Problem gamblers exhibit reward hypersensitivity in medial frontal cortex during gambling.
paper
Cited
Public
Unavailable
- Authors
- Oberg, Scott A K; Christie, Gregory J; Tata, Matthew S
- Year
- 2011
- Journal
- Neuropsychologia
- PMID
- 21982697
- DOI
- 10.1016/j.neuropsychologia.2011.09.037
Problem gambling (PG) is increasingly conceptualized as an addiction akin to substance abuse, rather than an impulse control disorder, however the mechanism of addiction remains unclear. Neuroimaging investigations have supported a "reward deficiency" hypothesis for PG by suggesting a blunted response to gambling, particularly in the striatum. Here we describe electrophysiological evidence of a hypersensitive response to gambling feedback in problem gamblers. Previous research in healthy participants has shown that feedback during gambling tasks triggers stereotypical neural responses including the Feedback-Related Mediofrontal Negativity (FRN), the feedback-related P300, and an increase in induced theta-band (4-8 Hz) power. We tested the theory that abnormal feedback processing characterizes brain activity in problem gamblers while gambling. EEG was recorded from non-gamblers and self-identified gamblers as they engaged in a computerized version of the Iowa Gambling Task. Feedback about valence (win vs. loss) triggered a FRN in both groups, but in gamblers this was preceded by an early-latency hypersensitive fronto-central difference to feedback. This early FRN was correlated with gambling severity and was localized to medial frontal cortex using distributed source imaging (CLARA). Gamblers also differed in responses to risk, showing a blunted P300 component and less EEG power in the theta band. Here we suggest that a more nuanced interpretation of reward deficiency is called for with respect to PG. For certain aspects of brain function, gamblers may exhibit hypersensitivity to reward feedback more akin to drug sensitization than reward deficiency. Our results also suggest that the neurologically normal brain employs dissociable systems in the processing of feedback from tasks involving risky decision making.
No figures extracted from this document.
No chunks — full text not yet ingested.
No entities extracted from this document yet.
No uploaded files.
Not in any collection.
No citations found.
In this knowledge base
External
| Title | Authors | Journal | Year | Link |
|---|---|---|---|---|
| Hyposensitivity to losses under risk but hypersensitivity to gains under ambiguity during feedback evaluation. | Zhao J et al. | — | 2025 | → |
| Neurophysiological Correlates of Near-Wins in Gambling: A Systematic Literature Review. | Dores AR et al. | — | 2025 | → |
| Impact of online poker gambling on behavioural and neurophysiological responses to a virtual gambling task. | Giustiniani J et al. | — | 2024 | → |
| Problematic Gaming and Gambling: A Systematic Review of Task-Specific EEG Protocols. | Simkute D et al. | — | 2024 | → |
| Processing abnormalities in monetary outcome evaluations among male individuals with opioid use disorder: evidence from feedback-related negativity. | Yang L et al. | — | 2024 | → |
| Spatio-temporal EEG dynamics during decision-making in online poker players with problem gambling. | Giustiniani J et al. | — | 2024 | → |
| Treatment strategies for smartphone addiction: efficacy study of transcranial direct current stimulation and exergaming. | Chen J et al. | — | 2024 | → |
| Distinct neural activations correlate with maximization of reward magnitude versus frequency. | Balasubramani PP et al. | — | 2023 | → |
| Distinct neural dynamics underlying risk and ambiguity during valued-based decision making. | Deng L et al. | — | 2023 | → |
| Is Empathy Associated with Gambling and Its Addiction? A Scoping Review of Empirical Studies. | Wu AMS et al. | — | 2023 | → |
| Safety on demand: Post-hypnotic suggestions of safety reduce neural signals of reward sensitivity with long-term beneficial effects. | Böhmer J et al. | — | 2022 | → |
