Interleukin-1 and tumor necrosis factor-alpha synergistically mediate neurotoxicity: involvement of nitric oxide and of N-methyl-D-aspartate receptors.
paper
Cited
Public
Unavailable
- Authors
- Chao, C C; Hu, S; Ehrlich, L; Peterson, P K
- Year
- 1995
- Journal
- Brain, behavior, and immunity
- PMID
- 8903852
- DOI
- 10.1006/brbi.1995.1033
The cytokines interleukin (IL)-1 and tumor necrosis factor (TNF)-alpha, produced by glial cells within the brain, appear to contribute to the neuropathogenesis of several inflammatory neurodegenerative diseases; however, little is known about the mechanism underlying cytokine-induced neurotoxicity. Using human fetal brain cell cultures composed of neurons and glial cells, we investigated the injurious effects of IL-1beta and TNF-alpha, cytokines which are known to induce nitric oxide (NO) production by astrocytes. Although neither cytokine alone was toxic, IL-1beta and TNF-alpha in combination caused marked neuronal injury. Brain cell cultures treated with IL-1beta plus TNF-alpha generated substantial amounts of NO. Blockade of NO production with a NO synthase inhibitor was accompanied by a marked reduction (about 45%) of neuronal injury, suggesting that NO production by astrocytes plays a role in cytokine-induced neurotoxicity. Addition of N-methly-D-aspartate (NMDA) receptor antagonists to brain cell cultures also blocked IL-1beta plus TNF-alpha-induced neurotoxicity (by 55%), implicating the involvement of NMDA receptors in cytokine-induced neurotoxicity. Treatment of brain cell cultures with IL-1beta plus TNF-alpha was found to inhibit [3H]-glutamate uptake and astrocyte glutamine synthetase activity, two major pathways involved in NMDA receptor-related neurotoxicity. These in vitro findings suggest that agents which suppress NO production or inhibit NMDA receptors may protect against neuronal damage in cytokine-induced neurodegenerative diseases.
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| NP031112, a thiadiazolidinone compound, prevents inflammation and neurodegeneration under excitotoxic conditions: potential therapeutic role in brain disorders. | Luna-Medina R et al. | β | 2007 | β |
| Tumor necrosis factor alpha stimulates NMDA receptor activity in mouse cortical neurons resulting in ERK-dependent death. | Jara JH et al. | β | 2007 | β |
| Activation of the hypothalamic-pituitary-adrenal axis and autonomic nervous system during inflammation and altered programming of the neuroendocrine-immune axis during fetal and neonatal development: lessons learned from the model inflammagen, lipopolysaccharide. | Karrow NA | β | 2006 | β |
| Chapter 22 Contribution of glia to pain processing in health and disease. | Watkins LR et al. | β | 2006 | β |
| Cognitive impairment in patients with chronic hepatitis treated with interferon alpha (IFNalpha): results from a prospective study. | Lieb K et al. | β | 2006 | β |
| Differential suppression of endotoxin-inducible inflammatory cytokines by nuclear factor kappa B (NFkappaB) inhibitor in rat microglia. | Nakajima K et al. | β | 2006 | β |
| Editorial: cytokine inhibition for treatment of Alzheimer's disease. | Rosenberg PB | β | 2006 | β |
| Glucagon-like peptide-1 inhibits LPS-induced IL-1beta production in cultured rat astrocytes. | Iwai T et al. | β | 2006 | β |
| Impact of 17beta-estradiol on cytokine-mediated apoptotic effects in primary hippocampal and neocortical cell cultures. | Kajta M et al. | β | 2006 | β |
| Lipopolysaccharide-activated SHP-1-deficient motheaten microglia release increased nitric oxide, TNF-alpha, and IL-1beta. | Zhao J et al. | β | 2006 | β |
| Neuroprotective properties of the innate immune system and bone marrow stem cells in Alzheimer's disease. | Simard AR et al. | β | 2006 | β |
| Pathophysiology of disk-related low back pain and sciatica. II. Evidence supporting treatment with TNF-alpha antagonists. | Mulleman D et al. | β | 2006 | β |
| Pathophysiology of disk-related sciatica. I.--Evidence supporting a chemical component. | Mulleman D et al. | β | 2006 | β |
