Association of neuropeptide y polymorphism with the occurrence of type 1 and type 2 alcoholism.
- Authors
- Ilveskoski, E; Kajander, O A; LehtimΓ€ki, T; Kunnas, T; Karhunen, P J; HeinΓ€lΓ€, P; Virkkunen, M; Alho, H
- Year
- 2001
- Journal
- Alcoholism, clinical and experimental research
- PMID
- 11696660
- DOI
- 10.1097/00000374-200110000-00003
BACKGROUND: The susceptibility to alcoholism can be explained partially by genetic factors. Neuropeptide Y (NPY) has emerged as one potential factor contributing the development of alcoholism. A recent study indicated that the NPY gene variant producing a leucine-to-proline substitution (T to C at position 1128) was associated with 34% higher average alcohol consumption. METHODS: The subjects consisted of 122 alcoholics classified as type 1 and type 2 subtypes by psychiatric evaluation. A random sample of 59 social drinkers was used as a control group to compare the distribution of NPY genotypes with those of alcoholics. RESULTS: In a logistical regression model, there was a significantly lower frequency of the leucine(7)/proline(7) heterozygotes among well characterized type 2 alcoholics, compared with the controls (10.8 vs. 24.1%, p = 0.028). CONCLUSIONS: We speculate that the genetic polymorphism producing the proline(7) substitution of NPY might not predispose to alcoholism, but indeed retard the transition to alcoholism.
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