Corticotropin-releasing factor-1 receptor involvement in behavioral neuroadaptation to ethanol: a urocortin1-independent mechanism.
- Authors
- Pastor, RaΓΊl; McKinnon, Carrie S; Scibelli, Angela C; Burkhart-Kasch, Sue; Reed, Cheryl; Ryabinin, Andrey E; Coste, Sarah C; Stenzel-Poore, Mary P; Phillips, Tamara J
- Year
- 2008
- Journal
- Proceedings of the National Academy of Sciences of the United States of America
- PMID
- 18591672
- DOI
- 10.1073/pnas.0710181105
- PMCID
- PMC2449366
A common expression of neuroadaptations induced by repeated exposure to addictive drugs is a persistent sensitized behavioral response to their stimulant properties. Neuroplasticity underlying drug-induced sensitization has been proposed to explain compulsive drug pursuit and consumption characteristic of addiction. The hypothalamic-pituitary-adrenal (HPA) axis-activating neuropeptide, corticotropin-releasing factor (CRF), may be the keystone in drug-induced neuroadaptation. Corticosterone-activated glucocorticoid receptors (GRs) mediate the development of sensitization to ethanol (EtOH), implicating the HPA axis in this process. EtOH-induced increases in corticosterone require CRF activation of CRF1 receptors. We posited that CRF1 signaling pathways are crucial for EtOH-induced sensitization. We demonstrate that mice lacking CRF1 receptors do not show psychomotor sensitization to EtOH, a phenomenon that was also absent in CRF1 + 2 receptor double-knockout mice. Deletion of CRF2 receptors alone did not prevent sensitization. A blunted endocrine response to EtOH was found only in the genotypes showing no sensitization. The CRF1 receptor antagonist CP-154,526 attenuated the acquisition and prevented the expression of EtOH-induced psychomotor sensitization. Because CRF1 receptors are also activated by urocortin-1 (Ucn1), we tested Ucn1 knockout mice for EtOH sensitization and found normal sensitization in this genotype. Finally, we show that the GR antagonist mifepristone does not block the expression of EtOH sensitization. CRF and CRF1 receptors, therefore, are involved in the neurobiological adaptations that underlie the development and expression of psychomotor sensitization to EtOH. A CRF/CRF1-mediated mechanism involving the HPA axis is proposed for acquisition, whereas an extrahypothalamic CRF/CRF1 participation is suggested for expression of sensitization to EtOH.
No figures extracted from this document.
No chunks β full text not yet ingested.
No entities extracted from this document yet.
No uploaded files.
No citations found.
In this knowledge base
External
| Title | Authors | Journal | Year | Link |
|---|---|---|---|---|
| C57BL/6J offspring mice reared by a single-mother exhibit, compared to mice reared in a biparental parenting structure, distinct neural activation patterns and heightened ethanol-induced anxiolysis. | Pasquetta L et al. | β | 2025 | β |
| Corticotropin releasing factor and drug seeking in substance use disorders: Preclinical evidence and translational limitations. | Mantsch JR | β | 2022 | β |
| FACTORS CONTRIBUTING TO THE ESCALATION OF ALCOHOL CONSUMPTION. | Bowen MT et al. | β | 2022 | β |
| Sex-specific plasticity in CRF regulation of inhibitory control in central amygdala CRF1 neurons after chronic voluntary alcohol drinking. | Agoglia AE et al. | β | 2022 | β |
| GPCR and Alcohol-Related Behaviors in Genetically Modified Mice. | Neasta J et al. | β | 2020 | β |
| Role of corticotropin-releasing factor in alcohol and nicotine addiction. | Simpson S et al. | β | 2020 | β |
| CRF modulation of central monoaminergic function: Implications for sex differences in alcohol drinking and anxiety. | Pleil KE et al. | β | 2018 | β |
| Targeted overexpression of CRH receptor subtype 1 in central amygdala neurons: effect on alcohol-seeking behavior. | Broccoli L et al. | β | 2018 | β |
| Circuit and synaptic mechanisms of repeated stress: Perspectives from differing contexts, duration, and development. | Bath KG et al. | β | 2017 | β |
| Corticotropin-Releasing Factor (CRF) and Addictive Behaviors. | Roberto M et al. | β | 2017 | β |
| An Update on CRF Mechanisms Underlying Alcohol Use Disorders and Dependence. | Quadros IM et al. | β | 2016 | β |
| Behavioral sensitization to ethanol: Neural basis and factors that influence its acquisition and expression. | Camarini R et al. | β | 2016 | β |
| Impaired Ethanol-Induced Sensitization and Decreased Cannabinoid Receptor-1 in a Model of Posttraumatic Stress Disorder. | Matchynski-Franks JJ et al. | β | 2016 | β |
| Acetaldehyde self-administration by a two-bottle choice paradigm: consequences on emotional reactivity, spatial learning, and memory. | Plescia F et al. | β | 2015 | β |
| Effects of nicotine on ethanol-induced locomotor sensitization: A model of neuroadaptation. | Gubner NR et al. | β | 2015 | β |
