Discrepant target detection and action monitoring in obsessive-compulsive disorder.
paper
Cited
Public
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- Authors
- Johannes, S; Wieringa, B M; Nager, W; Rada, D; Dengler, R; Emrich, H M; Münte, T F; Dietrich, D E
- Year
- 2001
- Journal
- Psychiatry research
- PMID
- 11738544
- DOI
- 10.1016/s0925-4927(01)00117-2
Obsessive-compulsive disorder (OCD) has been related to altered mechanisms of action monitoring and target detection, and it has been hypothesized that hyperactive striatal-cortical circuits constitute the underlying pathophysiology. This study used event-related brain potentials (ERPs) to explore this hypothesis. A choice reaction time experiment was carried out in a group of OCD patients and a normal comparison group. The P3b component of the ERP to targets was taken as an indicator of the target-evaluation process and the response-locked error-related negativity (ERN) served as an indicator of action monitoring. We hypothesized that the OCD group would show a shortened P3b latency and an amplitude-enhanced ERN. Consistent with our expectations, the P3b latency was shorter and the ERN amplitude was higher in the OCD group. Unexpectedly, we also observed a prolonged ERN latency in the OCD group and a more posterior topography of this component. The data provide partial support for the hypothesis of a hyperactive neural network in OCD. In addition the disorder must involve pathophysiological processes that are presumably related to other aspects of its complex and heterogeneous clinical hallmarks.
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| Title | Year | PMID |
|---|---|---|
| Advances in Electrophysiological Research. | 2015 | 26259089 |
| The error-related negativity (ERN) and psychopathology: toward an endophenotype. | 2008 | 18694617 |
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