A Prospective Comparison of Bipolar I and II Subjects With and Without Comorbid Alcohol Dependence From the COGA Dataset.
paper
Primary
Public
- Authors
- Preuss, Ulrich W; Hesselbrock, M N; Hesselbrock, V M
- Year
- 2020
- Journal
- Frontiers in psychiatry
- PMID
- 33408647
- DOI
- 10.3389/fpsyt.2020.522228
- PMCID
- PMC7779525
Comorbidity of alcohol use disorders in bipolar subjects is high as indicated by epidemiological and clinical studies. Though a more severe course of bipolar disorder in subjects with comorbid alcohol dependence has been reported, fewer studies considered the longitudinal course of alcohol dependence in bipolar subjects and the prospective course of comorbid bipolar II subjects. Beside baseline analysis, longitudinal data of the COGA (Collaborative Study on Genetics in Alcoholism) were used to evaluate the course of bipolar I and II disordered subjects with and without comorbid alcohol dependence over more than 5 years of follow-up. Characteristics of bipolar disorder, alcohol dependence and comorbid psychiatric disorders were assessed using semi-structured interviews (SSAGA) at baseline and at a 5-year follow-up. Two hundred twenty-eight bipolar I and II patients were subdivided into groups with and without comorbid alcohol dependence. Of the 152 bipolar I and 76 bipolar II patients, 172 (75, 4%) had a comorbid diagnosis of alcohol dependence. Bipolar I patients with alcohol dependence, in particular women, had a more severe course of bipolar disorder, worse social functioning and more suicidal behavior than all other groups of subjects during the 5-year follow-up. In contrast, alcohol dependence improved significantly in both comorbid bipolar I and II individuals during this time. A 5-year prospective evaluation of bipolar patients with and without alcohol dependence confirmed previous investigations suggesting a more severe course of bipolar disorder in comorbid bipolar I individuals, whereas bipolar II individuals were less severely impaired by comorbid alcohol use disorder. While severity of alcohol dependence improved during this time in comorbid alcohol-dependent bipolar I patients, the unfavorable outcome for these individuals might be due to the higher comorbidity with personality and other substance use disorders which, together with alcohol dependence, eventually lead to poorer symptomatic and functional clinical outcomes.
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| Name | Type |
|---|---|
| Abstinent, moderate and severe alcohol using BP I and II subjects local | cohort |
| Affective episode local | phenotype |
| affective symptoms | phenotype |
| age at onset | phenotype |
| age at onset of first suicide attempt local | phenotype |
| aggression | phenotype |
| alcohol | phenotype |
| Alcohol and Substance Use Disorder local | phenotype |
| Alcohol and Substance Use Disorders local | phenotype |
| alcohol dependence | phenotype |
| Alcohol-dependent bipolar subjects local | phenotype |
| alcoholic liver disease | phenotype |
| Alcohol-related aggression | phenotype |
| alcohol-related behaviors | phenotype |
| Alcohol-related violence local | phenotype |
| Alcohol Use | phenotype |
| Alcohol Use Disorder | phenotype |
| alcohol use disorders | phenotype |
| amphetamines | drug |
| Anticonvulsants local | drug |
| antidepressants | drug |
| antisocial personality disorder | phenotype |
| anxiety | phenotype |
| appearance | phenotype |
| Appropriate relatives local | cohort |
| axis I disorder | phenotype |
| baseline assessment | cohort |
| Baseline bipolar cohort local | cohort |
| behavior | phenotype |
| benzodiazepines | drug |
| binge drinking | phenotype |
| bipolar disorder | phenotype |
| Bipolar group 1 local | cohort |
| Bipolar group 2 local | cohort |
| Bipolar group 3 local | cohort |
| Bipolar group 4 local | cohort |
| bipolar I disorder | phenotype |
| bipolar I disorder alone local | phenotype |
| Bipolar I group 3 local | cohort |
| Bipolar I group 4 local | cohort |
| bipolar II disorder | phenotype |
| Bipolar II group 1 local | cohort |
| Bipolar II group 2 local | cohort |
| Bipolar patient cohort (n=77) local | cohort |
| Bipolar subjects local | cohort |
| Chronic bipolar disorder local | phenotype |
| cocaine | phenotype |
| COGA sample | cohort |
| Collaborative Study on the Genetics of Alcoholism (COGA) | cohort |
| Comorbid alcohol-dependent bipolar subjects local | cohort |
| Comorbid disorder local | phenotype |
| comorbid subjects local | cohort |
| comparison subjects | cohort |
| Complications local | phenotype |
| Conduct and antisocial behavior local | phenotype |
| conduct disorder | phenotype |
| Control families | cohort |
| craving | phenotype |
| current sample | cohort |
| depression | phenotype |
| depressive symptoms | phenotype |
