[18F]MK-9470 PET measurement of cannabinoid CB1 receptor availability in chronic cannabis users.
paper
Cited
Public
Unavailable
- Authors
- Ceccarini, Jenny; Kuepper, Rebecca; Kemels, Dieter; van Os, Jim; Henquet, CΓ©cile; Van Laere, Koen
- Year
- 2015
- Journal
- Addiction biology
- PMID
- 24373053
- DOI
- 10.1111/adb.12116
Ξ(9) -Tetrahydrocannabinol, the main psychoactive component of cannabis, exerts its central effects through activation of the cerebral type 1 cannabinoid (CB1 ) receptor. Pre-clinical studies have provided evidence that chronic cannabis exposure is linked to decreased CB1 receptor expression and this is thought to be a component underlying drug tolerance and dependence. In this study, we make first use of the selective high-affinity positron emission tomography (PET) ligand [(18) F]MK-9470 to obtain in vivo measurements of cerebral CB1 receptor availability in 10 chronic cannabis users (ageβ=β26.0βΒ±β4.1 years). Each patient underwent [(18) F]MK-9470 PET within the first week following the last cannabis consumption. A population of 10 age-matched healthy subjects (ageβ=β23.0βΒ±β2.9 years) was used as control group. Parametric modified standardized uptake value images, reflecting CB1 receptor availability, were calculated. Statistical parametric mapping and volume-of-interest (VOI) analyses of CB1 receptor availability were performed. Compared with controls, cannabis users showed a global decrease in CB1 receptor availability (-11.7 percent). VOI-based analysis demonstrated that the CB1 receptor decrease was significant in the temporal lobe (-12.7 percent), anterior (-12.6 percent) and posterior cingulate cortex (-13.5 percent) and nucleus accumbens (-11.2 percent). Voxel-based analysis confirmed this decrease and regional pattern in CB1 receptor availability in cannabis users. These findings revealed that chronic cannabis use may alter specific regional CB1 receptor expression through neuroadaptive changes in CB1 receptor availability, opening the way for the examination of specific CB1 -cannabis addiction interactions which may predict future cannabis-related treatment outcome.
No figures extracted from this document.
No chunks β full text not yet ingested.
No entities extracted from this document yet.
No uploaded files.
Not in any collection.
No citations found.
In this knowledge base
External
| Title | Authors | Journal | Year | Link |
|---|---|---|---|---|
| Cannabinoid-based Pharmacology for the Management of Substance Use Disorders. | LujΓ‘n MΓ et al. | β | 2026 | β |
| Longer chronic cannabis use in humans is associated with impaired implicit motor learning and supranormal resting state cortical activity. | Prashad S et al. | β | 2026 | β |
| PET Molecular Imaging of the Endocannabinoid System in Psychiatric Disorders. | Cui C et al. | β | 2026 | β |
| Pharmacotherapy for Cannabis Use Disorder: Preclinical and Clinical Models. | Bedillion MF et al. | β | 2026 | β |
| Abnormal developmental of hippocampal subfields and amygdalar subnuclei volumes in young adults with heavy cannabis use: A three-year longitudinal study. | Zhang X et al. | β | 2025 | β |
| A preliminary investigation of tobacco co-use on endocannabinoid activity in people with cannabis use. | Rabin RA et al. | β | 2025 | β |
| Cannabinoid CB1 receptor-sensitive neurodevelopmental processes and trajectories. | Tseng KY et al. | β | 2025 | β |
| Cannabis Perturbs Dynamic Brain States. | Lege KS et al. | β | 2025 | β |
| Cannabis use and suicide in people with a diagnosis of schizophrenia: a systematic review and meta-analysis of longitudinal, case control, and cross-sectional studies. | Mulligan LD et al. | β | 2025 | β |
| CBD and the 5-HT1A receptor: A medicinal and pharmacological review. | Alexander C et al. | β | 2025 | β |
| Effect of Cannabis Usage on Thyroid Eye Disease. | Zong AM et al. | β | 2025 | β |
| Endocannabinoid signaling in stress, nausea, and vomiting. | DeVuono MV et al. | β | 2025 | β |
| Longer chronic cannabis use in humans is associated with impaired implicit motor learning and supranormal resting state cortical activity | Prashad S et al. | β | 2025 | β |
| PET Imaging in Psychiatric Disorders. | Ferrando R et al. | β | 2025 | β |
