The lifetime cost of bipolar disorder in the US: an estimate for new cases in 1998.
paper
Cited
Public
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- Authors
- Begley, C E; Annegers, J F; Swann, A C; Lewis, C; Coan, S; Schnapp, W B; Bryant-Comstock, L
- Year
- 2001
- Journal
- PharmacoEconomics
- PMID
- 11465308
- DOI
- 10.2165/00019053-200119050-00004
OBJECTIVE: To develop a cost model that estimates the total and per case lifetime cost of bipolar disorder for 1998 incident cases in the US. STUDY DESIGN: Lifetime cost simulation model. PERSPECTIVE: Societal. METHODS: Age- and gender-specific incidence of bipolar disorder in 1998 was estimated by simulation based on existing prevalence data. The course of illness and mental health service cost of 6 clinically defined prognostic groups was estimated based on the research literature and the judgement of panels of experts. Excess cost of general medical care was estimated based on claims data from a large insurer. Indirect cost was projected including excess unemployment and reduced earnings reported in the National Comorbidity Survey. Comorbidity treatment and indirect cost related to alcohol (ethanol) and drug abuse was added based on a National Institute on Drug Abuse study. RESULTS: The present value of the lifetime cost of persons with onset of bipolar disorder in 1998 was estimated at 24 billion US dollars ($US). Average cost per case ranged from $US11,720 for persons with a single manic episode to $US624,785 for persons with nonresponsive/chronic episodes. CONCLUSION: The model indicates the potential cost savings of preventing a case of bipolar disorder and underscores the importance of achieving a stable outcome in new cases to limit the economic consequences of the disorder.
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| Title | Authors | Journal | Year | Link |
|---|---|---|---|---|
| Challenges in the development of treatment guidelines for bipolar disorder. | Fountoulakis KN et al. | β | 2025 | β |
| Managing a Complex Case of Bipolar Disorder in a Patient With Recurrent Hospitalizations. | Okpaleke Amazu C et al. | β | 2024 | β |
| Predicting Conversion to Insulin Sensitivity With Metformin: A Promising Tool for Clinicians in Addressing Insulin Resistance and Improving Outcomes in Patients With Treatment Resistant Bipolar Depression. | Gannon JM et al. | β | 2024 | β |
| A Prospective Comparison of Bipolar I and II Subjects with and without Comorbid Cannabis Use Disorders from the COGA Dataset. | Preuss UW et al. | β | 2023 | β |
| Assessments of functional outcomes and its determinants among bipolar disorder patients in Northwest Ethiopia comprehensive specialized hospitals: a multicenter hospital-based study. | Mengistu ME et al. | β | 2023 | β |
| Diagnosis of bipolar disorders and body mass index predict clustering based on similarities in cortical thickness-ENIGMA study in 2436 individuals. | McWhinney SR et al. | β | 2022 | β |
| Long-Term Healthcare Utilization and the Cost of Bipolar Disorder Among Participants in a Large Employer's Health Benefit Plan. | Leung N et al. | β | 2022 | β |
| Association between body mass index and subcortical brain volumes in bipolar disorders-ENIGMA study in 2735 individuals. | McWhinney SR et al. | β | 2021 | β |
| Prescriber Attitudes, Experiences, and Proclivities Toward Digital Medicine and How They Influence Adoption of Digital Medicine Platforms. | Ruetsch C et al. | β | 2021 | β |
| The Association between Patient Activation and Outcomes among Severely Mentally Ill Patients. | Forma F et al. | β | 2021 | β |
| The costs of bipolar disorder in the United Kingdom. | Simon J et al. | β | 2021 | β |
| Effects of Lithium Combined with Second-Generation Antipsychotics for the Treatment of Manic Episodes in Patients with Bipolar Disorder: A Naturalistic Study in China. | Liu Y et al. | β | 2020 | β |
