Reduced ethanol-induced conditioned taste aversion and conditioned place preference in GIRK2 null mutant mice.
- Authors
- Hill, Katherine G; Alva, Herminia; Blednov, Yuri A; Cunningham, Christopher L
- Year
- 2003
- Journal
- Psychopharmacology
- PMID
- 12721779
- DOI
- 10.1007/s00213-003-1472-4
RATIONALE: Previous studies have shown that GIRK2 channel function is enhanced by ethanol and that GIRK2 null mutant mice are less sensitive to some of ethanol's effects, including anxiolysis, habituated locomotor stimulation, and acute handling-induced convulsions than wild types. Under some conditions, GIRK2 knockout mice consume more ethanol than wild types, but it is unclear whether they do so because they are more sensitive to ethanol's rewarding effects or less sensitive to its aversive effects. OBJECTIVE: To further assess the role of GIRK2 in ethanol action, GIRK2 null mutant and wild type mice were tested in conditioning models that measure the motivational effects of ethanol. METHOD: In a conditioned taste aversion (CTA) procedure, knockout and wild type mice were given ethanol (0.0, 2.0, 2.5, or 3.5 g/kg, IP) following 1-h access to saccharin every 48 h over a 10 day period. In a conditioned place preference (CPP) procedure, knockout and wild type mice were given ethanol (2.0 or 3.0 g/kg, IP) paired with one stimulus (grid or hole floor) and saline paired with the other. After four 5-min trials with each stimulus, a 60-min choice test was done. RESULTS: The results demonstrated a genotypic difference in both paradigms. In CTA, there was no difference between genotypes at 0.0 or 3.5 g/kg ethanol, but at the 2.0 and 2.5 g/kg doses, wild types developed a stronger aversion to saccharin than knockouts. In CPP, wild types developed place preference, but knockouts did not. CONCLUSIONS: These studies show that GIRK2 deletion reduced ethanol's impact in tasks that are commonly used to index the drug's rewarding and aversive effects. These findings could reflect either a learning/memory deficit or decreased sensitivity to ethanol's motivational effects in null mutant mice. The latter interpretation is more consistent with previous data showing that knockout mice consume higher doses of ethanol than wild type mice.
No figures extracted from this document.
No chunks — full text not yet ingested.
No entities extracted from this document yet.
No uploaded files.
No citations found.
In this knowledge base
External
| Title | Authors | Journal | Year | Link |
|---|---|---|---|---|
| A critical residue mediates proper assembly and gating of GIRK2 channels. | Nguyen H et al. | — | 2026 | → |
| A critical review of ethanol effects on neuronal firing: A metabolic perspective. | Popova D et al. | — | 2024 | → |
| Direct modulation of G protein-gated inwardly rectifying potassium (GIRK) channels. | Nguyen H et al. | — | 2024 | → |
| Upregulated GIRK2 Counteracts Ethanol-Induced Changes in Excitability and Respiration in Human Neurons. | Prytkova I et al. | — | 2024 | → |
| Alcohol reverses the effects of KCNJ6 (GIRK2) noncoding variants on excitability of human glutamatergic neurons. | Popova D et al. | — | 2023 | → |
| Effects of Methylone Pre-Exposure on Fluoxetine-Induced Conditioned Taste Avoidance in Male and Female Sprague-Dawley Rats. | Manke HN et al. | — | 2023 | → |
| Ethanol-Induced Suppression of G Protein-Gated Inwardly Rectifying K<sup>+</sup>-Dependent Signaling in the Basal Amygdala. | Marron Fernandez de Velasco E et al. | — | 2023 | → |
| The collaborative study on the genetics of alcoholism: Genetics. | Johnson EC et al. | — | 2023 | → |
| GIRK Channels as Candidate Targets for the Treatment of Substance Use Disorders. | Kotajima-Murakami H et al. | — | 2022 | → |
| Impact of the Aversive Effects of Drugs on Their Use and Abuse. | Riley AL et al. | — | 2022 | → |
| Neuronal G protein-gated K<sup>+</sup> channels. | Luo H et al. | — | 2022 | → |
| Advances in Targeting GIRK Channels in Disease. | Zhao Y et al. | — | 2021 | → |
| Structural insights into GIRK2 channel modulation by cholesterol and PIP<sub>2</sub>. | Mathiharan YK et al. | — | 2021 | → |
| Therapeutic potential of targeting G protein-gated inwardly rectifying potassium (GIRK) channels in the central nervous system. | Jeremic D et al. | — | 2021 | → |
| Understanding the neurobiological effects of drug abuse: Lessons from zebrafish models. | Müller TE et al. | — | 2020 | → |
| Ethanol-induced conditioned place preference and aversion differentially alter plasticity in the bed nucleus of stria terminalis | Pati D et al. | — | 2019 | — |
| Ethanol-induced conditioned place preference and aversion differentially alter plasticity in the bed nucleus of stria terminalis. | Pati D et al. | — | 2019 | → |
| A randomized controlled study of the effect of ifenprodil on alcohol use in patients with alcohol dependence. | Sugaya N et al. | — | 2018 | → |
| Chronic Alcohol, Intrinsic Excitability, and Potassium Channels: Neuroadaptations and Drinking Behavior. | Cannady R et al. | — | 2018 | → |