| Perinatal infections and cerebral palsy. | Hermansen MC et al. | β | 2006 | β |
| Potential role of N-methyl-D-aspartate receptors as executors of neurodegeneration resulting from diverse insults: focus on memantine. | Wenk GL et al. | β | 2006 | β |
| Prenatal exposure to interleukin-6 results in inflammatory neurodegeneration in hippocampus with NMDA/GABA(A) dysregulation and impaired spatial learning. | Samuelsson AM et al. | β | 2006 | β |
| Proinflammatory cytokines released from microglia inhibit gap junctions in astrocytes: potentiation by beta-amyloid. | MΓͺme W et al. | β | 2006 | β |
| Roles of glia-derived cytokines on neuronal degeneration and regeneration. | Suzumura A et al. | β | 2006 | β |
| TNF alpha affects the expression of GFAP and S100B: implications for Alzheimer's disease. | Edwards MM et al. | β | 2006 | β |
| Viruses and the brain: from inflammation to dementia. | Wang T et al. | β | 2006 | β |
| Activation of microglial NADPH oxidase is synergistic with glial iNOS expression in inducing neuronal death: a dual-key mechanism of inflammatory neurodegeneration. | Mander P et al. | β | 2005 | β |
| Apolipoprotein J (clusterin) activates rodent microglia in vivo and in vitro. | Xie Z et al. | β | 2005 | β |
| Clinical aspects of inflammation in Alzheimer's disease. | Rosenberg PB | β | 2005 | β |
| Closed head injury--an inflammatory disease? | Schmidt OI et al. | β | 2005 | β |
| Differential effects of oligomeric and fibrillar amyloid-beta 1-42 on astrocyte-mediated inflammation. | White JA et al. | β | 2005 | β |
| Do pathogen exposure and innate immunity cause brain diseases? | Simard AR et al. | β | 2005 | β |
| Dose-dependent activation of microglial cells by Toll-like receptor agonists alone and in combination. | Ebert S et al. | β | 2005 | β |
| Inflammatory response and glia activation in developing rat hippocampus after status epilepticus. | Ravizza T et al. | β | 2005 | β |
| Interleukin-1 and neuronal injury. | Allan SM et al. | β | 2005 | β |
| Interleukin 1beta and interleukin 6 relationship with paediatric head trauma severity and outcome. | Chiaretti A et al. | β | 2005 | β |
| Investigations with cultured human microglia on pathogenic mechanisms of Alzheimer's disease and other neurodegenerative diseases. | Walker DG et al. | β | 2005 | β |
| Leptomeningeal cells activate microglia and astrocytes to induce IL-10 production by releasing pro-inflammatory cytokines during systemic inflammation. | Wu Z et al. | β | 2005 | β |
| Macrophages and neurodegeneration. | Hendriks JJ et al. | β | 2005 | β |
| Neuroinflammatory responses from microglia recovered from HIV-1-infected and seronegative subjects. | Ghorpade A et al. | β | 2005 | β |
| Nitric oxide from inflammatory-activated glia synergizes with hypoxia to induce neuronal death. | Mander P et al. | β | 2005 | β |
| Prostaglandin EP4 receptor agonist protects against acute neurotoxicity. | Ahmad AS et al. | β | 2005 | β |
| Repression of interferon-gamma-induced inducible nitric oxide synthase (iNOS) gene expression in microglia by sodium butyrate is mediated through specific inhibition of ERK signaling pathways. | Park JS et al. | β | 2005 | β |
| Retinoic acid inhibits expression of TNF-alpha and iNOS in activated rat microglia. | Dheen ST et al. | β | 2005 | β |
| Stimulation of microglial metabotropic glutamate receptor mGlu2 triggers tumor necrosis factor alpha-induced neurotoxicity in concert with microglial-derived Fas ligand. | Taylor DL et al. | β | 2005 | β |
| Systemic inflammation induces apoptosis with variable vulnerability of different brain regions. | Semmler A et al. | β | 2005 | β |
| Valproate pretreatment protects dopaminergic neurons from LPS-induced neurotoxicity in rat primary midbrain cultures: role of microglia. | Peng GS et al. | β | 2005 | β |
| A new anti-inflammatory agent KL-1037 represses proinflammatory cytokine and inducible nitric oxide synthase (iNOS) gene expression in activated microglia. | Kim WK et al. | β | 2004 | β |