| Regular cannabis use modulates gamma functional connectivity with V1 during visual processing. | Webert LK et al. | β | 2025 | β |
| The Role of Fatty Acid Binding Proteins in Neuropsychiatric Diseases: A Narrative Review. | Powell A et al. | β | 2025 | β |
| Cannabis use disorder: from neurobiology to treatment. | Le Foll B et al. | β | 2024 | β |
| Effects of Cannabidiol and Delta-9-Tetrahydrocannabinol on Plasma Endocannabinoid Levels in Healthy Volunteers: A Randomized Double-Blind Four-Arm Crossover Study. | Chester LA et al. | β | 2024 | β |
| Empathy-related differences in the anterior cingulate functional connectivity of regular cannabis users when compared to controls. | Olalde-Mathieu VE et al. | β | 2024 | β |
| Fatty Acid Amide Hydrolase and Cannabinoid Receptor Type 1 Genes Regulation is Modulated by Social Isolation in Rats. | Girella A et al. | β | 2024 | β |
| Beyond monoamines: II. Novel applications for PET imaging in psychiatric disorders. | Royse SK et al. | β | 2023 | β |
| Circulating Endocannabinoids and N-Acylethanolamines in Individuals with Cannabis Use Disorder-Preliminary Findings. | Boachie N et al. | β | 2023 | β |
| Investigating the "two-hit hypothesis": Effects of prenatal maternal immune activation and adolescent cannabis use on neurodevelopment in mice. | Guma E et al. | β | 2023 | β |
| Mechanisms of cannabinoid tolerance. | Piscura MK et al. | β | 2023 | β |
| Molecular brain differences and cannabis involvement: A systematic review of positron emission tomography studies. | Xu H et al. | β | 2023 | β |
| Sex differences in neuroendocrine, sympathetic nervous system, and affect responses to acute stress in cannabis users. | Larson ER et al. | β | 2023 | β |
| The endocannabinoid system as a putative target for the development of novel drugs for the treatment of psychiatric illnesses. | Hill MN et al. | β | 2023 | β |
| The Inflammatory Signals Associated with Psychosis: Impact of Comorbid Drug Abuse. | Herrera-Imbroda J et al. | β | 2023 | β |
| The Relationship Between Circulating Endogenous Cannabinoids and the Effects of Smoked Cannabis. | Kearney-Ramos T et al. | β | 2023 | β |
| Acute effects of Ξ<sup>9</sup>-tetrahydrocannabinol and cannabidiol on auditory mismatch negativity. | Greenwood LM et al. | β | 2022 | β |
| Alcohol-Endocannabinoid Interactions: Implications for Addiction-Related Behavioral Processes. | Serrano A et al. | β | 2022 | β |
| Biomarkers of the Endocannabinoid System in Substance Use Disorders. | Navarrete F et al. | β | 2022 | β |
| Cannabinoid receptor availability modulates the magnitude of dopamine release in vivo in the human reward system: A preliminary multitracer positron emission tomography study. | Ceccarini J et al. | β | 2022 | β |
| Cannabis Use and Neuroadaptation: A Call for Ξ <i><sup>9</sup></i> -Tetrahydrocannabinol Challenge Studies. | Ramaekers JG et al. | β | 2022 | β |
| Cannabis Use and the Endocannabinoid System: A Clinical Perspective. | Haney M | β | 2022 | β |
| Functional brain connectomes reflect acute and chronic cannabis use. | Ramaekers JG et al. | β | 2022 | β |
| <i>Cannabis sativa</i> as a Treatment for Obesity: From Anti-Inflammatory Indirect Support to a Promising Metabolic Re-Establishment Target. | Cavalheiro EKFF et al. | β | 2022 | β |
| Impact of cyclooxygenase-2 inhibition on cannabis withdrawal and circulating endocannabinoids in daily cannabis smokers. | Haney M et al. | β | 2022 | β |
| Is resting-state functional connectivity altered in regular cannabis users? A systematic review of the literature. | Thomson H et al. | β | 2022 | β |
| Molecular Alterations of the Endocannabinoid System in Psychiatric Disorders. | Navarro D et al. | β | 2022 | β |
| Psychedelic experience dose-dependently modulated by cannabis: results of a prospective online survey. | Kuc J et al. | β | 2022 | β |
| Synaptic changes induced by cannabinoid drugs and cannabis use disorder. | Augustin SM et al. | β | 2022 | β |
| The effects of fatty acid amide hydrolase inhibition and monoacylglycerol lipase inhibition on habit formation in mice. | Gianessi CA et al. | β | 2022 | β |
| Altered amygdala-cortical connectivity in individuals with Cannabis use disorder. | Aloi J et al. | β | 2021 | β |
