Million Veteran Program: A mega-biobank to study genetic influences on health and disease.
paper
Cited
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- Authors
- Gaziano, John Michael; Concato, John; Brophy, Mary; Fiore, Louis; Pyarajan, Saiju; Breeling, James; Whitbourne, Stacey; Deen, Jennifer; Shannon, Colleen; Humphries, Donald; Guarino, Peter; Aslan, Mihaela; Anderson, Daniel; LaFleur, Rene; Hammond, Timothy; Schaa, Kendra; Moser, Jennifer; Huang, Grant; Muralidhar, Sumitra; Przygodzki, Ronald; O'Leary, Timothy J
- Year
- 2016
- Journal
- Journal of clinical epidemiology
- PMID
- 26441289
- DOI
- 10.1016/j.jclinepi.2015.09.016
OBJECTIVE: To describe the design and ongoing conduct of the Million Veteran Program (MVP), as an observational cohort study and mega-biobank in the Department of Veterans Affairs (VA) health care system. STUDY DESIGN AND SETTING: Data are being collected from participants using questionnaires, the VA electronic health record, and a blood sample for genomic and other testing. Several ongoing projects are linked to MVP, both as peer-reviewed research studies and as activities to help develop an infrastructure for future, broad-based research uses. RESULTS: Formal planning for MVP commenced in 2009; the protocol was approved in 2010, and enrollment began in 2011. As of August 3, 2015, and with a steady state of β50 recruiting sites nationwide, N = 397,104 veterans have been enrolled. Among N = 199,348 with currently available genotyping data, most participants (as expected) are male (92.0%) between the ages of 50 and 69 years (55.0%). On the basis of self-reported race, white (77.2%) and African American (13.5%) populations are well represented. CONCLUSIONS: By helping to promote the future integration of genetic testing in health care delivery, including clinical decision making, the MVP is designed to contribute to the development of precision medicine.
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| Integrating artificial intelligence in strabismus management: current research landscape and future directions. | Wu D et al. | β | 2024 | β |
| INviting Veterans InTo Enrollment in Alzheimer's Disease Research Centers (INVITE-ADRC): An NIA and VA-sponsored initiative to increase veteran participation in aging and dementia research. | Padula CB et al. | β | 2024 | β |
| Latin American Trans-ancestry INitiative for OCD genomics (LATINO): Study protocol. | Crowley JJ et al. | β | 2024 | β |
| Lipid levels and risk of acute pancreatitis using bidirectional Mendelian randomization. | Wang B et al. | β | 2024 | β |
| Long-Term Body Mass Index Variability and Adverse Cardiovascular Outcomes. | Almuwaqqat Z et al. | β | 2024 | β |
| Low-frequency and rare genetic variants associated with rheumatoid arthritis risk. | Kronzer VL et al. | β | 2024 | β |
| Measurement Invariance of the Neurobehavioral Symptom Inventory in Male and Female Million Veteran Program Enrollees Completing the Comprehensive Traumatic Brain Injury Evaluation. | Ozturk ED et al. | β | 2024 | β |
| Measuring Frailty Using Self-Report or Automated Tools to Identify Risk of Cardiovascular Events and Mortality: The Million Veteran Program. | Qazi S et al. | β | 2024 | β |
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| Mendelian Randomization as a Tool for Cardiovascular Research: A Review. | Levin MG et al. | β | 2024 | β |
| Meta-Analysis of Genome-Wide Association Studies Reveals Genetic Mechanisms of Supraventricular Arrhythmias. | Weng LC et al. | β | 2024 | β |
| Migraine Prevalence, Environmental Risk, and Comorbidities in Men and Women Veterans. | Gasperi M et al. | β | 2024 | β |
| Military and occupational exposures among Veterans in the Million Veteran Program by survey self-report: a descriptive study. | Sordillo JE et al. | β | 2024 | β |
| Multi-ancestry GWAS meta-analyses of lung cancer reveal susceptibility loci and elucidate smoking-independent genetic risk. | Gorman BR et al. | β | 2024 | β |
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| Novel loci and biomedical consequences of iron homoeostasis variation. | Allara E et al. | β | 2024 | β |
| Novel recruitment approaches and operational results for a statewide population Cohort for cancer research: The Healthy Oregon Project. | Zhang Z et al. | β | 2024 | β |
