Fyn-kinase as a determinant of ethanol sensitivity: relation to NMDA-receptor function.
paper
Cited
Public
Unavailable
- Authors
- Miyakawa, T; Yagi, T; Kitazawa, H; Yasuda, M; Kawai, N; Tsuboi, K; Niki, H
- Year
- 1997
- Journal
- Science (New York, N.Y.)
- PMID
- 9381182
- DOI
- 10.1126/science.278.5338.698
Animals vary in their sensitivity to ethanol, a trait at least partly determined by genetic factors. In order to identify possible responsible genes, mice lacking Fyn, a non-receptor type tyrosine kinase, were investigated. These mice were hypersensitive to the hypnotic effect of ethanol. The administration of ethanol enhanced tyrosine phosphorylation of the N-methyl-D-aspartate receptor (NMDAR) in the hippocampus of control mice but not in Fyn-deficient mice. An acute tolerance to ethanol inhibition of NMDAR-mediated excitatory postsynaptic potentials in hippocampal slices developed in control mice but not in Fyn-deficient mice. These results indicate that Fyn affects behavioral, biochemical, and physiological responses to ethanol.
No figures extracted from this document.
No chunks β full text not yet ingested.
No entities extracted from this document yet.
No uploaded files.
Not in any collection.
No citations found.
In this knowledge base
External
| Title | Authors | Journal | Year | Link |
|---|---|---|---|---|
| FYN Tyrosine Kinase Gene Polymorphisms in Alcohol-Dependent Korean Patients. | Huh SY et al. | β | 2025 | β |
| Synaptic Effects Induced by Alcohol. | Lovinger DM et al. | β | 2025 | β |
| Plasma Amino Acid Concentrations in Patients with Alcohol and/or Cocaine Use Disorders and Their Association with Psychiatric Comorbidity and Sex. | GarcΓa-Marchena N et al. | β | 2022 | β |
| Single-dose ethanol intoxication causes acute and lasting neuronal changes in the brain. | Knabbe J et al. | β | 2022 | β |
| The role of the type 7 adenylyl cyclase isoform in alcohol use disorder and depression. | Tabakoff B et al. | β | 2022 | β |
| cAMP-Fyn signaling in the dorsomedial striatum direct pathway drives excessive alcohol use. | Ehinger Y et al. | β | 2021 | β |
| cAMP-Fyn signaling in the dorsomedial striatum direct pathway drives excessive alcohol use | Ehinger Y et al. | β | 2020 | β |
| Chronic alcohol disrupts hypothalamic responses to stress by modifying CRF and NMDA receptor function. | Marty VN et al. | β | 2020 | β |
| Neonatal ethanol exposure triggers apoptosis in the murine retrosplenial cortex: Role of inhibition of NMDA receptor-driven action potential firing. | Bird CW et al. | β | 2020 | β |
| Nonphosphorylatable Src Ser75 Mutation Increases Ethanol Preference and Consumption in Mice. | Kato G | β | 2019 | β |
| The Fyn kinase inhibitor, AZD0530, suppresses mouse alcohol self-administration and seeking. | Morisot N et al. | β | 2019 | β |
| A Critical Review of Methods and Results in the Search for Genetic Contributors to Alcohol Sensitivity. | Schuckit MA | β | 2018 | β |
| GABA and Glutamate Synaptic Coadaptations to Chronic Ethanol in the Striatum. | Cuzon Carlson VC | β | 2018 | β |
| Alcohol-dependent molecular adaptations of the NMDA receptor system. | Morisot N et al. | β | 2017 | β |
| Cyclooxygenase 2: protein-protein interactions and posttranslational modifications. | Alexanian A et al. | β | 2017 | β |
| Src-dependent phosphorylation of ΞΌ-opioid receptor at Tyr<sup>336</sup> modulates opiate withdrawal. | Zhang L et al. | β | 2017 | β |
| Synaptic targets: Chronic alcohol actions. | Roberto M et al. | β | 2017 | β |
| The Insula and Taste Learning. | Yiannakas A et al. | β | 2017 | β |
| Effects of sex and DTNBP1 (dysbindin) null gene mutation on the developmental GluN2B-GluN2A switch in the mouse cortex and hippocampus. | Sinclair D et al. | β | 2016 | β |
| Tyrosine phosphorylation of glutamate receptors by non-receptor tyrosine kinases: roles in depression-like behavior. | Mao LM et al. | β | 2016 | β |
| Alteration of glutamate/GABA balance during acute alcohol intoxication in rats: effect of Xingnaojing injection. | Wei J et al. | β | 2015 | β |
| Identification of new phosphorylation sites of AMPA receptors in the rat hippocampus--A resource for neuroscience research. | Ghafari M et al. | β | 2015 | β |
