The catenin p120(ctn) interacts with Kaiso, a novel BTB/POZ domain zinc finger transcription factor.
paper
Cited
Public
Unavailable
- Authors
- Daniel, J M; Reynolds, A B
- Year
- 1999
- Journal
- Molecular and cellular biology
- PMID
- 10207085
- DOI
- 10.1128/MCB.19.5.3614
- PMCID
- PMC84161
p120(ctn) is an Armadillo repeat domain protein with structural similarity to the cell adhesion cofactors beta-catenin and plakoglobin. All three proteins interact directly with the cytoplasmic domain of the transmembrane cell adhesion molecule E-cadherin; beta-catenin and plakoglobin bind a carboxy-terminal region in a mutually exclusive manner, while p120 binds the juxtamembrane region. Unlike beta-catenin and plakoglobin, p120 does not interact with alpha-catenin, the tumor suppressor adenomatous polyposis coli (APC), or the transcription factor Lef-1, suggesting that it has unique binding partners and plays a distinct role in the cadherin-catenin complex. Using p120 as bait, we conducted a yeast two-hybrid screen and identified a novel transcription factor which we named Kaiso. Kaiso's deduced amino acid sequence revealed an amino-terminal BTB/POZ protein-protein interaction domain and three carboxy-terminal zinc fingers of the C2H2 DNA-binding type. Kaiso thus belongs to a rapidly growing family of POZ-ZF transcription factors that include the Drosophila developmental regulators Tramtrak and Bric Γ brac, and the human oncoproteins BCL-6 and PLZF, which are causally linked to non-Hodgkins' lymphoma and acute promyelocytic leukemia, respectively. Monoclonal antibodies to Kaiso were generated and used to immunolocalize the protein and confirm the specificity of the p120-Kaiso interaction in mammalian cells. Kaiso specifically coprecipitated with a variety of p120-specific monoclonal antibodies but not with antibodies to alpha- or beta-catenin, E-cadherin, or APC. Like other POZ-ZF proteins, Kaiso localized to the nucleus and was associated with specific nuclear dots. Yeast two-hybrid interaction assays mapped the binding domains to Arm repeats 1 to 7 of p120 and the carboxy-terminal 200 amino acids of Kaiso. In addition, Kaiso homodimerized via its POZ domain but it did not heterodimerize with BCL-6, which heterodimerizes with PLZF. The involvement of POZ-ZF proteins in development and cancer makes Kaiso an interesting candidate for a downstream effector of cadherin and/or p120 signaling.
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| AF6/s-afadin is a dual residency protein and localizes to a novel subnuclear compartment. | Buchert M et al. | β | 2007 | β |
| Cyclin-dependent kinase 2/cyclin E complex is involved in p120 catenin (p120ctn)-dependent cell growth control: a new role for p120ctn in cancer. | Chartier NT et al. | β | 2007 | β |
| Dancing in and out of the nucleus: p120(ctn) and the transcription factor Kaiso. | Daniel JM | β | 2007 | β |
| Developmental functions of the P120-catenin sub-family. | McCrea PD et al. | β | 2007 | β |
| Diverse functions of p120ctn in tumors. | van Hengel J et al. | β | 2007 | β |
| Mechanisms of disease: methyl-binding domain proteins as potential therapeutic targets in cancer. | Sansom OJ et al. | β | 2007 | β |
| Nuclear functions of endocytic proteins. | Pilecka I et al. | β | 2007 | β |
| p120-catenin is required for the collective invasion of squamous cell carcinoma cells via a phosphorylation-independent mechanism. | Macpherson IR et al. | β | 2007 | β |
| P120 catenin is required for thickening of Schwann cell myelin. | Perrin-Tricaud C et al. | β | 2007 | β |
| p120-catenin: Past and present. | Reynolds AB | β | 2007 | β |
| Specific phosphorylation of p120-catenin regulatory domain differently modulates its binding to RhoA. | CastaΓ±o J et al. | β | 2007 | β |
