Amelioration of fetal alcohol-related neurodevelopmental disorders in rats: exploring pharmacological and environmental treatments.
- Authors
- Hannigan, J H; Berman, R F
- Year
- 2000
- Journal
- Neurotoxicology and teratology
- PMID
- 10642119
- DOI
- 10.1016/s0892-0362(99)00050-1
Fetal alcohol syndrome (FAS) and alcohol-related neurodevelopmental disorders (ARNDs) in children are characterized by life-long compromises in learning, memory, and adaptive responses. Until the advent of effective prevention measures, it will remain necessary to seek ways to treat the life-long neurobehavioral consequences of prenatal alcohol exposure. To date, there are no clinical remedies to recommend for either specific or global fetal alcohol effects. This article reviews our basic research in animal models that assesses the potential of global environmental manipulations or specific psychopharmacological treatments to ameliorate the neurobehavioral effects of prenatal exposure to alcohol. Postweaning environmental enrichment can improve behavioral performance and ameliorate or even eliminate deficits in prenatal alcohol-exposed rats, although there is persistent impairment in neuronal plasticity, as indicated by the failure of hippocampal pyramidal cells to increase dendrite spine density. Behavioral and neural responses to CNS stimulants differ in rats exposed prenatally to alcohol, although it is not clear that these shifts in dose-response curves would predict benefit to children. Although the present results may sound a note of optimism for the development of effective treatment strategies for children with FAS or ARNDs, it is important to consider that application of these findings in rodents may not be straightforward. We also need to know the critical features of specific environments that influence brain development, and the limits of pharmacotherapy, as well as critical periods of exposure. Continued study of the beneficial, ameliorative effects of environmental enrichment, rehabilitative training, and of pharmacological therapies in animal models, will remain a valuable source of information for eventually devising treatments specific for children with FAS and ARNDs.
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| Title | Authors | Journal | Year | Link |
|---|---|---|---|---|
| Environmental enrichment reverses prenatal ethanol exposure-induced attention-deficits in rats. | Wang R et al. | — | 2025 | → |
| Environmental enrichment and complementary clinical interventions as therapeutic approaches for alcohol use disorder in animal models and humans. | Camarini R et al. | — | 2024 | → |
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| Effects of postnatal ethanol exposure and maternal separation on mood, cognition and hippocampal arborization in adolescent rats. | Bianco CD et al. | — | 2021 | → |
| Prenatal Ethanol Exposure and Postnatal Environmental Intervention Alter Dopaminergic Neuron and Microglia Morphology in the Ventral Tegmental Area During Adulthood. | Aghaie CI et al. | — | 2020 | → |
| Effects of ethanol and varenicline on female Sprague-Dawley rats in a third trimester model of fetal alcohol syndrome. | Montgomery KS et al. | — | 2018 | → |
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