| Health, subjective financial situation and well-being: a longitudinal observational study. | Downward P et al. | β | 2020 | β |
| Smartphone as a monitoring tool for bipolar disorder: a systematic review including data analysis, machine learning algorithms and predictive modelling. | Antosik-WΓ³jciΕska AZ et al. | β | 2020 | β |
| The Economic Burden of Bipolar Disorder in the United States: A Systematic Literature Review. | Bessonova L et al. | β | 2020 | β |
| Sustained Reduction in Health Care Service Usage after Adjunctive Treatment of Intensive Short-Term Dynamic Psychotherapy in Patients with Bipolar Disorder. | Abbass A et al. | β | 2019 | β |
| Use of "Lights" for Bipolar Depression. | Sit D et al. | β | 2019 | β |
| A Dynamical Bifurcation Model of Bipolar Disorder Based on Learned Expectation and Asymmetry in Mood Sensitivity. | Chang SS et al. | β | 2018 | β |
| Analysis on speech signal features of manic patients. | Zhang J et al. | β | 2018 | β |
| Associations of Comorbid Anxiety With Medication Adherence and Psychiatric Symptomatology in a Population of Nonadherent Bipolar Disorder Subjects. | Aftab A et al. | β | 2018 | β |
| Mice with reduced DAT levels recreate seasonal-induced switching between states in bipolar disorder. | Young JW et al. | β | 2018 | β |
| Narrative identity in female patients with remitted bipolar disorder: a negative past and a foreshortened future. | Pedersen AM et al. | β | 2018 | β |
| Parenting practices in middle childhood mediate the relation between growing up with a parent having bipolar disorder and offspring psychopathology from childhood into early adulthood. | Iacono V et al. | β | 2018 | β |
| Spotlight on once-monthly long-acting injectable aripiprazole and its potential as maintenance treatment for bipolar I disorder in adult patients. | Torres-Llenza V et al. | β | 2018 | β |
| The economic burden of bipolar I disorder in the United States in 2015. | Cloutier M et al. | β | 2018 | β |
| The role of lifetime anxiety history in the course of bipolar spectrum disorders. | Titone MK et al. | β | 2018 | β |
| The International College of Neuropsychopharmacology (CINP) Treatment Guidelines for Bipolar Disorder in Adults (CINP-BD-2017), Part 1: Background and Methods of the Development of Guidelines. | Fountoulakis KN et al. | β | 2017 | β |
| Patients With High Mental Health Costs Incur Over 30Β Percent More Costs Than Other High-Cost Patients. | de Oliveira C et al. | β | 2016 | β |
| Peripapillary retinal nerve fiber layer thickness in bipolar disorder. | Mehraban A et al. | β | 2016 | β |
| Psychiatry meets pharmacogenetics for the treatment of revolving door patients with psychiatric disorders. | Panza F et al. | β | 2016 | β |
| Using Smartphones to Monitor Bipolar Disorder Symptoms: A Pilot Study. | Beiwinkel T et al. | β | 2016 | β |
| Volume, metabolites and neuroinflammation of the hippocampus in bipolar disorder - A combined magnetic resonance imaging and positron emission tomography study. | Haarman BC et al. | β | 2016 | β |
| A technology-enabled adherence enhancement system for people with bipolar disorder: results from a feasibility and patient acceptance analysis. | Sajatovic M et al. | β | 2015 | β |
| Cost-effectiveness of lurasidone vs quetiapine extended-release (XR) in patients with bipolar depression. | Rajagopalan K et al. | β | 2015 | β |
| Cost-of-illness studies for bipolar disorder: systematic review of international studies. | Jin H et al. | β | 2015 | β |
| Investigating the mechanism(s) underlying switching between states in bipolar disorder. | Young JW et al. | β | 2015 | β |
| Lost productive life years caused by chronic conditions in Australians aged 45-64 years, 2010-2030. | Schofield DJ et al. | β | 2015 | β |