| Role of the Fyn -93A>G polymorphism (rs706895) in acute rejection after liver transplantation. | Thude H et al. | β | 2015 | β |
| Structural reorganization of pyramidal neurons in the medial prefrontal cortex of alcohol dependent rats is associated with altered glial plasticity. | Kim A et al. | β | 2015 | β |
| Acute and chronic effects of ethanol on learning-related synaptic plasticity. | Zorumski CF et al. | β | 2014 | β |
| Neurochemical mechanisms of alcohol withdrawal. | Becker HC et al. | β | 2014 | β |
| Pleiotrophin differentially regulates the rewarding and sedative effects of ethanol. | Vicente-RodrΓguez M et al. | β | 2014 | β |
| The mammalian circadian clock in the suprachiasmatic nucleus exhibits rapid tolerance to ethanol in vivo and in vitro. | Lindsay JH et al. | β | 2014 | β |
| Alzheimer's disease risk factor lymphocyte-specific protein tyrosine kinase regulates long-term synaptic strengthening, spatial learning and memory. | Kim EJ et al. | β | 2013 | β |
| Dephosphorylation of GluN2B C-terminal tyrosine residues does not contribute to acute ethanol inhibition of recombinant NMDA receptors. | Hughes BA et al. | β | 2013 | β |
| Ethanol affects NMDA receptor signaling at climbing fiber-Purkinje cell synapses in mice and impairs cerebellar LTD. | He Q et al. | β | 2013 | β |
| Fyn-dependent gene networks in acute ethanol sensitivity. | Farris SP et al. | β | 2013 | β |
| Synaptic effects induced by alcohol. | Lovinger DM et al. | β | 2013 | β |
| The neurobiology of alcohol consumption and alcoholism: an integrative history. | Tabakoff B et al. | β | 2013 | β |
| Acute effects of ethanol on glutamate receptors. | MΓΆykkynen T et al. | β | 2012 | β |
| Adenosine and glutamate signaling in neuron-glial interactions: implications in alcoholism and sleep disorders. | Nam HW et al. | β | 2012 | β |
| Decreased sensitivity of NMDA receptors on dopaminergic neurons from the posterior ventral tegmental area following chronic nondependent alcohol consumption. | Fitzgerald GJ et al. | β | 2012 | β |
| Glucocorticoid and polyamine interactions in the plasticity of glutamatergic synapses that contribute to ethanol-associated dependence and neuronal injury. | Prendergast MA et al. | β | 2012 | β |
| Interactions among positions in the third and fourth membrane-associated domains at the intersubunit interface of the N-methyl-D-aspartate receptor forming sites of alcohol action. | Ren H et al. | β | 2012 | β |
| Neuropeptide modulation of central amygdala neuroplasticity is a key mediator of alcohol dependence. | Gilpin NW et al. | β | 2012 | β |
| Pilot study of iPS-derived neural cells to examine biologic effects of alcohol on human neurons in vitro. | Lieberman R et al. | β | 2012 | β |
| Prion protein is a key determinant of alcohol sensitivity through the modulation of N-methyl-D-aspartate receptor (NMDAR) activity. | Petit-Paitel A et al. | β | 2012 | β |
| Regulation of NMDA receptors by the tyrosine kinase Fyn. | Trepanier CH et al. | β | 2012 | β |
| Timing-dependent reduction in ethanol sedation and drinking preference by NMDA receptor co-agonist d-serine. | Lockridge A et al. | β | 2012 | β |
| Alcohol inhibition of the NMDA receptor function, long-term potentiation, and fear learning requires striatal-enriched protein tyrosine phosphatase. | Hicklin TR et al. | β | 2011 | β |
| Ethanol-induced increase in Fyn kinase activity in the dorsomedial striatum is associated with subcellular redistribution of protein tyrosine phosphatase Ξ±. | Gibb SL et al. | β | 2011 | β |
| Functional adaptation of the N-methyl-D-aspartate receptor to inhibition by ethanol is modulated by striatal-enriched protein tyrosine phosphatase and p38 mitogen-activated protein kinase. | Wu PH et al. | β | 2011 | β |
| Fyn polymorphisms are associated with distinct personality traits in healthy Chinese-Han subjects. | Li J et al. | β | 2011 | β |
| p59fyn is associated with the development of hepatic steatosis due to chronic ethanol consumption. | Fukunishi S et al. | β | 2011 | β |
| Phosphoprotein associated with glycosphingolipid-enriched microdomains differentially modulates SRC kinase activity in brain maturation. | Lindquist S et al. | β | 2011 | β |
| Regulation of NMDA receptor subunits after acute ethanol treatment in rat brain. | Roh MS et al. | β | 2011 | β |
