Comparing structural equation models that use different measures of the level of response to alcohol.
- Authors
- Schuckit, Marc A; Smith, Tom L; Trim, Ryan S; Tolentino, Neil J; Hall, Shana A
- Year
- 2010
- Journal
- Alcoholism, clinical and experimental research
- PMID
- 20201931
- DOI
- 10.1111/j.1530-0277.2010.01158.x
BACKGROUND: The two measures of a low level of response (LR) to alcohol, an alcohol challenge and the retrospective Self-Report of the Effects of Alcohol questionnaire (SRE), each identify individuals at high risk for heavy drinking and alcohol problems. These measures also perform similarly in identifying subjects with unique functional brain imaging characteristics. However, few data are available regarding whether alcohol challenge-based and SRE-based LRs operate similarly in structural equation models (SEMs) that search for characteristics, which help to mediate how LR impacts alcohol outcomes. METHODS: Two hundred and ninety-four men from the San Diego Prospective Study were evaluated for their LR to alcohol using alcohol challenges at approximately age 20. At approximately age 35, the same subjects filled out the SRE regarding the number of drinks needed for effects 15 to 20 years earlier. The two different LR scores for these men were used in SEM analyses evaluating how LR relates to future heavy drinking and to drinking in peers (PEER), alcohol expectancies (EXPECT), and drinking to cope (COPE) as potential mediators of the LR to drinking pattern (ALCOUT) relationships. RESULTS: While the 2 LR measures that were determined 15 years apart related to each other at a modest level (r = 0.17, p < 0.01), the SEM results were similar regardless of the LR source. In both alcohol challenge-based and SRE-based LR models, LR related directly to ALCOUT, with partial mediation from PEER and COPE, but not through EXPECT in these 35-year-old men. CONCLUSIONS: Consistent with the >60% overlap in prediction of outcomes for the 2 LR measures, and with results from functional brain imaging, alcohol challenge- and SRE-based LR values operated similarly in SEM models in these men.
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External
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|---|---|---|---|---|
| Survey measures of subjective response to alcohol are improved by incorporating questions about the intensity of alcohol effects. | Wang FL et al. | — | 2026 | → |
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| The Ability of Functional Magnetic Resonance Imaging to Predict Heavy Drinking and Alcohol Problems 5 Years Later. | Schuckit MA et al. | — | 2016 | → |
| Two alternative approaches to conventional person-mean imputation scoring of the Self-Rating of the Effects of Alcohol Scale (SRE). | Lee MR et al. | — | 2015 | → |
| Type 2 ryanodine receptors are highly sensitive to alcohol. | Ye Y et al. | — | 2014 | → |
| Early subjective response and acquired tolerance as predictors of alcohol use and related problems in a clinical sample. | Corbin WR et al. | — | 2013 | → |
| Stability of scores and correlations with drinking behaviors over 15 years for the Self-Report of the Effects of Alcohol Questionnaire. | Schuckit MA et al. | — | 2013 | → |
| Comparison across two generations of prospective models of how the low level of response to alcohol affects alcohol outcomes. | Schuckit MA et al. | — | 2012 | → |
| Sex differences in how a low sensitivity to alcohol relates to later heavy drinking. | Schuckit MA et al. | — | 2012 | → |
| Structuring a college alcohol prevention program on the low level of response to alcohol model: a pilot study. | Schuckit MA et al. | — | 2012 | → |
| Alcohol effects on cerebral blood flow in subjects with low and high responses to alcohol. | Tolentino NJ et al. | — | 2011 | → |
| A prospective evaluation of how a low level of response to alcohol predicts later heavy drinking and alcohol problems. | Schuckit MA et al. | — | 2011 | → |
| Comment on the paper by Quinn and Fromme entitled subjective response to alcohol challenge: a quantitative review. | Schuckit MA | — | 2011 | → |
| Testing a level of response to alcohol-based model of heavy drinking and alcohol problems in 1,905 17-year-olds. | Schuckit MA et al. | — | 2011 | → |