Nicotine addiction and comorbidity with alcohol abuse and mental illness.
paper
Cited
Public
Unavailable
- Authors
- Dani, John A; Harris, R Adron
- Year
- 2005
- Journal
- Nature neuroscience
- PMID
- 16251989
- DOI
- 10.1038/nn1580
The World Health Organization estimates that one-third of the global adult population smokes. Because tobacco use is on the rise in developing countries, death resulting from tobacco use continues to rise. Nicotine, the main addictive component of tobacco, initiates synaptic and cellular changes that underlie the motivational and behavioral alterations that culminate in addiction. Nicotine addiction progresses rapidly in adolescents and is most highly expressed in vulnerable people who have psychiatric illness or other substance abuse problems.
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|---|---|---|---|---|
| Disruption of <i>chrna5</i> blunts aversion and adaptive transcriptomic responses to nicotine and alcohol. | Goel T et al. | β | 2026 | β |
| Identifying treatment responders to the combination of varenicline and naltrexone. | Donato S et al. | β | 2026 | β |
| A biomimetic Fe(III)-metal-organic framework nanosphere-based dual modal probe for aqueous and intracellular sensing of nicotine and its metabolite cotinine. | Dhillon AK et al. | β | 2025 | β |
| Acetylcholine and Depression: Scrutinizing Future Therapeutic Targets for Novel Drug Development. | Pannu A et al. | β | 2025 | β |
| Development of deep learning auto-encoder algorithms for predicting alcohol use in Korean adolescents based on cross-sectional data. | Lee S | β | 2025 | β |
| Differences in resting state functional connectivity in striatal and frontal networks associated with task-behaviour elicited by gamified two-stage decision task. | Brydevall M et al. | β | 2025 | β |
| Early-life exposure to tobacco smoke increase risk of frailty in adulthood: evidence from a large prospective cohort study. | Li Z et al. | β | 2025 | β |
| Environmental pollutant-induced cholinergic disruption: Advances and perspectives in mechanistic insights, target heterogeneity, and neurotoxic synergy. | Li W et al. | β | 2025 | β |
| Nicotine Misuse and Treatment of Schizophrenia Exacerbations in Men: An Observational Study in Poland. | Grabowski J et al. | β | 2025 | β |
| Pavlovian conditioning with the internal stimulus effects of intravenous nicotine heightens later nicotine taking with variation by dose and sex. | Barrett ST et al. | β | 2025 | β |
| Substance Use and Social Influence as Risk Factors for Nicotine and Tobacco Product Use in Adolescents and Young Adults who use Electronic Nicotine Delivery Systems. | Hatz LE et al. | β | 2025 | β |
| Activation and Regulation of Pancreatic Stellate Cells in Chronic Pancreatic Fibrosis: A Potential Therapeutic Approach for Chronic Pancreatitis. | Kong F et al. | β | 2024 | β |
| Anxiety symptoms and anxiety sensitivity in relation to cigarette dependence, perceived barriers for smoking cessation and quit problems among adult Latinx smokers. | Zvolensky MJ et al. | β | 2024 | β |
| A Systematic Review on Drugs Acting as Nicotinic Acetylcholine Receptor Agonists in the Treatment of Dementia. | Crestini A et al. | β | 2024 | β |
| Co-action and changes in alcohol use during a smoking cessation attempt. | Vinci C et al. | β | 2024 | β |
| Dynamic effects of ventral hippocampal NRG3/ERBB4 signaling on nicotine withdrawal-induced responses. | Fisher ML et al. | β | 2024 | β |
| Polycyclic Aromatic Hydrocarbons Mediate the Association between Tobacco Smoking and Alcohol Use Disorder. | Lee D et al. | β | 2024 | β |
| The association of genetic polymorphisms within the dopaminergic system with nicotine dependence: A narrative review. | Yang J et al. | β | 2024 | β |
| The association of psychological distress and economic and health worries with tobacco smoking behavior during the COVID-19 pandemic: a two-year longitudinal cohort study. | Alpers SE et al. | β | 2024 | β |
| Editorial: Biomarkers of mental well-being continuum across life span: from excelling to crisis. | Koshibu K | β | 2023 | β |
| Nicotine Use and Metabotropic Glutamate Receptor 5 in Individuals With Major Depressive and Posttraumatic Stress Disorders. | Baldassarri SR et al. | β | 2023 | β |
| Perceived Racial/Ethnic Discrimination and Smoking Outcome Expectancies among Adult Latinx Smokers Living in the United States. | Zvolensky MJ et al. | β | 2023 | β |
| Risk for alcohol use problems in severe mental illness: Interactions with sex and racial/ethnic minority status. | Levit JD et al. | β | 2023 | β |
| The Role of Microglial Depletion Approaches in Pathological Condition of CNS. | Tahmasebi F et al. | β | 2023 | β |
| Tryptophan and Substance Abuse: Mechanisms and Impact. | Davidson M et al. | β | 2023 | β |
| An inhibitory brainstem input to dopamine neurons encodes nicotine aversion. | Liu C et al. | β | 2022 | β |
| Examining Attitudes, Expectations, and Tobacco Cessation Treatment Outcomes Among Incarcerated Tobacco Smokers. | Acuna N et al. | β | 2022 | β |