| Roles of the SH2 and SH3 domains in the regulation of neuronal Src kinase functions. | Groveman BR et al. | β | 2011 | β |
| Src family kinases: modulators of neurotransmitter receptor function and behavior. | Ohnishi H et al. | β | 2011 | β |
| beta-adducin (Add2) KO mice show synaptic plasticity, motor coordination and behavioral deficits accompanied by changes in the expression and phosphorylation levels of the alpha- and gamma-adducin subunits. | Porro F et al. | β | 2010 | β |
| Candidate genes for alcohol preference identified by expression profiling in alcohol-preferring and -nonpreferring reciprocal congenic rats. | Liang T et al. | β | 2010 | β |
| Contribution of intracellular Ca2+ concentration and protein dephosphorylation to the induction of dopamine release from PC12 cells by the green odor compound hexanal. | Kobayashi Y et al. | β | 2010 | β |
| Correlated changes in NMDA receptor phosphorylation, functional activity, and sedation by chronic ethanol consumption. | Wu PH et al. | β | 2010 | β |
| Ethanol acutely inhibits ionotropic glutamate receptor-mediated responses and long-term potentiation in the developing CA1 hippocampus. | Puglia MP et al. | β | 2010 | β |
| Decreased expression of Fyn protein and disbalanced alternative splicing patterns in platelets from patients with schizophrenia. | Hattori K et al. | β | 2009 | β |
| Genetic association between -93A/G polymorphism in the Fyn kinase gene and alcohol dependence in Spanish men. | Pastor IJ et al. | β | 2009 | β |
| Involvement of protein kinase C and Src tyrosine kinase in acute tolerance to ethanol inhibition of spinal NMDA-induced pressor responses in rats. | Hsieh WK et al. | β | 2009 | β |
| Tyrosine phosphorylation of the 2B subunit of the NMDA receptor is necessary for taste memory formation. | Barki-Harrington L et al. | β | 2009 | β |
| Actin depolymerization contributes to ethanol inhibition of NMDA receptors in primary cultured cerebellar granule cells. | Popp RL et al. | β | 2008 | β |
| Activin induces long-lasting N-methyl-D-aspartate receptor activation via scaffolding PDZ protein activin receptor interacting protein 1. | Kurisaki A et al. | β | 2008 | β |
| Alcohol related changes in regulation of NMDA receptor functions. | Nagy J | β | 2008 | β |
| Communication networks in the brain: neurons, receptors, neurotransmitters, and alcohol. | Lovinger DM | β | 2008 | β |
| Ethanol inhibition of recombinant NMDA receptors is not altered by coexpression of CaMKII-alpha or CaMKII-beta. | Xu M et al. | β | 2008 | β |
| Fyn is a novel target of (-)-epigallocatechin gallate in the inhibition of JB6 Cl41 cell transformation. | He Z et al. | β | 2008 | β |
| Glutamatergic substrates of drug addiction and alcoholism. | Gass JT et al. | β | 2008 | β |
| Localization of phospho-tyrosine489-beta-adducin immunoreactivity in the hypothalamic tanycytes and its involvement in energy homeostasis. | Gotoh H et al. | β | 2008 | β |
| Mind bomb-2 is an E3 ligase that ubiquitinates the N-methyl-D-aspartate receptor NR2B subunit in a phosphorylation-dependent manner. | Jurd R et al. | β | 2008 | β |
| Protein kinases and addiction. | Lee AM et al. | β | 2008 | β |
| Review. Genetics of addictions: strategies for addressing heterogeneity and polygenicity of substance use disorders. | Wong CC et al. | β | 2008 | β |
| Adaptive plasticity of NMDA receptors and dendritic spines: implications for enhanced vulnerability of the adolescent brain to alcohol addiction. | Carpenter-Hyland EP et al. | β | 2007 | β |
| Alterations of NR2B and PSD-95 expression after early-life epileptiform discharges in developing neurons. | Jiang Q et al. | β | 2007 | β |
| Candidate genes, pathways and mechanisms for alcoholism: an expanded convergent functional genomics approach. | Rodd ZA et al. | β | 2007 | β |
| Ethanol inhibits persistent activity in prefrontal cortical neurons. | Tu Y et al. | β | 2007 | β |
| Fyn-mediated phosphorylation of NR2B Tyr-1336 controls calpain-mediated NR2B cleavage in neurons and heterologous systems. | Wu HY et al. | β | 2007 | β |
| Maternal alcohol consumption increases sphingosine levels in the brains of progeny mice. | Dasgupta S et al. | β | 2007 | β |