| Observational and genetic association of non-alcoholic fatty liver disease and calcific aortic valve disease. | Hao QY et al. | β | 2024 | β |
| On the utility of using the All of Us Research Program as a resource to study military service members and veterans. | Porter B | β | 2024 | β |
| Parkinson Disease Genetics Extended to African and Hispanic Ancestries in the VA Million Veteran Program. | Pankratz N et al. | β | 2024 | β |
| Pleiotropy and genetically inferred causality linking multisite chronic pain to substance use disorders. | Koller D et al. | β | 2024 | β |
| Polygenic Risk for Type 2 Diabetes in African Americans. | Irvin MR et al. | β | 2024 | β |
| Prevalence, Morbidity, and Mortality of Men With Sex Chromosome Aneuploidy in the Million Veteran Program Cohort. | Davis SM et al. | β | 2024 | β |
| Protein Identification for Stroke Progression via Mendelian Randomization in Million Veteran Program and UK Biobank. | Elmore AR et al. | β | 2024 | β |
| Protein-truncating variant in APOL3 increases chronic kidney disease risk in epistasis with APOL1 risk alleles. | Zhang DY et al. | β | 2024 | β |
| Racial and Ethnic Disparities in Dietary Intake and Quality Among United States Veterans. | Nguyen XT et al. | β | 2024 | β |
| Rare coding variant analysis for human diseases across biobanks and ancestries. | Jurgens SJ et al. | β | 2024 | β |
| Recalibrating the Genetics and Epidemiology of Colorectal Cancer Consortium Environmental Risk Score for Use in US Veterans. | Williams AR et al. | β | 2024 | β |
| Red Meat Intake and the Risk of Cardiovascular Diseases: A Prospective Cohort Study in the Million Veteran Program. | Wang DD et al. | β | 2024 | β |
| Review on GPU accelerated methods for genome-wide SNP-SNP interactions. | Ren W et al. | β | 2024 | β |
| Self-reported oral health is associated with systemic health outcomes and all-cause mortality. | Yu YH et al. | β | 2024 | β |
| SMIM1 absence is associated with reduced energy expenditure and excess weight. | Stefanucci L et al. | β | 2024 | β |
| Social connection and suicidal thoughts and behaviors in the Million Veteran Program cohort. | Bourassa KJ et al. | β | 2024 | β |
| Subjective cognitive concerns, APOE Ξ΅4, PTSD symptoms, and risk for dementia among older veterans. | Neale ZE et al. | β | 2024 | β |
| Synthetic surrogates improve power for genome-wide association studies of partially missing phenotypes in population biobanks. | McCaw ZR et al. | β | 2024 | β |
| Systems genetics of metabolic health in the BXD mouse genetic reference population. | Li X et al. | β | 2024 | β |
| The genetic landscape of substance use disorders. | Gerring ZF et al. | β | 2024 | β |
| The impact of assortative mating, participation bias and socioeconomic status on the polygenic risk of behavioural and psychiatric traits. | Cabrera-Mendoza B et al. | β | 2024 | β |
| The Million Veteran Program 1990-1991 Gulf War Era Survey: An Evaluation of Veteran Response, Characteristics, and Representativeness of the Gulf War Era Veteran Population. | Harrington KM et al. | β | 2024 | β |
| The Role of Genetics in Managing Peripheral Arterial Disease. | Biagetti G et al. | β | 2024 | β |
| Transcriptome-wide association analysis identifies candidate susceptibility genes for prostate-specific antigen levels in men without prostate cancer. | Chen DM et al. | β | 2024 | β |
| Twenty-Five Years of Germline Genetic Testing and What May Lie Ahead. | Pratt VM et al. | β | 2024 | β |
| Type 1 Diabetes Genetic Risk in 109,954 Veterans With Adult-Onset Diabetes: The Million Veteran Program (MVP). | Yang PK et al. | β | 2024 | β |
| Unraveling COVID-19 relationship with anxiety disorders and symptoms using genome-wide data. | Asgel Z et al. | β | 2024 | β |
| Using electronic health records for clinical pharmacology research: Challenges and considerations. | Jafari E et al. | β | 2024 | β |
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| Whole-genome analysis of plasma fibrinogen reveals population-differentiated genetic regulators with putative liver roles. | Huffman JE et al. | β | 2024 | β |
| 15 years of GWAS discovery: Realizing the promise. | Abdellaoui A et al. | β | 2023 | β |
