Sex differences in nicotine action.
paper
Cited
Public
Unavailable
- Authors
- Pogun, Sakire; Yararbas, Gorkem
- Year
- 2009
- Journal
- Handbook of experimental pharmacology
- PMID
- 19184653
- DOI
- 10.1007/978-3-540-69248-5_10
Accumulating evidence suggests that the antecedents, consequences, and mechanisms of drug abuse and dependence are not identical in males and females and that gender may be an important variable in treatment and prevention. Although there has been a decline in smoking prevalence in developed countries, females are less successful in quitting. Tobacco use is accepted to be a form of addiction, which manifests sex differences. There is also evidence for sex differences in the central effects of nicotine in laboratory animals. Although social factors impact smoking substantially in humans, findings from nonhuman subjects in controlled experiments provide support that sex differences in nicotine/tobacco addiction have a biological basis. Differences in the pharmacokinetic properties of nicotine or the effect of gonadal hormones may underlie some but not all sex differences observed. Laboratory-based information is very important in developing treatment strategies. Literature findings suggest that including sex as a factor in nicotine/tobacco-related studies will improve our success rates in individually tailored smoking cessation programs.
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| Title | Year | PMID |
|---|---|---|
| Early-onset tobacco use and suicide-related behavior - A prospective study from adolescence to young adulthood. | 2018 | 29245024 |
External
| Title | Authors | Journal | Year | Link |
|---|---|---|---|---|
| Sex- and Genotype-Dependent Nicotine-Induced Behaviors in Adult Rats With a Human Polymorphism (rs2304297) in the 3'-Untranslated Region of the CHRNA6 Gene. | Castro EM et al. | — | 2026 | → |
| Sex, hormones, and lung health. | Silveyra P et al. | — | 2026 | → |
| Predictive Factors for Smoking Cessation Among People With Lung Cancer Attending French Cessation Services, According to Sex. | Le Faou AL et al. | — | 2025 | → |
| Sex differences in dorsal striatal volume and interest in quitting smoking. | Huang S et al. | — | 2025 | → |
| Anxiety Sensitivity and Distress Tolerance in Relation to Smoking Abstinence Expectancies Among Black Individuals Who Smoke. | Garey L et al. | — | 2024 | → |
| Anxiety symptoms and anxiety sensitivity in relation to cigarette dependence, perceived barriers for smoking cessation and quit problems among adult Latinx smokers. | Zvolensky MJ et al. | — | 2024 | → |
| Evaluating Alcohol Use Severity in Terms of Cigarette Smoking-Related Processes and Anxiety/Depression Among Adult Latinx Smokers. | Zvolensky MJ et al. | — | 2024 | → |
| Methoxsalen Inhibits the Acquisition of Nicotine Self-Administration: Attenuation by Cotinine Replacement in Male Rats. | Ding ZM et al. | — | 2024 | → |
| Acute nicotine exposure blocks aromatase in the limbic brain of healthy women: A [<sup>11</sup>C]cetrozole PET study. | Dubol M et al. | — | 2023 | → |
| Development of a nicotine aerosol self-administration model in rats and the effects of e-liquid flavors. | Marusich JA et al. | — | 2023 | → |
| Examining racial differences in smoking outcomes among smokers enrolled in an intravenous nicotine infusion study. | Schwartz EKC et al. | — | 2023 | → |
| Gender differences in weight gain during attempted and successful smoking cessation on dulaglutide treatment: a predefined secondary analysis of a randomised trial. | Baur F et al. | — | 2023 | → |
| Perceived Racial/Ethnic Discrimination and Smoking Outcome Expectancies among Adult Latinx Smokers Living in the United States. | Zvolensky MJ et al. | — | 2023 | → |
| Role of perceived discrimination and anxiety sensitivity in cigarette smoking among english-speaking latinx adults living in the United States. | Zvolensky MJ et al. | — | 2023 | → |
| Sex and diet-dependent gene alterations in human and rat brains with a history of nicotine exposure. | Vargas-Medrano J et al. | — | 2023 | → |
| Sex Differences in Lung Cancer. | May L et al. | — | 2023 | → |
| Association of Polymorphism <i>CHRNA5</i> and <i>CHRNA3</i> Gene in People Addicted to Nicotine. | Chmielowiec K et al. | — | 2022 | → |
| Biological determinants impact the neurovascular toxicity of nicotine and tobacco smoke: A pharmacokinetic and pharmacodynamics perspective. | Archie SR et al. | — | 2022 | → |