| The novel cellular mechanism of human 5-HT6 receptor through an interaction with Fyn. | Yun HM et al. | β | 2007 | β |
| Alcohol potently modulates climbing fiber-->Purkinje neuron synapses: role of metabotropic glutamate receptors. | Carta M et al. | β | 2006 | β |
| Alcohol-related genes: contributions from studies with genetically engineered mice. | Crabbe JC et al. | β | 2006 | β |
| Altered gene expression in the subdivisions of the amygdala of Fyn-deficient mice as revealed by laser capture microdissection and mKIAA cDNA array analysis. | Kai N et al. | β | 2006 | β |
| Candidate genes and their regulatory elements: alcohol preference and tolerance. | Saba L et al. | β | 2006 | β |
| Chronic ethanol exposure and protracted abstinence alter NMDA receptors in central amygdala. | Roberto M et al. | β | 2006 | β |
| Coincident signaling in mesolimbic structures underlying alcohol reinforcement. | Zhang TA et al. | β | 2006 | β |
| Effects of acamprosate on sleep during alcohol withdrawal: A double-blind placebo-controlled polysomnographic study in alcohol-dependent subjects. | Staner L et al. | β | 2006 | β |
| Ethanol and the tobacco-specific carcinogen, NNK, contribute to signaling in immortalized human pancreatic duct epithelial cells. | Askari MD et al. | β | 2006 | β |
| Ethanol-induced hypnotic tolerance is absent in N-methyl-D-aspartate receptor epsilon 1 subunit knockout mice. | Sato Y et al. | β | 2006 | β |
| Ethanol inhibition of NMDA-induced responses and acute tolerance to the inhibition in rat rostral ventrolateral medulla in vivo: Involvement of cAMP-dependent protein kinases. | Lin HH et al. | β | 2006 | β |
| Ethanol inhibition of NMDA receptors under conditions of altered protein kinase A activity. | Xu M et al. | β | 2006 | β |
| Ethanol inhibits clearance of brain serotonin by a serotonin transporter-independent mechanism. | Daws LC et al. | β | 2006 | β |
| Ethanol-related behaviors in mice lacking the NMDA receptor NR2A subunit. | Boyce-Rustay JM et al. | β | 2006 | β |
| Functional dissection of Reelin signaling by site-directed disruption of Disabled-1 adaptor binding to apolipoprotein E receptor 2: distinct roles in development and synaptic plasticity. | Beffert U et al. | β | 2006 | β |
| Fyn is required for haloperidol-induced catalepsy in mice. | Hattori K et al. | β | 2006 | β |
| Intracellular signaling pathways that regulate behavioral responses to ethanol. | Newton PM et al. | β | 2006 | β |
| Investigating gene-to-behavior pathways in psychiatric disorders: the use of a comprehensive behavioral test battery on genetically engineered mice. | Takao K et al. | β | 2006 | β |
| NMDA-receptor proteins are upregulated in the hippocampus of postnatal heterozygous reeler mice. | Isosaka T et al. | β | 2006 | β |
| Physical and functional interaction of Fyn tyrosine kinase with a brain-enriched Rho GTPase-activating protein TCGAP. | Liu H et al. | β | 2006 | β |
| The Role of Intracellular Sodium in the Regulation of NMDA-Receptor-Mediated Channel Activity and Toxicity. | Yu XM | β | 2006 | β |
| Absence of Fyn and Src causes a reeler-like phenotype. | Kuo G et al. | β | 2005 | β |
| Acute effects of ethanol on hippocampal long-term potentiation and long-term depression are mediated by different mechanisms. | Izumi Y et al. | β | 2005 | β |
| Depolarization activates ERK and proline-rich tyrosine kinase 2 (PYK2) independently in different cellular compartments in hippocampal slices. | Corvol JC et al. | β | 2005 | β |
| Developmentally regulated actions of alcohol on hippocampal glutamatergic transmission. | Mameli M et al. | β | 2005 | β |
| Effect of perinatal alcohol exposure on ibotenic acid-induced excitotoxic cortical lesions in newborn hamsters. | Adde-Michel C et al. | β | 2005 | β |
| Ethanol alters trafficking and functional N-methyl-D-aspartate receptor NR2 subunit ratio via H-Ras. | Suvarna N et al. | β | 2005 | β |
| Ethanol triggers neural crest apoptosis through the selective activation of a pertussis toxin-sensitive G protein and a phospholipase Cbeta-dependent Ca2+ transient. | Garic-Stankovic A et al. | β | 2005 | β |
| Ethanol-withdrawal seizures are controlled by tissue plasminogen activator via modulation of NR2B-containing NMDA receptors. | Pawlak R et al. | β | 2005 | β |
