A twin-pronged attack on complex traits.
paper
Cited
Public
Unavailable
- Authors
- Martin, N; Boomsma, D; Machin, G
- Year
- 1997
- Journal
- Nature genetics
- PMID
- 9398838
- DOI
- 10.1038/ng1297-387
Before one starts the hunt for quantitative trait loci (QTLs) for a complex trait, it is necessary to show that the trait is genetically influenced. This evidence is most likely to come from the classical twin study--the demonstration that monozygotic twins are more similar for the trait than dizygotic twins. The strengths and weaknesses of twin studies are discussed, and it is suggested that, far from becoming irrelevant with advances in molecular biology, they can improve the efficiency of QTL detection and play an important role in unravelling developmental genetic mechanisms.
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| Increased DNA methylation at the AXIN1 gene in a monozygotic twin from a pair discordant for a caudal duplication anomaly. | Oates NA et al. | β | 2006 | β |
| Measured Gene-Environment Interactions in Psychopathology: Concepts, Research Strategies, and Implications for Research, Intervention, and Public Understanding of Genetics. | Moffitt TE et al. | β | 2006 | β |
| Relative contribution of genetic and nongenetic modifiers to intestinal obstruction in cystic fibrosis. | Blackman SM et al. | β | 2006 | β |
| Risk factors for asthma in young adults: a co-twin control study. | Thomsen SF et al. | β | 2006 | β |
| Spousal correlations for lifestyle factors and selected diseases in Chinese couples. | Jurj AL et al. | β | 2006 | β |
| The East Flanders Prospective Twin Survey (EFPTS). | Derom CA et al. | β | 2006 | β |
| The feasibility of creating a population-based national twin registry in the United States. | Chulada PC et al. | β | 2006 | β |
| The Qingdao Twin Registry: a focus on chronic disease research. | Pang Z et al. | β | 2006 | β |
| A school-based twin study of handedness among adolescents in Taiwan. | Su CH et al. | β | 2005 | β |
| BRAF polymorphisms and risk of melanocytic neoplasia. | James MR et al. | β | 2005 | β |
| Characterizing the ADHD phenotype for genetic studies. | Stevenson J et al. | β | 2005 | β |
| Discordant MZ twins with cleft lip and palate: a model for identifying genes in complex traits. | Mansilla MA et al. | β | 2005 | β |
| Epigenetic influences may explain dental differences in monozygotic twin pairs. | Townsend GC et al. | β | 2005 | β |
| Fishing for pleiotropic QTLs in a polygenic sea. | Bauman LE et al. | β | 2005 | β |
| Genetic and environmental contributions to loneliness in adults: the Netherlands twin register study. | Boomsma DI et al. | β | 2005 | β |
| Genetic and environmental influences on antisocial behaviors: evidence from behavioral-genetic research. | Moffitt TE | β | 2005 | β |
| Genetic components of functional connectivity in the brain: the heritability of synchronization likelihood. | Posthuma D et al. | β | 2005 | β |
| Genetic influences on early word recognition abilities and disabilities: a study of 7-year-old twins. | Harlaar N et al. | β | 2005 | β |
| Genetic pleiotropy between asthma and obesity in a community-based sample of twins. | Hallstrand TS et al. | β | 2005 | β |
| Genetic time-series analysis identifies a major QTL for in vivo alcohol metabolism not predicted by in vitro studies of structural protein polymorphism at the ADH1B or ADH1C loci. | Birley AJ et al. | β | 2005 | β |
| Heritability of plasma sex hormones and hormone binding globulin in adult male twins. | Ring HZ et al. | β | 2005 | β |
| Human cytokine response to ex vivo amyloid-beta stimulation is mediated by genetic factors. | Posthuma D et al. | β | 2005 | β |
| Modifier genetics: cystic fibrosis. | Cutting GR | β | 2005 | β |
| Origins of individual differences in theory of mind: from nature to nurture? | Hughes C et al. | β | 2005 | β |
| Personality development: stability and change. | Caspi A et al. | β | 2005 | β |
| Robust estimation of experimentwise P values applied to a genome scan of multiple asthma traits identifies a new region of significant linkage on chromosome 20q13. | Ferreira MA et al. | β | 2005 | β |
| Self-rated health in a longitudinal perspective: a 9-year follow-up twin study. | Svedberg P et al. | β | 2005 | β |
| The development of antisocial behaviour from childhood to adolescence. A longitudinal twin study. | Tuvblad C et al. | β | 2005 | β |
| Workshop Abstracts. | Gurwitz D | β | 2005 | β |
