Sweet taste preferences are partly genetically determined: identification of a trait locus on chromosome 16.
paper
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- Authors
- Keskitalo, Kaisu; Knaapila, Antti; Kallela, Mikko; Palotie, Aarno; Wessman, Maija; Sammalisto, Sampo; Peltonen, Leena; Tuorila, Hely; Perola, Markus
- Year
- 2007
- Journal
- The American journal of clinical nutrition
- PMID
- 17616763
- DOI
- 10.1093/ajcn/86.1.55
BACKGROUND: Humans have an innate preference for sweet taste, but the degree of liking for sweet foods varies individually. OBJECTIVE: The proportion of inherited sweet taste preference was studied. A genome-wide linkage analysis was performed to locate the underlying genetic elements in the genome. DESIGN: A total of 146 subjects (32% men, 68% women) aged 18-78 y from 26 Finnish families evaluated the intensity and pleasantness of 3 suprathreshold solutions of sucrose (3.0%, 7.5%, and 18.75%) and plain water and the intensity of filter paper impregnated with 6-n-propylthiouracil (PROP). The subjects also reported the pleasantness and the use frequency of 5 sweet foods (chocolate, candy, ice cream, sweet desserts, and sweet pastry) and completed a food-behavior questionnaire that measured their craving for sweet foods. RESULTS: Of the chemosensory functions, the pleasantness rating of the strongest (18.75%) sucrose solution and the intensity rating of PROP yielded the highest heritability estimates (41% and 66%, respectively). The pleasantness and the use frequency of sweet foods (both variables calculated as a mean of ratings for 5 food items) and the craving for sweet foods showed significant heritability (40%, 50%, and 31%, respectively). A logarithm of odds score of 3.5 (P=0.00003) was detected for use frequency of sweet foods on chromosome 16p11.2 (marker D16S753). CONCLUSIONS: Sweet taste preferences are partly inherited. Chromosome 16p11.2 may harbor genetic variations that affect the consumption of sweet foods.
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|---|---|---|
| Endophenotypes for Alcohol Use Disorder: An Update on the Field. | 2015 | 26236574 |
| Genetics of sweet taste preferences. | 2011 | 21743773 |
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