| A review of the effects of acute and chronic cannabinoid exposure on the stress response. | Glodosky NC et al. | β | 2021 | β |
| Assessment of transient dopamine responses to smoked cannabis. | Calakos KC et al. | β | 2021 | β |
| Brain imaging of cannabinoid type I (CB<sub>1</sub> ) receptors in women with cannabis use disorder and male and female healthy controls. | Spindle TR et al. | β | 2021 | β |
| Chlorpyrifos and Ξ<sup>9</sup> Tetrahydrocannabinol exposure and effects on parameters associated with the endocannabinoid system and risk factors for obesity. | Silva MH | β | 2021 | β |
| Fatty acid amide hydrolase is lower in young cannabis users. | Jacobson MR et al. | β | 2021 | β |
| Progress on the application of positron emission tomography imaging of cannabinoid type 1 receptor in neuropsychiatric diseases. | Ma L et al. | β | 2021 | β |
| Reduced responsiveness of the reward system is associated with tolerance to cannabis impairment in chronic users. | Mason NL et al. | β | 2021 | β |
| The acute and non-acute effects of cannabis on reward processing: A systematic review. | Skumlien M et al. | β | 2021 | β |
| The why behind the high: determinants of neurocognition during acute cannabis exposure. | Ramaekers JG et al. | β | 2021 | β |
| 2-Arachidonoylglycerol Modulation of Anxiety and Stress Adaptation: From Grass Roots to Novel Therapeutics. | Bedse G et al. | β | 2020 | β |
| Blunted highs: Pharmacodynamic and behavioral models of cannabis tolerance. | Ramaekers JG et al. | β | 2020 | β |
| Brain structural changes in cannabis dependence: association with MAGL. | Manza P et al. | β | 2020 | β |
| Cannabis and the Developing Adolescent Brain. | Fischer AS et al. | β | 2020 | β |
| Cannabis Use and the Risk for Psychosis and Affective Disorders. | Sideli L et al. | β | 2020 | β |
| Deconstructing the neurobiology of cannabis use disorder. | Ferland JN et al. | β | 2020 | β |
| Evidence for the Endocannabinoid System as a Therapeutic Target in the Treatment of Cannabis Use Disorder. | Martin EL et al. | β | 2020 | β |
| Impact of cannabis on non-medical opioid use and symptoms of posttraumatic stress disorder: a nationwide longitudinal VA study. | De Aquino JP et al. | β | 2020 | β |
| Interaction of Cannabis Use and Aging: From Molecule to Mind. | Yoo HB et al. | β | 2020 | β |
| <i>Mgll</i> Knockout Mouse Resistance to Diet-Induced Dysmetabolism Is Associated with Altered Gut Microbiota. | Dione N et al. | β | 2020 | β |
| Meet Your Stress Management Professionals: The Endocannabinoids. | deRoon-Cassini TA et al. | β | 2020 | β |
| Psychosis-Relevant Effects of Intravenous Delta-9-Tetrahydrocannabinol: A Mega Analysis of Individual Participant-Data from Human Laboratory Studies. | Ganesh S et al. | β | 2020 | β |
| Quantification of the Cannabinoid Type 1 Receptor Availability in the Mouse Brain. | Miederer I et al. | β | 2020 | β |
| Vaporized Cannabis Extracts Have Reinforcing Properties and Support Conditioned Drug-Seeking Behavior in Rats. | Freels TG et al. | β | 2020 | β |
| A systematic review of phytocannabinoid exposure on the endocannabinoid system: Implications for psychosis. | Jacobson MR et al. | β | 2019 | β |
| Bi-directional modulation of food habit expression by the endocannabinoid system. | Gianessi CA et al. | β | 2019 | β |
| Cannabinoid interventions for PTSD: Where to next? | Ney LJ et al. | β | 2019 | β |
| Cerebellar alterations in cannabis users: A systematic review. | Blithikioti C et al. | β | 2019 | β |
| Endocannabinoid signaling in psychiatric disorders: a review of positron emission tomography studies. | Sloan ME et al. | β | 2019 | β |
| <i>Cannabis</i>: From a Plant That Modulates Feeding Behaviors toward Developing Selective Inhibitors of the Peripheral Endocannabinoid System for the Treatment of Obesity and Metabolic Syndrome. | Hirsch S et al. | β | 2019 | β |
| In Vivo Imaging of Translocator Protein in Long-term Cannabis Users. | Da Silva T et al. | β | 2019 | β |
| Is There a Role for GPCR Agonist Radiotracers in PET Neuroimaging? | Colom M et al. | β | 2019 | β |
| Lifestyle and Metabolic Syndrome: Contribution of the Endocannabinoidome. | Di Marzo V et al. | β | 2019 | β |
