Local potassium signaling couples neuronal activity to vasodilation in the brain.
paper
Cited
Public
Unavailable
- Authors
- Filosa, Jessica A; Bonev, Adrian D; Straub, Stephen V; Meredith, Andrea L; Wilkerson, M Keith; Aldrich, Richard W; Nelson, Mark T
- Year
- 2006
- Journal
- Nature neuroscience
- PMID
- 17013381
- DOI
- 10.1038/nn1779
The mechanisms by which active neurons, via astrocytes, rapidly signal intracerebral arterioles to dilate remain obscure. Here we show that modest elevation of extracellular potassium (K+) activated inward rectifier K+ (Kir) channels and caused membrane potential hyperpolarization in smooth muscle cells (SMCs) of intracerebral arterioles and, in cortical brain slices, induced Kir-dependent vasodilation and suppression of SMC intracellular calcium (Ca2+) oscillations. Neuronal activation induced a rapid (<2 s latency) vasodilation that was greatly reduced by Kir channel blockade and completely abrogated by concurrent cyclooxygenase inhibition. Astrocytic endfeet exhibited large-conductance, Ca2+-sensitive K+ (BK) channel currents that could be activated by neuronal stimulation. Blocking BK channels or ablating the gene encoding these channels prevented neuronally induced vasodilation and suppression of arteriolar SMC Ca2+, without affecting the astrocytic Ca2+ elevation. These results support the concept of intercellular K+ channel-to-K+ channel signaling, through which neuronal activity in the form of an astrocytic Ca2+ signal is decoded by astrocytic BK channels, which locally release K+ into the perivascular space to activate SMC Kir channels and cause vasodilation.
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| Expression of the voltage- and Ca2+-dependent BK potassium channel subunits BKΞ²1 and BKΞ²4 in rodent astrocytes. | Seidel KN et al. | β | 2011 | β |
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| Molecular and electrophysiological evidence for the expression of BK channels in oligodendroglial precursor cells. | Buttigieg J et al. | β | 2011 | β |
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| Astrocytic endfoot Ca2+ and BK channels determine both arteriolar dilation and constriction. | Girouard H et al. | β | 2010 | β |
| ATP, glia and central respiratory control. | Erlichman JS et al. | β | 2010 | β |
| Brain oscillations: ideal scenery to understand the neurovascular coupling. | Riera JJ et al. | β | 2010 | β |
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| Cerebral blood flow response to functional activation. | Paulson OB et al. | β | 2010 | β |
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| Do astrocytes really exocytose neurotransmitters? | Hamilton NB et al. | β | 2010 | β |
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| A review of the role of glial cells in understanding retinal disease. | Fletcher EL et al. | β | 2008 | β |
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