| Exposure to Nicotine Vapor Produced by an Electronic Nicotine Delivery System Causes Short-Term Increases in Impulsive Choice in Adult Male Rats. | Flores RJ et al. | β | 2022 | β |
| High-throughput cell-based assays for identifying antagonists of multiple smoking-associated human nicotinic acetylcholine receptor subtypes. | Kassner M et al. | β | 2022 | β |
| <i>Adiponectin</i>. rs266729 Polymorphism and Nicotine Dependence Interaction: Genetic Investigations on the Anxiety Susceptibility. | Zhao X et al. | β | 2022 | β |
| Prevalence and factors associated with smoking in a nationally representative sample of Greek adults: The Hellenic National Nutrition and Health Survey (HNNHS). | Michas G et al. | β | 2022 | β |
| Socioeconomic status, individual behaviors and risk for mental disorders: A Mendelian randomization study. | Cai J et al. | β | 2022 | β |
| UFR2709, an Antagonist of Nicotinic Acetylcholine Receptors, Delays the Acquisition and Reduces Long-Term Ethanol Intake in Alcohol-Preferring UChB Bibulous Rats. | GΓ‘lvez G et al. | β | 2022 | β |
| Understanding the links between cardiovascular and psychiatric conditions. | Amarasekera S et al. | β | 2022 | β |
| WITHDRAWN: Prevalence and factors associated with smoking in a nationally representative sample of Greek adults: The Hellenic National Nutrition and Health Survey (HNNHS). | Michas G et al. | β | 2022 | β |
| Ξ²2* nicotinic acetylcholine receptor subtypes mediate nicotine-induced enhancement of Pavlovian conditioned responding to an alcohol cue. | Maddux JM et al. | β | 2022 | β |
| Bidirectional sex-dependent regulation of Ξ±6 and Ξ²3 nicotinic acetylcholine receptors by protein kinase CΞ΅. | Moen JK et al. | β | 2021 | β |
| Cell-Type-Specific Adaptions in Striatal Medium-Sized Spiny Neurons and Their Roles in Behavioral Responses to Drugs of Abuse. | Allichon MC et al. | β | 2021 | β |
| Characterization and expression analysis of tandemly duplicated nicotinic acetylcholine receptors in pearl oysters after stimulation of pathogen-related molecular patterns. | Cao Y et al. | β | 2021 | β |
| Neuroimaging evidence for structural correlates in adolescents resilient to polysubstance use: A five-year follow-up study. | Filippi I et al. | β | 2021 | β |
| Risk factors for hazardous drinking in university students from South Africa and Belgium: a cross-cultural comparison study. | InaΓ§ Y et al. | β | 2021 | β |
| Smoking Addiction and Strategies for Cessation. | DiSilvio B et al. | β | 2021 | β |
| Adolescent Cannabinoid and Nicotine Exposure Differentially Alters Adult Nicotine Self-Administration in Males and Females. | Dukes AJ et al. | β | 2020 | β |
| A multiple mediation model of trait worry and hazardous drinking among treatment-seeking smokers: the roles of coping and conformity drinking motives. | Hallford G et al. | β | 2020 | β |
| An online randomised controlled trial of mental contrasting with implementation intentions as a smoking behaviour change intervention. | Mutter ER et al. | β | 2020 | β |
| Are national antitobacco campaigns reaching high-risk adolescents? A cross-sectional analysis from PATH Wave 2. | Weiger CV et al. | β | 2020 | β |
| Association between the ACE-I/D polymorphism and nicotine dependence amongst patients with lung cancer. | Nadalin S et al. | β | 2020 | β |
| Associations of cigarette smoking with psychiatric disorders: evidence from a two-sample Mendelian randomization study. | Yuan S et al. | β | 2020 | β |
| BDNF and nicotine dependence: associations and potential mechanisms. | Huang Z et al. | β | 2020 | β |
| Behavior and Substance Addictions in Children: A Behavioral Model and Potential Solutions. | Belisle J et al. | β | 2020 | β |
| Eating disorders in a community-based sample of women with alcohol use disorder and nicotine dependence. | Munn-Chernoff MA et al. | β | 2020 | β |
| Effect of 4-Fluoro-N-(4-sulfamoylbenzyl) Benzene Sulfonamide on cognitive deficits and hippocampal plasticity during nicotine withdrawal in rats. | Rehman NU et al. | β | 2020 | β |
| Enduring neuroimmunological consequences of developmental experiences: From vulnerability to resilience. | Reddaway J et al. | β | 2020 | β |
| Molecular Mechanisms Associated with Nicotine Pharmacology and Dependence. | Fowler CD et al. | β | 2020 | β |
| Nicotine encourages oxidative stress and impairment of rats' brain mitigated by Spirulina platensis lipopolysaccharides and low-dose ionizing radiation. | Elsonbaty SM et al. | β | 2020 | β |
| Orbitofrontal, dorsal striatum, and habenula functional connectivity in psychiatric patients with substance use problems. | Oh H et al. | β | 2020 | β |
| The Impact of Differential Parenting: Study Protocol on a Longitudinal Study Investigating Child and Parent Factors on Children's Psychosocial Health in Hong Kong. | Ng CSM et al. | β | 2020 | β |
| Unique, long-term effects of nicotine on adolescent brain. | Leslie FM | β | 2020 | β |