| Addressing the Challenge of Biomedical Data Inequality: An Artificial Intelligence Perspective. | Gao Y et al. | β | 2023 | β |
| Admixture mapping of peripheral artery disease in a Dominican population reveals a putative risk locus on 2q35. | Cullina S et al. | β | 2023 | β |
| Advances and Applications of Polygenic Scores for Coronary Artery Disease. | Patel AP et al. | β | 2023 | β |
| Alzheimer's disease and related dementias among aging veterans: Examining gene-by-environment interactions with post-traumatic stress disorder and traumatic brain injury. | Logue MW et al. | β | 2023 | β |
| A multi-ancestry polygenic risk score improves risk prediction for coronary artery disease. | Patel AP et al. | β | 2023 | β |
| An Examination of Racial/Ethnic Differences on the Neurobehavioral Symptom Inventory Among Veterans Completing the Comprehensive Traumatic Brain Injury Evaluation: A Veterans Affairs Million Veteran Program Study. | Sakamoto MS et al. | β | 2023 | β |
| A platform for phenotyping disease progression and associated longitudinal risk factors in large-scale EHRs, with application to incident diabetes complications in the UK Biobank. | Kim DH et al. | β | 2023 | β |
| Association Between Fuchs Endothelial Corneal Dystrophy, Diabetes Mellitus, and Multimorbidity. | Nealon CL et al. | β | 2023 | β |
| Association of African Ancestry-Specific APOE Missense Variant R145C With Risk of Alzheimer Disease. | Le Guen Y et al. | β | 2023 | β |
| Association of dietary fatty acids with the risk of atherosclerotic cardiovascular disease in a prospective cohort of United States veterans. | Ivey KL et al. | β | 2023 | β |
| A two-sample mendelian randomization analysis excludes causal relationships between non-alcoholic fatty liver disease and kidney stones. | Li X et al. | β | 2023 | β |
| Autoimmune alleles at the major histocompatibility locus modify melanoma susceptibility. | Talwar JV et al. | β | 2023 | β |
| Bayesian multivariate genetic analysis improves translational insights. | Urbut SM et al. | β | 2023 | β |
| Cardiovascular Disease Risk Assessment Using Traditional Risk Factors and Polygenic Risk Scores in the Million Veteran Program. | Vassy JL et al. | β | 2023 | β |
| Case Studies for Overcoming Challenges in Using Big Data in Cancer. | Sweeney SM et al. | β | 2023 | β |
| Challenges Related to the Use of Next-Generation Sequencing for the Optimization of Drug Therapy. | Zhou Y et al. | β | 2023 | β |
| Data resource profile: nutrition data in the VA million veteran program. | Nguyen XT et al. | β | 2023 | β |
| Data sharing to advance gene-targeted therapies in rare diseases. | Lekstrom-Himes J et al. | β | 2023 | β |
| Degree of adherence to plant-based diet and total and cause-specific mortality: prospective cohort study in the Million Veteran Program. | Wang DD et al. | β | 2023 | β |
| Dietary Ο-3 fatty acids and the incidence of atrial fibrillation in the Million Veteran Program. | Guardino ET et al. | β | 2023 | β |
| Diversity is key for cross-ancestry transferability of glaucoma genetic risk scores in Hispanic Veterans in the Million Veteran Program. | Waksmunski AR et al. | β | 2023 | β |
| Does low-density lipoprotein fully explain atherosclerotic risk in familial hypercholesterolemia? | Clarke SL | β | 2023 | β |
| Effect of case and control definitions on genome-wide association study (GWAS) findings. | Isgut M et al. | β | 2023 | β |
| Effects of 25-Hydroxyvitamin D Levels on Renal Function: A Bidirectional Mendelian Randomization Study. | Adi M et al. | β | 2023 | β |
| Evaluating approaches for constructing polygenic risk scores for prostate cancer in men of African and European ancestry. | Darst BF et al. | β | 2023 | β |
| Factor structure of the posttraumatic stress disorder checklist (PCL-17) in 279,897 million veteran program participants. | Overstreet C et al. | β | 2023 | β |
| Fast kernel-based association testing of non-linear genetic effects for biobank-scale data. | Fu B et al. | β | 2023 | β |
| Fine mapping and accurate prediction of complex traits using Bayesian Variable Selection models applied to biobank-size data. | de Los Campos G et al. | β | 2023 | β |
| Framework of the Centralized Interactive Phenomics Resource (CIPHER) standard for electronic health data-based phenomics knowledgebase. | Honerlaw J et al. | β | 2023 | β |