| Cochlear ablation in mice lacking SHP-1 results in an extended period of cell death of anteroventral cochlear nucleus neurons. | Zhao J et al. | β | 2004 | β |
| Cytokine production, glutamate release and cell death in rat cultured astrocytes treated with unconjugated bilirubin and LPS. | Fernandes A et al. | β | 2004 | β |
| Genetic contributions to Parkinson's disease. | Huang Y et al. | β | 2004 | β |
| Glial activation modulates glutamate neurotoxicity in cerebellar granule cell cultures. | PΓ©rez-Capote K et al. | β | 2004 | β |
| Neuroimmune activation and neuroinflammation in chronic pain and opioid tolerance/hyperalgesia. | DeLeo JA et al. | β | 2004 | β |
| Neuronal injury mediated via stimulation of microglial toll-like receptor-9 (TLR9). | Iliev AI et al. | β | 2004 | β |
| On the potential role of glutamate transport in mental fatigue. | RΓΆnnbΓ€ck L et al. | β | 2004 | β |
| Role of microglia in central nervous system infections. | Rock RB et al. | β | 2004 | β |
| Suppression of proinflammatory cytokines interleukin-1beta and tumor necrosis factor-alpha in astrocytes by a V1 vasopressin receptor agonist: a cAMP response element-binding protein-dependent mechanism. | Zhao L et al. | β | 2004 | β |
| Treatment with an acetylcholinesterase inhibitor in Alzheimer patients modulates the expression and production of the pro-inflammatory and anti-inflammatory cytokines. | Reale M et al. | β | 2004 | β |
| 1,3-selenazol-4-one derivatives inhibit inducible nitric oxide-mediated nitric oxide production in lipopolysaccharide-induced BV-2 cells. | Park YJ et al. | β | 2003 | β |
| Administration of the p38 MAPK inhibitor SB203580 affords brain protection with a wide therapeutic window against focal ischemic insult. | Piao CS et al. | β | 2003 | β |
| Bidirectional concentration-dependent effects of tumor necrosis factor alpha in Shigella dysenteriae-related seizures. | Yuhas Y et al. | β | 2003 | β |
| Chronic glial activation, neurodegeneration, and APP immunoreactive deposits following acute administration of double-stranded RNA. | Melton LM et al. | β | 2003 | β |
| Dextromethorphan protects dopaminergic neurons against inflammation-mediated degeneration through inhibition of microglial activation. | Liu Y et al. | β | 2003 | β |
| Glia activation and cytokine increase in rat hippocampus by kainic acid-induced status epilepticus during postnatal development. | Rizzi M et al. | β | 2003 | β |
| Increased brain-derived neurotrophic factor expression in white blood cells of relapsing-remitting multiple sclerosis patients. | Gielen A et al. | β | 2003 | β |
| Inflammatory neurodegeneration mediated by nitric oxide, glutamate, and mitochondria. | Brown GC et al. | β | 2003 | β |
| Parkinson's disease and exposure to infectious agents and pesticides and the occurrence of brain injuries: role of neuroinflammation. | Liu B et al. | β | 2003 | β |
| Regulated expression of sodium-dependent glutamate transporters and synthetase: a neuroprotective role for activated microglia and macrophages in HIV infection? | Gras G et al. | β | 2003 | β |
| Role of microglia in inflammation-mediated neurodegenerative diseases: mechanisms and strategies for therapeutic intervention. | Liu B et al. | β | 2003 | β |
| Tumor necrosis factor-alpha at the crossroads of neuronal life and death during HIV-associated dementia. | Saha RN et al. | β | 2003 | β |
| Clinical chorioamnionitis, elevated cytokines, and brain injury in term infants. | Shalak LF et al. | β | 2002 | β |
| CrmA protects against apoptosis and ceramide formation in PC12 cells. | Goswami R et al. | β | 2002 | β |
| Different pathways for iNOS-mediated toxicity in vitro dependent on neuronal maturation and NMDA receptor expression. | Golde S et al. | β | 2002 | β |
| Effects of IL6 and IL1beta on aFGF expression and excitotoxicity in NT2N cells. | Thorns V et al. | β | 2002 | β |
| Exploring the formation of Alzheimer's disease senile plaques in silico. | Edelstein-keshet L et al. | β | 2002 | β |