| Functional roles of NMDA receptor NR2A and NR2B subunits in the acute intoxicating effects of ethanol in mice. | Boyce-Rustay JM et al. | β | 2005 | β |
| Gene expression in animals with different acute responses to ethanol. | Hoffman P et al. | β | 2005 | β |
| Memantine inhibits ethanol-induced NMDA receptor up-regulation in rat hippocampal neurons. | Maler JM et al. | β | 2005 | β |
| Role of altered structure and function of NMDA receptors in development of alcohol dependence. | Nagy J et al. | β | 2005 | β |
| Role of AP-1 in ethanol-induced N-methyl-D-aspartate receptor 2B subunit gene up-regulation in mouse cortical neurons. | Qiang M et al. | β | 2005 | β |
| [The NMDA receptor system: genetic risk factor for alcoholism]. | Schumann G et al. | β | 2005 | β |
| The "ups and downs" of signaling cascades in addiction. | Ron D et al. | β | 2005 | β |
| Acute effects of alcohol on larval zebrafish: a genetic system for large-scale screening. | Lockwood B et al. | β | 2004 | β |
| Auditory-conditioned-fear-dependent c-Fos expression is altered in the emotion-related brain structures of Fyn-deficient mice. | Kubota O et al. | β | 2004 | β |
| Cadherin-related neuronal receptor 1 (CNR1) has cell adhesion activity with beta1 integrin mediated through the RGD site of CNR1. | Mutoh T et al. | β | 2004 | β |
| Characterization of acute functional tolerance to the hypnotic effects of ethanol in mice. | Ponomarev I et al. | β | 2004 | β |
| Chronic ethanol induces synaptic but not extrasynaptic targeting of NMDA receptors. | Carpenter-Hyland EP et al. | β | 2004 | β |
| Deletion of the fyn-kinase gene alters sensitivity to GABAergic drugs: dependence on beta2/beta3 GABAA receptor subunits. | Boehm SL et al. | β | 2004 | β |
| Ethanol effects on cell signaling mechanisms. | Morrow AL et al. | β | 2004 | β |
| Ethanol-response genes and their regulation analyzed by a microarray and comparative genomic approach in the nematode Caenorhabditis elegans. | Kwon JY et al. | β | 2004 | β |
| Fyn kinase does not reduce ethanol inhibition of zinc-insensitive NR2A-containing N-methyl-D-aspartate receptors. | Woodward JJ | β | 2004 | β |
| Imidazoquinoxaline Src-family kinase p56Lck inhibitors: SAR, QSAR, and the discovery of (S)-N-(2-chloro-6-methylphenyl)-2-(3-methyl-1-piperazinyl)imidazo- [1,5-a]pyrido[3,2-e]pyrazin-6-amine (BMS-279700) as a potent and orally active inhibitor with excellent in vivo antiinflammatory activity. | Chen P et al. | β | 2004 | β |
| Over-expression of the fyn-kinase gene reduces hypnotic sensitivity to ethanol in mice. | Boehm SL et al. | β | 2004 | β |
| Pharmacogenetic insights to monoaminergic dysfunction in alcohol dependence. | Heinz A et al. | β | 2004 | β |
| Signaling cascades regulating NMDA receptor sensitivity to ethanol. | Ron D | β | 2004 | β |
| The dual response of protein kinase Fyn to neural trauma: early induction in neurons and delayed induction in reactive astrocytes. | Chun JT et al. | β | 2004 | β |
| Tyrosine phosphorylation and regulation of the AMPA receptor by SRC family tyrosine kinases. | Hayashi T et al. | β | 2004 | β |
| Acute ethanol affects phosphorylation state of the NMDA receptor complex: implication of tyrosine phosphatases and protein kinase A. | Ferrani-Kile K et al. | β | 2003 | β |
| Analysis of genetic variations of protein tyrosine kinase fyn and their association with alcohol dependence in two independent cohorts. | Schumann G et al. | β | 2003 | β |
| Candidate genes for alcohol dependence: animal studies. | Schumann G et al. | β | 2003 | β |
| Deletion of the fyn-kinase gene alters behavioral sensitivity to ethanol. | Boehm SL et al. | β | 2003 | β |
| Ectopic corticospinal tract and corticothalamic tract neurons in the cerebral cortex of yotari and reeler mice. | Yamamoto T et al. | β | 2003 | β |
| Ethanol and brain plasticity: receptors and molecular networks of the postsynaptic density as targets of ethanol. | Chandler LJ | β | 2003 | β |
| Ethanol modulation of excitatory and inhibitory synaptic transmission in rat and monkey dentate granule neurons. | Ariwodola OJ et al. | β | 2003 | β |
| Ethanol withdrawal hyper-responsiveness mediated by NMDA receptors in spinal cord motor neurons. | Li HF et al. | β | 2003 | β |