| Frequencies of pharmacogenomic alleles across biogeographic groups in a large-scale biobank. | Li B et al. | β | 2023 | β |
| From 'Omics to Multi-omics Technologies: the Discovery of Novel Causal Mediators. | Mohammadi-Shemirani P et al. | β | 2023 | β |
| From real-world electronic health record data to real-world results using artificial intelligence. | Knevel R et al. | β | 2023 | β |
| Future Treatment Options and Regimens for Nonalcoholic Fatty Liver Disease. | Francque S et al. | β | 2023 | β |
| Genetic architecture of ADHD and overlap with other psychiatric disorders and cognition-related phenotypes. | RibasΓ©s M et al. | β | 2023 | β |
| Genetic Inhibition of APOL1 Pore-Forming Function Prevents APOL1-Mediated Kidney Disease. | Hung AM et al. | β | 2023 | β |
| Genetic risk prediction in Hispanics/Latinos: milestones, challenges, and social-ethical considerations. | Maldonado BL et al. | β | 2023 | β |
| Genetics of Alzheimer's Disease in the African American Population. | Logue MW et al. | β | 2023 | β |
| Genetics of varicose veins reveals polygenic architecture and genetic overlap with arterial and venous disease. | Levin MG et al. | β | 2023 | β |
| Genetic Underpinnings of the Transition From Alcohol Consumption to Alcohol Use Disorder: Shared and Unique Genetic Architectures in a Cross-Ancestry Sample. | Kember RL et al. | β | 2023 | β |
| Genome-wide analysis of a model-derived binge eating disorder phenotype identifies risk loci and implicates iron metabolism. | Burstein D et al. | β | 2023 | β |
| Genome-wide association studies and cross-population meta-analyses investigating short and long sleep duration. | Austin-Zimmerman I et al. | β | 2023 | β |
| Genome-Wide Association Study of CKD Progression. | Robinson-Cohen C et al. | β | 2023 | β |
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| Glaucoma in Black Individuals: How Far Have We Come and Where Do We Go From Here? | Kitayama K et al. | β | 2023 | β |
| GWAS Meta-Analysis of Suicide Attempt: Identification of 12 Genome-Wide Significant Loci and Implication of Genetic Risks for Specific Health Factors. | Docherty AR et al. | β | 2023 | β |
| HaploBlocks: Efficient Detection of Positive Selection in Large Population Genomic Datasets. | Kirsch-Gerweck B et al. | β | 2023 | β |
| Human height: a model common complex trait. | Conery M et al. | β | 2023 | β |
| Identification of Novel, Replicable Genetic Risk Loci for Suicidal Thoughts and Behaviors Among US Military Veterans. | Kimbrel NA et al. | β | 2023 | β |
| Immunogenetic Determinants of Susceptibility to Head and Neck Cancer in the Million Veteran Program Cohort. | Liu Y et al. | β | 2023 | β |
| Importance of Diversity in Precision Medicine: Generalizability of Genetic Associations Across Ancestry Groups Toward Better Identification of Disease Susceptibility Variants. | Cruz LA et al. | β | 2023 | β |
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| LDAK-GBAT: Fast and powerful gene-based association testing using summary statistics. | Berrandou TE et al. | β | 2023 | β |
| Loneliness and depression: bidirectional mendelian randomization analyses using data from three large genome-wide association studies. | Sbarra DA et al. | β | 2023 | β |
| Mendelian Randomization Analysis of Genetic Proxies of Thiazide Diuretics and the Reduction of Kidney Stone Risk. | Triozzi JL et al. | β | 2023 | β |
| Mendelian randomization study of diabetes and dementia in the Million Veteran Program. | Litkowski EM et al. | β | 2023 | β |
| Meta-analysis of African ancestry genome-wide association studies identified novel locus and validates multiple loci associated with kidney function. | Kintu C et al. | β | 2023 | β |
| Modeling the longitudinal changes of ancestry diversity in the Million Veteran Program. | Wendt FR et al. | β | 2023 | β |
| Moderate alcohol consumption on the risk of stroke in the Million Veteran Program. | Song RJ et al. | β | 2023 | β |
| Multiancestry Genome-Wide Association Study of Aortic Stenosis Identifies Multiple Novel Loci in the Million Veteran Program. | Small AM et al. | β | 2023 | β |
| Multi-ancestry genome-wide association study of cannabis use disorder yields insight into disease biology and public health implications. | Levey DF et al. | β | 2023 | β |