| Modeling bipolar disorder in mice by increasing acetylcholine or dopamine: chronic lithium treats most, but not all features. | van Enkhuizen J et al. | β | 2015 | β |
| Negative cognitive styles synergistically predict suicidal ideation in bipolar spectrum disorders: a 3-year prospective study. | Stange JP et al. | β | 2015 | β |
| Symptom severity, self-reported adherence, and electronic pill monitoring in poorly adherent patients with bipolar disorder. | Sajatovic M et al. | β | 2015 | β |
| The real world cost and health resource utilization associated to manic episodes: The MANACOR study. | Hidalgo-Mazzei D et al. | β | 2015 | β |
| Childhood maltreatment and the course of bipolar disorders among adults: epidemiologic evidence of dose-response effects. | Sala R et al. | β | 2014 | β |
| Comparative study of cost of care of outpatients with bipolar disorder and schizophrenia. | Somaiya M et al. | β | 2014 | β |
| Cost of illness for bipolar disorder: a systematic review of the economic burden. | Kleine-Budde K et al. | β | 2014 | β |
| Dietary intake and plasma metabolomic analysis of polyunsaturated fatty acids in bipolar subjects reveal dysregulation of linoleic acid metabolism. | Evans SJ et al. | β | 2014 | β |
| Glia and immune cell signaling in bipolar disorder: insights from neuropharmacology and molecular imaging to clinical application. | Watkins CC et al. | β | 2014 | β |
| Public health significance of bipolar disorder: implications for early intervention and prevention. | Conus P et al. | β | 2014 | β |
| Taking or not taking medications: psychiatric treatment perceptions in patients diagnosed with bipolar disorder. | Vargas-Huicochea I et al. | β | 2014 | β |
| Towards the clinical implementation of pharmacogenetics in bipolar disorder. | Salloum NC et al. | β | 2014 | β |
| Bipolar disorder and co-occurring cannabis use disorders: characteristics, co-morbidities and clinical correlates. | Lev-Ran S et al. | β | 2013 | β |
| Costs of the principal mood disorders: a study of comparative direct and indirect costs incurred by those with bipolar I, bipolar II and unipolar disorders. | Parker G et al. | β | 2013 | β |
| Patterns of atypical antipsychotic therapy use in adults with bipolar I disorder in the USA. | Chen W et al. | β | 2013 | β |
| Pharmacogenomics of bipolar disorder. | Severino G et al. | β | 2013 | β |
| The societal cost of bipolar disorder in Sweden. | Ekman M et al. | β | 2013 | β |
| Aripiprazole in combination with lamotrigine for the long-term treatment of patients with bipolar I disorder (manic or mixed): a randomized, multicenter, double-blind study (CN138-392). | Carlson BX et al. | β | 2012 | β |
| Customization in prescribing for bipolar disorder. | Hodgkin D et al. | β | 2012 | β |
| Effects of the anticonvulsant lacosamide compared to valproate and lamotrigine on cocaine-enhanced reward in rats. | BΓ©guin C et al. | β | 2012 | β |
| Medical costs and vasculometabolic comorbidities among patients with bipolar disorder in Taiwan - a population-based and matched-control study. | Hsieh MH et al. | β | 2012 | β |
| Quetiapine: a pharmacoeconomic review of its use in bipolar disorder. | Plosker GL | β | 2012 | β |
| Risk or resilience? Empathic abilities in patients with bipolar disorders and their first-degree relatives. | Seidel EM et al. | β | 2012 | β |
| Systematic review of the neural basis of social cognition in patients with mood disorders. | Cusi AM et al. | β | 2012 | β |
| The impact of back problems on retirement wealth. | Schofield D et al. | β | 2012 | β |
| Treatment use and costs among privately insured youths with diagnoses of bipolar disorder. | Dusetzina SB et al. | β | 2012 | β |