| Glial cell responses to herpesvirus infections: role in defense and immunopathogenesis. | Lokensgard JR et al. | β | 2002 | β |
| Glutamine synthetase in brain: effect of ammonia. | SuΓ‘rez I et al. | β | 2002 | β |
| IL-1 beta is released from the host brain following transplantation but does not compromise embryonic dopaminergic neuron survival. | Clarke DJ et al. | β | 2002 | β |
| Increased sensitivity to N-methyl-D-aspartate receptor-induced excitotoxicity in cerebellar granule cells from interleukin-1 receptor type I-deficient mice. | Pelidou SH et al. | β | 2002 | β |
| Infection markers and early signs of neonatal encephalopathy in the term infant. | Shalak LF et al. | β | 2002 | β |
| Interleukin-10 reverses acute detrimental effects of endotoxin-induced inflammation on perinatal cerebral hypoxia-ischemia. | FrΓΈen JF et al. | β | 2002 | β |
| Local application of disc-related cytokines on spinal nerve roots. | Aoki Y et al. | β | 2002 | β |
| Lumbar nerve root injury induces central nervous system neuroimmune activation and neuroinflammation in the rat: relationship to painful radiculopathy. | Rutkowski MD et al. | β | 2002 | β |
| Role and mechanisms of interleukin-1 in the modulation of neurotoxicity. | Ma XC et al. | β | 2002 | β |
| Role of nitric oxide in inflammation-mediated neurodegeneration. | Liu B et al. | β | 2002 | β |
| Susceptibility of sensory neurons to apoptosis following infection by bovine herpesvirus type 1. | Delhon GA et al. | β | 2002 | β |
| The acute and sensitization effects of tumor necrosis factor-Ξ±: implications for immunotherapy as well as psychiatric and neurological conditions. | Hayley S et al. | β | 2002 | β |
| Activation of microglia by secreted amyloid precursor protein evokes release of glutamate by cystine exchange and attenuates synaptic function. | Barger SW et al. | β | 2001 | β |
| Apoptotic death of neurons exhibiting peripherin aggregates is mediated by the proinflammatory cytokine tumor necrosis factor-alpha. | Robertson J et al. | β | 2001 | β |
| Cytokines and acute neurodegeneration. | Allan SM et al. | β | 2001 | β |
| Cytokines and the central nervous system. | SzelΓ©nyi J | β | 2001 | β |
| Differential effects of cytokines and redox potential on glutamate uptake in rat cortical glial cultures. | Liao SL et al. | β | 2001 | β |
| Glial activation in the immature rat brain: implication of inflammatory transcription factors and cytokine expression. | Acarin L et al. | β | 2001 | β |
| Increased nitric oxide products in CSF in primary progressive MS may reflect brain atrophy. | Peltola J et al. | β | 2001 | β |
| Inflammatory neurodegeneration mediated by nitric oxide from activated glia-inhibiting neuronal respiration, causing glutamate release and excitotoxicity. | Bal-Price A et al. | β | 2001 | β |
| Minocycline provides neuroprotection against N-methyl-D-aspartate neurotoxicity by inhibiting microglia. | Tikka TM et al. | β | 2001 | β |
| Polymorphism of tumor necrosis factor-beta and alcohol dehydrogenase genes and alcoholic brain atrophy in Japanese patients. | Yamauchi M et al. | β | 2001 | β |
| Potentiation of 3-hydroxyglutarate neurotoxicity following induction of astrocytic iNOS in neonatal rat hippocampal cultures. | KΓΆlker S et al. | β | 2001 | β |
| Reduction in glial immunity and neuropathology by a PAF antagonist and an MMP and TNFalpha inhibitor in SCID mice with HIV-1 encephalitis. | Persidsky Y et al. | β | 2001 | β |
| Severe traumatic brain injury. | Finfer SR et al. | β | 2001 | β |
| The fetal inflammatory response syndrome and cerebral palsy: yet another challenge and dilemma for the obstetrician. | Svigos JM | β | 2001 | β |
| Beta-amyloid stimulation of inducible nitric-oxide synthase in astrocytes is interleukin-1beta- and tumor necrosis factor-alpha (TNFalpha)-dependent, and involves a TNFalpha receptor-associated factor- and NFkappaB-inducing kinase-dependent signaling mechanism. | Akama KT et al. | β | 2000 | β |
| Borna disease virus persistence causes inhibition of glutamate uptake by feline primary cortical astrocytes. | Billaud JN et al. | β | 2000 | β |