| Gender differences in the associations between tobacco smoke exposure and depressive symptoms among U.S. adults: NHANES 2007-2018. | Fan Z et al. | — | 2022 | → |
| Sex-Specific Association between Environmental Tobacco Smoke Exposure and Asthma Severity among Adults with Current Asthma. | Becerra BJ et al. | — | 2022 | → |
| Unique effects of nicotine across the lifespan. | Ren M et al. | — | 2022 | → |
| Association between Time to First Cigarette and Health-Related Quality of Life of Middle-Aged Male Current Smokers: A Nationwide Representative Study in Korea. | Jo SE et al. | — | 2021 | → |
| Determinants and Reference Ranges of Serum Immunoglobulins in Middle-Aged and Elderly Individuals: a Population-Based Study. | Khan SR et al. | — | 2021 | → |
| Effects of nicotine on DARPP-32 and CaMKII signaling relevant to addiction. | Lee AM et al. | — | 2021 | → |
| Flavor and product messaging are the two most important drivers of electronic cigarette selection in a choice-based task. | Baker AN et al. | — | 2021 | → |
| Homeless women's perspectives on smoking and smoking cessation programs: A qualitative study. | Rubin SB et al. | — | 2021 | → |
| Nicotine exposure during lactation causes disruption of hedonic eating behavior and alters dopaminergic system in adult female rats. | Peixoto TC et al. | — | 2021 | → |
| Protecting women and girls from tobacco and alcohol promotion. | Feeny E et al. | — | 2021 | → |
| Sex Difference in the Association between Electronic Cigarette Use and Subsequent Cigarette Smoking among U.S. Adolescents: Findings from the PATH Study Waves 1-4. | Duan Z et al. | — | 2021 | → |
| Sex Differences in the Ventral Tegmental Area and Nucleus Accumbens Proteome at Baseline and Following Nicotine Exposure. | Lee AM et al. | — | 2021 | → |
| Assessment of individual differences in response to acute bupropion or varenicline treatment using a long-access nicotine self-administration model and behavioral economics in female rats. | Kazan T et al. | — | 2020 | → |
| Role of corticotropin-releasing factor in alcohol and nicotine addiction. | Simpson S et al. | — | 2020 | → |
| Variability in nicotine conditioned place preference and stress-induced reinstatement in mice: Effects of sex, initial chamber preference, and guanfacine. | Lee AM et al. | — | 2020 | → |
| Anti-inflammatory agents for smoking cessation? Focus on cognitive deficits associated with nicotine withdrawal in male mice. | Saravia R et al. | — | 2019 | → |
| Examining sex differences in pleiotropic effects for depression and smoking using polygenic and gene-region aggregation techniques. | Schmitz LL et al. | — | 2019 | → |
| Sex differences in nicotine-enhanced Pavlovian conditioned approach in rats. | Stringfield SJ et al. | — | 2019 | → |
| Early-onset tobacco use and suicide-related behavior - A prospective study from adolescence to young adulthood. | Korhonen T et al. | — | 2018 | → |
| Nicotinic Cholinergic System in the Hypothalamus Modulates the Activity of the Hypothalamic Neuropeptides During the Stress Response. | Balkan B et al. | — | 2018 | → |
| The Intersection of Sex Differences, Tobacco Use, and Inflammation: Implications for Psychiatric Disorders. | Ashare RL et al. | — | 2018 | → |
| Delivery of nicotine aerosol to mice via a modified electronic cigarette device. | Lefever TW et al. | — | 2017 | → |
| Nicotine Alters the Gut Microbiome and Metabolites of Gut-Brain Interactions in a Sex-Specific Manner. | Chi L et al. | — | 2017 | → |
| Nicotine dependence is associated with depression and childhood trauma in smokers with schizophrenia: results from the FACE-SZ dataset. | Rey R et al. | — | 2017 | → |
| Sex differences in nicotine preference. | Pogun S et al. | — | 2017 | → |
| Sex/Gender Differences in Cotinine Levels Among Daily Smokers in the Pennsylvania Adult Smoking Study. | Chen A et al. | — | 2017 | → |
| Social context has differential effects on acquisition of nicotine self-administration in male and female rats. | Peartree NA et al. | — | 2017 | → |
| Estradiol promotes the rewarding effects of nicotine in female rats. | Flores RJ et al. | — | 2016 | → |
| Exposure to nicotine increases nicotinic acetylcholine receptor density in the reward pathway and binge ethanol consumption in C57BL/6J adolescent female mice. | Locker AR et al. | — | 2016 | → |
| Gender-related Differences in Food Craving and Obesity. | Hallam J et al. | — | 2016 | → |