| Adherence, persistence of use, and costs associated with second-generation antipsychotics for bipolar disorder. | Rascati KL et al. | β | 2011 | β |
| Are screening scales for bipolar disorder good enough to be used in clinical practice? | Zimmerman M et al. | β | 2011 | β |
| Economic impacts of illness in older workers: quantifying the impact of illness on income, tax revenue and government spending. | Schofield DJ et al. | β | 2011 | β |
| Estimation of resource utilisation difference between lithium and valproate treatment groups from the VALID study. | Li SC et al. | β | 2011 | β |
| Reliability and validity of the Chinese Version of the Mood Disorder Questionnaire. | Lin CJ et al. | β | 2011 | β |
| Surgical treatment of morbid obesity among patients with bipolar disorder: a research agenda. | Ahmed AT et al. | β | 2011 | β |
| White matter hyperintensities: from medical comorbidities to bipolar disorders and back. | Gunde E et al. | β | 2011 | β |
| Altered self-report of empathic responding in patients with bipolar disorder. | Cusi A et al. | β | 2010 | β |
| Cost effectiveness of adjunctive quetiapine fumarate extended-release tablets with mood stabilizers in the maintenance treatment of bipolar I disorder. | Woodward TC et al. | β | 2010 | β |
| Cross-species assessments of motor and exploratory behavior related to bipolar disorder. | Henry BL et al. | β | 2010 | β |
| Diagnosis and treatment of postpartum bipolar depression. | Kelly E et al. | β | 2010 | β |
| Disorder-specific psychosocial interventions for bipolar disorder--a systematic review of the evidence for mental health nursing practice. | Crowe M et al. | β | 2010 | β |
| Exploratory analysis of psychiatric-related utilization and costs associated with paliperidone ER compared with other oral atypical antipsychotics using pharmacy claims from an administrative database. | Panish JM et al. | β | 2010 | β |
| Indirect costs associated with nonadherence to treatment for bipolar disorder. | Bagalman E et al. | β | 2010 | β |
| One-year post-hospital medical costs and relapse rates of bipolar disorder patients in Taiwan: a population-based study. | Tang CH et al. | β | 2010 | β |
| Overdiagnosis of bipolar disorder and disability payments. | Zimmerman M et al. | β | 2010 | β |
| Pattern of healthcare resource utilization and direct costs associated with manic episodes in Spain. | Tafalla M et al. | β | 2010 | β |
| Screening for bipolar disorder during pregnancy and the postpartum period. | Sharma V et al. | β | 2010 | β |
| Something borrowed, something blue: why is bipolar disorder an orphan? | Nierenberg AA | β | 2010 | β |
| The association of weight gain with mood symptoms and functional outcomes following a first manic episode: prospective 12-month data from the Systematic Treatment Optimization Program for Early Mania (STOP-EM). | Bond DJ et al. | β | 2010 | β |
| The cost of relapse for patients with a manic/mixed episode of bipolar disorder in the EMBLEM study. | Hong J et al. | β | 2010 | β |
| Weight gain, obesity, and metabolic indices following a first manic episode: prospective 12-month data from the Systematic Treatment Optimization Program for Early Mania (STOP-EM). | Bond DJ et al. | β | 2010 | β |
| Workplace productivity, employment issues, and resource utilization in patients with bipolar I disorder. | McMorris BJ et al. | β | 2010 | β |
| A systematic review of the evidence of the burden of bipolar disorder in Europe. | Fajutrao L et al. | β | 2009 | β |
| Bipolar disorder and mechanisms of action of mood stabilizers. | Rapoport SI et al. | β | 2009 | β |
| Cost analysis in a Medicaid program for patients with bipolar disorder who initiated atypical antipsychotic monotherapy. | Qiu Y et al. | β | 2009 | β |