| A simulation study concerning the effect of varying the residual phenotypic correlation on the power of bivariate quantitative trait loci linkage analysis. | Evans DM et al. | β | 2004 | β |
| A twin study of competence and behavioral/emotional problems among adolescents in taiwan. | Kuo PH et al. | β | 2004 | β |
| Expression of beta-cell autoimmunity does not differ between potential dizygotic twins and siblings of patients with type 1 diabetes. | Redondo MJ et al. | β | 2004 | β |
| Genetic and environmental contributions to stability and change of ADHD symptoms between 8 and 13 years of age: a longitudinal twin study. | Larsson JO et al. | β | 2004 | β |
| Genetic architecture of ingestive behavior in humans. | Faith MS et al. | β | 2004 | β |
| Genetic epidemiological approaches in the study of risk factors for cardiovascular disease. | Iliadou A et al. | β | 2004 | β |
| Major quantitative trait locus for eosinophil count is located on chromosome 2q. | Evans DM et al. | β | 2004 | β |
| Multivariate QTL linkage analysis suggests a QTL for platelet count on chromosome 19q. | Evans DM et al. | β | 2004 | β |
| The genetics of eating disorders. | Berrettini W | β | 2004 | β |
| A 90-year-old monozygotic female twin pair discordant for Alzheimer's disease. | JΓ€rvenpÀÀ T et al. | β | 2003 | β |
| A note on cluster headache in a population-based twin register. | Svensson D et al. | β | 2003 | β |
| A twin study of anxiety-related behaviours in pre-school children. | Eley TC et al. | β | 2003 | β |
| Birth weight and risk of angina pectoris: analysis in Swedish twins. | Hubinette A et al. | β | 2003 | β |
| Epigenetics and bipolar disorder: new opportunities and challenges. | Petronis A | β | 2003 | β |
| Epileptic seizures and syndromes in twins: the importance of genetic factors. | Kjeldsen MJ et al. | β | 2003 | β |
| Genetic and environmental influences on human psychological differences. | Bouchard TJ et al. | β | 2003 | β |
| Genetic influences and neonatal lung disease. | Hallman M et al. | β | 2003 | β |
| Genetic linkage and association between chromosome 1q and working memory function in schizophrenia. | Gasperoni TL et al. | β | 2003 | β |
| Genetic polymorphisms and personality in healthy adults: a systematic review and meta-analysis. | MunafΓ² MR et al. | β | 2003 | β |
| Genetic susceptibility in type 1 diabetes and its associated autoimmune disorders. | Ide A et al. | β | 2003 | β |
| Has the "Equal Environments" assumption been tested in twin studies? | Eaves L et al. | β | 2003 | β |
| Heritability of cortisol levels: review and simultaneous analysis of twin studies. | Bartels M et al. | β | 2003 | β |
| Localization of genes involved in the metabolic syndrome using multivariate linkage analysis. | Olswold C et al. | β | 2003 | β |
| Novel association suggests multiple independent QTLs within chromosome 5q21-33 region control variation in total humans IgE levels. | Ahmadi KR et al. | β | 2003 | β |
| Psychiatric genetics in Australia. | Mowry BJ | β | 2003 | β |
| Regional cerebral glucose metabolism in monozygotic twins discordant for Alzheimer's disease. | JΓ€rvenpÀÀ T et al. | β | 2003 | β |
| Shared rearing environment in migraine: results from twins reared apart and twins reared together. | Svensson DA et al. | β | 2003 | β |
| Stability of exploratory multivariate data modeling in longitudinal data. | Sengul H et al. | β | 2003 | β |
| Surfactant protein A and B genetic variants in respiratory distress syndrome in singletons and twins. | Marttila R et al. | β | 2003 | β |
| The value of twins in dental research. | Townsend GC et al. | β | 2003 | β |
| Beta-2 adrenergic receptor gene variations and coping styles in twins. | Busjahn A et al. | β | 2002 | β |
| Biometrical genetics. | Evans DM et al. | β | 2002 | β |
| Classical twin studies and beyond. | Boomsma D et al. | β | 2002 | β |
| Genetic and environmental factors in febrile seizures: a Danish population-based twin study. | Kjeldsen MJ et al. | β | 2002 | β |
| Genetic influence on early age-related maculopathy: a twin study. | Hammond CJ et al. | β | 2002 | β |
| Introducing genetic psychophysiology. | de Geus EJ | β | 2002 | β |
| Lifetime prevalence and characteristics of recurrent primary headaches in a population-based sample of Swedish twins. | Svensson DA et al. | β | 2002 | β |
| Repeated blood pressure measurements in a sample of Swedish twins: heritabilities and associations with polymorphisms in the renin-angiotensin-aldosterone system. | Iliadou A et al. | β | 2002 | β |