| Chronic sodium salicylate treatment exacerbates brain neurodegeneration in rats infected with Trypanosoma brucei. | Quan N et al. | β | 2000 | β |
| Cytokine-cytokine interactions and the brain. | Turrin NP et al. | β | 2000 | β |
| Cytokine effects on glutamate uptake by human astrocytes. | Hu S et al. | β | 2000 | β |
| Cytokine involvement in dynorphin-induced allodynia. | Laughlin TM et al. | β | 2000 | β |
| Inflammation is a component of neurodegeneration in response to Venezuelan equine encephalitis virus infection in mice. | Schoneboom BA et al. | β | 2000 | β |
| Inflammatory cytokines and related genes are induced in the rat hippocampus by limbic status epilepticus. | De Simoni MG et al. | β | 2000 | β |
| Inhibition of kainic acid induced expression of interleukin-1 beta and interleukin-1 receptor antagonist mRNA in the rat brain by NMDA receptor antagonists. | Eriksson C et al. | β | 2000 | β |
| Neuronal, astroglial and microglial cytokine expression after an excitotoxic lesion in the immature rat brain. | Acarin L et al. | β | 2000 | β |
| Role of NMDA receptor signaling in the regulation of inflammatory gene expression after focal brain ischemia. | Jander S et al. | β | 2000 | β |
| Sequential mRNA expression for immediate early genes, cytokines, and neurotrophins in spinal cord injury. | Hayashi M et al. | β | 2000 | β |
| Analysis of NO synthase expression in neuronal, astroglial and fibroblast-like derivatives differentiating from PCC7-Mz1 embryonic carcinoma cells. | Gath I et al. | β | 1999 | β |
| Annual review prize lecture cytokines - killers in the brain? | Rothwell NJ | β | 1999 | β |
| Apoptotic pathways mobilized in microglia and neurones as a consequence of chromogranin A-induced microglial activation. | Kingham PJ et al. | β | 1999 | β |
| Differential development of Toxoplasma gondii in neural cells. | Fagard R et al. | β | 1999 | β |
| Gp-41-mediated astrocyte inducible nitric oxide synthase mRNA expression: involvement of interleukin-1beta production by microglia. | Hu S et al. | β | 1999 | β |
| Inflammatory pathogenesis in Alzheimer's disease: biological mechanisms and cognitive sequeli. | Gahtan E et al. | β | 1999 | β |
| Involvement of tumor necrosis factor alpha and interleukin-1beta in enhancement of pentylenetetrazole-induced seizures caused by Shigella dysenteriae. | Yuhas Y et al. | β | 1999 | β |
| Mechanisms of tumor necrosis factor alpha action on neurodegeneration: interaction with insulin-like growth factor-1. | Loddick SA et al. | β | 1999 | β |
| Glial glutamate transport as target for nitric oxide: consequences for neurotoxicity. | Ye ZC et al. | β | 1998 | β |
| Rationale for immune-based therapies for HIV-1 infection. | Valdez H et al. | β | 1998 | β |
| The expression of cytokines and their receptors in normal and mildly reactive human brain. | Morris CS et al. | β | 1998 | β |
| The neuronal death induced by endotoxic shock but not that induced by excitatory amino acids requires TNF-alpha. | de Bock F et al. | β | 1998 | β |
| The role of tumour necrosis factor, interleukin 6, interferon-gamma and inducible nitric oxide synthase in the development and pathology of the nervous system. | MuΓ±oz-FernΓ‘ndez MA et al. | β | 1998 | β |
| Tumor necrosis factor alpha and nucleus-pulposus-induced nerve root injury. | Olmarker K et al. | β | 1998 | β |
| Cytokine production in the brain following closed head injury: dexanabinol (HU-211) is a novel TNF-alpha inhibitor and an effective neuroprotectant. | Shohami E et al. | β | 1997 | β |
| Expression pattern and cellular origin of cytokines in the normal and Toxoplasma gondii-infected murine brain. | SchlΓΌter D et al. | β | 1997 | β |
| Maternal intrauterine infection, cytokines, and brain damage in the preterm newborn. | Dammann O et al. | β | 1997 | β |
| Voltametric assessment of brain nitric oxide during heatstroke in rats. | Canini F et al. | β | 1997 | β |
| Brain TNF: damage limitation or damaged reputation? | Rothwell NJ et al. | β | 1996 | β |