Additional support for the association of SLITRK1 var321 and Tourette syndrome.
- Authors
- O'Roak, B J; Morgan, T M; Fishman, D O; Saus, E; Alonso, P; GratacΓ²s, M; Estivill, X; Teltsh, O; Kohn, Y; Kidd, K K; Cho, J; Lifton, R P; State, M W
- Year
- 2010
- Journal
- Molecular psychiatry
- PMID
- 20351724
- DOI
- 10.1038/mp.2009.105
- PMCID
- PMC3292207
Multidimensional scaling (MDS) and haplotype analysis of var321 carriers. (a) Scatter plot showing axes 1 and 4 of the MDS analysis on 1117 European descent (Non-Jewish), 758 Jewish, and var321 samples. Axis 1 is the horizontal axis and clearly separates the two groups. On the right, the European descent (Non-Jewish) samples (blue) cluster along axis 1 with values >β0.01. On the left, the Jewish samples (green) cluster along axis 1 with values <β0.01. Var321 carriers are indicated by arrows and all fall within the two clusters. The two TS probands from1 are F3 and F4. Var321 carriers without var525 and their family members, SP family (burgundy) and F4 family (purple), are represented by diamonds. Var321βvar525 carriers are shown as triangles, predicted non-Jewish (light-blue) and Jewish (red). (b) Diagram of the maximum haplotype sharing between individual haplotypes carrying the var321 allele. Shared colors are haplotype regions that could not be differentiated between samples. Unshared colors are unique haplotype regions. Scale bar is 200 kb, broken regions represent 1000 kb that were omitted to reduce image size. Expanded inset is 18 kb surrounding SLITRK1 and shows phased haplotypes. *Individual is homozygous for var321βvar525. TS, Tourette Syndrome; OCD, obsessive-compulsive disorder; OC, obsessive-compulsive symptoms; TTM, trichotillomania; F3 and F4, TS affected from original study; SP, Spanish family with OCD proband and unaffected carrier father; HVP, human variation panel sample; AN, Ashkenazi control; TSA1, TS, OCD, TTM affected and TSA2, OCD affected, from TSAICG study.
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