Cocaine reward models: conditioned place preference can be established in dopamine- and in serotonin-transporter knockout mice.
paper
Cited
Public
Unavailable
- Authors
- Sora, I; Wichems, C; Takahashi, N; Li, X F; Zeng, Z; Revay, R; Lesch, K P; Murphy, D L; Uhl, G R
- Year
- 1998
- Journal
- Proceedings of the National Academy of Sciences of the United States of America
- PMID
- 9636213
- DOI
- 10.1073/pnas.95.13.7699
- PMCID
- PMC22727
Cocaine and methylphenidate block uptake by neuronal plasma membrane transporters for dopamine, serotonin, and norepinephrine. Cocaine also blocks voltage-gated sodium channels, a property not shared by methylphenidate. Several lines of evidence have suggested that cocaine blockade of the dopamine transporter (DAT), perhaps with additional contributions from serotonin transporter (5-HTT) recognition, was key to its rewarding actions. We now report that knockout mice without DAT and mice without 5-HTT establish cocaine-conditioned place preferences. Each strain displays cocaine-conditioned place preference in this major mouse model for assessing drug reward, while methylphenidate-conditioned place preference is also maintained in DAT knockout mice. These results have substantial implications for understanding cocaine actions and for strategies to produce anticocaine medications.
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