No association between Cholinergic Muscarinic Receptor 2 (CHRM2) genetic variation and cognitive abilities in three independent samples.
- Authors
- Lind, Penelope A; Luciano, Michelle; Horan, Michael A; Marioni, Riccardo E; Wright, Margaret J; Bates, Timothy C; Rabbitt, Patrick; Harris, Sarah E; Davidson, Yvonne; Deary, Ian J; Gibbons, Linda; Pickles, Andrew; Ollier, William; Pendleton, Neil; Price, Jackie F; Payton, Antony; Martin, Nicholas G
- Year
- 2009
- Journal
- Behavior genetics
- PMID
- 19418213
- DOI
- 10.1007/s10519-009-9274-z
Cognitive ability has a substantial genetic component and more than 15 candidate genes have been identified over the past 8 years. One gene that has been associated with general cognitive ability is the cholinergic muscarinic 2 receptor (CHRM2). In an attempt to replicate this finding we typed marker rs8191992 (the originally reported CHRM2 SNP) in two population based cohorts-one Scottish aged over 50 years (N = 2,091) and the other English comprising non-demented elderly participants (N = 758)-and a family-based Australian adolescent sample (N = 1,537). An additional 29 SNPs in CHRM2 were typed in the Australian sample and a further seven in the English cohort. No significant association was found between CHRM2 and diverse measures of cognitive ability in any of the samples. In conclusion, this study does not support a role for CHRM2 in cognitive ability.
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External
| Title | Authors | Journal | Year | Link |
|---|---|---|---|---|
| CHRM2 and GRIN2A polymorphisms in tardive dyskinesia and cognitive impairments in Chinese Han schizophrenia. | Lu C et al. | — | 2026 | → |
| Association between genetic variants of the cholinergic system and postoperative delirium and cognitive dysfunction in elderly patients. | Heinrich M et al. | — | 2021 | → |
| How neuroscience can inform the study of individual differences in cognitive abilities. | McFarland DJ | — | 2017 | → |
| Association of the Cholinergic Muscarinic M2 Receptor with Autonomic Nervous System Activity in Patients with Schizophrenia on High-Dose Antipsychotics. | Miyauchi M et al. | — | 2016 | → |
| Polymorphisms in human muscarinic receptor subtype genes. | Michel MC et al. | — | 2012 | → |
| Recruiting egg donors online: an analysis of in vitro fertilization clinic and agency websites' adherence to American Society for Reproductive Medicine guidelines. | Keehn J et al. | — | 2012 | → |
| CHRM2, parental monitoring, and adolescent externalizing behavior: evidence for gene-environment interaction. | Dick DM et al. | — | 2011 | → |
| Gene-environment interaction in psychological traits and disorders. | Dick DM | — | 2011 | → |
| Preliminary evidence for associations of CHRM2 with substance use and disinhibition in adolescence. | Hendershot CS et al. | — | 2011 | → |
| The impact of genetic research on our understanding of normal cognitive ageing: 1995 to 2009. | Payton A | — | 2009 | → |