DNA hypermethylation of the alpha synuclein promoter in patients with alcoholism.
paper
Cited
Public
Unavailable
- Authors
- BΓΆnsch, Dominikus; Lenz, Bernd; Kornhuber, Johannes; Bleich, Stefan
- Year
- 2005
- Journal
- Neuroreport
- PMID
- 15671870
- DOI
- 10.1097/00001756-200502080-00020
The aim of this study was to investigate whether the DNA methylation pattern within the alpha synuclein promoter region is altered in intoxicated and early abstinence patients with alcoholism undergoing alcohol withdrawal. We observed a significant increase of the alpha synuclein promoter DNA methylation in patients with alcoholism which was significantly associated with their elevated homocysteine levels. No significant differences of the promoter DNA methylation within a control gene (presenilin-1) in alcoholics and controls were found. The present results hint to a gene specific DNA promoter hypermethylation within the alpha synuclein gene. Since hypermethylation of DNA is an important epigenetic factor in the down regulation of gene expression and since alpha synuclein has been linked to craving these findings may explain the reduced value of craving under alcohol drinking conditions.
No figures extracted from this document.
No chunks β full text not yet ingested.
No entities extracted from this document yet.
No uploaded files.
Not in any collection.
No citations found.
In this knowledge base
External
| Title | Authors | Journal | Year | Link |
|---|---|---|---|---|
| A case control study investigating the methylation levels of GHRL and GHSR genes in alcohol use disorder. | Γzkan-KotiloΔlu S et al. | β | 2024 | β |
| Human genetics and epigenetics of alcohol use disorder. | Zhou H et al. | β | 2024 | β |
| The Impact of Alcohol-Induced Epigenetic Modifications in the Treatment of Alcohol use Disorders. | Fanfarillo F et al. | β | 2024 | β |
| Advances in DNA, histone, and RNA methylation mechanisms in the pathophysiology of alcohol use disorder. | Cruise TM et al. | β | 2023 | β |
| Molecular characteristics of porcine alpha-synuclein splicing variants. | Larsen K et al. | β | 2021 | β |
| The Molecular Basis of Alcohol Use Disorder (AUD). Genetics, Epigenetics, and Nutrition in AUD: An Amazing Triangle. | Siomek-Gorecka A et al. | β | 2021 | β |
| Acute alcohol withdrawal and recovery in men lead to profound changes in DNA methylation profiles: a longitudinal clinical study. | Witt SH et al. | β | 2020 | β |
| Alpha-Synuclein in Alcohol Use Disorder, Connections with Parkinson's Disease and Potential Therapeutic Role of 5' Untranslated Region-Directed Small Molecules. | Cahill CM et al. | β | 2020 | β |
| Epigenetic changes on rat chromosome 4 contribute to disparate alcohol drinking behavior in alcohol-preferring and -nonpreferring rats. | Spence JP et al. | β | 2020 | β |
| Factors Affecting Differential Methylation of DNA Promoters in Arsenic-Exposed Populations. | Zhang Y et al. | β | 2019 | β |
| Correlation between plasma homocysteine levels and craving in alcohol dependent stabilized patients. | Coppola M et al. | β | 2018 | β |
| DNA Methylation and Psychiatric Disorders. | Liu C et al. | β | 2018 | β |
| Leptin Expression and Gene Methylation Patterns in Alcohol-Dependent Patients with Ethyltoxic Cirrhosis-Normalization After Liver Transplantation and Implications for Future Research. | Proskynitopoulos PJ et al. | β | 2018 | β |
| Neurological and neuropsychological effects of low and moderate prenatal alcohol exposure. | Comasco E et al. | β | 2018 | β |
| Transcriptional Regulators as Targets for Alcohol Pharmacotherapies. | Savarese AM et al. | β | 2018 | β |
| Alcohol and nicotine codependence-associated DNA methylation changes in promoter regions of addiction-related genes. | Xu H et al. | β | 2017 | β |
| Alcohol-dose-dependent DNA methylation and expression in the nucleus accumbens identifies coordinated regulation of synaptic genes. | Cervera-Juanes R et al. | β | 2017 | β |
| DNA modifications in models of alcohol use disorders. | Tulisiak CT et al. | β | 2017 | β |
| Drug Addiction and DNA Modifications. | Brown AN et al. | β | 2017 | β |
| Emerging Role of Epigenetic Mechanisms in Alcohol Addiction. | Berkel TD et al. | β | 2017 | β |
