Dopamine D(1) receptors participate in cocaine-induced place preference via regulation of ryanodine receptor expression.
- Authors
- Kurokawa, Kazuhiro; Mizuno, Koji; Shibasaki, Masahiro; Ohkuma, Seitaro
- Year
- 2011
- Journal
- Journal of pharmacological sciences
- PMID
- 21897053
- DOI
- 10.1254/jphs.11106fp
Ryanodine receptors (RyRs) with three different isoforms in the brain play a role to facilitate Ca(2+) release from the intracellular Ca(2+) pool. Although cocaine is a strongly addictive psychostimulant that dramatically affects the central nervous system function, the role of RyRs and regulation of their expression by cocaine-induced place preference have not yet been defined well. The present study investigated the regulation of RyR expression in mice under intermittent cocaine treatment using the place preference procedure. The cocaine-induced place preference was inhibited by intracerebroventricular pretreatment with dantrolene, a RyRs antagonist, in a dose-dependent manner. The levels of RyR-1 and -2 in the limbic forebrain and frontal cortex significantly increased in the cocaine-conditioned mice, whereas that of RyR-3 in these two brain regions showed no changes. Although the up-regulation of RyRs was not affected by blockade of L-type voltage-gated calcium channels, the increase of RyR-1 and -2 in the limbic forebrain and frontal cortex was completely abolished by SCH23390, a selective antagonist of dopamine D(1) receptors, but not by sulpiride, a selective antagonist of dopamine D(2) receptors. These findings indicate that RyRs play a critical role in the development of cocaine-induced place preference and that the up-regulation of RyRs in the brain of a mouse showing cocaine-induced place preference is regulated by dopamine D(1) receptors.
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| Genetic mapping in collaborative cross mouse strains identifies loci that affect initial sensitivity to cocaine. | Schoenrock SA et al. | β | 2025 | β |
| Subcellular localization and transcriptional regulation of brain ryanodine receptors. Functional implications. | Torres R et al. | β | 2023 | β |
| Spatial Learning Is Associated with Antagonist Outcomes for DNA Methylation and DNA Hydroxymethylation in the Transcriptional Regulation of the Ryanodine Receptor 3. | Torres RF et al. | β | 2021 | β |
| Loss of Ryanodine Receptor 2 impairs neuronal activity-dependent remodeling of dendritic spines and triggers compensatory neuronal hyperexcitability. | Bertan F et al. | β | 2020 | β |
| Neuronal Ryanodine Receptors in Development and Aging. | Abu-Omar N et al. | β | 2018 | β |
| Evaluation of effect of minocycline on rewarding potential and alcohol relapse in place preference model in mice. | Gajbhiye SV et al. | β | 2017 | β |
| Genomewide Association Study of Alcohol Dependence Identifies Risk Loci Altering Ethanol-Response Behaviors in Model Organisms. | Adkins AE et al. | β | 2017 | β |
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| Sensitization of ethanol-induced place preference as a result of up-regulation of type 1 inositol 1,4,5-trisphosphate receptors in mouse nucleus accumbens. | Kurokawa K et al. | β | 2014 | β |
| Dopamine D1 receptor signaling system regulates ryanodine receptor expression in ethanol physical dependence. | Kurokawa K et al. | β | 2013 | β |
| Regulatory mechanisms and pathophysiological significance of IP3 receptors and ryanodine receptors in drug dependence. | Mizuno K et al. | β | 2013 | β |
| Dantrolene blockade of ryanodine receptor impairs ethanol-induced behavioral stimulation, ethanol intake and loss of righting reflex. | Tarragon E et al. | β | 2012 | β |
| Increase of ryanodine receptors by dopamine D1 receptors is negatively regulated by Ξ³-aminobutyric acid type B receptors in primary cultures of mouse cerebral cortical neurons. | Kurokawa K et al. | β | 2012 | β |
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