The Irish Affected Sib Pair Study of Alcohol Dependence: study methodology and validation of diagnosis by interview and family history.
- Authors
- Prescott, Carol A; Sullivan, Patrick F; Myers, John M; Patterson, Diana G; Devitt, Margaret; Halberstadt, Lisa J; Walsh, Dermot; Kendler, Kenneth S
- Year
- 2005
- Journal
- Alcoholism, clinical and experimental research
- PMID
- 15770118
- DOI
- 10.1097/01.alc.0000156085.50418.07
BACKGROUND: This article is the first report of the Irish Affected Sib Pair Study of Alcohol Dependence, whose goal is to detect the genomic location of susceptibility loci for alcohol dependence (AD). This article describes phenotypic characteristics of the probands, siblings, and parents included in the sample and examines agreement among different sources of diagnostic information, including the validity of family history (FH) assessment. METHODS: Structured diagnostic interviews were conducted with 1414 individuals from 591 families ascertained in Ireland. AD was assessed among 1201 probands and affected siblings with use of the Semi-Structured Assessment for the Genetics of Alcoholism and among 213 parents with use of a modified version of the Structured Clinical Interview for DSM. Probands and siblings were also assessed for drinking history, comorbid disorders, and other clinical characteristics. FH reports based on FH-Research Diagnostic Criteria were obtained for 1113 of these individuals as well as for 3652 first-degree relatives who were not interviewed. RESULTS: Sample characteristics confirm the severity of AD among the affected individuals. Agreement between FH ratings and diagnoses based on direct interviews was high for both parent-offspring and sibling-sibling comparisons (e.g., positive and negative predictive values > 80% for a range of cutoffs). Agreement among individuals about their family members was also high for a single item (1 month or more of drinking problems, tetrachoric r = 0.86-0.98), the total number of DSM-IV AD symptoms (polychoric r = 0.86-0.96), and classifications based on a range of cutoffs (kappa = 0.75-0.80). Use of multiple informants improved classification accuracy only slightly (6-10%). CONCLUSIONS: The authors successfully collected data for a large sample of affected sibling pairs for molecular genetic analysis of AD. Individuals with AD were able to provide accurate evaluations of alcoholism symptoms in their parents and adult siblings. A single screening item performed nearly as well as the full scale. Collecting information from multiple informants may not be cost effective for the gain in predictive accuracy. FH information collected from affected informants can be a valuable source of diagnostic information for family studies of alcoholism.
No figures extracted from this document.
No chunks — full text not yet ingested.
No entities extracted from this document yet.
No uploaded files.
No citations found.
In this knowledge base
External
| Title | Authors | Journal | Year | Link |
|---|---|---|---|---|
| Case-only exome variation analysis of severe alcohol dependence using a multivariate hierarchical gene clustering approach. | Gentry AE et al. | — | 2023 | → |
| Polygenic Risk Score Prediction of Alcohol Dependence Symptoms Across Population-Based and Clinically Ascertained Samples. | Savage JE et al. | — | 2018 | → |
| Genomewide Association Study of Alcohol Dependence Identifies Risk Loci Altering Ethanol-Response Behaviors in Model Organisms. | Adkins AE et al. | — | 2017 | → |
| The Subjective Response to Nitrous Oxide is a Potential Pharmaco-Endophenotype for Alcohol Use Disorder: A Preliminary Study with Heavy Drinkers. | Walsh K et al. | — | 2017 | → |
| Association of respondent psychiatric comorbidity with family history of comorbidity: Results from the National Epidemiologic Survey on Alcohol and Related Conditions-III. | Jung J et al. | — | 2016 | → |
| Examination of the population attributable risk of different risk factor domains for suicidal thoughts and behaviors. | Bruffaerts R et al. | — | 2015 | → |
| Brain reward region responsivity of adolescents with and without parental substance use disorders. | Stice E et al. | — | 2014 | → |
| Why Do Some Irish Drink So Much? Family, Historical and Regional Effects on Students' Alcohol Consumption and Subjective Normative Thresholds. | Delaney L et al. | — | 2013 | → |
