | Grimaldi A et al. | β | 2008 | β |
| Molecular characterization of a novel patched-related protein in Apis mellifera and Drosophila melanogaster. | Pastenes L et al. | β | 2008 | β |
| Molecular-genetic systems of development: functional dynamics and molecular evolution. | Gunbin KV et al. | β | 2008 | β |
| Evolution of the control of sexual identity in nematodes. | Pires-daSilva A | β | 2007 | β |
| Greased hedgehogs: new links between hedgehog signaling and cholesterol metabolism. | Breitling R | β | 2007 | β |
| Mining predicted essential genes of Brugia malayi for nematode drug targets. | Kumar S et al. | β | 2007 | β |
| Muscle-epidermis interactions affect exoskeleton patterning in Caenorhabditis elegans. | Broday L et al. | β | 2007 | β |
| Transcriptional repressor and activator activities of SMA-9 contribute differentially to BMP-related signaling outputs. | Liang J et al. | β | 2007 | β |
| Unravelling the moulting degradome: new opportunities for chemotherapy? | Craig H et al. | β | 2007 | β |
| Comprehensive analysis of gene expression patterns of hedgehog-related genes. | Hao L et al. | β | 2006 | β |
| The hedgehog-related gene qua-1 is required for molting in Caenorhabditis elegans. | Hao L et al. | β | 2006 | β |
| The V0-ATPase mediates apical secretion of exosomes containing Hedgehog-related proteins in Caenorhabditis elegans. | LiΓ©geois S et al. | β | 2006 | β |