| The transcriptional repressor Glis2 is a novel binding partner for p120 catenin. | Hosking CR et al. | β | 2007 | β |
| Transcription and epigenetic profile of the promoter, first exon and first intron of the human tyrosine hydroxylase gene. | Romano G et al. | β | 2007 | β |
| A family of human zinc finger proteins that bind methylated DNA and repress transcription. | Filion GJ et al. | β | 2006 | β |
| An increase in the number of adhesion proteins with altered expression is associated with an increased risk of cancer death for colon carcinoma patients. | Bondi J et al. | β | 2006 | β |
| Blocked acinar development, E-cadherin reduction, and intraepithelial neoplasia upon ablation of p120-catenin in the mouse salivary gland. | Davis MA et al. | β | 2006 | β |
| Catenins: keeping cells from getting their signals crossed. | Perez-Moreno M et al. | β | 2006 | β |
| Frodo links Dishevelled to the p120-catenin/Kaiso pathway: distinct catenin subfamilies promote Wnt signals. | Park JI et al. | β | 2006 | β |
| Identification of the junctional plaque protein plakophilin 3 in cytoplasmic particles containing RNA-binding proteins and the recruitment of plakophilins 1 and 3 to stress granules. | Hofmann I et al. | β | 2006 | β |
| Kaiso-deficient mice show resistance to intestinal cancer. | Prokhortchouk A et al. | β | 2006 | β |
| p120-catenin mediates inflammatory responses in the skin. | Perez-Moreno M et al. | β | 2006 | β |
| P120ctn overexpression enhances beta-catenin-E-cadherin binding and down regulates expression of survivin and cyclin D1 in BEL-7404 hepatoma cells. | Nong CZ et al. | β | 2006 | β |
| POZ for effect--POZ-ZF transcription factors in cancer and development. | Kelly KF et al. | β | 2006 | β |
| The X-linked methyl binding protein gene Kaiso is highly expressed in brain but is not mutated in Rett syndrome patients. | Della Ragione F et al. | β | 2006 | β |
| A role for Kaiso-p120ctn complexes in cancer? | van Roy FM et al. | β | 2005 | β |
| Building the synovium: cadherin-11 mediates fibroblast-like synoviocyte cell-to-cell adhesion. | Kiener HP et al. | β | 2005 | β |
| Epithelial biology. | Scully C et al. | β | 2005 | β |
| Expression and nuclear location of the transcriptional repressor Kaiso is regulated by the tumor microenvironment. | Soubry A et al. | β | 2005 | β |
| Identification of a novel BTB-zinc finger transcriptional repressor, CIBZ, that interacts with CtBP corepressor. | Sasai N et al. | β | 2005 | β |
| Kaiso/p120-catenin and TCF/beta-catenin complexes coordinately regulate canonical Wnt gene targets. | Park JI et al. | β | 2005 | β |
| Mucosal diseases series. | Scully C | β | 2005 | β |
| Once upon a time there was beta-catenin in cadherin-mediated signalling. | Gavard J et al. | β | 2005 | β |
| Regulation of endocytosis, nuclear translocation, and signaling of fibroblast growth factor receptor 1 by E-cadherin. | Bryant DM et al. | β | 2005 | β |
| The catenin p120ctn inhibits Kaiso-mediated transcriptional repression of the beta-catenin/TCF target gene matrilysin. | Spring CM et al. | β | 2005 | β |
| The epigenetic breakdown of cancer cells: from DNA methylation to histone modifications. | Ballestar E et al. | β | 2005 | β |
| The human enhancer blocker CTC-binding factor interacts with the transcription factor Kaiso. | Defossez PA et al. | β | 2005 | β |
| The p120 family of cell adhesion molecules. | Hatzfeld M | β | 2005 | β |
| The tissue-specific methylation of the human tyrosine hydroxylase gene reveals new regulatory elements in the first exon. | ArΓ‘nyi T et al. | β | 2005 | β |
| WTH3, which encodes a small G protein, is differentially regulated in multidrug-resistant and sensitive MCF7 cells. | Tian K et al. | β | 2005 | β |