| Daily cannabis use in adolescents who smoke tobacco is associated with altered late-stage feedback processing: A high-density electrical mapping study. | Morie KP et al. | — | 2021 | → |
| Rostral Anterior Cingulate Activations inversely relate to Reward Payoff Maximation & predict Depressed Mood | Balasubramani PP et al. | — | 2021 | — |
| Neural Dynamics of the Combined Discounting of Delay and Probability During the Evaluation of a Delayed Risky Reward. | Wang G et al. | — | 2020 | → |
| Neural response to rewards predicts risk-taking in late but not early adolescent females. | Freeman C et al. | — | 2020 | → |
| Behavioral and Electrophysiological Arguments in Favor of a Relationship between Impulsivity, Risk-Taking, and Success on the Iowa Gambling Task. | Giustiniani J et al. | — | 2019 | → |
| Blunted neural response to gains versus losses associated with both risk-prone and risk-averse behavior in a clinically diverse sample. | Huggins AA et al. | — | 2019 | → |
| Brain oscillatory activity of skill and chance gamblers during a slot machine game. | Alicart H et al. | — | 2019 | → |
| Event-related potentials in response to feedback following risk-taking in the hot version of the Columbia Card Task. | de Groot K et al. | — | 2019 | → |
| Neural Dynamics of Processing Probability Weight and Monetary Magnitude in the Evaluation of a Risky Reward. | Wang G et al. | — | 2019 | → |
| The importance of agency in human reward processing. | Hassall CD et al. | — | 2019 | → |
| Chronotype and Mental Health: Recent Advances. | Taylor BJ et al. | — | 2018 | → |
| Event-Related Potentials in Relation to Risk-Taking: A Systematic Review. | Chandrakumar D et al. | — | 2018 | → |
| The Brain's Reward Response Occurs Even Without Actual Reward! | Fielding A et al. | — | 2018 | → |
| A KCNJ6 gene polymorphism modulates theta oscillations during reward processing. | Kamarajan C et al. | — | 2017 | → |
| Does size matter? An examination of problem gamblers' skin conductance responses to large and small magnitude rewards. | Lole L et al. | — | 2017 | → |
| Evidences from Rewarding System, FRN and P300 Effect in Internet-Addiction in Young People SHORT TITLE: Rewarding System and EEG in Internet-Addiction. | Balconi M et al. | — | 2017 | → |
| Neural correlates of the impact of prior outcomes on subsequent monetary decision-making in frequent poker players. | Brevers D et al. | — | 2017 | → |
| The roles of valuation and reward processing in cognitive function and psychiatric disorders. | Hélie S et al. | — | 2017 | → |
| Amplified Striatal Responses to Near-Miss Outcomes in Pathological Gamblers. | Sescousse G et al. | — | 2016 | → |
| Behavioral addictions in addiction medicine: from mechanisms to practical considerations. | Banz BC et al. | — | 2016 | → |
| Electrophysiology for addiction medicine: From methodology to conceptualization of reward deficits. | Stewart JL et al. | — | 2016 | → |
| Representing the consequences of our actions trial by trial: Complex and flexible encoding of feedback valence and magnitude. | Padrón I et al. | — | 2016 | → |
| Reward-related neural dysfunction across depression and impulsivity: A dimensional approach. | Ait Oumeziane B et al. | — | 2016 | → |
| Severity of gambling problems modulates autonomic reactions to near outcomes in gambling. | Ulrich N et al. | — | 2016 | → |
| The research domain criteria framework: The case for anterior cingulate cortex. | Holroyd CB et al. | — | 2016 | → |
| Theta-band oscillatory activity differs between gamblers and nongamblers comorbid with attention-deficit hyperactivity disorder in a probabilistic reward-learning task. | Abouzari M et al. | — | 2016 | → |
| Abnormal gray matter and white matter volume in 'Internet gaming addicts'. | Lin X et al. | — | 2015 | → |
| [Gambling addiction: insights from neuroscience and neuroimaging]. | Sescousse G | — | 2015 | → |
