Common genetic and environmental vulnerability for alcohol and tobacco use in a volunteer sample of older female twins.
- Authors
- Hopfer, C J; Stallings, M C; Hewitt, J K
- Year
- 2001
- Journal
- Journal of studies on alcohol
- PMID
- 11838905
- DOI
- 10.15288/jsa.2001.62.717
OBJECTIVE: A growing body of literature supports a shared genetic vulnerability underlying the use of alcohol and tobacco. We report patterns of genetic and environmental correlations for alcohol and tobacco use in a volunteer sample of older, white, female twins using three different levels of severity for alcohol use and smoking. METHOD: A community-based sample of 1,926 female twins aged 50 to 96 was recruited through advertisements in a newsletter of the American Association of Retired Persons. Subjects were asked to rate alcohol and tobacco use over their lifetimes. Three levels of severity for alcohol use and smoking were coded: ever drank, weekly drinking, problem drinking; ever smoked, daily smoking of one-half pack or more, daily smoking of at least one pack or more. Twin correlations for alcohol and tobacco use measures were fit using a structural equation-modeling package (Mx). RESULTS: There were significant genetic correlations between problem drinking and ever smoking and using at least one-half pack per day. For problem drinking/ever smoking, R = 1.0 (95% CI: 0.32-1.0); for problem drinking/smoking at least one-half pack/day, R = 1.0 (95% CI: 0.43-1.0). CONCLUSIONS: The shared genetic influence on alcohol use and smoking in women is clearest for those subjects with the highest severity of alcohol use and problem drinking.
No figures extracted from this document.
No chunks — full text not yet ingested.
No entities extracted from this document yet.
No uploaded files.
No citations found.
In this knowledge base
External
| Title | Authors | Journal | Year | Link |
|---|---|---|---|---|
| Heme-thiolate monooxygenase cytochrome P450 1B1, an old dog with many new tricks. | Kim JW et al. | — | 2025 | → |
| The role of nicotinic receptors in alcohol consumption. | Kamens HM et al. | — | 2023 | → |
| GWAS and network analysis of co-occurring nicotine and alcohol dependence identifies significantly associated alleles and network. | Xiang B et al. | — | 2019 | → |
| A Critical Review of Methods and Results in the Search for Genetic Contributors to Alcohol Sensitivity. | Schuckit MA | — | 2018 | → |
| A Genetic Epidemiological Mega Analysis of Smoking Initiation in Adolescents. | Maes HH et al. | — | 2017 | → |
| Examination of rare missense variants in the CHRNA5-A3-B4 gene cluster to level of response to alcohol in the San Diego Sibling Pair study. | Choquet H et al. | — | 2013 | → |
| Genome-wide association studies of maximum number of drinks. | Pan Y et al. | — | 2013 | → |
| Polymorphisms in the human cytochrome P450 and arylamine N-acetyltransferase: susceptibility to head and neck cancers. | Khlifi R et al. | — | 2013 | → |
| Stability and change of genetic and environmental effects on the common liability to alcohol, tobacco, and cannabis DSM-IV dependence symptoms. | Palmer RH et al. | — | 2013 | → |
| Connecting ncRNA Cigarette Smoking Studies with Tobacco Use Behaviors and Health Outcomes. | Ehringer MA | — | 2012 | → |
| Externalizing behaviors are associated with SNPs in the CHRNA5/CHRNA3/CHRNB4 gene cluster. | Stephens SH et al. | — | 2012 | → |
| The genetic correlation between cigarette smoking and alcohol drinking among Chinese adult male twins: an ordinal bivariate genetic analysis. | Zhang T et al. | — | 2012 | → |
| A meta-analysis of two genome-wide association studies identifies 3 new loci for alcohol dependence. | Wang KS et al. | — | 2011 | → |
| CHRNB2 promoter region: association with subjective effects to nicotine and gene expression differences. | Hoft NR et al. | — | 2011 | → |
| Protein kinase C epsilon modulates nicotine consumption and dopamine reward signals in the nucleus accumbens. | Lee AM et al. | — | 2011 | → |
| Addressing tobacco use disorder in smokers in early remission from alcohol dependence: the case for integrating smoking cessation services in substance use disorder treatment programs. | Kalman D et al. | — | 2010 | → |
| Association of CHRN genes with "dizziness" to tobacco. | Ehringer MA et al. | — | 2010 | → |
| Common genetic influences on the timing of first use for alcohol, cigarettes, and cannabis in young African-American women. | Sartor CE et al. | — | 2009 | → |
| Timing of first alcohol use and alcohol dependence: evidence of common genetic influences. | Sartor CE et al. | — | 2009 | → |
| Chromosome 15q25.1 genetic markers associated with level of response to alcohol in humans. | Joslyn G et al. | — | 2008 | → |
| Genetic approaches to addiction: genes and alcohol. | Ducci F et al. | — | 2008 | → |
| Genetic polymorphisms in cytochrome P4501B1 and susceptibility to head and neck cancer. | Singh AP et al. | — | 2008 | → |
| Genetics of nicotine dependence and pharmacotherapy. | Lessov-Schlaggar CN et al. | — | 2008 | → |
| Smoking status relationships with the food and fluid intakes of free-living humans. | de Castro JM et al. | — | 2008 | → |
| The CHRNA5/A3/B4 gene cluster variability as an important determinant of early alcohol and tobacco initiation in young adults. | Schlaepfer IR et al. | — | 2008 | → |
| The genetic components of alcohol and nicotine co-addiction: from genes to behavior. | Schlaepfer IR et al. | — | 2008 | → |
| Association of the neuronal nicotinic receptor beta2 subunit gene (CHRNB2) with subjective responses to alcohol and nicotine. | Ehringer MA et al. | — | 2007 | → |
| Lack of association of alcohol dependence and habitual smoking with catechol-O-methyltransferase. | Foroud T et al. | — | 2007 | → |
| The role of childhood risk factors in initiation of alcohol use and progression to alcohol dependence. | Sartor CE et al. | — | 2007 | → |
| [Heritability and candidate genes in tobacco use]. | Hamdani N et al. | — | 2006 | → |
| Heritability of cigarette smoking and alcohol use in Chinese male twins: the Qingdao twin registry. | Lessov-Schlaggar CN et al. | — | 2006 | → |
| Sex differences in the influence of COMT Val158Met on alcoholism and smoking in plains American Indians. | Enoch MA et al. | — | 2006 | → |
| Association of habitual smoking and drinking with single nucleotide polymorphism (SNP) in 40 candidate genes: data from random population-based Japanese samples. | Liu Y et al. | — | 2005 | → |
| Current awareness in geriatric psychiatry. | — | — | 2002 | → |