| Alcohol Interaction with Cocaine, Methamphetamine, Opioids, Nicotine, Cannabis, and Ξ³-Hydroxybutyric Acid. | Singh AK | β | 2019 | β |
| Cigarette smoke exposure effects on the brainstem expression of nicotinic acetylcholine receptors (nAChRs), and on cardiac, respiratory and sleep physiologies. | Vivekanandarajah A et al. | β | 2019 | β |
| Early smoking-onset age and risk of cardiovascular disease and mortality. | Fa-Binefa M et al. | β | 2019 | β |
| Ethnopharmacological Applications Targeting Alcohol Abuse: Overview and Outlook. | Singh L et al. | β | 2019 | β |
| Genome-wide association study in Finnish twins highlights the connection between nicotine addiction and neurotrophin signaling pathway. | HΓ€llfors J et al. | β | 2019 | β |
| Massive expansion and diversity of nicotinic acetylcholine receptors in lophotrochozoans. | Jiao Y et al. | β | 2019 | β |
| NAChR Ξ±4Ξ²2 Subtype and their Relation with Nicotine Addiction, Cognition, Depression and Hyperactivity Disorder. | Laikowski MM et al. | β | 2019 | β |
| Prevalence and Predictors of Current and Former Tobacco Use among Older Adults in Indonesia | Pengpid S et al. | β | 2019 | β |
| Smoking patterns and preferences for technology assisted smoking cessation interventions among adults with opioid and alcohol use disorders. | Tofighi B et al. | β | 2019 | β |
| UFR2709, a Nicotinic Acetylcholine Receptor Antagonist, Decreases Ethanol Intake in Alcohol-Preferring Rats. | Quiroz G et al. | β | 2019 | β |
| Activation of AMPK by metformin improves withdrawal signs precipitated by nicotine withdrawal. | Brynildsen JK et al. | β | 2018 | β |
| A review of the effects of nicotine on social functioning. | Martin LM et al. | β | 2018 | β |
| Convergent Neuronal Plasticity and Metaplasticity Mechanisms of Stress, Nicotine, and Alcohol. | Ostroumov A et al. | β | 2018 | β |
| Deficits of perceived spatial separation-induced prepulse inhibition in patients with bipolar disorder compared to healthy controls. | Bo Q et al. | β | 2018 | β |
| Erysodine, a competitive antagonist at neuronal nicotinic acetylcholine receptors, decreases ethanol consumption in alcohol-preferring UChB rats. | Quiroz G et al. | β | 2018 | β |
| Nicotinic receptors mediate stress-nicotine detrimental interplay via dopamine cells' activity. | Morel C et al. | β | 2018 | β |
| Rate of Tobacco Smoking Among Psychiatric Outpatients Attending a Tertiary Care Hospital in Oman: β¨A Cross-sectional Study. | Al Risi K et al. | β | 2018 | β |
| Simultaneous alcohol & tobacco use expectancies in young adult co-users. | Trim RS et al. | β | 2018 | β |
| Tobacco use during a clinical trial of mecamylamine for alcohol dependence: Medication effects on smoking and associations with reductions in drinking. | Roberts W et al. | β | 2018 | β |
| Video game addiction in emerging adulthood: Cross-sectional evidence of pathology in video game addicts as compared to matched healthy controls. | Stockdale L et al. | β | 2018 | β |
| Young adults report increased pleasure from smoking cigarettes when drinking alcohol but not when using marijuana. | Gubner NR et al. | β | 2018 | β |
| Alcohol and nicotine interactions: pre-clinical models of dependence. | Tarren JR et al. | β | 2017 | β |
| Compromised neuroplasticity in cigarette smokers under nicotine withdrawal is restituted by the nicotinic Ξ±<sub>4</sub>Ξ²<sub>2</sub>-receptor partial agonist varenicline. | Batsikadze G et al. | β | 2017 | β |
| Endogenous opioid system: a promising target for future smoking cessation medications. | Norman H et al. | β | 2017 | β |
| Impact of Age at Smoking Initiation on Smoking-Related Morbidity and All-Cause Mortality. | Choi SH et al. | β | 2017 | β |
| Nicotine enhances alcohol intake and dopaminergic responses through Ξ²2* and Ξ²4* nicotinic acetylcholine receptors. | Tolu S et al. | β | 2017 | β |
| Nicotine-induced enhancement of Pavlovian alcohol-seeking behavior in rats. | Maddux JN et al. | β | 2017 | β |
| Pathways to smoking behaviours: biological insights from the Tobacco and Genetics Consortium meta-analysis. | MinicΓ£ CC et al. | β | 2017 | β |
| Re-exposure to nicotine-associated context from adolescence enhances alcohol intake in adulthood. | Zipori D et al. | β | 2017 | β |
| Anxiolytic- and antidepressant-like effects of the methadone metabolite 2-ethyl-5-methyl-3,3-diphenyl-1-pyrroline (EMDP). | Forcelli PA et al. | β | 2016 | β |
| A Primer on the Genetics of Comorbid Eating Disorders and Substance Use Disorders. | Munn-Chernoff MA et al. | β | 2016 | β |
| A review of epidemiologic research on smoking behavior among persons with alcohol and illicit substance use disorders. | Weinberger AH et al. | β | 2016 | β |
| Correlates of nicotine withdrawal severity in smokers during a smoke-free psychiatric hospitalization. | Soyster P et al. | β | 2016 | β |
| Crucial roles of the CHRNB3-CHRNA6 gene cluster on chromosome 8 in nicotine dependence: update and subjects for future research. | Wen L et al. | β | 2016 | β |
| Current insights into the mechanisms and development of treatments for heavy drinking cigarette smokers. | Roche DJ et al. | β | 2016 | β |