| Interactions among attention-deficit hyperactivity disorder (ADHD) and problem gambling in a probabilistic reward-learning task. | Abouzari M et al. | — | 2015 | → |
| Left Hemispheric Imbalance and Reward Mechanisms Affect Gambling Behavior: The Contribution of the Metacognition and Cortical Brain Oscillations. | Balconi M et al. | — | 2015 | → |
| Neural Correlates of Successful and Unsuccessful Strategical Mechanisms Involved in Uncertain Decision-Making. | Giustiniani J et al. | — | 2015 | → |
| Reward and punishment hyposensitivity in problem gamblers: A study of event-related potentials using a principal components analysis. | Lole L et al. | — | 2015 | → |
| Reward Sensitivity (Behavioral Activation System), Cognitive, and Metacognitive Control in Gambling Behavior: Evidences From Behavioral, Feedback-Related Negativity, and P300 Effect. | Balconi M et al. | — | 2015 | → |
| The Subthalamic Nucleus, Limbic Function, and Impulse Control. | Rossi PJ et al. | — | 2015 | → |
| Apathy in Parkinson's disease: neurophysiological evidence of impaired incentive processing. | Martínez-Horta S et al. | — | 2014 | → |
| Applying incentive sensitization models to behavioral addiction. | Rømer Thomsen K et al. | — | 2014 | → |
| Cognition and emotional decision-making in chronic low back pain: an ERPs study during Iowa gambling task. | Tamburin S et al. | — | 2014 | → |
| Decision and dopaminergic system: an ERPs study of Iowa gambling task in Parkinson's disease. | Mapelli D et al. | — | 2014 | → |
| Event-related potentials in substance use disorders: a narrative review based on articles from 1984 to 2012. | Campanella S et al. | — | 2014 | → |
| External error monitoring in subclinical obsessive-compulsive subjects: electrophysiological evidence from a Gambling Task. | Zhu C et al. | — | 2014 | → |
| How we learn to make decisions: rapid propagation of reinforcement learning prediction errors in humans. | Krigolson OE et al. | — | 2014 | → |
| Risk assessment and reward processing in problem gambling investigated by event-related potentials and fMRI-constrained source analysis. | Miedl SF et al. | — | 2014 | → |
| A developmental study of the feedback-related negativity from 10-17 years: age and sex effects for reward versus non-reward. | Crowley MJ et al. | — | 2013 | → |
| An fMRI study on sunk cost effect. | Zeng J et al. | — | 2013 | → |
| Can event-related potentials serve as neural markers for wins, losses, and near-wins in a gambling task? A principal components analysis. | Lole L et al. | — | 2013 | → |
| Elevated functional connectivity in a striatal-amygdala circuit in pathological gamblers. | Peters J et al. | — | 2013 | → |
| Fronto-striatal dysregulation in drug addiction and pathological gambling: Consistent inconsistencies? | Limbrick-Oldfield EH et al. | — | 2013 | → |
| Increased functional connectivity between prefrontal cortex and reward system in pathological gambling. | Koehler S et al. | — | 2013 | → |
| Iowa Gambling Task (IGT): twenty years after - gambling disorder and IGT. | Brevers D et al. | — | 2013 | → |
| Modafinil increases reward salience in a slot machine game in low and high impulsivity pathological gamblers. | Smart K et al. | — | 2013 | → |
| What makes Internet addicts continue playing online even when faced by severe negative consequences? Possible explanations from an fMRI study. | Dong G et al. | — | 2013 | → |
| An electrophysiological monetary incentive delay (e-MID) task: a way to decompose the different components of neural response to positive and negative monetary reinforcement. | Broyd SJ et al. | — | 2012 | → |
| Better than I thought: positive evaluation bias in hypomania. | Mason L et al. | — | 2012 | → |
| Right on cue? Striatal reactivity in problem gamblers. | van Holst RJ et al. | — | 2012 | → |
| The process addictions and the new ASAM definition of addiction. | Smith DE | — | 2012 | → |