Anti-stress action of a corticotropin-releasing factor antagonist on behavioral reactivity to stressors of varying type and intensity.
paper
Cited
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- Authors
- Heinrichs, S C; Menzaghi, F; Pich, E M; Baldwin, H A; Rassnick, S; Britton, K T; Koob, G F
- Year
- 1994
- Journal
- Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology
- PMID
- 7865099
- DOI
- 10.1038/sj.npp.1380104
Central administration of a Corticotropin-Releasing Factor (CRF) antagonist is well documented to attenuate a variety of behavioral responses to several distinct stressors; however, it is not yet clear whether the activation of CRF neurons is dependent on the type or intensity of the experimental stressor, or rather on the particular behavioral response to stress under study. To test the generality of the stress-protective effect of the CRF antagonist, alpha-helical CRF9-41, (1, 5 or 25 micrograms intracerebroventricularly), the present experiments employed a sensitive index of anxiogenic-like behavior by measuring suppression in exploration on the elevated plus-maze following exposure to social, swim, or restraint stressors. A 1 but not 5 or 25 micrograms dose of the CRF antagonist administered just prior to social, swim, or restraint stress reversed the stress-induced inhibition of exploratory behavior. Chlordiazepoxide and the steroid anesthetic, alphaxalone, also attenuated the anxiogenic-like effect of restraint stress and elevated the baseline exploratory behavior of nonstressed control groups. Although the stressors produced a graded secretion of adrenocorticotropin (ACTH) with the ranking restraint > swim > social, the relative amplitude of behavioral reactivity to social, swim, and restraint stress was comparable. The relative efficacy of the CRF antagonist to reverse the stressor effects was also comparable. These results suggest that antagonism of activated brain CRF systems attenuates the behavioral response to stress regardless of the type or intensity of the stressor as measured by ACTH secretion.
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|---|---|---|---|---|
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| MECHANISMS IN ENDOCRINOLOGY: Anorexia nervosa and endocrinology: a clinical update. | StΓΈving RK | β | 2019 | β |
| How early media exposure may affect cognitive function: A review of results from observations in humans and experiments in mice. | Christakis DA et al. | β | 2018 | β |
| Social isolation alters central nervous system monoamine content in prairie voles following acute restraint. | McNeal N et al. | β | 2018 | β |
| Corticotropin-Releasing Factor (CRF) and Addictive Behaviors. | Roberto M et al. | β | 2017 | β |
| Localization of the delta opioid receptor and corticotropin-releasing factor in the amygdalar complex: role in anxiety. | Reyes BAS et al. | β | 2017 | β |
| Relaxin' the brain: a case for targeting the nucleus incertus network and relaxin-3/RXFP3 system in neuropsychiatric disorders. | Kumar JR et al. | β | 2017 | β |
| HPA Axis Interactions with Behavioral Systems. | Packard AE et al. | β | 2016 | β |
| Targeting the Brain Stress Systems for the Treatment of Tobacco/Nicotine Dependence: Translating Preclinical and Clinical Findings. | Verplaetse TL et al. | β | 2016 | β |
| CRH Engagement of the Locus Coeruleus Noradrenergic System Mediates Stress-Induced Anxiety. | McCall JG et al. | β | 2015 | β |
| Fibroblast growth factor 8 deficiency compromises the functional response of the serotonergic system to stress. | Brooks LR et al. | β | 2014 | β |
| Possible involvement of GABAergic and nitriergic systems for antianxiety-like activity of piperine in unstressed and stressed mice. | Gilhotra N et al. | β | 2014 | β |
| Possible involvement of nitric oxide mechanism in the neuroprotective effect of rutin against immobilization stress induced anxiety like behaviour, oxidative damage in mice. | Machawal L et al. | β | 2014 | β |
| Repeated intravenous administrations of teneurin-C terminal associated peptide (TCAP)-1 attenuates reinstatement of cocaine seeking by corticotropin-releasing factor (CRF) in rats. | Erb S et al. | β | 2014 | β |
| Ethanol withdrawal-induced depressive symptoms in animals and therapeutic potential of sigma1 receptor ligands. | Skuza G | β | 2013 | β |
| The mGlu2/3 Receptor Agonists LY354740 and LY379268 Differentially Regulate Restraint-Stress-Induced Expression of c-Fos in Rat Cerebral Cortex. | Menezes MM et al. | β | 2013 | β |
| Translational reciprocity: bridging the gap between preclinical studies and clinical treatment of stress effects on the adolescent brain. | Neigh GN et al. | β | 2013 | β |
| Antianxiety-like activity of gallic acid in unstressed and stressed mice: possible involvement of nitriergic system. | Dhingra D et al. | β | 2012 | β |
| Overstimulation of newborn mice leads to behavioral differences and deficits in cognitive performance. | Christakis DA et al. | β | 2012 | β |