| Deterioration in social functioning local | phenotype |
| Drug-related problems local | phenotype |
| Drug-related treatment local | phenotype |
| DSM-IV | phenotype |
| DSM IV Anxiety Disorder local | phenotype |
| dysthymia | phenotype |
| ECA Study local | cohort |
| Electroconvulsive therapy local | drug |
| Emotion | phenotype |
| Euthymic mood local | phenotype |
| euthymic mood state local | phenotype |
| families | cohort |
| first-degree relatives | cohort |
| follow-up local | cohort |
| Formal thought local | phenotype |
| Functional outcome | phenotype |
| functional recovery | phenotype |
| GAF local | phenotype |
| GAF scores local | phenotype |
| general population | cohort |
| Global level of functioning local | phenotype |
| Group 1 | cohort |
| Group 2 | cohort |
| Group 3 | cohort |
| group 4 | cohort |
| Group 4 Subjects local | cohort |
| High-risk group local | phenotype |
| hospitalization | phenotype |
| hypnotics local | drug |
| Hypomanic episodes local | phenotype |
| Inpatient Samples local | cohort |
| Level of consciousness local | phenotype |
| lifetime mixed episodes local | phenotype |
| lithium | drug |
| major depressive disorder | phenotype |
| mania | phenotype |
| Manic episode | phenotype |
| Manic or mixed bipolar I individuals local | phenotype |
| marijuana | phenotype |
| medication | drug |
| Medication compliance | phenotype |
| memory | phenotype |
| Men with bipolar disorder local | cohort |
| mixed episode local | phenotype |
| Mixed episodes local | phenotype |
| mood disorders | phenotype |
| Mood episodes local | phenotype |
| mood recurrence local | phenotype |
| Most severe affective episode local | phenotype |
| National Epidemiologic Survey on Alcohol and Related Conditions | cohort |
| Neuroleptics local | drug |
| non-comorbid bipolar II disorder local | phenotype |
| not-re-interviewed individuals local | cohort |
| number of suicide attempts local | phenotype |
| Number of symptoms during most severe depressive episode local | phenotype |
| Number of symptoms during most severe manic episode local | phenotype |
| offspring | cohort |
| opiates | drug |
| Orientation | phenotype |
| Other groups local | cohort |
| panic disorder | phenotype |
| participants | cohort |
| personality disorders | phenotype |
| Physical consequences | phenotype |
| Poorer outcomes local | phenotype |
| Previous study local | cohort |
| probands | cohort |
| Prospective study on manic or mixed bipolar I individuals local | cohort |
| psychiatric disorders | phenotype |
| psychopathology | phenotype |
| rapid cycling local | phenotype |
| Rapid cycling local | phenotype |
| recall bias | phenotype |
| re-interviewed individuals local | cohort |
| schizophrenia | phenotype |
| sedatives | drug |
| Severe depressive episode symptoms local | phenotype |
| sex | phenotype |
| siblings | cohort |
| social functioning | phenotype |
| Socioeconomic outcome local | phenotype |
| SSAGA | cohort |
| SSAGA interview participants local | cohort |
| study cohort | cohort |
| substance abuse | phenotype |
| substance use | phenotype |
| suicide | phenotype |
| suicide risk | phenotype |
| Symptomatic outcome local | phenotype |
| Symptomatic recovery local | phenotype |
| Treatment adherence local | phenotype |
| Treatment compliance local | phenotype |
| Treatment non-adherence local | phenotype |
| unemployment | phenotype |
| violence | phenotype |
| violent behavior | phenotype |
| Withdrawal symptoms from cocaine local | phenotype |
| women | cohort |
| Women with bipolar disorder local | cohort |
| Worse course of bipolar disorder local | phenotype |
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In this knowledge base
| Title | Year | PMID |
|---|---|---|
| A Prospective Comparison of Bipolar I and II Subjects with and without Comorbid Cannabis Use Disorders from the COGA Dataset. | 2023 | 37626487 |
External
| Title | Authors | Journal | Year | Link |
|---|---|---|---|---|
| Exploring the temporal relationship between mood, alcohol- and nicotine use in bipolar disorder using time-series analyses. | Glastad SH et al. | — | 2025 | → |
| Longitudinal Interplay Between Alcohol Use, Mood, and Functioning in Bipolar Spectrum Disorders. | Sperry SH et al. | — | 2024 | → |
| A Prospective Comparison of Bipolar I and II Subjects with and without Comorbid Cannabis Use Disorders from the COGA Dataset. | Preuss UW et al. | — | 2023 | → |
| Patterns of ethanol intake in male rats with partial dopamine transporter deficiency. | Kuiper LB et al. | — | 2023 | → |
| Predictors of psychiatric hospitalization among outpatients with bipolar disorder in the real-world clinical setting. | Tokumitsu K et al. | — | 2023 | → |
| Comorbid Bipolar and Alcohol Use Disorder-A Therapeutic Challenge. | Grunze H et al. | — | 2021 | → |