A comparison of factors associated with substance-induced versus independent depressions.
- Authors
- Schuckit, Marc A; Smith, Tom L; Danko, George P; Pierson, Juliann; Trim, Ryan; Nurnberger, John I; Kramer, John; Kuperman, Samuel; Bierut, Laura J; Hesselbrock, Victor
- Year
- 2007
- Journal
- Journal of studies on alcohol and drugs
- PMID
- 17960298
- DOI
- 10.15288/jsad.2007.68.805
OBJECTIVE: This article expands on the results from a 1997 report from the Collaborative Study on the Genetics of Alcoholism (COGA), using a new phase of the protocol to evaluate the prevalence and characteristics of substance-induced and independent major depressive episodes (MDEs) in a population of alcoholics and nonalcoholics. METHOD: Data were evaluated from Phase II of the six-center-wide COGA investigation using information gathered beginning in January 1997. Data were generated through face-to-face evaluations using the updated version of the Semi-Structured Assessment for the Genetics of Alcoholism (SSAGA-II) interview, with distinctions between substanceinduced and independent MDEs based on the chronology of development of full depressive syndromes. The analyses focused on the 2,548 men and women who were divided into 351 individuals who had only an independent MDE (Group 1), 238 subjects who experienced only substance-induced MDEs, and 1,959 individuals with no MDE history. RESULTS: The two MDE groups were similar in age, marital status, and religion; but those with substance-induced depressions (Group 2) were more likely to be original alcoholic probands, be males, be nonwhite, and have less education. They were also more likely to have alcohol, drug, or antisocial personality diagnoses and to report higher maximum drinks. In addition, only Group 2 subjects reported an elevated family history of alcohol diagnoses compared with the nondepressed Group 3. Subjects with independent MDEs were different from the comparison Group 3 regarding the family histories of independent MDEs. However, symptoms during the worst depressive episode were quite similar across Groups 1 and 2. CONCLUSIONS: This study corroborates a high rate of substance-induced MDEs among alcoholics, with these disorders explaining about half of the lifetime depressive episodes. The results also support the validity of the distinction between substance-induced and independent depressions regarding external validators of gender, substance-use patterns, and family histories of independent MDEs.
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|---|---|---|---|---|
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| The Relationship between Selected Factors (Temperament, Bipolar Traits, Sleep Quality, Severity of Addiction) and Depressive Symptoms in Alcohol-Dependent Men. | Nowakowska-DomagaΕa K et al. | β | 2023 | β |
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| Sex-Dependent Alcohol Instrumentalization Goals in Non-Addicted Alcohol Consumers versus Patients with Alcohol Use Disorder: Longitudinal Change and Outcome Prediction. | MΓΌller CP et al. | β | 2021 | β |
| Alcohol Induced Depression: Clinical, Biological and Genetic Features. | FarrΓ© A et al. | β | 2020 | β |
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| Depression and risky alcohol use: an examination of the role of difficulties regulating positive emotions in trauma-exposed individuals. | Schick MR et al. | β | 2019 | β |
| Factors linking suicidal ideation with drinking to cope and alcohol problems in emerging adult college drinkers. | Gonzalez VM | β | 2019 | β |
| Indexing the 'dark side of addiction': substance-induced affective symptoms and alcohol use disorders. | Ehlers CL et al. | β | 2019 | β |
| Outcome of Patients With High Depressive Symptoms on Admission to Methadone Maintenance Treatment. | Malik E et al. | β | 2019 | β |
| Animal models of psychoactive drug use and addiction - Present problems and future needs for translational approaches. | MΓΌller CP | β | 2018 | β |
| Modeling risk for child abuse and harsh parenting in families with depressed and substance-abusing parents. | Kelley ML et al. | β | 2015 | β |
| Predictors of subgroups based on maximum drinks per occasion over six years for 833 adolescents and young adults in COGA. | Schuckit MA et al. | β | 2014 | β |
| Substance-induced depression and independent depression in proximal risk for suicidal behavior. | Conner KR et al. | β | 2014 | β |
| DSM-5 criteria for substance use disorders: recommendations and rationale. | Hasin DS et al. | β | 2013 | β |
| Prospective study of substance-induced and independent major depressive disorder among individuals with substance use disorders in a nationally representative sample. | Magidson JF et al. | β | 2013 | β |
| Relationships among independent major depressions, alcohol use, and other substance use and related problems over 30 years in 397 families. | Schuckit MA et al. | β | 2013 | β |
| Commentary on 'reduced subjective response to acute ethanol administration among young men with a broad bipolar phenotype'. | Schuckit MA | β | 2012 | β |
| Differentiating first episode substance induced and primary psychotic disorders with concurrent substance use in young people. | Fraser S et al. | β | 2012 | β |
| Genome-wide association study of comorbid depressive syndrome and alcohol dependence. | Edwards AC et al. | β | 2012 | β |
| High versus low level of response to alcohol: evidence of differential reactivity to emotional stimuli. | Paulus MP et al. | β | 2012 | β |
| Psychiatric comorbidity in cocaine users treated in therapeutic community: substance-induced versus independent disorders. | Vergara-Moragues E et al. | β | 2012 | β |
| Psychometric properties of the sixth version of the Addiction Severity Index (ASI-6) in Brazil. | Kessler F et al. | β | 2012 | β |
| A comparison of independent depression and substance-induced depression in cannabis-, cocaine-, and opioid-dependent treatment seekers. | Dakwar E et al. | β | 2011 | β |
| A CRHR1 haplotype moderates the effect of adverse childhood experiences on lifetime risk of major depressive episode in African-American women. | Kranzler HR et al. | β | 2011 | β |
| Clarifying the relationship between alcohol and depression. | Conner KR | β | 2011 | β |
| Pretreatment clinical and risk correlates of substance use disorder patients with primary depression. | Cohn AM et al. | β | 2011 | β |
| Psychiatric comorbidity in illicit drug users: substance-induced versus independent disorders. | Torrens M et al. | β | 2011 | β |
| 5-HTTLPR polymorphism, mood disorders and MDMA use in a 3-year follow-up study. | MartΓn-Santos R et al. | β | 2010 | β |
| A double-blind, placebo-controlled trial combining sertraline and naltrexone for treating co-occurring depression and alcohol dependence. | Pettinati HM et al. | β | 2010 | β |
| Comorbidity of insomnia and depression. | Staner L | β | 2010 | β |
| Tobacco use moderates the association between major depression and obesity. | Leventhal AM et al. | β | 2010 | β |
| Refining the depression-nicotine dependence link: patterns of depressive symptoms in psychiatric outpatients with current, past, and no history of nicotine dependence. | Leventhal AM et al. | β | 2009 | β |
| Subtypes of major depression in substance dependence. | Niciu MJ et al. | β | 2009 | β |
| Depressed mood in childhood and subsequent alcohol use through adolescence and young adulthood. | Crum RM et al. | β | 2008 | β |
| The prognostic implications of DSM-IV abuse criteria in drinking adolescents. | Schuckit MA et al. | β | 2008 | β |