| ZENON, a novel POZ Kruppel-like DNA binding protein associated with differentiation and/or survival of late postmitotic neurons. | Kiefer H et al. | β | 2005 | β |
| Alpha-catenin: at the junction of intercellular adhesion and actin dynamics. | Kobielak A et al. | β | 2004 | β |
| A novel interaction between kinesin and p120 modulates p120 localization and function. | Yanagisawa M et al. | β | 2004 | β |
| Cell adhesion and signalling by cadherins and Ig-CAMs in cancer. | Cavallaro U et al. | β | 2004 | β |
| Cytoplasmic localization of p120ctn and E-cadherin loss characterize lobular breast carcinoma from preinvasive to metastatic lesions. | SarriΓ³ D et al. | β | 2004 | β |
| Differential expression of p120 catenin in glial cells of the adult rat brain. | Chauvet N et al. | β | 2004 | β |
| E- and N-cadherin differ with respect to their associated p120ctn isoforms and their ability to suppress invasive growth in pancreatic cancer cells. | Seidel B et al. | β | 2004 | β |
| Emerging roles for p120-catenin in cell adhesion and cancer. | Reynolds AB et al. | β | 2004 | β |
| Epigenetic gene silencing in acute promyelocytic leukemia. | Villa R et al. | β | 2004 | β |
| ICBP90, an E2F-1 target, recruits HDAC1 and binds to methyl-CpG through its SRA domain. | Unoki M et al. | β | 2004 | β |
| Inducible expression of p120Cas1B isoform corroborates the role for p120-catenin as a positive regulator of E-cadherin function in intestinal cancer cells. | Roura S et al. | β | 2004 | β |
| Kaiso is a genome-wide repressor of transcription that is essential for amphibian development. | Ruzov A et al. | β | 2004 | β |
| NLS-dependent nuclear localization of p120ctn is necessary to relieve Kaiso-mediated transcriptional repression. | Kelly KF et al. | β | 2004 | β |
| Non-canonical Wnt signals are modulated by the Kaiso transcriptional repressor and p120-catenin. | Kim SW et al. | β | 2004 | β |
| Nuclear bodies and compartments: functional roles and cellular signalling in health and disease. | Zimber A et al. | β | 2004 | β |
| Nuclear import of the BTB/POZ transcriptional regulator Kaiso. | Kelly KF et al. | β | 2004 | β |
| p120 catenin associates with microtubules: inverse relationship between microtubule binding and Rho GTPase regulation. | Franz CM et al. | β | 2004 | β |
| Reading the DNA methylation signal. | Bird A et al. | β | 2004 | β |
| Reduced expression and aberrant localization of p120catenin in human squamous cell carcinoma of the skin. | Ishizaki Y et al. | β | 2004 | β |
| Regulation of the rapsyn promoter by kaiso and delta-catenin. | Rodova M et al. | β | 2004 | β |
| Sertoli-Sertoli and Sertoli-germ cell interactions and their significance in germ cell movement in the seminiferous epithelium during spermatogenesis. | Mruk DD et al. | β | 2004 | β |
| Variation in cadherins and catenins expression is linked to both proliferation and transformation of Rhabdomyosarcoma. | Charrasse S et al. | β | 2004 | β |
| Vertebrate development requires ARVCF and p120 catenins and their interplay with RhoA and Rac. | Fang X et al. | β | 2004 | β |
| Working out the strength and flexibility of desmosomes. | Getsios S et al. | β | 2004 | β |
| Adhesion-independent mechanism for suppression of tumor cell invasion by E-cadherin. | Wong AS et al. | β | 2003 | β |
| Cell adhesion molecule regulation of nucleocytoplasmic trafficking. | Aplin AE | β | 2003 | β |
| Clinical, cellular, and molecular aspects of cancer invasion. | Mareel M et al. | β | 2003 | β |
| Comparative study of methyl-CpG-binding domain proteins. | Roloff TC et al. | β | 2003 | β |
| Contextual binding of p120ctn to E-cadherin at the basolateral plasma membrane in polarized epithelia. | Miranda KC et al. | β | 2003 | β |