| Preclinical evidence implicating corticotropin-releasing factor signaling in ethanol consumption and neuroadaptation. | Phillips TJ et al. | β | 2015 | β |
| Reduction of ethanol intake by corticotropin-releasing factor receptor-1 antagonist in "heavy-drinking" mice in a free-choice paradigm. | Correia D et al. | β | 2015 | β |
| How do we 'learn' addiction? Risk factors and mechanisms getting addicted to alcohol. | HΓ€gele C et al. | β | 2014 | β |
| Synthesis of new thiazolo[4,5-d]pyrimidines as Corticotropin releasing factor modulators. | Kuppast B et al. | β | 2014 | β |
| Addiction and the adrenal cortex. | Vinson GP et al. | β | 2013 | β |
| Advanced transgenic approaches to understand alcohol-related phenotypes in animals. | Bilbao A | β | 2013 | β |
| Positive environmental modification of depressive phenotype and abnormal hypothalamic-pituitary-adrenal axis activity in female C57BL/6J mice during abstinence from chronic ethanol consumption. | Pang TY et al. | β | 2013 | β |
| Stress-response pathways are altered in the hippocampus of chronic alcoholics. | McClintick JN et al. | β | 2013 | β |
| Anxiogenic and stress-inducing effects of peripherally administered acetaldehyde in mice: similarities with the disulfiram-ethanol reaction. | Escrig MA et al. | β | 2012 | β |
| Chronic tolerance to the locomotor stimulating effect of ethanol in preweanling rats as a function of social stress. | Arias C et al. | β | 2012 | β |
| Corticotropin-releasing factor acting on corticotropin-releasing factor receptor type 1 is critical for binge alcohol drinking in mice. | Kaur S et al. | β | 2012 | β |
| Ethanol drinking-in-the-dark facilitates behavioral sensitization to ethanol in C57BL/6J, BALB/cByJ, but not in mu-opioid receptor deficient CXBK mice. | TarragΓ³n E et al. | β | 2012 | β |
| Locomotor sensitization to EtOH: contribution of Ξ²-Endorphin. | Dempsey S et al. | β | 2012 | β |
| Mifepristone in the central nucleus of the amygdala reduces yohimbine stress-induced reinstatement of ethanol-seeking. | Simms JA et al. | β | 2012 | β |
| Neuropeptide Y signaling modulates the expression of ethanol-induced behavioral sensitization in mice. | Hayes DM et al. | β | 2012 | β |
| Role of corticotropin-releasing factor and corticosterone in behavioral sensitization to ethanol. | Pastor R et al. | β | 2012 | β |
| Stress and the HPA axis: role of glucocorticoids in alcohol dependence. | Stephens MA et al. | β | 2012 | β |
| Dissection of corticotropin-releasing factor system involvement in locomotor sensitivity to methamphetamine. | Giardino WJ et al. | β | 2011 | β |
| Ethanol concentration-dependent effects and the role of stress on ethanol drinking in corticotropin-releasing factor type 1 and double type 1 and 2 receptor knockout mice. | Pastor R et al. | β | 2011 | β |
| Mianserin, but not ondansetron, reduces the locomotor stimulating effect of ethanol in preweanling rats. | Arias C et al. | β | 2011 | β |
| Paternal deprivation affects the development of corticotrophin-releasing factor-expressing neurones in prefrontal cortex, amygdala and hippocampus of the biparental Octodon degus. | Seidel K et al. | β | 2011 | β |
| Role of corticotropin-releasing factor in drug addiction: potential for pharmacological intervention. | Logrip ML et al. | β | 2011 | β |
| Urocortin-1 within the centrally-projecting Edinger-Westphal nucleus is critical for ethanol preference. | Giardino WJ et al. | β | 2011 | β |
| A differential role for neuropeptides in acute and chronic adaptive responses to alcohol: behavioural and genetic analysis in Caenorhabditis elegans. | Mitchell P et al. | β | 2010 | β |
| CB1 receptor blockade decreases ethanol intake and associated neurochemical changes in fawn-hooded rats. | FemenΓa T et al. | β | 2010 | β |
| Genetic and environmental influences on ethanol consumption: perspectives from preclinical research. | Pautassi RM et al. | β | 2010 | β |
| H2 haplotype at chromosome 17q21.31 protects against childhood sexual abuse-associated risk for alcohol consumption and dependence. | Nelson EC et al. | β | 2010 | β |
| Repeated ethanol administration modifies the temporal structure of sucrose intake patterns in mice: effects associated with behavioral sensitization. | Pastor R et al. | β | 2010 | β |
| Social isolation and stress related hormones modulate the stimulating effect of ethanol in preweanling rats. | Arias C et al. | β | 2010 | β |
| The role of CRF and CRF-related peptides in the dark side of addiction. | Koob GF | β | 2010 | β |
| Functional CRH variation increases stress-induced alcohol consumption in primates. | Barr CS et al. | β | 2009 | β |
| Corticotropin-releasing factor, neuroplasticity (sensitization), and alcoholism. | Koob GF | β | 2008 | β |
| Dopamine enhances fast excitatory synaptic transmission in the extended amygdala by a CRF-R1-dependent process. | Kash TL et al. | β | 2008 | β |