| The epigenesis of planum temporale asymmetry in twins. | Eckert MA et al. | β | 2002 | β |
| The influence of genetics and environmental factors in the pathogenesis of acne: a twin study of acne in women. | Bataille V et al. | β | 2002 | β |
| The interindividual differences in the 3-demthylation of caffeine alias CYP1A2 is determined by both genetic and environmental factors. | Rasmussen BB et al. | β | 2002 | β |
| The Korean Twin Registry--methods, current stage, and interim results. | Sung J et al. | β | 2002 | β |
| The personalities of twins: just ordinary folks. | Johnson W et al. | β | 2002 | β |
| The power of multivariate quantitative-trait loci linkage analysis is influenced by the correlation between variables. | Evans DM | β | 2002 | β |
| The Swedish Twin Registry: a unique resource for clinical, epidemiological and genetic studies. | Lichtenstein P et al. | β | 2002 | β |
| A comparison of family functioning, temperament, and childhood conditions in monozygotic twin pairs discordant for lifetime bulimia nervosa. | Wade TD et al. | β | 2001 | β |
| An Australian twin study of the genetic basis of preeclampsia and eclampsia. | Treloar SA et al. | β | 2001 | β |
| An integrative approach for studying the etiology of alcoholism and other addictions. | Jacob T et al. | β | 2001 | β |
| Are twins and singletons comparable? A study of disease-related and lifestyle characteristics in adult women. | Andrew T et al. | β | 2001 | β |
| Bringing up bashful baby. Developmental pathways to social phobia. | Stein MB et al. | β | 2001 | β |
| Causes of epilepsies: insights from discordant monozygous twins. | Briellmann RS et al. | β | 2001 | β |
| Comparison of multivariate tests for genetic linkage. | Amos C et al. | β | 2001 | β |
| Development and representativeness of a large population-based cohort of native Californian twins. | Cockburn MG et al. | β | 2001 | β |
| Genes, evolution, and personality. | Bouchard TJ et al. | β | 2001 | β |
| Genetic and environmental factors in epilepsy: a population-based study of 11900 Danish twin pairs. | Kjeldsen MJ et al. | β | 2001 | β |
| Genetic and environmental influences on the associations between attention problems and other problem behaviors. | Schmitz S et al. | β | 2001 | β |
| Genetic contribution to bone metabolism, calcium excretion, and vitamin D and parathyroid hormone regulation. | Hunter D et al. | β | 2001 | β |
| Genetic linkage methods for quantitative traits. | Amos CI et al. | β | 2001 | β |
| Height discordance in monozygotic females is not attributable to discordant inactivation of X-linked stature determining genes. | Healey SC et al. | β | 2001 | β |
| Heritability of leptin levels and the shared genetic effects on body mass index and leptin in adult Finnish twins. | Kaprio J et al. | β | 2001 | β |
| Is the genetic liability in multifactorial disorders higher in concordant than discordant monozygotic twin pairs? A population-based family twin study of migraine without aura. | Gervil M et al. | β | 2001 | β |
| Retrotransposons as epigenetic mediators of phenotypic variation in mammals. | Whitelaw E et al. | β | 2001 | β |
| Seizures in family members of patients with hippocampal sclerosis. | Briellmann RS et al. | β | 2001 | β |
| The genetic epidemiology of thinness. | Bulik CM et al. | β | 2001 | β |
| Twins, chorionicity and zygosity. | Derom R et al. | β | 2001 | β |
| Twins in cardiovascular genetic research. | Luft FC | β | 2001 | β |
| Characterizing the quantitative genetic contribution to rheumatoid arthritis using data from twins. | MacGregor AJ et al. | β | 2000 | β |
| Environmental and heritable factors in the causation of cancer--analyses of cohorts of twins from Sweden, Denmark, and Finland. | Lichtenstein P et al. | β | 2000 | β |
| Factors affecting pupil size after dilatation: the Twin Eye Study. | Hammond CJ et al. | β | 2000 | β |
| Familial association between allergic disorders and depression in adult Finnish twins. | Wamboldt MZ et al. | β | 2000 | β |
| Genetic and environmental factors in age-related nuclear cataracts in monozygotic and dizygotic twins. | Hammond CJ et al. | β | 2000 | β |
| Genetics of risk factors for melanoma: an adult twin study of nevi and freckles. | Bataille V et al. | β | 2000 | β |
| Heritability of central systolic pressure augmentation: a twin study. | Snieder H et al. | β | 2000 | β |
| Perinatal risk factors for asthma in Finnish adolescent twins. | RΓ€sΓ€nen M et al. | β | 2000 | β |