| Repeated restraint stress increases basolateral amygdala neuronal activity in an age-dependent manner. | Zhang W et al. | β | 2012 | β |
| The behavioral, anatomical and pharmacological parallels between social attachment, love and addiction. | Burkett JP et al. | β | 2012 | β |
| The differential role of NOS inhibitors on stress-induced anxiety and neuroendocrine alterations in the rat. | Joung HY et al. | β | 2012 | β |
| The imposition of, but not the propensity for, social subordination impairs exploratory behaviors and general cognitive abilities. | Colas-Zelin D et al. | β | 2012 | β |
| ΞΊ opioid regulation of anxiety-like behavior during acute ethanol withdrawal. | Valdez GR et al. | β | 2012 | β |
| Activation of corticotropin-releasing factor receptors from the basolateral or central amygdala increases the tonic immobility response in guinea pigs: an innate fear behavior. | Donatti AF et al. | β | 2011 | β |
| Central CRH administration changes formalin pain responses in male and female rats. | Lariviere WR et al. | β | 2011 | β |
| Stress conditioning in mice: alterations in immunity and tumor growth. | Benaroya-Milshtein N et al. | β | 2011 | β |
| Stress-induced and cue-induced craving for alcohol in heavy drinkers: Preliminary evidence of genetic moderation by the OPRM1 and CRH-BP genes. | Ray LA | β | 2011 | β |
| Behavioral effects of neuropeptides in rodent models of depression and anxiety. | Rotzinger S et al. | β | 2010 | β |
| Brain neuropeptide Y and corticotropin-releasing hormone in mediating stress and anxiety. | Thorsell A | β | 2010 | β |
| CRF-1 antagonist and CRF-2 agonist decrease binge-like ethanol drinking in C57BL/6J mice independent of the HPA axis. | Lowery EG et al. | β | 2010 | β |
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| GABAergic and nitriergic modulation by curcumin for its antianxiety-like activity in mice. | Gilhotra N et al. | β | 2010 | β |
| Neurobiological mechanisms of addiction: focus on corticotropin-releasing factor. | Koob GF et al. | β | 2010 | β |
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| The role of CRF and CRF-related peptides in the dark side of addiction. | Koob GF | β | 2010 | β |
| Defensive behavioral strategies and enhanced state anxiety during chronic subordinate colony housing are accompanied by reduced hypothalamic vasopressin, but not oxytocin, expression. | Reber SO et al. | β | 2008 | β |
| Disruption of the CRF(2) receptor pathway decreases the somatic expression of opiate withdrawal. | Papaleo F et al. | β | 2008 | β |
| Increased fear- and stress-related anxiety-like behavior in mice lacking tuberoinfundibular peptide of 39 residues. | Fegley DB et al. | β | 2008 | β |
| Neurokinin 1 receptor antagonism promotes active stress coping via enhanced septal 5-HT transmission. | Ebner K et al. | β | 2008 | β |
| Type 1 corticotropin-releasing factor receptor expression reported in BAC transgenic mice: implications for reconciling ligand-receptor mismatch in the central corticotropin-releasing factor system. | Justice NJ et al. | β | 2008 | β |
| Disruption of the CRF/CRF1 receptor stress system exacerbates the somatic signs of opiate withdrawal. | Papaleo F et al. | β | 2007 | β |
| Application of experimental stressors in laboratory rodents. | Heinrichs SC et al. | β | 2006 | β |
| Development of CRF1 receptor antagonists as antidepressants and anxiolytics: progress to date. | Valdez GR | β | 2006 | β |
| Mirtazapine inhibits salivary cortisol concentrations in anorexia nervosa. | SchΓΌle C et al. | β | 2006 | β |
| A stress-induced anxious state in male rats: corticotropin-releasing hormone induces persistent changes in associative learning and startle reactivity. | Servatius RJ et al. | β | 2005 | β |
| Long-term effects of social stress on brain and behavior: a focus on hippocampal functioning. | Buwalda B et al. | β | 2005 | β |
| Acute stress impairs spatial memory in male but not female rats: influence of estrous cycle. | Conrad CD et al. | β | 2004 | β |
| Corticotropin-releasing factor in brain: a role in activation, arousal, and affect regulation. | Heinrichs SC et al. | β | 2004 | β |
| Disorders of consciousness: anatomical and physiological mechanisms. | Valatx JL | β | 2004 | β |
| Does amygdaloid corticotropin-releasing hormone (CRH) mediate anxiety-like behaviors? Dissociation of anxiogenic effects and CRH release. | Merali Z et al. | β | 2004 | β |
| Effects of the vanilloid agonist olvanil and antagonist capsazepine on rat behaviors. | Kasckow JW et al. | β | 2004 | β |
| Fast positive feedback between the adrenocortical stress response and a brain mechanism involved in aggressive behavior. | Kruk MR et al. | β | 2004 | β |
| Increased anxiety-like behavior and ethanol self-administration in dependent rats: reversal via corticotropin-releasing factor-2 receptor activation. | Valdez GR et al. | β | 2004 | β |
