Mismatch negativity: no difference between controls and abstinent alcoholics.
- Authors
- Fein, George; Whitlow, Bridget; Finn, Peter
- Year
- 2004
- Journal
- Alcoholism, clinical and experimental research
- PMID
- 14745312
- DOI
- 10.1097/01.ALC.0000107199.26934.46
- PMCID
- PMC1868692
BACKGROUND: A number of studies have examined the amplitude of the mismatch negativity (MMN) evoked potential as a measure of a brain inhibitory deficit in alcoholics or those at risk for alcoholism. The current study examined MMN in alcoholics abstinent an average of 6.7 years (with a minimum of six months abstinence) compared to controls. This study examined the association of MMN with alcoholism family history density, with indices of the presence and severity of externalizing disorders (a risk-factor for alcoholism), and with alcohol use variables. METHODS: Electroencephalograms were gathered on 76 subjects (38 controls, 38 abstinent alcoholics) during a nonattending mismatch negativity experiment. Measures of alcoholism family history density, disinhibited personality traits, and antisocial symptoms served as measures of risk-factors known to be associated with a genetic liability to alcoholism. Alcohol use variables were used as measures of alcoholism severity. RESULTS: There were no differences in MMN amplitude or latency between controls and abstinent alcoholics. There also were no significant associations between MMN measures and the measures of risk for alcoholism or with the severity of alcohol use or duration of abstinence. CONCLUSIONS: The results suggest that MMN is neither affected in chronic alcoholics nor associated with alcoholism vulnerability, and thus does not reflect a trait marker of alcoholism or alcoholism risk. The current results do not address effects on MMN of acute alcohol ingestion or withdrawal from alcohol.
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| Event-related potentials and use of psychotropic medication in major psychiatric disorders. | Kool L et al. | — | 2022 | → |
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| Using Mismatch Negativity to Investigate the Pathophysiology of Substance Use Disorders and Comorbid Psychosis. | Ramlakhan JU et al. | — | 2018 | → |
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| Advances in Electrophysiological Research. | Kamarajan C et al. | — | 2015 | → |
| Alcohol use in bipolar disorder: A neurobiological model to help predict susceptibility, select treatments and attenuate cortical insult. | Chitty KM et al. | — | 2015 | → |
| Event-related potentials in substance use disorders: a narrative review based on articles from 1984 to 2012. | Campanella S et al. | — | 2014 | → |
| Risky alcohol use predicts temporal mismatch negativity impairments in young people with bipolar disorder. | Chitty KM et al. | — | 2014 | → |
| Understanding alcohol use disorders with neuroelectrophysiology. | Rangaswamy M et al. | — | 2014 | → |
| The mismatch negativity (MMN)--a unique window to disturbed central auditory processing in ageing and different clinical conditions. | Näätänen R et al. | — | 2012 | → |
| Recent EEG and ERP findings in substance abusers. | Ceballos NA et al. | — | 2009 | → |
| Can mismatch negativity be linked to synaptic processes? A glutamatergic approach to deviance detection. | Strelnikov K | — | 2007 | → |
| Mismatch negativity impairment associated with alcohol consumption in chronic alcoholics: a scalp current density study. | Marco-Pallarés J et al. | — | 2007 | → |
| EEG spectral changes in treatment-naive, actively drinking alcoholics. | Fein G et al. | — | 2005 | → |
| Effects of chronic alcohol consumption in a visual attention task and an auditory oddball task: an event-related potential study. | Bijl S et al. | — | 2005 | → |
| The utility of neurophysiological markers in the study of alcoholism. | Porjesz B et al. | — | 2005 | → |
| Mismatch negativity: no difference between treatment-naive alcoholics and controls. | Fein G et al. | — | 2004 | → |