| Epigenetic mediators and consequences of excessive alcohol consumption. | Mahnke AH et al. | β | 2017 | β |
| Epigenetics in Parkinson's Disease. | Pavlou MAS et al. | β | 2017 | β |
| Genome-wide analysis of the nucleus accumbens identifies DNA methylation signals differentiating low/binge from heavy alcohol drinking. | Cervera-Juanes R et al. | β | 2017 | β |
| Review: DNA methylation and alcohol use disorders: Progress and challenges. | Zhang H et al. | β | 2017 | β |
| An Exploratory Association Study of Alcohol Use Disorder and DNA Methylation. | Hagerty SL et al. | β | 2016 | β |
| DNA co-methylation modules in postmortem prefrontal cortex tissues of European Australians with alcohol use disorders. | Wang F et al. | β | 2016 | β |
| Potential Role of Epigenetic Mechanism in Manganese Induced Neurotoxicity. | Tarale P et al. | β | 2016 | β |
| The Epigenetic Regulation of GATA4-Dependent Brain Natriuretic Peptide Expression during Alcohol Withdrawal. | Glahn A et al. | β | 2016 | β |
| Brain plasticity and cognitive functions after ethanol consumption in C57BL/6J mice. | Stragier E et al. | β | 2015 | β |
| Changes in the methylation status of DAT, SERT, and MeCP2 gene promoters in the blood cell in families exposed to alcohol during the periconceptional period. | Lee BY et al. | β | 2015 | β |
| Current and Future Prospects for Epigenetic Biomarkers of Substance Use Disorders. | Andersen AM et al. | β | 2015 | β |
| DNA methylation of the LEP gene is associated with craving during alcohol withdrawal. | Hillemacher T et al. | β | 2015 | β |
| Frequency of alcohol consumption in humans; the role of metabotropic glutamate receptors and downstream signaling pathways. | Meyers JL et al. | β | 2015 | β |
| Integrative epigenetic profiling analysis identifies DNA methylation changes associated with chronic alcohol consumption. | Weng JT et al. | β | 2015 | β |
| Alcohol induces cell proliferation via hypermethylation of ADHFE1 in colorectal cancer cells. | Moon JW et al. | β | 2014 | β |
| A pilot examination of the genome-wide DNA methylation signatures of subjects entering and exiting short-term alcohol dependence treatment programs. | Philibert RA et al. | β | 2014 | β |
| A Study on MTHFR C677T Gene Polymorphism and Alcohol Dependence among Meiteis of Manipur, India. | Singh HS et al. | β | 2014 | β |
| Epigenetic alteration of the dopamine transporter gene in alcohol-dependent patients is associated with age. | Nieratschker V et al. | β | 2014 | β |
| Epigenetic mechanisms are involved in the regulation of ethanol consumption in mice. | Qiang M et al. | β | 2014 | β |
| Genetic risk prediction and neurobiological understanding of alcoholism. | Levey DF et al. | β | 2014 | β |
| Impaired one carbon metabolism and DNA methylation in alcohol toxicity. | Kruman II et al. | β | 2014 | β |
| Methylation of a CpG site near the ALDH1A2 gene is associated with loss of control over drinking and related phenotypes. | Harlaar N et al. | β | 2014 | β |
| Molecular basis of alcoholism. | Most D et al. | β | 2014 | β |
| The epigenetic landscape of alcoholism. | Krishnan HR et al. | β | 2014 | β |
| A Framework to Examine the Role of Epigenetics in Health Disparities among Native Americans. | Brockie TN et al. | β | 2013 | β |
| Alcohol and the methylome: design and analysis considerations for research using human samples. | Harlaar N et al. | β | 2013 | β |
| Array-based profiling of DNA methylation changes associated with alcohol dependence. | Zhang H et al. | β | 2013 | β |
| Chromatin remodeling--a novel strategy to control excessive alcohol drinking. | Warnault V et al. | β | 2013 | β |
| DNA methylation, a hand behind neurodegenerative diseases. | Lu H et al. | β | 2013 | β |
| Effects of ethanol exposure during early pregnancy in hyperactive, inattentive and impulsive behaviors and MeCP2 expression in rodent offspring. | Kim P et al. | β | 2013 | β |
| Epigenetic consequences of a changing human diet. | Haggarty P | β | 2013 | β |
| Epigenetic control of gene expression in the alcoholic brain. | Ponomarev I | β | 2013 | β |
| Epigenetic landscape of Parkinson's disease: emerging role in disease mechanisms and therapeutic modalities. | Ammal Kaidery N et al. | β | 2013 | β |