| Fyn kinase and NR2B-containing NMDA receptors regulate acute ethanol sensitivity but not ethanol intake or conditioned reward. | Yaka R et al. | β | 2003 | β |
| Fyn tyrosine kinase is a critical regulator of disabled-1 during brain development. | Arnaud L et al. | β | 2003 | β |
| Inhibition by ethanol of NMDA-induced responses and acute tolerance to the inhibition in rat sympathetic preganglionic neurons in vitro and in vivo. | Lin HH et al. | β | 2003 | β |
| Inhibition of protein kinase C reduces ischemia-induced tyrosine phosphorylation of the N-methyl-d-aspartate receptor. | Cheung HH et al. | β | 2003 | β |
| Interactions between Src family protein tyrosine kinases and PSD-95. | Kalia LV et al. | β | 2003 | β |
| Invertebrate models of drug abuse. | Wolf FW et al. | β | 2003 | β |
| NMDA receptors in alcoholism. | Hoffman PL | β | 2003 | β |
| N-methyl-D-aspartate glutamate receptors and alcoholism: reward, dependence, treatment, and vulnerability. | Krystal JH et al. | β | 2003 | β |
| p250GAP, a neural RhoGAP protein, is associated with and phosphorylated by Fyn. | Taniguchi S et al. | β | 2003 | β |
| Polymorphisms in the N-methyl-D-aspartate receptor 1 and 2B subunits are associated with alcoholism-related traits. | Wernicke C et al. | β | 2003 | β |
| Role of Fyn tyrosine kinase in ethanol consumption by mice. | Cowen MS et al. | β | 2003 | β |
| Scaffolding of Fyn kinase to the NMDA receptor determines brain region sensitivity to ethanol. | Yaka R et al. | β | 2003 | β |
| Selective breeding, quantitative trait locus analysis, and gene arrays identify candidate genes for complex drug-related behaviors. | Tabakoff B et al. | β | 2003 | β |
| The N-methyl-D-aspartate receptor subunit NR2B: localization, functional properties, regulation, and clinical implications. | Loftis JM et al. | β | 2003 | β |
| Transient ischemia enhances tyrosine phosphorylation and binding of the NMDA receptor to the Src homology 2 domain of phosphatidylinositol 3-kinase in the rat hippocampus. | Takagi N et al. | β | 2003 | β |
| Tyrosine dephosphorylation and ethanol inhibition of N-Methyl-D-aspartate receptor function. | Alvestad RM et al. | β | 2003 | β |
| Decay of ethanol-induced suppression of glycine-activated current of ventral tegmental area neurons. | Ye JH et al. | β | 2002 | β |
| Ethanol antagonizes kainate receptor-mediated inhibition of evoked GABA(A) inhibitory postsynaptic currents in the rat hippocampal CA1 region. | Crowder TL et al. | β | 2002 | β |
| Ethanol-induced Cas tyrosine phosphorylation and Fyn kinase activation in rat brain. | Nishio H et al. | β | 2002 | β |
| Ethanol-mediated inhibition of mitogen-activated protein kinase phosphorylation in mouse brain. | Kalluri HS et al. | β | 2002 | β |
| Fermenting fruit and the historical ecology of ethanol ingestion: is alcoholism in modern humans an evolutionary hangover? | Dudley R | β | 2002 | β |
| Fyn tyrosine kinase in Sertoli cells is involved in mouse spermatogenesis. | Maekawa M et al. | β | 2002 | β |
| Molecular mechanisms of analgesia induced by opioids and ethanol: is the GIRK channel one of the keys? | Ikeda K et al. | β | 2002 | β |
| NMDA receptors lose their inhibitions. | Lovinger DM | β | 2002 | β |
| Novel antagonists of alcohol inhibition of l1-mediated cell adhesion: multiple mechanisms of action. | Wilkemeyer MF et al. | β | 2002 | β |
| Phosphorylation of c-Cbl protooncogene product following ethanol administration in rat cerebellum: possible involvement of Fyn kinase. | Nishio H et al. | β | 2002 | β |
| Resistance to alcohol withdrawal-induced behaviour in Fyn transgenic mice and its reversal by ifenprodil. | Stork O et al. | β | 2002 | β |
| Retinoic acid inhibits hepatic Jun N-terminal kinase-dependent signaling pathway in ethanol-fed rats. | Chung J et al. | β | 2002 | β |
| Role of GABA(A) receptors in the ethanol-mediated inhibition of extracellular signal-regulated kinase. | Kalluri HS et al. | β | 2002 | β |
| Studying the neurobiology of stimulant and alcohol abuse and dependence in genetically manipulated mice. | Stephens DN et al. | β | 2002 | β |
| Activated Fyn phosphorylates alpha-synuclein at tyrosine residue 125. | Nakamura T et al. | β | 2001 | β |
| Altered effects of ethanol in NR2A(DeltaC/DeltaC) mice expressing C-terminally truncated NR2A subunit of NMDA receptor. | Gordey M et al. | β | 2001 | β |