| Role of the Endocannabinoidome in Human and Mouse Atherosclerosis. | Piscitelli F et al. | β | 2019 | β |
| The neuropsychopharmacology of cannabis: A review of human imaging studies. | Bloomfield MAP et al. | β | 2019 | β |
| Cannabis Users Show Enhanced Expression of CB<sub>1</sub>-5HT<sub>2A</sub> Receptor Heteromers in Olfactory Neuroepithelium Cells. | Galindo L et al. | β | 2018 | β |
| Effects of regular cannabis use on neurocognition, brain structure, and function: a systematic review of findings in adults. | Nader DA et al. | β | 2018 | β |
| Integrating Endocannabinoid Signaling and Cannabinoids into the Biology and Treatment of Posttraumatic Stress Disorder. | Hill MN et al. | β | 2018 | β |
| Is cannabis a risk factor for suicide attempts in men and women with psychotic illness? | Waterreus A et al. | β | 2018 | β |
| Sweet flowers are slow, and weeds make haste: leveraging methodology from research on tobacco, alcohol, and opioid analgesics to make rapid and policy-relevant advances in cannabis science. | Herrmann ES et al. | β | 2018 | β |
| The Importance of Drug and Sex Effects in Psychiatric Research. | Hillmer AT | β | 2018 | β |
| Theoretical Explanation for Reduced Body Mass Index and Obesity Rates in <i>Cannabis</i> Users. | Clark TM et al. | β | 2018 | β |
| Building smart cannabis policy from the science up. | Weiss SRB et al. | β | 2017 | β |
| Chemical Tools for Studying Lipid-Binding Class A G Protein-Coupled Receptors. | Cooper A et al. | β | 2017 | β |
| Don't Worry, Be Happy: Endocannabinoids and Cannabis at the Intersection of Stress and Reward. | Volkow ND et al. | β | 2017 | β |
| Effects of Extended Cannabis Abstinence on Cognitive Outcomes in Cannabis Dependent Patients with Schizophrenia vs Non-Psychiatric Controls. | Rabin RA et al. | β | 2017 | β |
| Endocannabinoid Signaling in the Control of Social Behavior. | Wei D et al. | β | 2017 | β |
| Mechanisms contributing to cognitive deficits in cannabis users. | Mizrahi R et al. | β | 2017 | β |
| The serotonin 5-HT<sub>2C</sub> receptor and the non-addictive nature of classic hallucinogens. | Canal CE et al. | β | 2017 | β |
| Effect of cannabis on glutamate signalling in the brain: A systematic review of human and animal evidence. | Colizzi M et al. | β | 2016 | β |
| Endocannabinoid Signaling Regulates Sleep Stability. | Pava MJ et al. | β | 2016 | β |
| Exercise as an adjunctive treatment for cannabis use disorder. | Brellenthin AG et al. | β | 2016 | β |
| Fatty Acid Amide Hydrolase Binding in Brain of Cannabis Users: Imaging With the Novel Radiotracer [<sup>11</sup>C]CURB. | Boileau I et al. | β | 2016 | β |
| Keep off the grass? Cannabis, cognition and addiction. | Curran HV et al. | β | 2016 | β |
| Metabolic syndrome in people with a psychotic illness: is cannabis protective? | Waterreus A et al. | β | 2016 | β |
| PET imaging for addiction medicine: From neural mechanisms to clinical considerations. | Wiers CE et al. | β | 2016 | β |
| Presynaptic G Protein-Coupled Receptors: Gatekeepers of Addiction? | Johnson KA et al. | β | 2016 | β |
| Rapid Changes in Cannabinoid 1 Receptor Availability in Cannabis-Dependent Male Subjects After Abstinence From Cannabis. | D'Souza DC et al. | β | 2016 | β |
| Rapid Changes in CB1 Receptor Availability in Cannabis Dependent Males after Abstinence from Cannabis. | D'Souza DC et al. | β | 2016 | β |
| Reduced Brain Cannabinoid Receptor Availability in Schizophrenia. | Ranganathan M et al. | β | 2016 | β |
| Variable activation in striatal subregions across components of a social influence task in young adult cannabis users. | Gilman JM et al. | β | 2016 | β |
| Endocannabinoid signalling in reward and addiction. | Parsons LH et al. | β | 2015 | β |
| Monoacylglycerol lipase (MGLL) polymorphism rs604300 interacts with childhood adversity to predict cannabis dependence symptoms and amygdala habituation: Evidence from an endocannabinoid system-level analysis. | Carey CE et al. | β | 2015 | β |
| Changes in cerebral CB1 receptor availability after acute and chronic alcohol abuse and monitored abstinence. | Ceccarini J et al. | β | 2014 | β |
| Disrupted gamma-band neural oscillations during coherent motion perception in heavy cannabis users. | Skosnik PD et al. | β | 2014 | β |