| Epigenetics in Parkinson's and Alzheimer's diseases. | Marques S et al. | β | 2013 | β |
| Ethanol-induced Htr3a promoter methylation changes in mouse blood and brain. | Barker JM et al. | β | 2013 | β |
| Ethanol induces epigenetic modulation of prodynorphin and pronociceptin gene expression in the rat amygdala complex. | D'Addario C et al. | β | 2013 | β |
| Genetics and epigenetics of alcohol dependence. | Nieratschker V et al. | β | 2013 | β |
| Genome-wide DNA methylation patterns in discordant sib pairs with alcohol dependence. | Zhao R et al. | β | 2013 | β |
| DNA methylation patterns in alcoholics and family controls. | Thapar M et al. | β | 2012 | β |
| Environmental toxicants--induced epigenetic alterations and their reversers. | Kim M et al. | β | 2012 | β |
| Epigenetics-beyond the genome in alcoholism. | Starkman BG et al. | β | 2012 | β |
| Epigenetics of drug abuse: predisposition or response. | Nielsen DA et al. | β | 2012 | β |
| Genetics and epigenetics of Parkinson's disease. | CoppedΓ¨ F | β | 2012 | β |
| Hypermethylation of OPRM1 promoter region in European Americans with alcohol dependence. | Zhang H et al. | β | 2012 | β |
| MALAT-1, a non protein-coding RNA is upregulated in the cerebellum, hippocampus and brain stem of human alcoholics. | Kryger R et al. | β | 2012 | β |
| Methylation matters? Decreased methylation status of genomic DNA in the blood of schizophrenic twins. | BΓΆnsch D et al. | β | 2012 | β |
| Nutrition and the epigenome. | Haggarty P | β | 2012 | β |
| The impact of recent alcohol use on genome wide DNA methylation signatures. | Philibert RA et al. | β | 2012 | β |
| Behavioral epigenetics. | Lester BM et al. | β | 2011 | β |
| Biochemical and morphological consequences of human Ξ±-synuclein expression in a mouse Ξ±-synuclein null background. | Prasad K et al. | β | 2011 | β |
| Biological mechanisms in alcohol dependence--new perspectives. | Hillemacher T | β | 2011 | β |
| Ethanol and acetaldehyde exposure induces specific epigenetic modifications in the prodynorphin gene promoter in a human neuroblastoma cell line. | D'Addario C et al. | β | 2011 | β |
| Molecular and behavioral aspects of the actions of alcohol on the adult and developing brain. | Alfonso-Loeches S et al. | β | 2011 | β |
| Orexin A expression and promoter methylation in patients with alcohol dependence comparing acute and protracted withdrawal. | Bayerlein K et al. | β | 2011 | β |
| Orexin expression and promoter-methylation in peripheral blood of patients suffering from major depressive disorder. | Rotter A et al. | β | 2011 | β |
| Subtle decreases in DNA methylation and gene expression at the mouse Igf2 locus following prenatal alcohol exposure: effects of a methyl-supplemented diet. | Downing C et al. | β | 2011 | β |
| Allelic imbalance of expression and epigenetic regulation within the alpha-synuclein wild-type and p.Ala53Thr alleles in Parkinson disease. | Voutsinas GE et al. | β | 2010 | β |
| Determination of Methylated CpG Sites in the Promoter Region of Catechol-O-Methyltransferase (COMT) and their Involvement in the Etiology of Tobacco Smoking. | Xu Q et al. | β | 2010 | β |
| Ethnic diversity of DNA methylation in the OPRM1 promoter region in lymphocytes of heroin addicts. | Nielsen DA et al. | β | 2010 | β |
| Genetic research: who is at risk for alcoholism. | Foroud T et al. | β | 2010 | β |
| How the epigenome contributes to the development of psychiatric disorders. | Bredy TW et al. | β | 2010 | β |
| Neuroscience of alcoholism: molecular and cellular mechanisms. | Moonat S et al. | β | 2010 | β |
| Prevalence of the metabolic syndrome in men and women with alcohol dependence: results from a cross-sectional study during behavioural treatment in a controlled environment. | Kahl KG et al. | β | 2010 | β |
| Role of epigenetics in Alzheimer's and Parkinson's disease. | Kwok JB | β | 2010 | β |
| Search for genetic markers and functional variants involved in the development of opiate and cocaine addiction and treatment. | Yuferov V et al. | β | 2010 | β |
| Alcoholism: a systems approach from molecular physiology to addictive behavior. | Spanagel R | β | 2009 | β |