| Multi-ancestry study of the genetics of problematic alcohol use in over 1 million individuals. | Zhou H et al. | β | 2023 | β |
| Multi-trait genome-wide association analyses leveraging alcohol use disorder findings identify novel loci for smoking behaviors in the Million Veteran Program. | Cheng Y et al. | β | 2023 | β |
| Navigating bottlenecks and trade-offs in genomic data analysis. | Berger B et al. | β | 2023 | β |
| Opening the Precision Diabetes Care through Digital Healthcare. | Lee J et al. | β | 2023 | β |
| Optimization of the Electronic Health Record for Research. | Murtha JA et al. | β | 2023 | β |
| Overview of Efforts to Increase Women Enrollment in the Veterans Affairs Million Veteran Program. | Whitbourne SB et al. | β | 2023 | β |
| Perspective of artificial intelligence in healthcare data management: A journey towards precision medicine. | Gupta NS et al. | β | 2023 | β |
| Pharmacogenetic allele variant frequencies: An analysis of the VA's Million Veteran Program (MVP) as a representation of the diversity in US population. | Markianos K et al. | β | 2023 | β |
| Plant-based diets and the incidence of cardiovascular disease: the Million Veteran Program. | Li Y et al. | β | 2023 | β |
| Polygenic risk of any, metastatic, and fatal prostate cancer in the Million Veteran Program. | Pagadala MS et al. | β | 2023 | β |
| Pragmatic Approach to Applying Polygenic Risk Scores to Diverse Populations. | Patel AP et al. | β | 2023 | β |
| Proteogenomic links to human metabolic diseases. | Koprulu M et al. | β | 2023 | β |
| Proteomics: Progress and Promise of High-Throughput Proteomics in Chronic Kidney Disease. | Schlosser P et al. | β | 2023 | β |
| Quantification of race/ethnicity representation in Alzheimer's disease neuroimaging research in the USA: a systematic review. | Lim AC et al. | β | 2023 | β |
| Racial and Ethnic Biases and Psychiatric Misdiagnoses: Toward More Equitable Diagnosis and Treatment. | Teplin LA et al. | β | 2023 | β |
| Racial and Ethnic Bias in the Diagnosis of Alcohol Use Disorder in Veterans. | Vickers-Smith R et al. | β | 2023 | β |
| RNA alternative splicing impacts the risk for alcohol use disorder. | Li R et al. | β | 2023 | β |
| Self-reported physical functioning, cardiometabolic health conditions, and health care utilization patterns in Million Veteran Program enrollees with Traumatic Brain Injury Screening and Evaluation Program data. | Clark AL et al. | β | 2023 | β |
| Sex differences in the polygenic architecture of hearing problems in adults. | De Angelis F et al. | β | 2023 | β |
| Sex modifies the effect of genetic risk scores for polycystic ovary syndrome on metabolic phenotypes. | Actkins KV et al. | β | 2023 | β |
| Shared genetic architecture between irritable bowel syndrome and psychiatric disorders reveals molecular pathways of the gut-brain axis. | Tesfaye M et al. | β | 2023 | β |
| Sleep duration, daytime napping, and risk of peripheral artery disease: multinational cohort and Mendelian randomization studies. | Yuan S et al. | β | 2023 | β |
| Systems genetics approaches for understanding complex traits with relevance for human disease. | Allayee H et al. | β | 2023 | β |
| The causal effects of lipid traits on kidney function in Africans: bidirectional and multivariable Mendelian-randomization study. | Kintu C et al. | β | 2023 | β |
| The Genetics of Coronary Artery Disease: A Vascular Perspective. | Quaye LNK et al. | β | 2023 | β |
| The phenotype-genotype reference map: Improving biobank data science through replication. | Bastarache L et al. | β | 2023 | β |
| The relationship between alcohol- and sleep-related traits: Results from polygenic risk score and Mendelian randomization analyses. | Chakravorty S et al. | β | 2023 | β |
| Toward Identification of Functional Sequences and Variants in Noncoding DNA. | Monti R et al. | β | 2023 | β |
| Trumpet plots: visualizing the relationship between allele frequency and effect size in genetic association studies. | Corte L et al. | β | 2023 | β |
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| Uncovering myocardial infarction genetic signatures using GWAS exploration in Saudi and European cohorts. | Al-Ali AK et al. | β | 2023 | β |