| Effects of varenicline on operant self-administration of alcohol and/or nicotine in a rat model of co-abuse. | Funk D et al. | β | 2016 | β |
| Gene-Environment Interactions Between Depressive Symptoms and Smoking Quantity. | Keskitalo-Vuokko K et al. | β | 2016 | β |
| Ineffectiveness of nicotinic acetylcholine receptor antagonists for treatment-resistant depression: a meta-analysis. | Wang HR et al. | β | 2016 | β |
| Maternal Exposure to Ethanol During Pregnancy and Lactation Affects Glutamatergic System and Induces Oxidative Stress in Offspring Hippocampus. | Cesconetto PA et al. | β | 2016 | β |
| Neuromodulation, Emotional Feelings and Affective Disorders. | Wang F et al. | β | 2016 | β |
| Nicotine Modifies Corticostriatal Plasticity and Amphetamine Rewarding Behaviors in Mice(1,2,3). | Storey GP et al. | β | 2016 | β |
| Nicotinic acetylcholine receptor availability in cigarette smokers: effect of heavy caffeine or marijuana use. | Brody AL et al. | β | 2016 | β |
| The Effect of Varenicline on the Neural Processing of Fearful Faces and the Subjective Effects of Alcohol in Heavy Drinkers. | Gowin JL et al. | β | 2016 | β |
| Translational Research on Nicotine Dependence. | Falcone M et al. | β | 2016 | β |
| Advances in nicotine research in Addiction Biology. | Bernardi RE | β | 2015 | β |
| Alcohol and cigarette smoke components activate human pancreatic stellate cells: implications for the progression of chronic pancreatitis. | Lee AT et al. | β | 2015 | β |
| Cigarettes and alcohol: The influence of nicotine on operant alcohol self-administration and the mesolimbic dopamine system. | Ostroumov A et al. | β | 2015 | β |
| Combined varenicline and naltrexone treatment reduces smoking topography intensity in heavy-drinking smokers. | Roche DJ et al. | β | 2015 | β |
| Defining and predicting short-term alcohol use changes during a smoking cessation attempt. | Berg KM et al. | β | 2015 | β |
| Dopamine and norepinephrine receptors participate in methylphenidate enhancement of in vivo hippocampal synaptic plasticity. | Jenson D et al. | β | 2015 | β |
| Dopaminergic and cholinergic learning mechanisms in nicotine addiction. | Subramaniyan M et al. | β | 2015 | β |
| Effects of combined nicotine and fluoxetine treatment on adult hippocampal neurogenesis and conditioned place preference. | Faillace MP et al. | β | 2015 | β |
| Effects of the BDNF Val66Met Polymorphism on Anxiety-Like Behavior Following Nicotine Withdrawal in Mice. | Lee BG et al. | β | 2015 | β |
| Identifying Shared Latent Dimensions of Psychological Symptoms: Implications for the Psychological Correlates of Smoking. | Ameringer KJ et al. | β | 2015 | β |
| Incarceration and Current Tobacco Smoking Among Black and Caribbean Black Americans in the National Survey of American Life. | Bailey ZD et al. | β | 2015 | β |
| Nicotine Dependence Reveals Distinct Responses from Neurons and Their Resident Nicotinic Receptors in Medial Habenula. | Shih PY et al. | β | 2015 | β |
| Nicotinic alteration of decision-making. | NaudΓ© J et al. | β | 2015 | β |
| Nicotinic Mechanisms Modulate Ethanol Withdrawal and Modify Time Course and Symptoms Severity of Simultaneous Withdrawal from Alcohol and Nicotine. | Perez E et al. | β | 2015 | β |
| Pharmacological Options for Smoking Cessation in Heavy-Drinking Smokers. | Yardley MM et al. | β | 2015 | β |
| Pharmacological stress is required for the anti-alcohol effect of the Ξ±3Ξ²4* nAChR partial agonist AT-1001. | Cippitelli A et al. | β | 2015 | β |
| Promoting pre-quit physical activity to reduce cue reactivity among low-income sedentary smokers: A randomized proof of concept study. | Nair US et al. | β | 2015 | β |
| The effect of varenicline on the development and expression of nicotine-induced behavioral sensitization and cross-sensitization in rats. | Goutier W et al. | β | 2015 | β |
| The immunomodulation of nicotinic acetylcholine receptor subunits in Zhikong scallop Chlamys farreri. | Shi X et al. | β | 2015 | β |
| The role of varenicline on alcohol-primed self-administration and seeking behavior in rats. | Randall PA et al. | β | 2015 | β |
| Updated findings of the association and functional studies of DRD2/ANKK1 variants with addictions. | Ma Y et al. | β | 2015 | β |
| Varenicline decreases nicotine but not alcohol self-administration in genetically selected Marchigian Sardinian alcohol-preferring (msP) rats. | Scuppa G et al. | β | 2015 | β |
| Varenicline, naltrexone, and their combination for heavy-drinking smokers: preliminary neuroimaging findings. | Ray LA et al. | β | 2015 | β |
| An initial investigation of the relationships between hoarding and smoking. | Raines AM et al. | β | 2014 | β |
| Cigarette smoking and drug use among a nationally representative sample of HIV-positive individuals. | Pacek LR et al. | β | 2014 | β |
| Clarifying the relationship between impulsive delay discounting and nicotine dependence. | Amlung M et al. | β | 2014 | β |