| DNA methylation impacts on learning and memory in aging. | Liu L et al. | β | 2009 | β |
| Epigenetic regulation and gene expression of vasopressin and atrial natriuretic peptide in alcohol withdrawal. | Hillemacher T et al. | β | 2009 | β |
| Increased OPRM1 DNA methylation in lymphocytes of methadone-maintained former heroin addicts. | Nielsen DA et al. | β | 2009 | β |
| N-methyl-D-aspartate 2b receptor subtype (NR2B) promoter methylation in patients during alcohol withdrawal. | Biermann T et al. | β | 2009 | β |
| Promoter specific methylation of the dopamine transporter gene is altered in alcohol dependence and associated with craving. | Hillemacher T et al. | β | 2009 | β |
| Prospects for epigenetic epidemiology. | Foley DL et al. | β | 2009 | β |
| Alpha synuclein protein levels are increased in serum from recently abstinent cocaine abusers. | Mash DC et al. | β | 2008 | β |
| Elevated alpha-synuclein mRNA levels in individual UV-laser-microdissected dopaminergic substantia nigra neurons in idiopathic Parkinson's disease. | GrΓΌndemann J et al. | β | 2008 | β |
| Emerging role of epigenetics in the actions of alcohol. | Shukla SD et al. | β | 2008 | β |
| Epigenetic alterations of the dopaminergic system in major psychiatric disorders. | Abdolmaleky HM et al. | β | 2008 | β |
| Epigenetic and pharmacoepigenomic studies of major psychoses and potentials for therapeutics. | Abdolmaleky HM et al. | β | 2008 | β |
| Epigenetic codes in cognition and behaviour. | GrΓ€ff J et al. | β | 2008 | β |
| Epigenetic principles and mechanisms underlying nervous system functions in health and disease. | Mehler MF | β | 2008 | β |
| Genetic approaches to addiction: genes and alcohol. | Ducci F et al. | β | 2008 | β |
| Neuropeptide Y receptor genes are associated with alcohol dependence, alcohol withdrawal phenotypes, and cocaine dependence. | Wetherill L et al. | β | 2008 | β |
| Promoter-wide hypermethylation of the ribosomal RNA gene promoter in the suicide brain. | McGowan PO et al. | β | 2008 | β |
| Review. Neurogenetic studies of alcohol addiction. | Crabbe JC | β | 2008 | β |
| alpha-Synuclein and Parkinson disease susceptibility. | Winkler S et al. | β | 2007 | β |
| Association of alcohol craving with alpha-synuclein (SNCA). | Foroud T et al. | β | 2007 | β |
| Daily variations of homocysteine concentration may influence methylation of DNA in normal healthy individuals. | BΓΆnsch D et al. | β | 2007 | β |
| Epigenetic regulation in psychiatric disorders. | Tsankova N et al. | β | 2007 | β |
| Global DNA hypomethylation and DNA hypermethylation of the alpha synuclein promoter in females with anorexia nervosa. | Frieling H et al. | β | 2007 | β |
| Hyperhomocysteinemia due to cystathionine beta synthase deficiency induces dysregulation of genes involved in hepatic lipid homeostasis in mice. | Hamelet J et al. | β | 2007 | β |
| Linkage disequilibrium and association analysis of alpha-synuclein and alcohol and drug dependence in two American Indian populations. | Clarimon J et al. | β | 2007 | β |
| Differential regulation of the alcohol dehydrogenase 1B (ADH1B) and ADH1C genes by DNA methylation and histone deacetylation. | Dannenberg LO et al. | β | 2006 | β |
| Epigenetic DNA hypermethylation of the HERP gene promoter induces down-regulation of its mRNA expression in patients with alcohol dependence. | Bleich S et al. | β | 2006 | β |
| Epigenetic effects of ethanol on liver and gastrointestinal injury. | Shukla SD et al. | β | 2006 | β |
| Homocysteine regulates expression of Herp by DNA methylation involving the AARE and CREB binding sites. | Lenz B et al. | β | 2006 | β |
| Hypomethylation of MB-COMT promoter is a major risk factor for schizophrenia and bipolar disorder. | Abdolmaleky HM et al. | β | 2006 | β |
| Lowered DNA methyltransferase (DNMT-3b) mRNA expression is associated with genomic DNA hypermethylation in patients with chronic alcoholism. | BΓΆnsch D et al. | β | 2006 | β |
| Advances in alcoholism research in Germany. | Schmidt LG et al. | β | 2005 | β |
| Evidence of increased homocysteine levels in alcoholism: the Franconian alcoholism research studies (FARS). | Bleich S et al. | β | 2005 | β |