| Academic Medical Centers and the U.S. Department of Veterans Affairs: A 75-Year Partnership Influences Medical Education, Scientific Discovery, and Clinical Care. | Petrakis IL et al. | β | 2022 | β |
| A Diabetes Genetic Risk Score Is Associated With All-Cause Dementia and Clinically Diagnosed Vascular Dementia in the Million Veteran Program. | Litkowski EM et al. | β | 2022 | β |
| Advances in integrative African genomics. | Zhang C et al. | β | 2022 | β |
| Affective response to physical activity as a deep phenotype in a non-randomized pilot study. | Lee HH et al. | β | 2022 | β |
| A genome-wide association study of suicide attempts in the million veterans program identifies evidence of pan-ancestry and ancestry-specific risk loci. | Kimbrel NA et al. | β | 2022 | β |
| A <i>MUC5B</i> Gene Polymorphism, rs35705950-T, Confers Protective Effects Against COVID-19 Hospitalization but Not Severe Disease or Mortality. | Verma A et al. | β | 2022 | β |
| A multiancestry genome-wide association study of unexplained chronic ALT elevation as a proxy for nonalcoholic fatty liver disease with histological and radiological validation. | Vujkovic M et al. | β | 2022 | β |
| A Multidimensional Bioinformatic Platform for the Study of Human Response to Surgery. | Eckhoff AM et al. | β | 2022 | β |
| A multi-population phenome-wide association study of genetically-predicted height in the Million Veteran Program. | Raghavan S et al. | β | 2022 | β |
| A Phenome-Wide Association Study of genes associated with COVID-19 severity reveals shared genetics with complex diseases in the Million Veteran Program. | Verma A et al. | β | 2022 | β |
| APOL1 Risk Variants, Acute Kidney Injury, and Death in Participants With African Ancestry Hospitalized With COVID-19 From the Million Veteran Program. | Hung AM et al. | β | 2022 | β |
| Are polygenic risk scores for systolic blood pressure and LDL-cholesterol associated with treatment effectiveness, and clinical outcomes among those on treatment? | Tapela NM et al. | β | 2022 | β |
| Are polygenic risk scores ready for the cancer clinic?-a perspective. | Klein RJ et al. | β | 2022 | β |
| Association of Gulf War Illness with Characteristics in Deployed vs. Non-Deployed Gulf War Era Veterans in the Cooperative Studies Program 2006/Million Veteran Program 029 Cohort: A Cross-Sectional Analysis. | Duong LM et al. | β | 2022 | β |
| Association of Kidney Comorbidities and Acute Kidney Failure With Unfavorable Outcomes After COVID-19 in Individuals With the Sickle Cell Trait. | Verma A et al. | β | 2022 | β |
| A translational genomics approach identifies IL10RB as the top candidate gene target for COVID-19 susceptibility. | Voloudakis G et al. | β | 2022 | β |
| Big Data for Tiny Patients: A Precision Medicine Approach to Bronchopulmonary Dysplasia. | Cheema Z et al. | β | 2022 | β |
| Biobanking in Latinos: current status, principles for conduct, and contribution of a new biobank, El Banco por Salud, designed to improve the health of Latino patients of Mexican ancestry with type 2 diabetes. | Parra OD et al. | β | 2022 | β |
| Breakthroughs in therapies for NASH and remaining challenges. | Ratziu V et al. | β | 2022 | β |
| Candidate loci shared among periodontal disease, diabetes and bone density. | Yu YH et al. | β | 2022 | β |
| Causal effect of renal function on venous thromboembolism: a two-sample Mendelian randomization investigation. | Yuan S et al. | β | 2022 | β |
| Characterization of Million Veteran Program (MVP) enrollees with Comprehensive Traumatic Brain Injury Evaluation (CTBIE) data: An analysis of neurobehavioral symptoms. | Ozturk ED et al. | β | 2022 | β |
| Characterizing Sex Differences in Clinical and Functional Outcomes Among Military Veterans with a Comprehensive Traumatic Brain Injury Evaluation (CTBIE): A Million Veteran Program (MVP) Study. | Merritt VC et al. | β | 2022 | β |
| Clinical utility of polygenic risk scores for coronary artery disease. | Klarin D et al. | β | 2022 | β |
| Cohort Profile: The Porton Down Veterans cohort study. | Archer G et al. | β | 2022 | β |
| Common genetic variation associated with Mendelian disease severity revealed through cryptic phenotype analysis. | Blair DR et al. | β | 2022 | β |
