In vitro and in vivo models of acute alcohol exposure.
paper
Cited
Public
Unavailable
- Authors
- Dolganiuc, Angela; Szabo, Gyongyi
- Year
- 2009
- Journal
- World journal of gastroenterology
- PMID
- 19291816
- DOI
- 10.3748/wjg.15.1168
- PMCID
- PMC2658858
Alcohol abuse is a global problem due to the financial burden on society and the healthcare system. While the harmful health effects of chronic alcohol abuse are well established, more recent data suggest that acute alcohol consumption also affects human wellbeing. Thus, there is a need for research models in order to fully understand the effect of acute alcohol abuse on different body systems and organs. The present manuscript summarizes the interdisciplinary advantages and disadvantages of currently available human and non-human models of acute alcohol abuse, and identifies their suitability for biomedical research.
No figures extracted from this document.
No chunks β full text not yet ingested.
No entities extracted from this document yet.
No uploaded files.
Not in any collection.
No citations found.
In this knowledge base
External
| Title | Authors | Journal | Year | Link |
|---|---|---|---|---|
| Alcohol alters blood-testis barrier function in an in vitro model. | Edenfield RC et al. | β | 2025 | β |
| Alcohol Consumption and Acute Coronary Syndrome: Epidemiology, Pathophysiology, and Clinical Perspectives. | Iliakis P et al. | β | 2025 | β |
| Circular RNA RORΞ² regulates TGFΞ²R1 in alcohol-induced fibroblast-to-myofibroblast differentiation. | Sueblinvong V et al. | β | 2025 | β |
| Ethanol consumption aggravates amyloid pathology and neuroinflammation in Alzheimer's disease associated with inflammasome activation and ASC speck propagation. | Brezani V et al. | β | 2025 | β |
| Exocarpium Citri Grandis ameliorates alcoholic liver disease by modulation of hepatic lipid metabolism and iron homeostasis. | Li YJ et al. | β | 2025 | β |
| Physiologic and molecular effects of alcohol in the esophagus: a narrative review. | Shaker A | β | 2025 | β |
| Cannabidiol (CBD) modulates the transcriptional profile of ethanol-exposed human dermal fibroblast cells. | Gurgul A et al. | β | 2024 | β |
| Mimicking chronic alcohol effects through a controlled and sustained ethanol release device. | Kim W et al. | β | 2024 | β |
| Single-site iron-anchored amyloid hydrogels as catalytic platforms for alcohol detoxification. | Su J et al. | β | 2024 | β |
| Characteristics of FXa-storing platelets in hemophilia B mice and the influence of alcohol on the platelets. | Han W et al. | β | 2023 | β |
| Impact of alcohol exposure on neural development and network formation in human cortical organoids. | Adams JW et al. | β | 2023 | β |
| Targeting the ATF6-Mediated ER Stress Response and Autophagy Blocks Integrin-Driven Prostate Cancer Progression. | Macke AJ et al. | β | 2023 | β |
| Alcohol, Opioid, and Combined Alcohol and Opioid Use Disorders Affect Shared and Unique Pathways: A Proteomic Analysis of Postmortem Brains | Leung E et al. | β | 2022 | β |
| Assessment of BMP responses in an <i>in vitro</i> model of acute ethanol toxicity. | Habeeb N et al. | β | 2022 | β |
| Chromatin modifier developmental pluripotency associated factor 4 (DPPA4) is a candidate gene for alcohol-induced developmental disorders. | Auvinen P et al. | β | 2022 | β |
| MicroRNA-150-5p is upregulated in the brain microvasculature during prenatal alcohol exposure and inhibits the angiogenic factor Vezf1. | Perales G et al. | β | 2022 | β |
| Prolonged ethanol exposure modulates constitutive internalization and recycling of 5-HT1A receptors. | Wang S et al. | β | 2022 | β |
| Prospective DNA Methylation Analysis of the CpG GABRA2 Receptor Subunit in Alcohol Dependence during Detoxification. | Preuss UW et al. | β | 2022 | β |
| Antifungal activity and toxicological parameters of 8-hydroxyquinoline-5-sulfonamides using alternative animal models. | Pippi B et al. | β | 2021 | β |
| Anti-inflammatory Effects of Alcohol Are Associated with JNK-STAT3 Downregulation in an <i>In Vitro</i> Inflammation Model in HepG2 Cells. | MΓΆrs K et al. | β | 2021 | β |
| Chronic Alcohol Exposure of Cells Using Controlled Alcohol-Releasing Capillaries. | Kim W et al. | β | 2021 | β |
| Ethanol affects fibroblast behavior differentially at low and high doses: A comprehensive, dose-response evaluation. | Kar N et al. | β | 2021 | β |
| Non-Smad, BMP-dependent signaling protects against the effects of acute ethanol toxicity. | Habeeb N et al. | β | 2021 | β |
| TSPAN5 influences serotonin and kynurenine: pharmacogenomic mechanisms related to alcohol use disorder and acamprosate treatment response. | Ho MF et al. | β | 2021 | β |