| Distribution of p120 catenin during rat brain development: potential role in regulation of cadherin-mediated adhesion and actin cytoskeleton organization. | Chauvet N et al. | β | 2003 | β |
| DNA methylation in animal development. | Meehan RR | β | 2003 | β |
| N-CoR mediates DNA methylation-dependent repression through a methyl CpG binding protein Kaiso. | Yoon HG et al. | β | 2003 | β |
| Nuclear functions for plasma membrane-associated proteins? | Benmerah A et al. | β | 2003 | β |
| Regulation of p120-catenin nucleocytoplasmic shuttling activity. | Roczniak-Ferguson A et al. | β | 2003 | β |
| Targeting of p0071 to desmosomes and adherens junctions is mediated by different protein domains. | Hatzfeld M et al. | β | 2003 | β |
| The organization of adherens junctions and desmosomes at the cardiac intercalated disc is independent of gap junctions. | Gutstein DE et al. | β | 2003 | β |
| Up-regulation, nuclear import, and tumor growth stimulation of the adhesion protein p120 in pancreatic cancer. | Mayerle J et al. | β | 2003 | β |
| Altered expression of the catenin p120 in human cancer: implications for tumor progression. | Thoreson MA et al. | β | 2002 | β |
| An octapeptide in the juxtamembrane domain of VE-cadherin is important for p120ctn binding and cell proliferation. | Ferber A et al. | β | 2002 | β |
| Cadherin and catenin alterations in human cancer. | Hajra KM et al. | β | 2002 | β |
| Dynamic testicular adhesion junctions are immunologically unique. I. Localization of p120 catenin in rat testis. | Johnson KJ et al. | β | 2002 | β |
| Isolation and characterization of XKaiso, a transcriptional repressor that associates with the catenin Xp120(ctn) in Xenopus laevis. | Kim SW et al. | β | 2002 | β |
| Methyl-CpG binding proteins and cancer: are MeCpGs more important than MBDs? | Prokhortchouk E et al. | β | 2002 | β |
| Nuclear localization of the tight junction protein ZO-2 in epithelial cells. | Islas S et al. | β | 2002 | β |
| p120(cat) Delocalization in cell lines of oral cancer. | Lo Muzio L et al. | β | 2002 | β |
| Reciprocal regulation by estradiol 17-beta of ezrin and cadherin-catenin complexes in pituitary GH3 cells. | Smith PM et al. | β | 2002 | β |
| Rett syndrome and MeCP2: linking epigenetics and neuronal function. | Shahbazian MD et al. | β | 2002 | β |
| Rho1 interacts with p120ctn and alpha-catenin, and regulates cadherin-based adherens junction components in Drosophila. | Magie CR et al. | β | 2002 | β |
| Signal transduction by cell adhesion receptors and the cytoskeleton: functions of integrins, cadherins, selectins, and immunoglobulin-superfamily members. | Juliano RL | β | 2002 | β |
| Specific sequences in p120ctn determine subcellular distribution of its multiple isoforms involved in cellular adhesion of normal and malignant epithelial cells. | Aho S et al. | β | 2002 | β |
| Symplekin, a constitutive protein of karyo- and cytoplasmic particles involved in mRNA biogenesis in Xenopus laevis oocytes. | Hofmann I et al. | β | 2002 | β |
| The p120(ctn)-binding partner Kaiso is a bi-modal DNA-binding protein that recognizes both a sequence-specific consensus and methylated CpG dinucleotides. | Daniel JM et al. | β | 2002 | β |
| Turn-off, drop-out: functional state switching of cadherins. | Lilien J et al. | β | 2002 | β |
| Cadherins and catenins, Wnts and SOXs: embryonic patterning in Xenopus. | St Amand AL et al. | β | 2001 | β |
| Identification of an invasive, N-cadherin-expressing epithelial cell type in endometriosis using a new cell culture model. | Zeitvogel A et al. | β | 2001 | β |
| Leaving the neighborhood: molecular mechanisms involved during epithelial-mesenchymal transition. | Savagner P | β | 2001 | β |