| EPA guidance on tobacco dependence and strategies for smoking cessation in people with mental illness. | RΓΌther T et al. | β | 2014 | β |
| Evidence from mouse and man for a role of neuregulin 3 in nicotine dependence. | Turner JR et al. | β | 2014 | β |
| Genome-wide association study on detailed profiles of smoking behavior and nicotine dependence in a twin sample. | Loukola A et al. | β | 2014 | β |
| Illuminating the role of cholinergic signaling in circuits of attention and emotionally salient behaviors. | Luchicchi A et al. | β | 2014 | β |
| Implicit alcohol cognitions in risky drinking nicotine users with and without co-morbid major depressive disorder. | Cohn AM et al. | β | 2014 | β |
| Nicotine is more addictive, not more cognitively therapeutic in a neurodevelopmental model of schizophrenia produced by neonatal ventral hippocampal lesions. | Berg SA et al. | β | 2014 | β |
| Operant self-administration of alcohol and nicotine in a preclinical model of co-abuse. | LΓͺ AD et al. | β | 2014 | β |
| Opiate dependence in schizophrenia: case presentation and literature review. | Kern AM et al. | β | 2014 | β |
| Perceived barriers to smoking cessation in selected vulnerable groups: a systematic review of the qualitative and quantitative literature. | Twyman L et al. | β | 2014 | β |
| Prenatal alcohol exposure increases postnatal acceptability of nicotine odor and taste in adolescent rats. | Mantella NM et al. | β | 2014 | β |
| Role of nicotine dependence in the association between the dopamine receptor gene DRD3 and major depressive disorder. | Korhonen T et al. | β | 2014 | β |
| Smoking cessation outcomes and predictors among individuals with co-occurring substance use and/or psychiatric disorders. | Okoli CT et al. | β | 2014 | β |
| Varenicline, low dose naltrexone, and their combination for heavy-drinking smokers: human laboratory findings. | Ray LA et al. | β | 2014 | β |
| Youth tobacco use type and associations with substance use disorders. | Cavazos-Rehg PA et al. | β | 2014 | β |
| A preliminary study on the effect of combined nicotine replacement therapy on alcohol responses and alcohol self-administration. | Udo T et al. | β | 2013 | β |
| A tale of two receptors: Dual roles for ionotropic acetylcholine receptors in regulating motor neuron excitation and inhibition. | Philbrook A et al. | β | 2013 | β |
| Depression and smoking: a 5-year prospective study of patients with major depressive disorder. | Holma IA et al. | β | 2013 | β |
| Divergent functional effects of sazetidine-a and varenicline during nicotine withdrawal. | Turner JR et al. | β | 2013 | β |
| Dual growth of adolescent smoking and drinking: evidence for an interaction between the mu-opioid receptor (OPRM1) A118G polymorphism and sex. | Kleinjan M et al. | β | 2013 | β |
| Effects of chronic low- and high-dose nicotine on cognitive flexibility in C57BL/6J mice. | Ortega LA et al. | β | 2013 | β |
| Genetic dissection of medial habenula-interpeduncular nucleus pathway function in mice. | Kobayashi Y et al. | β | 2013 | β |
| How can we use our knowledge of alcohol-tobacco interactions to reduce alcohol use? | McKee SA et al. | β | 2013 | β |
| Involvement of dorsal hippocampal and medial septal nicotinic receptors in cross state-dependent memory between WIN55, 212-2 and nicotine or ethanol in mice. | Alijanpour S et al. | β | 2013 | β |
| Longitudinal associations between smoking cessation medications and alcohol consumption among smokers in the International Tobacco Control Four Country survey. | McKee SA et al. | β | 2013 | β |
| Mesolimbic dopamine and habenulo-interpeduncular pathways in nicotine withdrawal. | Dani JA et al. | β | 2013 | β |
| Nicotine Blocks the Depressogenic Effects of Alcohol: Implications for Drinking-Smoking Co-Morbidity. | Kalejaiye O et al. | β | 2013 | β |
| Nicotine-motivated behavior in Caenorhabditis elegans requires the nicotinic acetylcholine receptor subunits acr-5 and acr-15. | Sellings L et al. | β | 2013 | β |
| Nicotinic acetylcholine receptors containing Ξ±6 subunits contribute to alcohol reward-related behaviours. | Powers MS et al. | β | 2013 | β |
| Problem drinking and associated factors in older adults in South Africa. | Peltzer K et al. | β | 2013 | β |
| Scrutiny of the CHRNA5-CHRNA3-CHRNB4 smoking behavior locus reveals a novel association with alcohol use in a Finnish population based study. | HΓ€llfors J et al. | β | 2013 | β |
| Structural basis for potentiation by alcohols and anaesthetics in a ligand-gated ion channel. | Sauguet L et al. | β | 2013 | β |
| Alcohol use predicts ER visits in individuals with alpha-1 antitrypsin deficiency (AATD) associated COPD. | Hoth KF et al. | β | 2012 | β |
| Analysis of detailed phenotype profiles reveals CHRNA5-CHRNA3-CHRNB4 gene cluster association with several nicotine dependence traits. | Broms U et al. | β | 2012 | β |
| Differential cigarette-related startle cue reactivity among light, moderate, and heavy smokers. | Cui Y et al. | β | 2012 | β |