| How Intravenous Nicotine Administration in Smokers Can Inform Tobacco Regulatory Science. | Jensen KP et al. | — | 2016 | → |
| Intravenous Nicotine Self-Administration in Smokers: Dose-Response Function and Sex Differences. | Jensen KP et al. | — | 2016 | → |
| Nicotinic cholinergic and dopaminergic receptor mRNA expression in male and female rats with high or low preference for nicotine. | Gozen O et al. | — | 2016 | → |
| Sex Differences in Midbrain Dopamine D2-Type Receptor Availability and Association with Nicotine Dependence. | Okita K et al. | — | 2016 | → |
| Sex differences in the acquisition and maintenance of cocaine and nicotine self-administration in rats. | Swalve N et al. | — | 2016 | → |
| The separate and combined effects of monoamine oxidase A inhibition and nicotine on resting state EEG. | Smith DM et al. | — | 2016 | → |
| Importance of sex differences in impulse control and addictions. | Mitchell MR et al. | — | 2015 | → |
| Sex Differences in Behavioral Dyscontrol: Role in Drug Addiction and Novel Treatments. | Carroll ME et al. | — | 2015 | → |
| Sex differences in time perception during smoking abstinence. | Ashare RL et al. | — | 2015 | → |
| A mechanistic hypothesis of the factors that enhance vulnerability to nicotine use in females. | O'Dell LE et al. | — | 2014 | → |
| Biases of attention in chronic smokers: men and women are not alike. | Perlato A et al. | — | 2014 | → |
| A role for matrix metalloproteinases in nicotine-induced conditioned place preference and relapse in adolescent female rats. | Natarajan R et al. | — | 2013 | → |
| Long-term alterations to dendritic morphology and spine density associated with prenatal exposure to nicotine. | Mychasiuk R et al. | — | 2013 | → |
| Marked global reduction in mGluR5 receptor binding in smokers and ex-smokers determined by [11C]ABP688 positron emission tomography. | Akkus F et al. | — | 2013 | → |
| [Predictors of outcome of a smoking cessation treatment by gender]. | Marqueta A et al. | — | 2013 | → |
| Weight concerns among Finnish ever-smokers: a population-based study. | Luostarinen M et al. | — | 2013 | → |
| Diurnal Evening Type is Associated with Current Smoking, Nicotine Dependence and Nicotine Intake in the Population Based National FINRISK 2007 Study. | Broms U et al. | — | 2012 | → |
| Gender-stratified gene and gene-treatment interactions in smoking cessation. | Lee W et al. | — | 2012 | → |
| Oral Nicotine Self-Administration in Rodents. | Collins AC et al. | — | 2012 | → |
| Potential contribution of aromatase inhibition to the effects of nicotine and related compounds on the brain. | Biegon A et al. | — | 2012 | → |
| Sex, ADHD symptoms, and smoking outcomes: an integrative model. | Van Voorhees EE et al. | — | 2012 | → |
| Sex differences in striatal dopamine D2/D3 receptor availability in smokers and non-smokers. | Brown AK et al. | — | 2012 | → |
| Hippocampal neuronal nitric oxide synthase (nNOS) is regulated by nicotine and stress in female but not in male rats. | Keser A et al. | — | 2011 | → |
| Individual differences in oral nicotine intake in rats. | Nesil T et al. | — | 2011 | → |
| Sexually diergic hypothalamic-pituitary-adrenal (HPA) responses to single-dose nicotine, continuous nicotine infusion, and nicotine withdrawal by mecamylamine in rats. | Gentile NE et al. | — | 2011 | → |
| Tamoxifen and mifepriston modulate nicotine induced conditioned place preference in female rats. | Yararbas G et al. | — | 2011 | → |
| The role of gender in a smoking cessation intervention: a cluster randomized clinical trial. | Puente D et al. | — | 2011 | → |
| [Are there specific characteristics of COPD in women?]. | Raherison C et al. | — | 2010 | → |
| Nicotine-induced conditioned place preference in rats: sex differences and the role of mGluR5 receptors. | Yararbas G et al. | — | 2010 | → |
| Sexually diergic, dose-dependent hypothalamic-pituitary-adrenal axis responses to nicotine in a dynamic in vitro perfusion system. | McKlveen JM et al. | — | 2010 | → |
| Smoking, nicotine and neuropsychiatric disorders. | Dome P et al. | — | 2010 | → |
| Female rats display dose-dependent differences to the rewarding and aversive effects of nicotine in an age-, hormone-, and sex-dependent manner. | Torres OV et al. | — | 2009 | → |
| Sex differences in the self-administration of cannabinoids and other drugs of abuse. | Fattore L et al. | — | 2009 | → |