| A unique role for Fyn in CNS myelination. | Sperber BR et al. | β | 2001 | β |
| Characterization of Fyn-mediated tyrosine phosphorylation sites on GluR epsilon 2 (NR2B) subunit of the N-methyl-D-aspartate receptor. | Nakazawa T et al. | β | 2001 | β |
| Differential effect of Fyn tyrosine kinase deletion on offensive and defensive aggression. | Miyakawa T et al. | β | 2001 | β |
| Dual role of Fyn in the regulation of FAK+6,7 by cannabinoids in hippocampus. | Derkinderen P et al. | β | 2001 | β |
| Ethanol sensitivity of recombinant human N-methyl-D-aspartate receptors. | Smothers CT et al. | β | 2001 | β |
| Fyn tyrosine kinase regulates oligodendroglial cell development but is not required for morphological differentiation of oligodendrocytes. | Sperber BR et al. | β | 2001 | β |
| Interaction of the SH2 domain of Fyn with a cytoskeletal protein, beta-adducin. | Shima T et al. | β | 2001 | β |
| N-Methyl-D-aspartate-induced c-Fos expression is enhanced in the forebrain structures related to emotion in Fyn-deficient mice. | Hattori K et al. | β | 2001 | β |
| Possible involvement of Fyn kinase in ethanol-stimulated Cas tyrosine phosphorylation in rat cerebellum and cerebral cortex. | Nishio H et al. | β | 2001 | β |
| Role of polyamines and NMDA receptors in ethanol dependence and withdrawal. | Littleton JM et al. | β | 2001 | β |
| Seizure activity results in increased tyrosine phosphorylation of the N-methyl-D-aspartate receptor in the hippocampus. | Moussa RC et al. | β | 2001 | β |
| The cadherin-related neuronal receptor family: a novel diversified cadherin family at the synapse. | Hamada S et al. | β | 2001 | β |
| The inebri-actometer: a device for measuring the locomotor activity of Drosophila exposed to ethanol vapor. | Parr J et al. | β | 2001 | β |
| Transgenic and gene "knockout" models in alcohol research. | Hoffman PL et al. | β | 2001 | β |
| Tyrosine phosphorylation of the N-methyl-D-aspartate receptor by exogenous and postsynaptic density-associated Src-family kinases. | Cheung HH et al. | β | 2001 | β |
| Alcohols inhibit N-methyl-D-aspartate receptors via a site exposed to the extracellular environment. | Peoples RW et al. | β | 2000 | β |
| Changes in circadian period and morphology of the hypothalamic suprachiasmatic nucleus in fyn kinase-deficient mice. | Shima T et al. | β | 2000 | β |
| Genetic control of acute ethanol-induced behaviors in Drosophila. | Singh CM et al. | β | 2000 | β |
| Mutation and association analysis of the Fyn kinase gene with alcoholism and schizophrenia. | Ishiguro H et al. | β | 2000 | β |
| Peptide signaling paths related to intoxication, memory and addiction. | Lands WE | β | 2000 | β |
| Regulation of NMDA receptor subunits and nitric oxide synthase expression during cocaine withdrawal. | Loftis JM et al. | β | 2000 | β |
| Signals leading to apoptosis-dependent inhibition of neovascularization by thrombospondin-1. | JimΓ©nez B et al. | β | 2000 | β |
| Sustained ethanol inhibition of native AMPA receptors on medial septum/diagonal band (MS/DB) neurons. | Frye GD et al. | β | 2000 | β |
| Acute effects of ethanol on GABAA and glycine receptor function. | Mihic SJ | β | 1999 | β |
| Alcohol and genetics: new animal models. | Browman KE et al. | β | 1999 | β |
| An ethanol-sensitive variant of the PC12 neuronal cell line: sensitivity to alcohol is associated with increased cell adhesion and decreased glucose accumulation. | Dwyer DS et al. | β | 1999 | β |
| Drugs of abuse and brain gene expression. | Torres G et al. | β | 1999 | β |
| Effect of ethanol on phosphorylation of the NMDAR2B subunit in mouse cortical neurons. | Kalluri HS et al. | β | 1999 | β |
| Effects of c-Src tyrosine kinase on ethanol sensitivity of recombinant NMDA receptors expressed in HEK 293 cells. | Anders DL et al. | β | 1999 | β |
| Enhanced synaptic transmission and reduced threshold for LTP induction in fyn-transgenic mice. | Lu YF et al. | β | 1999 | β |
| Ethanol sensitivity of NMDA receptor function in developing cerebellar granule neurons. | Bhave SV et al. | β | 1999 | β |
| Fyn tyrosine kinase reduces the ethanol inhibition of recombinant NR1/NR2A but not NR1/NR2B NMDA receptors expressed in HEK 293 cells. | Anders DL et al. | β | 1999 | β |