| Framing Nicotine Addiction as a "Disease of the Brain": Social and Ethical Consequences. | Dingel MJ et al. | β | 2012 | β |
| Review of pharmacological treatment in mood disorders and future directions for drug development. | Li X et al. | β | 2012 | β |
| Sex differences in nicotine dependence among addictions clients accessing a smoking cessation programme in Vancouver, British Columbia, Canada. | Okoli CT et al. | β | 2012 | β |
| Smoking during pregnancy: lessons learned from epidemiological studies and experimental studies using animal models. | Abbott LC et al. | β | 2012 | β |
| The dynorphin/ΞΊ-opioid receptor system and its role in psychiatric disorders. | Tejeda HA et al. | β | 2012 | β |
| The nicotinic acetylcholine receptor as a target for antidepressant drug development. | Philip NS et al. | β | 2012 | β |
| Tobacco use in youth with mental illnesses. | DeHay T et al. | β | 2012 | β |
| Varenicline dose dependently enhances responding for nonpharmacological reinforcers and attenuates the reinforcement-enhancing effects of nicotine. | Levin ME et al. | β | 2012 | β |
| Variants located upstream of CHRNB4 on chromosome 15q25.1 are associated with age at onset of daily smoking and habitual smoking. | Kapoor M et al. | β | 2012 | β |
| Anxiety diagnoses in smokers seeking cessation treatment: relations with tobacco dependence, withdrawal, outcome and response to treatment. | Piper ME et al. | β | 2011 | β |
| A role for the DRD4 exon III VNTR in modifying the association between nicotine dependence and neuroticism. | Ellis JA et al. | β | 2011 | β |
| Characterizing patterns of smoking initiation in adolescence: comparison of methods for dealing with missing data. | Heron J et al. | β | 2011 | β |
| Chronic nicotine treatment differentially modifies acute nicotine and alcohol actions on GABA(A) and glutamate receptors in hippocampal brain slices. | Proctor WR et al. | β | 2011 | β |
| Differences in cigarette smoking behaviors among heroin inhalers versus heroin injectors. | Liu S et al. | β | 2011 | β |
| Drinking motives in female smokers: factor structure, alcohol dependence, and genetic influences. | Kristjansson SD et al. | β | 2011 | β |
| Functional nicotinic acetylcholine receptors containing Ξ±6 subunits are on GABAergic neuronal boutons adherent to ventral tegmental area dopamine neurons. | Yang K et al. | β | 2011 | β |
| Historical and current perspective on tobacco use and nicotine addiction. | Dani JA et al. | β | 2011 | β |
| Neurophysiology of Nicotine Addiction. | Dani JA et al. | β | 2011 | β |
| Nicotine dependence and its risk factors among users of veterans health services, 2008-2009. | Tsai J et al. | β | 2011 | β |
| Parallel anxiolytic-like effects and upregulation of neuronal nicotinic acetylcholine receptors following chronic nicotine and varenicline. | Turner JR et al. | β | 2011 | β |
| Partial agonists of the Ξ±3Ξ²4* neuronal nicotinic acetylcholine receptor reduce ethanol consumption and seeking in rats. | Chatterjee S et al. | β | 2011 | β |
| Prevalence of comorbid disorders in problem and pathological gambling: systematic review and meta-analysis of population surveys. | Lorains FK et al. | β | 2011 | β |
| Previous ethanol experience enhances synaptic plasticity of NMDA receptors in the ventral tegmental area. | Bernier BE et al. | β | 2011 | β |
| Reward, addiction, withdrawal to nicotine. | De Biasi M et al. | β | 2011 | β |
| Addictive nicotine alters local circuit inhibition during the induction of in vivo hippocampal synaptic potentiation. | Zhang TA et al. | β | 2010 | β |
| A tobacco reconceptualization in psychiatry: toward the development of tobacco-free psychiatric facilities. | Moss TG et al. | β | 2010 | β |
| Closing tobacco-related disparities: Using community organizations to increase consumer demand. | Christiansen BA et al. | β | 2010 | β |
| Coadministration of intravenous nicotine and oral alcohol in rats. | LΓͺ AD et al. | β | 2010 | β |
| Delineation of the role of nicotinic acetylcholine receptor genes in alcohol preference in mice. | Symons MN et al. | β | 2010 | β |
| Emotional, behavioural problems and cigarette smoking in adolescence: findings of a Greek cross-sectional study. | Giannakopoulos G et al. | β | 2010 | β |
| Ethanol action on dopaminergic neurons in the ventral tegmental area: interaction with intrinsic ion channels and neurotransmitter inputs. | Morikawa H et al. | β | 2010 | β |
| Gender-specific profiles of tobacco use among non-institutionalized people with serious mental illness. | Johnson JL et al. | β | 2010 | β |
| Genes associated with alcohol abuse and tobacco smoking in the human nucleus accumbens and ventral tegmental area. | Flatscher-Bader T et al. | β | 2010 | β |
| In alcohol-dependent drinkers, what does the presence of nicotine dependence tell us about psychiatric and addictive disorders comorbidity? | Le Strat Y et al. | β | 2010 | β |
| Influence of chronic nicotine administration on cerebral type 1 cannabinoid receptor binding: an in vivo micro-PET study in the rat using [18F]MK-9470. | GΓ©rard N et al. | β | 2010 | β |