| Comparing heritability estimators under alternative structures of linkage disequilibrium. | Min A et al. | β | 2022 | β |
| Coronary Artery Disease Risk of Familial Hypercholesterolemia Genetic Variants Independent of Clinically Observed Longitudinal Cholesterol Exposure. | Clarke SL et al. | β | 2022 | β |
| Cross-Ancestry Investigation of Venous Thromboembolism Genomic Predictors. | Thibord F et al. | β | 2022 | β |
| Cross-ancestry meta-analysis of opioid use disorder uncovers novel loci with predominant effects in brain regions associated with addiction. | Kember RL et al. | β | 2022 | β |
| Development and Evaluation of a Rules-based Algorithm for Primary Open-Angle Glaucoma in the VA Million Veteran Program. | Nealon CL et al. | β | 2022 | β |
| Dietary Sodium and Potassium Intake and Risk of Non-Fatal Cardiovascular Diseases: The Million Veteran Program. | Wang DD et al. | β | 2022 | β |
| Differential and shared genetic effects on kidney function between diabetic and non-diabetic individuals. | Winkler TW et al. | β | 2022 | β |
| Efficient Algorithms and Implementation of a Semiparametric Joint Model for Longitudinal and Competing Risk Data: With Applications to Massive Biobank Data. | Li S et al. | β | 2022 | β |
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| Egg consumption and risk of acute stroke in the Million Veteran Program. | Al-Ramady O et al. | β | 2022 | β |
| Estimating SNP heritability in presence of population substructure in biobank-scale datasets. | Lin Z et al. | β | 2022 | β |
| Fibromuscular Dysplasia and Abdominal Aortic Aneurysms Are Dimorphic Sex-Specific Diseases With Shared Complex Genetic Architecture. | Katz AE et al. | β | 2022 | β |
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| Gene Sequencing Identifies Perturbation in Nitric Oxide Signaling as a Nonlipid Molecular Subtype of Coronary Artery Disease. | Khera AV et al. | β | 2022 | β |
| Genetic and Psychosocial Risk Factors Associated with Suicide Among Community Veterans: Implications for Screening, Treatment and Precision Medicine. | Boscarino JA et al. | β | 2022 | β |
| Genetic architecture of heart failure with preserved versus reduced ejection fraction. | Joseph J et al. | β | 2022 | β |
| Genetic insights into smoking behaviours in 10,558 men of African ancestry from continental Africa and the UK. | Piga NN et al. | β | 2022 | β |
| Genetics in chronic kidney disease: conclusions from a Kidney Disease: Improving Global Outcomes (KDIGO) Controversies Conference. | KDIGO Conference Participants | β | 2022 | β |
| Genome-wide and phenome-wide analysis of ideal cardiovascular health in the VA Million Veteran Program. | Huang RDL et al. | β | 2022 | β |
| Genome-Wide Investigation of Maximum Habitual Alcohol Intake in US Veterans in Relation to Alcohol Consumption Traits and Alcohol Use Disorder. | Deak JD et al. | β | 2022 | β |
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| Glaucoma Genetic Risk Scores in the Million Veteran Program. | Waksmunski AR et al. | β | 2022 | β |
| Hearing loss and tinnitus: association studies for complex-hearing disorders in mouse and man. | Boussaty EC et al. | β | 2022 | β |
| Identifying factors contributing to increased susceptibility to COVID-19 risk: a systematic review of Mendelian randomization studies. | Luo S et al. | β | 2022 | β |
| Identifying intragenic functional modules of genomic variations associated with cancer phenotypes by learning representation of association networks. | Kim M et al. | β | 2022 | β |
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| Large-scale genome-wide association study of coronary artery disease in genetically diverse populations. | Tcheandjieu C et al. | β | 2022 | β |
| Machine learning-based tissue of origin classification for cancer of unknown primary diagnostics using genome-wide mutation features. | Nguyen L et al. | β | 2022 | β |
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| Mild-to-Moderate Kidney Dysfunction and Cardiovascular Disease: Observational and Mendelian Randomization Analyses. | Gaziano L et al. | β | 2022 | β |
| Million Veteran Program's response to COVID-19: Survey development and preliminary findings. | Whitbourne SB et al. | β | 2022 | β |
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