| Power of linkage versus association analysis of quantitative traits, by use of variance-components models, for sibship data. | Sham PC et al. | β | 2000 | β |
| Twins. Novel uses to study complex traits and genetic diseases. | MacGregor AJ et al. | β | 2000 | β |
| Twin studies of eating disorders: a review. | Bulik CM et al. | β | 2000 | β |
| Twin studies of schizophrenia: from bow-and-arrow concordances to star wars Mx and functional genomics. | Cardno AG et al. | β | 2000 | β |
| A major quantitative-trait locus for mole density is linked to the familial melanoma gene CDKN2A: a maximum-likelihood combined linkage and association analysis in twins and their sibs. | Zhu G et al. | β | 1999 | β |
| A note on the power provided by sibships of sizes 2, 3, and 4 in genetic covariance modeling of a codominant QTL. | Dolan CV et al. | β | 1999 | β |
| A simulation study of the effects of assignment of prior identity-by-descent probabilities to unselected sib pairs, in covariance-structure modeling of a quantitative-trait locus. | Dolan CV et al. | β | 1999 | β |
| Behavioral genetics as a tool for developmental psychology: anxiety and depression in children and adolescents. | Eley TC | β | 1999 | β |
| Behavioural genetics: An introduction. | Sluyter F et al. | β | 1999 | β |
| Bivariate genetic analysis of fasting insulin and glucose levels. | Snieder H et al. | β | 1999 | β |
| Cigarette smoking. | Bergen AW et al. | β | 1999 | β |
| Dissecting the genetic architecture of lipids, lipoproteins, and apolipoproteins: lessons from twin studies. | Snieder H et al. | β | 1999 | β |
| Genetic and environmental influences on total-body and central abdominal fat: the effect of physical activity in female twins. | Samaras K et al. | β | 1999 | β |
| Genetic predisposition, environment and cancer incidence: a nationwide twin study in Finland, 1976-1995. | Verkasalo PK et al. | β | 1999 | β |
| Identification of an acute ethanol response quantitative trait locus on mouse chromosome 2. | Demarest K et al. | β | 1999 | β |
| Likelihood-based approach to estimating twin concordance for dichotomous traits. | Witte JS et al. | β | 1999 | β |
| Linkage but lack of association for blood pressure and the alpha-adducin locus in normotensive twins. | Busjahn A et al. | β | 1999 | β |
| QT interval is linked to 2 long-QT syndrome loci in normal subjects. | Busjahn A et al. | β | 1999 | β |
| The emerging importance of genetics in epidemiologic research II. Issues in study design and gene mapping. | Ellsworth DL et al. | β | 1999 | β |
| The genetic mediation of individual differences in sensitivity to pain and its inhibition. | Mogil JS | β | 1999 | β |
| The relative role of genetic and environmental factors in migraine without aura. | Gervil M et al. | β | 1999 | β |
| The role of twin studies in the genetics of skin diseases. | Bataille V | β | 1999 | β |
| A comparison of power to detect a QTL in sib-pair data using multivariate phenotypes, mean phenotypes, and factor scores. | Boomsma DI et al. | β | 1998 | β |
| Chymase gene locus is not associated with myocardial infarction and is not linked to heart size or blood pressure. | Pfeufer A et al. | β | 1998 | β |
| Concordance for pre-eclampsia in monozygous twins. | Lachmeijer AM et al. | β | 1998 | β |
| Genetic influence on language delay in two-year-old children. | Dale PS et al. | β | 1998 | β |
| Genomics and human disease--variations on variation. | Brown PO et al. | β | 1998 | β |
| Heritability of blood pressure increases during mental stress. | Boomsma DI et al. | β | 1998 | β |
| Heteropagus conjoined twins due to fusion of two embryos. | Machin GA | β | 1998 | β |
| Hypospadias is related to birth weight in discordant monozygotic twins. | Fredell L et al. | β | 1998 | β |
| Intragenic polymorphisms of the vitamin D receptor gene associated with intervertebral disc degeneration. | Videman T et al. | β | 1998 | β |
| The East Flanders Prospective Twin Survey (Belgium): a population-based register. | Loos R et al. | β | 1998 | β |
| Twin registers in Europe: an overview. | Boomsma DI | β | 1998 | β |
| Twin zygosity testing for medical purposes. | St Clair DM et al. | β | 1998 | β |
| What is the evidence of genetic factors in the etiology of Graves' disease? A brief review. | Brix TH et al. | β | 1998 | β |
| What is the evidence of genetic factors in the etiology of Graves' disease? A brief review. | Brix TH et al. | β | 1998 | β |