| In vitro identification and electrophysiological characterization of dopamine neurons in the ventral tegmental area. | Zhang TA et al. | β | 2010 | β |
| Motivation to quit smoking among hospitalised individuals with and without mental health disorders. | Siru R et al. | β | 2010 | β |
| Neural substrates of alcohol-induced smoking urge in heavy drinking nondaily smokers. | King A et al. | β | 2010 | β |
| Nicotine addiction. | Benowitz NL | β | 2010 | β |
| Nicotine reduction revisited: science and future directions. | Hatsukami DK et al. | β | 2010 | β |
| Nicotine withdrawal in U.S. smokers with current mood, anxiety, alcohol use, and substance use disorders. | Weinberger AH et al. | β | 2010 | β |
| Nicotinic acetylcholine receptors and depression: a review of the preclinical and clinical literature. | Philip NS et al. | β | 2010 | β |
| Regulation of the nicotinic receptor alpha7 subunit by chronic stress and corticosteroids. | Hunter RG et al. | β | 2010 | β |
| Route of nicotine administration influences in vivo dopamine neuron activity: habituation, needle injection, and cannula infusion. | Dong Y et al. | β | 2010 | β |
| Smoking, nicotine and neuropsychiatric disorders. | Dome P et al. | β | 2010 | β |
| The nicotinic acetylcholine receptor partial agonist varenicline increases the ataxic and sedative-hypnotic effects of acute ethanol administration in C57BL/6J mice. | Kamens HM et al. | β | 2010 | β |
| Using propensity score modeling to minimize the influence of confounding risks related to prenatal tobacco exposure. | Fang H et al. | β | 2010 | β |
| Age dependent nicotinic influences over dopamine neuron synaptic plasticity. | Placzek AN et al. | β | 2009 | β |
| Alcohol intoxication and mental health among adolescents--a population review of 8983 young people, 13-19 years in North-TrΓΈndelag, Norway: the Young-HUNT Study. | Strandheim A et al. | β | 2009 | β |
| Assessing motivation to quit smoking in people with mental illness: a review. | Siru R et al. | β | 2009 | β |
| CNTRICS final task selection: long-term memory. | Ragland JD et al. | β | 2009 | β |
| Controls of tonic and phasic dopamine transmission in the dorsal and ventral striatum. | Zhang L et al. | β | 2009 | β |
| Differential contribution of genetic variation in multiple brain nicotinic cholinergic receptors to nicotine dependence: recent progress and emerging open questions. | Greenbaum L et al. | β | 2009 | β |
| Dopamine enables in vivo synaptic plasticity associated with the addictive drug nicotine. | Tang J et al. | β | 2009 | β |
| Dopamine signaling differences in the nucleus accumbens and dorsal striatum exploited by nicotine. | Zhang T et al. | β | 2009 | β |
| Enhanced nicotine sensitivity in nociceptin/orphanin FQ receptor knockout mice. | Sakoori K et al. | β | 2009 | β |
| From the American Academy of Pediatrics: Policy statement--Tobacco use: a pediatric disease. | Committee on Environmental HealthHealth et al. | β | 2009 | β |
| From the American Academy of Pediatrics: Technical report--Tobacco as a substance of abuse. | Sims TH et al. | β | 2009 | β |
| Functional alpha 7-containing nicotinic receptors of NG2-expressing cells in the hippocampus. | VΓ©lez-Fort M et al. | β | 2009 | β |
| Involvement of nicotinic receptors in methamphetamine- and MDMA-induced neurotoxicity: pharmacological implications. | Escubedo E et al. | β | 2009 | β |
| Nicotine causes opposite effects on alcohol intake: Evidence in an animal experimental model of abstinence and relapse from alcohol. | AlΓ©n F et al. | β | 2009 | β |
| Nicotine exposure during adolescence induces a depression-like state in adulthood. | IΓ±iguez SD et al. | β | 2009 | β |
| Nicotinic mechanisms influencing synaptic plasticity in the hippocampus. | Placzek AN et al. | β | 2009 | β |
| Preclinical pharmacology of the alpha4beta2 nAChR partial agonist varenicline related to effects on reward, mood and cognition. | Rollema H et al. | β | 2009 | β |
| Significant modulation of mitochondrial electron transport system by nicotine in various rat brain regions. | Wang J et al. | β | 2009 | β |
| Synaptic plasticity within midbrain dopamine centers contributes to nicotine addiction. | Placzek AN et al. | β | 2009 | β |
| Targeting reward-relevant nicotinic receptors in the discovery of novel pharmacotherapeutic agents to treat tobacco dependence. | Dwoskin LP et al. | β | 2009 | β |
| Varenicline reduces alcohol self-administration in heavy-drinking smokers. | McKee SA et al. | β | 2009 | β |
| Variants in nicotinic acetylcholine receptors alpha5 and alpha3 increase risks to nicotine dependence. | Chen X et al. | β | 2009 | β |
| A single dose of nicotine enhances reward responsiveness in nonsmokers: implications for development of dependence. | Barr RS et al. | β | 2008 | β |
| Chronic cigarette smoking modulates injury and short-term recovery of the medial temporal lobe in alcoholics. | Gazdzinski S et al. | β | 2008 | β |
