Exaggerated phase-amplitude coupling in the primary motor cortex in Parkinson disease.
- Authors
- de Hemptinne, Coralie; Ryapolova-Webb, Elena S; Air, Ellen L; Garcia, Paul A; Miller, Kai J; Ojemann, Jeffrey G; Ostrem, Jill L; Galifianakis, Nicholas B; Starr, Philip A
- Year
- 2013
- Journal
- Proceedings of the National Academy of Sciences of the United States of America
- PMID
- 23471992
- DOI
- 10.1073/pnas.1214546110
- PMCID
- PMC3606991
An important mechanism for large-scale interactions between cortical areas involves coupling between the phase and the amplitude of different brain rhythms. Could basal ganglia disease disrupt this mechanism? We answered this question by analysis of local field potentials recorded from the primary motor cortex (M1) arm area in patients undergoing neurosurgery. In Parkinson disease, coupling between Ξ²-phase (13-30 Hz) and Ξ³-amplitude (50-200 Hz) in M1 is exaggerated compared with patients with craniocervical dystonia and humans without a movement disorder. Excessive coupling may be reduced by therapeutic subthalamic nucleus stimulation. Peaks in M1 Ξ³-amplitude are coupled to, and precede, the subthalamic nucleus Ξ²-trough. The results prompt a model of the basal ganglia-cortical circuit in Parkinson disease incorporating phase-amplitude interactions and abnormal corticosubthalamic feedback and suggest that M1 local field potentials could be used as a control signal for automated programming of basal ganglia stimulators.
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