| Growth factor-mediated Fyn signaling regulates alpha-amino-3- hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptor expression in rodent neocortical neurons. | Narisawa-Saito M et al. | β | 1999 | β |
| Ionotropic glutamate receptors as sites of action for ethanol in the brain. | Woodward JJ | β | 1999 | β |
| Metabolic deficiencies in alcohol dehydrogenase Adh1, Adh3, and Adh4 null mutant mice. Overlapping roles of Adh1 and Adh4 in ethanol clearance and metabolism of retinol to retinoic acid. | Deltour L et al. | β | 1999 | β |
| Mutation of putative phosphorylation sites in the 5-hydroxytryptamine3 receptor does not eliminate its modulation by ethanol. | Machu TK et al. | β | 1999 | β |
| Overview of the effects of alcohol on the cerebral nervous system. | Woodward JJ | β | 1999 | β |
| Protein tyrosine phosphatase zeta/RPTPbeta interacts with PSD-95/SAP90 family. | Kawachi H et al. | β | 1999 | β |
| PSD-95 promotes Fyn-mediated tyrosine phosphorylation of the N-methyl-D-aspartate receptor subunit NR2A. | Tezuka T et al. | β | 1999 | β |
| Subunit- and site-specific pharmacology of the NMDA receptor channel. | Yamakura T et al. | β | 1999 | β |
| Supersensitivity to allosteric GABA(A) receptor modulators and alcohol in mice lacking PKCepsilon. | Hodge CW et al. | β | 1999 | β |
| The effect of transient global ischemia on the interaction of Src and Fyn with the N-methyl-D-aspartate receptor and postsynaptic densities: possible involvement of Src homology 2 domains. | Takagi N et al. | β | 1999 | β |
| The glutamatergic system and neurodegeneration in dementia: preventive strategies in Alzheimer's disease. | Cacabelos R et al. | β | 1999 | β |
| Weaver cerebellar granule neurons show altered expression of NMDA receptor subunits both in vivo and in vitro. | Liesi P et al. | β | 1999 | β |
| Abnormal synaptic transmission in the olfactory bulb of Fyn-kinase-deficient mice. | Kitazawa H et al. | β | 1998 | β |
| Acute effects of ethanol on recombinant kainate receptors: lack of role of protein phosphorylation. | Valenzuela CF et al. | β | 1998 | β |
| Alcohol and benzodiazepines: recent mechanistic studies. | Harris RA et al. | β | 1998 | β |
| Clinical assessment of DNA analysis for toxicology. | Weedn VW | β | 1998 | β |
| Diversity revealed by a novel family of cadherins expressed in neurons at a synaptic complex. | Kohmura N et al. | β | 1998 | β |
| Effects of ethanol on mitogen-activated protein kinase and stress-activated protein kinase cascades in normal and regenerating liver. | Chen J et al. | β | 1998 | β |
| Enhanced tyrosine phosphorylation of striatal NMDA receptor subunits: effect of dopaminergic denervation and L-DOPA administration. | Oh JD et al. | β | 1998 | β |
| Ethanol and neurotransmitter interactions--from molecular to integrative effects. | Faingold CL et al. | β | 1998 | β |
| Ethanol intoxication in Drosophila: Genetic and pharmacological evidence for regulation by the cAMP signaling pathway. | Moore MS et al. | β | 1998 | β |
| Ethanol tolerance and synaptic plasticity. | Chandler LJ et al. | β | 1998 | β |
| Fyn, a Src family tyrosine kinase. | Resh MD | β | 1998 | β |
| Genetics of alcohol and other abused drugs. | Crabbe JC et al. | β | 1998 | β |
| High ethanol tolerance in young adults is associated with the low-activity variant of the promoter of the human serotonin transporter gene. | TΓΌrker T et al. | β | 1998 | β |
| N-Methyl-D-aspartate inhibits apoptosis through activation of phosphatidylinositol 3-kinase in cerebellar granule neurons. A role for insulin receptor substrate-1 in the neurotrophic action of n-methyl-D-aspartate and its inhibition by ethanol. | Zhang FX et al. | β | 1998 | β |
| Protein kinase Cdelta mediates ethanol-induced up-regulation of L-type calcium channels. | Gerstin EH et al. | β | 1998 | β |
| The cadherin superfamily at the synapse: more members, more missions. | Uemura T | β | 1998 | β |
| The intracellular signaling network as a target for ethanol. | Hoek JB et al. | β | 1998 | β |
| Tyrosine kinase potentiates NMDA receptor currents by reducing tonic zinc inhibition. | Zheng F et al. | β | 1998 | β |
| New genetic technologies in alcohol research. | Homanics GE et al. | β | 1997 | β |