| Do the same genetic and environmental effects underlie the covariation of alcohol dependence, smoking, and aggressive behaviour? | von der Pahlen B et al. | β | 2008 | β |
| Elevated synaptophysin I in the prefrontal cortex of human chronic alcoholics. | Henriksson R et al. | β | 2008 | β |
| Monoamine oxidase inhibition for tobacco pharmacotherapy. | George TP et al. | β | 2008 | β |
| Nicotine and amphetamine acutely cross-potentiate their behavioral and neurochemical responses in female Holtzman rats. | Jutkiewicz EM et al. | β | 2008 | β |
| Nicotinic acetylcholine alpha4beta2 receptor regulates the motivational effect of intracranial self stimulation behavior in the runway method. | Sagara H et al. | β | 2008 | β |
| Nicotinic antagonist augmentation of selective serotonin reuptake inhibitor-refractory major depressive disorder: a preliminary study. | George TP et al. | β | 2008 | β |
| Prevalence, correlates, and comorbidity of 12-Month tobacco dependence among ever-smokers in South Korea, during 1984-2001. | Jeon HJ et al. | β | 2008 | β |
| Region-specific effects of N,N'-dodecane-1,12-diyl-bis-3-picolinium dibromide on nicotine-induced increase in extracellular dopamine in vivo. | Rahman S et al. | β | 2008 | β |
| Rewarding and aversive effects of nicotine are segregated within the nucleus accumbens. | Sellings LH et al. | β | 2008 | β |
| Subtypes of nicotinic acetylcholine receptors in nicotine reward, dependence, and withdrawal: evidence from genetically modified mice. | Fowler CD et al. | β | 2008 | β |
| The genetic components of alcohol and nicotine co-addiction: from genes to behavior. | Schlaepfer IR et al. | β | 2008 | β |
| Using neuroimaging to predict relapse to smoking: role of possible moderators and mediators. | SchΓΌtz CG | β | 2008 | β |
| Combined exposure to nicotine and ethanol throughout full gestation results in enhanced acquisition of nicotine self-administration in young adult rat offspring. | Matta SG et al. | β | 2007 | β |
| Disrupting addiction through the loss of drug-associated internal states. | Dani JA et al. | β | 2007 | β |
| Distributed network actions by nicotine increase the threshold for spike-timing-dependent plasticity in prefrontal cortex. | Couey JJ et al. | β | 2007 | β |
| Dopamine transporter binding in smokers and nonsmokers. | Newberg A et al. | β | 2007 | β |
| Genetics and smoking cessation improving outcomes in smokers at risk. | Lerman CE et al. | β | 2007 | β |
| Nicotine and ethanol activate protein kinase A synergistically via G(i) betagamma subunits in nucleus accumbens/ventral tegmental cocultures: the role of dopamine D(1)/D(2) and adenosine A(2A) receptors. | Inoue Y et al. | β | 2007 | β |
| Nicotine regulates multiple synaptic proteins by inhibiting proteasomal activity. | Rezvani K et al. | β | 2007 | β |
| Nicotinic acetylcholine receptors and nicotinic cholinergic mechanisms of the central nervous system. | Dani JA et al. | β | 2007 | β |
| Pharmacogenetics and smoking cessation with nicotine replacement therapy. | Ray R et al. | β | 2007 | β |
| Pharmacological profile of the alpha4beta2 nicotinic acetylcholine receptor partial agonist varenicline, an effective smoking cessation aid. | Rollema H et al. | β | 2007 | β |
| Rationale, pharmacology and clinical efficacy of partial agonists of alpha4beta2 nACh receptors for smoking cessation. | Rollema H et al. | β | 2007 | β |
| Regulation of synaptic transmission and plasticity by neuronal nicotinic acetylcholine receptors. | McKay BE et al. | β | 2007 | β |
| The biological bases of nicotine and alcohol co-addiction. | Li TK et al. | β | 2007 | β |
| The CB1 cannabinoid receptor antagonist rimonabant chronically prevents the nicotine-induced relapse to alcohol. | LΓ³pez-Moreno JA et al. | β | 2007 | β |
| The role of CYP2A6 in the emergence of nicotine dependence in adolescents. | Audrain-McGovern J et al. | β | 2007 | β |
| Varenicline, an alpha4beta2 nicotinic acetylcholine receptor partial agonist, selectively decreases ethanol consumption and seeking. | Steensland P et al. | β | 2007 | β |
| Alcohol-related genes: contributions from studies with genetically engineered mice. | Crabbe JC et al. | β | 2006 | β |
| A preliminary study of the effects of cigarette smoking on prepulse inhibition in schizophrenia: involvement of nicotinic receptor mechanisms. | George TP et al. | β | 2006 | β |
| Chronic smoking and alcoholism change expression of selective genes in the human prefrontal cortex. | Flatscher-Bader T et al. | β | 2006 | β |
| Cigarette smoking and the risk for alcohol use disorders among adolescent drinkers. | Grucza RA et al. | β | 2006 | β |
| Current and emerging pharmacotherapies for treating tobacco dependence. | Schnoll RA et al. | β | 2006 | β |
| Norlaudanosoline and nicotine increase endogenous ganglionic morphine levels: nicotine addiction. | Zhu W et al. | β | 2006 | β |
| The neurobiological basis for partial agonist treatment of nicotine dependence: varenicline. | Foulds J | β | 2006 | β |