The genetics of obsessive-compulsive disorder and Tourette's syndrome: what are the common factors?
- Authors
- Grados, Marco A
- Year
- 2009
- Journal
- Current psychiatry reports
- PMID
- 19302771
- DOI
- 10.1007/s11920-009-0025-x
Genetic discovery in obsessive-compulsive disorder and Tourette's syndrome has made significant progress in the past decade. The two disorders are phenomenologically, epidemiologically, and probably pathophysiologically related; however, as with most neuropsychiatric disorders, gene discovery has been challenging. Genetic epidemiology studies support the existence of susceptibility genes in both disorders, and more extensive genome-wide studies are under way. Gene pathways involving neurotransmitter (serotonin, dopamine, glutamate) and neurodevelopment (synaptic, homeobox) domains have been examined, but more complex genetic mechanisms remain largely unexplored. This review addresses the current state of genetic research in obsessive-compulsive disorder and Tourette's syndrome, emphasizing commonalities between the disorders. Questions on common genetic substrates, the use of endophenotypes, and the utility of genetic data to inform pharmacologic treatment are also addressed.
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In this knowledge base
| Title | Year | PMID |
|---|---|---|
| Copy number variation in obsessive-compulsive disorder and tourette syndrome: a cross-disorder study. | 2014 | 25062598 |
External
| Title | Authors | Journal | Year | Link |
|---|---|---|---|---|
| A dimensional perspective on the genetics of obsessive-compulsive disorder. | Strom NI et al. | — | 2021 | → |
| WISC-IV performance of children with Chronic Tic Disorder, Obsessive-Compulsive Disorder and Attention-Deficit/Hyperactivity Disorder: results from a German clinical study. | Wanderer S et al. | — | 2021 | → |
| A call for prevention and early intervention in obsessive-compulsive disorder. | Brakoulias V et al. | — | 2018 | → |
| Identification of candidate genes involved in the etiology of sporadic Tourette syndrome by exome sequencing. | Eriguchi Y et al. | — | 2017 | → |
| Cntnap4 differentially contributes to GABAergic and dopaminergic synaptic transmission. | Karayannis T et al. | — | 2014 | → |
| Copy number variation in obsessive-compulsive disorder and tourette syndrome: a cross-disorder study. | McGrath LM et al. | — | 2014 | → |
| Common and rare alleles of the serotonin transporter gene, SLC6A4, associated with Tourette's disorder. | Moya PR et al. | — | 2013 | → |