| Adult zebrafish as an in vivo drug testing model for ethanol induced acute hepatic injury. | Park KH et al. | β | 2020 | β |
| Assessment of Ethanol-Induced Toxicity on iPSC-Derived Human Neurons Using a Novel High-Throughput Mitochondrial Neuronal Health (MNH) Assay. | Zink A et al. | β | 2020 | β |
| Caffeine Potentiates Ethanol-Induced Neurotoxicity Through mTOR/p70S6K/4E-BP1 Inhibition in SH-SY5Y Cells. | Sangaunchom P et al. | β | 2020 | β |
| Intestinal Epithelial Cell-Derived Extracellular Vesicles Modulate Hepatic Injury via the Gut-Liver Axis During Acute Alcohol Injury. | Lamas-Paz A et al. | β | 2020 | β |
| Rosmarinic acid alleviates ethanol-induced lipid accumulation by repressing fatty acid biosynthesis. | Guo C et al. | β | 2020 | β |
| Acute Ethanol Exposure Promotes Autophagy-Lysosome Pathway-Dependent ASIC1a Protein Degradation and Protects Against Acidosis-Induced Neurotoxicity. | Zhou RP et al. | β | 2019 | β |
| Diallyl disulfide inhibits ethanol-induced pulmonary cell vitamin D and antimicrobial peptide cathelicidin depletion. | Ogunsakin O et al. | β | 2019 | β |
| Effects of etanercept, a tumor necrosis factor receptor fusion protein, on primary cell cultures prepared from intact human intervertebral disc tissue. | Caliskan T et al. | β | 2019 | β |
| Human ESC-derived expandable hepatic organoids enable therapeutic liver repopulation and pathophysiological modeling of alcoholic liver injury. | Wang S et al. | β | 2019 | β |
| Using human stem cells as a model system to understand the neural mechanisms of alcohol use disorders: Current status and outlook. | Scarnati MS et al. | β | 2019 | β |
| Chicken breast muscle hydrolysates ameliorate acute alcohol-induced liver injury in mice through alcohol dehydrogenase (ADH) activation and oxidative stress reduction. | Xiao C et al. | β | 2018 | β |
| Comparative and network-based proteomic analysis of low dose ethanol- and lipopolysaccharide-induced macrophages. | Kamal AHM et al. | β | 2018 | β |
| Ethanol Induces Platelet Apoptosis. | Liu L et al. | β | 2017 | β |
| Frontline Science: ATF3 is responsible for the inhibition of TNF-Ξ± release and the impaired migration of acute ethanol-exposed monocytes and macrophages. | Hu C et al. | β | 2017 | β |
| Low dose of alcohol attenuates pro-atherosclerotic activity of thrombin. | Toda M et al. | β | 2017 | β |
| Alcohol Increases Liver Progenitor Populations and Induces Disease Phenotypes in Human IPSC-Derived Mature Stage Hepatic Cells. | Tian L et al. | β | 2016 | β |
| Effects of 20 Selected Fruits on Ethanol Metabolism: Potential Health Benefits and Harmful Impacts. | Zhang YJ et al. | β | 2016 | β |
| Ethanol downregulates N-acyl phosphatidylethanolamine-phospholipase D expression in BV2 microglial cells via epigenetic mechanisms. | Correa F et al. | β | 2016 | β |
| Ethanol induces cytostasis of cortical basal progenitors. | Riar AK et al. | β | 2016 | β |
| Ethanol-mediated activation of the NLRP3 inflammasome in iPS cells and iPS cells-derived neural progenitor cells. | De Filippis L et al. | β | 2016 | β |
| In Vitro Modeling of Alcohol-Induced Liver Injury Using Human-Induced Pluripotent Stem Cells. | Tian L et al. | β | 2016 | β |
| Modeling Fetal Alcohol Spectrum Disorder: Validating an Ex Vivo Primary Hippocampal Cell Culture System. | Tunc-Ozcan E et al. | β | 2016 | β |
| Searching new antifungals: The use of in vitro and in vivo methods for evaluation of natural compounds. | Scorzoni L et al. | β | 2016 | β |
| Effect of L-ornithine L-aspartate on Liver Injury Due to Acute Ethyl Alcohol Intoxication in Rats. | Durgun HM et al. | β | 2015 | β |
| Preparation of total flavonoids from loquat flower and its protective effect on acute alcohol-induced liver injury in mice. | Wu SK et al. | β | 2015 | β |
| Chronic ethanol consumption inhibits glucokinase transcriptional activity by Atf3 and triggers metabolic syndrome in vivo. | Kim JY et al. | β | 2014 | β |
| P2X4 receptor regulates alcohol-induced responses in microglia. | Gofman L et al. | β | 2014 | β |
| MFG-E8 and HMGB1 are involved in the mechanism underlying alcohol-induced impairment of macrophage efferocytosis. | Wang X et al. | β | 2013 | β |
| Acute alcohol-induced liver injury. | Massey VL et al. | β | 2012 | β |
| Cellular and mitochondrial effects of alcohol consumption. | Manzo-Avalos S et al. | β | 2010 | β |
| Laboratory models available to study alcohol-induced organ damage and immune variations: choosing the appropriate model. | D'Souza El-Guindy NB et al. | β | 2010 | β |
| Prevention of tumor cell reimplantation during transurethral resection: the in-vitro antiadhesive and cytotoxic properties of an irrigant containing polyethylene glycol 400. | Sangeda RZ et al. | β | 2010 | β |