| Cost-effectiveness of quetiapine with lithium or divalproex for maintenance treatment of bipolar I disorder. | Woodward TC et al. | β | 2009 | β |
| Difficult to swallow: patient preferences for alternative valproate pharmaceutical formulations. | Bhosle M et al. | β | 2009 | β |
| Healthcare costs associated with treatment of bipolar disorder using a mood stabilizer plus adjunctive aripiprazole, quetiapine, risperidone, olanzapine or ziprasidone. | Jing Y et al. | β | 2009 | β |
| Predictors of nonadherence among individuals with bipolar disorder receiving treatment in a community mental health clinic. | Sajatovic M et al. | β | 2009 | β |
| Psychiatric admissions and hospitalization costs in bipolar disorder in Sweden. | Osby U et al. | β | 2009 | β |
| Risk of rehospitalization among bipolar disorder patients who are nonadherent to antipsychotic therapy after hospital discharge. | Hassan M et al. | β | 2009 | β |
| The relationship between antipsychotic medication adherence and patient outcomes among individuals diagnosed with bipolar disorder: a retrospective study. | Lage MJ et al. | β | 2009 | β |
| Chronic disease and labour force participation among older Australians. | Schofield DJ et al. | β | 2008 | β |
| Factors associated with prospective long-term treatment adherence among individuals with bipolar disorder. | Sajatovic M et al. | β | 2008 | β |
| Genetics of bipolar disorder. | Escamilla MA et al. | β | 2008 | β |
| Impact of bipolar disorder on the family: utilization and cost of health care resources. | Chatterton ML et al. | β | 2008 | β |
| Mode of action of mood stabilizers: is the arachidonic acid cascade a common target? | Rao JS et al. | β | 2008 | β |
| Neuronal peroxisome proliferator-activated receptor gamma signaling: regulation by mood-stabilizer valproate. | Lan MJ et al. | β | 2008 | β |
| The costs of breast cancer in a Mexican public health institution. | GΓ³mez-Rico JA et al. | β | 2008 | β |
| Treatment costs and health care utilization for patients with bipolar disorder in a large managed care population. | Guo JJ et al. | β | 2008 | β |
| Animal models of bipolar disorder and mood stabilizer efficacy: a critical need for improvement. | Gould TD et al. | β | 2007 | β |
| Antimanic therapies target brain arachidonic acid signaling: lessons learned about the regulation of brain fatty acid metabolism. | Lee HJ et al. | β | 2007 | β |
| Bipolar disorder: improving diagnosis and optimizing integrated care. | Culver JL et al. | β | 2007 | β |
| Bipolar disorders in Australia. A population-based study of excess costs. | Fisher LJ et al. | β | 2007 | β |
| Bipolar spectrum disorder: differential diagnosis and treatment. | Muzina DJ | β | 2007 | β |
| Cost effectiveness of olanzapine in prevention of affective episodes in bipolar disorder in the United Kingdom. | McKendrick J et al. | β | 2007 | β |
| Economic outcomes associated with atypical antipsychotics in bipolar disorder: a systematic review. | Fleurence RL et al. | β | 2007 | β |
| Impact of bipolar disorder: results from a screening study. | Stang P et al. | β | 2007 | β |
| Influence of medication choice and comorbid diabetes: the cost of bipolar disorder in a privately insured US population. | Harley C et al. | β | 2007 | β |
| Maintenance treatment in bipolar disorder: a focus on aripiprazole. | McIntyre RS et al. | β | 2007 | β |
| Prevalence, comorbidity, and service utilization for mood disorders in the United States at the beginning of the twenty-first century. | Kessler RC et al. | β | 2007 | β |
| Treatment costs related to bipolar disorder and comorbid conditions among Medicaid patients with bipolar disorder. | Guo JJ et al. | β | 2007 | β |
| Collaborative care for bipolar disorder: part I. Intervention and implementation in a randomized effectiveness trial. | Bauer MS et al. | β | 2006 | β |