| Effects of sex on ethanol conditioned place preference, activity and variability in C57BL/6J and DBA/2J mice. | Cunningham CL et al. | — | 2018 | → |
| Failure to Find Ethanol-Induced Conditioned Taste Aversion in Honey Bees (Apis mellifera L.). | Varnon CA et al. | — | 2018 | → |
| A KCNJ6 gene polymorphism modulates theta oscillations during reward processing. | Kamarajan C et al. | — | 2017 | → |
| Conditioned effects of ethanol on the immune system. | Gano A et al. | — | 2017 | → |
| G Protein-Gated Inwardly Rectifying Potassium Channel Subunit 3 Knock-Out Mice Show Enhanced Ethanol Reward. | Tipps ME et al. | — | 2016 | → |
| The residue I257 at S4-S5 linker in KCNQ1 determines KCNQ1/KCNE1 channel sensitivity to 1-alkanols. | Xie C et al. | — | 2016 | → |
| Advances in Electrophysiological Research. | Kamarajan C et al. | — | 2015 | → |
| Behavioral and Genetic Evidence for GIRK Channels in the CNS: Role in Physiology, Pathophysiology, and Drug Addiction. | Mayfield J et al. | — | 2015 | → |
| Fear conditioning suppresses large-conductance calcium-activated potassium channels in lateral amygdala neurons. | Sun P et al. | — | 2015 | → |
| GIRK3 gates activation of the mesolimbic dopaminergic pathway by ethanol. | Herman MA et al. | — | 2015 | → |
| GIRK Channels: A Potential Link Between Learning and Addiction. | Tipps ME et al. | — | 2015 | → |
| Alcohol modulation of G-protein-gated inwardly rectifying potassium channels: from binding to therapeutics. | Bodhinathan K et al. | — | 2014 | → |
| Association between KCNJ6 (GIRK2) gene polymorphism rs2835859 and post-operative analgesia, pain sensitivity, and nicotine dependence. | Nishizawa D et al. | — | 2014 | → |
| Mechanisms underlying the activation of G-protein-gated inwardly rectifying K+ (GIRK) channels by the novel anxiolytic drug, ML297. | Wydeven N et al. | — | 2014 | → |
| Serotonin induces depolarization in lateral amygdala neurons by activation of TRPC-like current and inhibition of GIRK current depending on 5-HT(2C) receptor. | Yamamoto R et al. | — | 2014 | → |
| Molecular mechanism underlying ethanol activation of G-protein-gated inwardly rectifying potassium channels. | Bodhinathan K et al. | — | 2013 | → |
| Alcohol dependence as a chronic pain disorder. | Egli M et al. | — | 2012 | → |
| Inhibition of G protein-activated inwardly rectifying K+ channels by different classes of antidepressants. | Kobayashi T et al. | — | 2011 | → |
| KCNJ6 is associated with adult alcohol dependence and involved in gene × early life stress interactions in adolescent alcohol drinking. | Clarke TK et al. | — | 2011 | → |
| The Varied Uses of Conditioned Place Preference in Behavioral Neuroscience Research: An Investigation of Alcohol Administration in Model Organisms. | Lucke-Wold B | — | 2011 | → |
| Behavioral differences between C57BL/6J x FVB/NJ and C57BL/6J x NZB/B1NJ F1 hybrid mice: relation to control of ethanol intake. | Ozburn AR et al. | — | 2010 | → |
| Emerging roles for G protein-gated inwardly rectifying potassium (GIRK) channels in health and disease. | Lüscher C et al. | — | 2010 | → |
| Inhibition of G-protein-activated inwardly rectifying K+ channels by the selective norepinephrine reuptake inhibitors atomoxetine and reboxetine. | Kobayashi T et al. | — | 2010 | → |
| Inhibitory effects of the antiepileptic drug ethosuximide on G protein-activated inwardly rectifying K+ channels. | Kobayashi T et al. | — | 2009 | → |
| Mapping a barbiturate withdrawal locus to a 0.44 Mb interval and analysis of a novel null mutant identify a role for Kcnj9 (GIRK3) in withdrawal from pentobarbital, zolpidem, and ethanol. | Kozell LB et al. | — | 2009 | → |
| Ethanol drinking in rodents: is free-choice drinking related to the reinforcing effects of ethanol? | Green AS et al. | — | 2008 | → |
| Long-term alterations in vulnerability to addiction to drugs of abuse and in brain gene expression after early life ethanol exposure. | Barbier E et al. | — | 2008 | → |
| Measuring reward with the conditioned place preference (CPP) paradigm: update of the last decade. | Tzschentke TM | — | 2007 | → |
| Alcohol-related genes: contributions from studies with genetically engineered mice. | Crabbe JC et al. | — | 2006 | → |
| Drug-induced conditioned place preference and aversion in mice. | Cunningham CL et al. | — | 2006 | → |
| Inhibition of G protein-activated inwardly rectifying K+ channels by ifenprodil. | Kobayashi T et al. | — | 2006 | → |
| Inhibition of G protein-activated inwardly rectifying K+ channels by the antidepressant paroxetine. | Kobayashi T et al. | — | 2006 | → |
| Barium potentiates the conditioned aversion to, but not the somatic signs of, morphine withdrawal in mice. | Sato M et al. | — | 2005 | → |
| Convergent analysis of cDNA and short oligomer microarrays, mouse null mutants and bioinformatics resources to study complex traits. | Ponomarev I et al. | — | 2004 | → |