| Modulation of mouse neural crest cell motility by N-cadherin and connexin 43 gap junctions. | Xu X et al. | β | 2001 | β |
| Monoclonal antibodies to Kaiso: a novel transcription factor and p120ctn-binding protein. | Daniel JM et al. | β | 2001 | β |
| p120 catenin affects cell motility via modulation of activity of Rho-family GTPases: a link between cell-cell contact formation and regulation of cell locomotion. | Grosheva I et al. | β | 2001 | β |
| Regulation of nucleocytoplasmic trafficking by cell adhesion receptors and the cytoskeleton. | Aplin AE et al. | β | 2001 | β |
| Regulation of Rho GTPases by p120-catenin. | Anastasiadis PZ et al. | β | 2001 | β |
| The Human DF3/MUC1 carcinoma-associated antigen signals nuclear localization of the catenin p120(ctn). | Li Y et al. | β | 2001 | β |
| The p120 catenin partner Kaiso is a DNA methylation-dependent transcriptional repressor. | Prokhortchouk A et al. | β | 2001 | β |
| ARVCF localizes to the nucleus and adherens junction and is mutually exclusive with p120(ctn) in E-cadherin complexes. | Mariner DJ et al. | β | 2000 | β |
| Depression in the level of cadherin and alpha-, beta-, gamma-catenins in transgenic Xenopus laevis highly expressing c-Src. | DvorΓ‘kovΓ‘ K et al. | β | 2000 | β |
| Epithelial mesenchymal transition by c-Fos estrogen receptor activation involves nuclear translocation of beta-catenin and upregulation of beta-catenin/lymphoid enhancer binding factor-1 transcriptional activity. | Eger A et al. | β | 2000 | β |
| Epsin 1 undergoes nucleocytosolic shuttling and its eps15 interactor NH(2)-terminal homology (ENTH) domain, structurally similar to Armadillo and HEAT repeats, interacts with the transcription factor promyelocytic leukemia Zn(2)+ finger protein (PLZF). | Hyman J et al. | β | 2000 | β |
| Exocyst is involved in cystogenesis and tubulogenesis and acts by modulating synthesis and delivery of basolateral plasma membrane and secretory proteins. | Lipschutz JH et al. | β | 2000 | β |
| N-Cadherin: structure, function and importance in the formation of new intercalated disc-like cell contacts in cardiomyocytes. | Zuppinger C et al. | β | 2000 | β |
| p0071, a member of the armadillo multigene family, is a constituent of sarcomeric I-bands in human skeletal muscle. | SchrΓΆder R et al. | β | 2000 | β |
| p120 catenin regulates the actin cytoskeleton via Rho family GTPases. | Noren NK et al. | β | 2000 | β |
| Selective uncoupling of p120(ctn) from E-cadherin disrupts strong adhesion. | Thoreson MA et al. | β | 2000 | β |
| The cadherin-catenin complex is expressed alternately with the adenomatous polyposis coli protein during rat incisor amelogenesis. | Sorkin BC et al. | β | 2000 | β |
| The p120 catenin family: complex roles in adhesion, signaling and cancer. | Anastasiadis PZ et al. | β | 2000 | β |
| The protein-tyrosine phosphatase SHP-1 binds to and dephosphorylates p120 catenin. | Keilhack H et al. | β | 2000 | β |
| Xarvcf, Xenopus member of the p120 catenin subfamily associating with cadherin juxtamembrane region. | Paulson AF et al. | β | 2000 | β |
| A novel BTB/POZ transcriptional repressor protein interacts with the Fanconi anemia group C protein and PLZF. | Hoatlin ME et al. | β | 1999 | β |
| Cadherins and their connections: adhesion junctions have broader functions. | Steinberg MS et al. | β | 1999 | β |
| Nuclear localization of the p120(ctn) Armadillo-like catenin is counteracted by a nuclear export signal and by E-cadherin expression. | van Hengel J et al. | β | 1999 | β |
| The juxtamembrane domain of cadherin regulates integrin-mediated adhesion and neurite outgrowth. | Lilien J et al. | β | 1999 | β |
| The role of the E-cadherin/catenin adhesion complex in the development and progression of cancer. | Nollet F et al. | β | 1999 | β |