| Community survey of bipolar disorder in Canada: lifetime prevalence and illness characteristics. | Schaffer A et al. | β | 2006 | β |
| [Epidemiology of medication prescriptions in bipolar disorder]. | Limosin F | β | 2006 | β |
| Incurring greater health care costs: risk stratification of employees with bipolar disorder. | Brook RA et al. | β | 2006 | β |
| Long-term use of atypical antipsychotics in bipolar disorder. | Ehret MJ et al. | β | 2006 | β |
| Misdiagnosis of bipolar disorder. | Singh T et al. | β | 2006 | β |
| Point-counterpoint: the importance of "open access" to psychotropics for our patients. | Schmetzer AD et al. | β | 2006 | β |
| Prevalence and effects of mood disorders on work performance in a nationally representative sample of U.S. workers. | Kessler RC et al. | β | 2006 | β |
| Psychopathology in the young offspring of parents with bipolar disorder: a controlled pilot study. | Hirshfeld-Becker DR et al. | β | 2006 | β |
| Burden of illness in bipolar depression. | Manning JS | β | 2005 | β |
| Canadian Network for Mood and Anxiety Treatments (CANMAT) guidelines for the management of patients with bipolar disorder: consensus and controversies. | Yatham LN et al. | β | 2005 | β |
| Identifying and improving non-adherence in bipolar disorders. | Colom F et al. | β | 2005 | β |
| Lost time, absence costs, and reduced productivity output for employees with bipolar disorder. | Kleinman NL et al. | β | 2005 | β |
| Pathways to care for patients with bipolar disorder. | Bhugra D et al. | β | 2005 | β |
| Patient-based utilities for bipolar disorder-related health states. | Revicki DA et al. | β | 2005 | β |
| Quality of care measures for the treatment of bipolar disorder. | Duffy FF et al. | β | 2005 | β |
| Service utilization and costs of olanzapine versus divalproex treatment for acute mania: results from a randomized, 47-week clinical trial. | Zhu B et al. | β | 2005 | β |
| Bipolar disorder. | Belmaker RH | β | 2004 | β |
| Bipolar disorder: a national health concern. | McIntyre RS et al. | β | 2004 | β |
| Datapoints: Costs associated with the treatment of patients with bipolar disorder in a managed care organization. | Knoth RL et al. | β | 2004 | β |
| Economic grand rounds: the economic burden of bipolar disorder. | Stimmel GL | β | 2004 | β |
| The World Federation of Societies of Biological Psychiatry (WFSBP) guidelines for the biological treatment of bipolar disorders, part III: maintenance treatment. | Grunze H et al. | β | 2004 | β |
| Undiagnosed Bipolar Disorder: New Syndromes and New Treatments. | Glick ID | β | 2004 | β |
| Unmet needs in bipolar depression. | Frye MA et al. | β | 2004 | β |
| Women and bipolar disorder across the life span. | Sit D | β | 2004 | β |
| Bipolar offspring: a window into bipolar disorder evolution. | Chang K et al. | β | 2003 | β |
| Clinical consequences of under-recognized bipolar spectrum disorder. | Dunner DL | β | 2003 | β |
| Costs of bipolar disorder. | Kleinman L et al. | β | 2003 | β |
| Frequency of hospitalisations and inpatient care costs of manic episodes: in patients with bipolar I disorder in France. | de Zelicourt M et al. | β | 2003 | β |
| Bipolar affective disorder-left out in the cold. Too late for the national service framework but local initiatives may be possible. | Morriss R et al. | β | 2002 | β |
| Bipolar I disorder: psychopathology, medical management and dental implications. | Friedlander AH et al. | β | 2002 | β |
| The Mood Disorder Questionnaire: A Simple, Patient-Rated Screening Instrument for Bipolar Disorder. | Hirschfeld RM | β | 2002 | β |
| The Wnt signaling pathway in bipolar disorder. | Gould TD et al. | β | 2002 | β |
| Olanzapine: a review of its use in the treatment of bipolar I disorder. | Bhana N et al. | β | 2001 | β |