| Parent psychopathology and offspring mental disorders: results from the WHO World Mental Health Surveys. | McLaughlin KA et al. | — | 2012 | → |
| Pathway based analysis of genotypes in relation to alcohol dependence. | Reimers MA et al. | — | 2012 | → |
| An Interdisciplinary Approach to Studying Gene-Environment Interactions: From Twin Studies to Gene Identification and Back. | Dick DM | — | 2011 | → |
| Brief report of a test of differential alcohol risk using sibling attributions of paternal alcoholism. | Boynton MH et al. | — | 2011 | → |
| Different phenotypic and genotypic presentations in alcohol dependence: age at onset matters. | Chen YC et al. | — | 2011 | → |
| Genomewide association analysis of symptoms of alcohol dependence in the molecular genetics of schizophrenia (MGS2) control sample. | Kendler KS et al. | — | 2011 | → |
| Limited associations of dopamine system genes with alcohol dependence and related traits in the Irish Affected Sib Pair Study of Alcohol Dependence (IASPSAD). | Hack LM et al. | — | 2011 | → |
| Measures of current alcohol consumption and problems: two independent twin studies suggest a complex genetic architecture. | Dick DM et al. | — | 2011 | → |
| A systematic gene-based screen of chr4q22-q32 identifies association of a novel susceptibility gene, DKK2, with the quantitative trait of alcohol dependence symptom counts. | Kalsi G et al. | — | 2010 | → |
| Empirically defined subtypes of alcohol dependence in an Irish family sample. | Sintov ND et al. | — | 2010 | → |
| Genetic research: who is at risk for alcoholism. | Foroud T et al. | — | 2010 | → |
| Genome-wide linkage scans for major depression in individuals with alcohol dependence. | Kuo PH et al. | — | 2010 | → |
| Harsh physical punishment as a specific childhood adversity linked to adult drinking consequences: evidence from China. | Cheng HG et al. | — | 2010 | → |
| Linkage analysis of alcohol dependence symptoms in the community. | Hansell NK et al. | — | 2010 | → |
| Associations of glutamate decarboxylase genes with initial sensitivity and age-at-onset of alcohol dependence in the Irish Affected Sib Pair Study of Alcohol Dependence. | Kuo PH et al. | — | 2009 | → |
| Predictive value of family history on severity of illness: the case for depression, anxiety, alcohol dependence, and drug dependence. | Milne BJ et al. | — | 2009 | → |
| Predictors of illicit substance dependence among individuals with alcohol dependence. | Sintov ND et al. | — | 2009 | → |
| The validity of the family history screen for assessing family history of mental disorders. | Milne BJ et al. | — | 2009 | → |
| Addiction science and its genetics. | Ball D | — | 2008 | → |
| Adult transition from at-risk drinking to alcohol dependence: the relationship of family history and drinking motives. | Beseler CL et al. | — | 2008 | → |
| Association of ADH and ALDH genes with alcohol dependence in the Irish Affected Sib Pair Study of alcohol dependence (IASPSAD) sample. | Kuo PH et al. | — | 2008 | → |
| Do the same genetic and environmental effects underlie the covariation of alcohol dependence, smoking, and aggressive behaviour? | von der Pahlen B et al. | — | 2008 | → |
| Genomewide linkage survey of nicotine dependence phenotypes. | Sullivan PF et al. | — | 2008 | → |
| How should we construct psychiatric family history scores? A comparison of alternative approaches from the Dunedin Family Health History Study. | Milne BJ et al. | — | 2008 | → |
| The genetics of alcohol and other drug dependence. | Dick DM et al. | — | 2008 | → |
| A genome-wide linkage analysis for the personality trait neuroticism in the Irish affected sib-pair study of alcohol dependence. | Kuo PH et al. | — | 2007 | → |
| Substance use disorder (SUD) morbidity versus number of parents with SUD. | Westermeyer J et al. | — | 2007 | → |
| Validity, reliability and objectivity of the family history method in psychiatry: a meta analysis. | Hardt J et al. | — | 2007 | → |
| Alcohol dependence is associated with the ZNF699 gene, a human locus related to Drosophila hangover, in the Irish Affected Sib Pair Study of Alcohol Dependence (IASPSAD) sample. | Riley BP et al. | — | 2006 | → |
| Genomewide linkage study in the Irish affected sib pair study of alcohol dependence: evidence for a susceptibility region for symptoms of alcohol dependence on chromosome 4. | Prescott CA et al. | — | 2006 | → |
| The genetics of alcohol dependence. | Dick DM et al. | — | 2006 | → |