| Region-specific alterations of neuronal nitric oxide synthase (nNOS) expression in the amygdala of the aged rats. | Joo KM et al. | β | 2004 | β |
| The therapeutic potential of CRF1 antagonists for anxiety. | Zorrilla EP et al. | β | 2004 | β |
| Antagonism of corticotropin-releasing factor attenuates the enhanced responsiveness to stress observed during protracted ethanol abstinence. | Valdez GR et al. | β | 2003 | β |
| A robust animal model of state anxiety: fear-potentiated behaviour in the elevated plus-maze. | Korte SM et al. | β | 2003 | β |
| Corticotropin releasing factor antagonist, alpha-helical CRF(9-41), reverses nicotine-induced conditioned, but not unconditioned, anxiety. | Tucci S et al. | β | 2003 | β |
| Corticotropin-releasing factor in the dorsal raphe nucleus regulates activity of lateral septal neurons. | Thomas E et al. | β | 2003 | β |
| Differential involvement of amygdaloid CRH system(s) in the salience and valence of the stimuli. | Merali Z et al. | β | 2003 | β |
| Hippocampal serotonergic system is involved in anxiety-like behavior induced by corticotropin-releasing factor. | Kagamiishi Y et al. | β | 2003 | β |
| A comparison of female and male rats' ETOH-induced ataxia and exploration following restraint or swim stress. | Tayyabkhan TR et al. | β | 2002 | β |
| Corticotropin-releasing factor antagonist attenuates stress-induced inhibition of seasonal ovarian recrudescence in the lizard Mabuya carinata. | Ganesh CB et al. | β | 2002 | β |
| Differential release of corticotropin-releasing hormone (CRH) in the amygdala during different types of stressors. | Hand GA et al. | β | 2002 | β |
| Effects of antalarmin, a CRF type 1 receptor antagonist, on anxiety-like behavior and motor activation in the rat. | Zorrilla EP et al. | β | 2002 | β |
| A dopaminergic mechanism is involved in the 'anxiogenic-like' response induced by chronic amphetamine treatment: a behavioral and neurochemical study. | Cancela LM et al. | β | 2001 | β |
| Alterations induced by gestational stress in brain morphology and behaviour of the offspring. | Weinstock M | β | 2001 | β |
| Animal models of social stress: effects on behavior and brain neurochemical systems. | Blanchard RJ et al. | β | 2001 | β |
| Corticosteroids in relation to fear, anxiety and psychopathology. | Korte SM | β | 2001 | β |
| Corticotropin-releasing hormone (CRH) as a regulator of waking. | Chang FC et al. | β | 2001 | β |
| The anxiolytic effect of the CRH(1) receptor antagonist R121919 depends on innate emotionality in rats. | Keck ME et al. | β | 2001 | β |
| The role of CRH in behavioral responses to stress. | Smagin GN et al. | β | 2001 | β |
| Update on endocrine disturbances in anorexia nervosa. | StΓΈving RK et al. | β | 2001 | β |
| Modulation of urocortin-induced hypophagia and weight loss by corticotropin-releasing factor receptor 1 deficiency in mice. | Bradbury MJ et al. | β | 2000 | β |
| A review of endocrine changes in anorexia nervosa. | StΓΈving RK et al. | β | 1999 | β |
| A role for corticotropin releasing factor and urocortin in behavioral responses to stressors. | Koob GF et al. | β | 1999 | β |
| Corticotropin-releasing factor, norepinephrine, and stress. | Koob GF | β | 1999 | β |
| Fear-potentiation in the elevated plus-maze test depends on stressor controllability and fear conditioning. | Korte SM et al. | β | 1999 | β |
| Neuroendocrine and behavioral effects of CRH blockade and stress in male rats. | Aloisi AM et al. | β | 1999 | β |
| Stress, corticotropin-releasing factor, and drug addiction. | Koob GF | β | 1999 | β |
| The rationale for corticotropin-releasing hormone receptor (CRH-R) antagonists to treat depression and anxiety. | Holsboer F | β | 1999 | β |
| Attenuation of behavioral abnormalities in autoimmune mice by chronic soluble interferon-gamma receptor treatment. | Schrott LM et al. | β | 1998 | β |
| Blockade of corticotropin-releasing hormone receptors reduces spontaneous waking in the rat. | Chang FC et al. | β | 1998 | β |
| Cardiovascular actions of neuropeptide Y and social stress. | Klemfuss H et al. | β | 1998 | β |
| Discovery of a novel superpotent and selective melanocortin-4 receptor antagonist (HS024): evaluation in vitro and in vivo. | Kask A et al. | β | 1998 | β |
| Corticotropin-releasing factor, but not corticosterone, is involved in stress-induced relapse to heroin-seeking in rats. | Shaham Y et al. | β | 1997 | β |
| Corticotropin-releasing factor CRF1, but not CRF2, receptors mediate anxiogenic-like behavior. | Heinrichs SC et al. | β | 1997 | β |
| Prior exposure to a brief restraint session facilitates the occurrence of fear in response to a conflict situation: behavioral and neurochemical correlates. | Martijena ID et al. | β | 1997 | β |
| Chronic infusion of a CRH1 receptor antisense oligodeoxynucleotide into the central nucleus of the amygdala reduced anxiety-related behavior in socially defeated rats. | Liebsch G et al. | β | 1995 | β |
| The role of CRF in behavioral aspects of stress. | Heinrichs SC et al. | β | 1995 | β |