An analysis of the genetics of alcohol intoxication in inbred mice.
paper
Cited
Public
Unavailable
- Authors
- Crabbe, John C; Metten, Pamela; Cameron, Andy J; Wahlsten, Douglas
- Year
- 2005
- Journal
- Neuroscience and biobehavioral reviews
- PMID
- 15642621
- DOI
- 10.1016/j.neubiorev.2004.08.002
We compared the behaviors of eight inbred mouse strains across 18 variables, using 11 behavioral assays, and gave ethanol (EtOH) as an intoxicant. Genetic influences on behavior and sensitivity to EtOH were pronounced, but strain sensitivities were generally only modestly correlated across tasks. Certain well-correlated clusters of responses suggested that some genes affect similar neurobiological substrates. No strains of mice were generally sensitive or resistant to intoxication across tasks. Anthropomorphically appealing concepts like 'muscle strength' had little explanatory power across tasks. A battery of selected tests was proposed for future studies. Overall, the results show that each mouse behavioral assay captures only a portion of ataxia, a genetically complex behavioral domain. Conversely, multiple behavioral capacities are apparently required for performance in each specific assay. Thus, if only one or two tests are used to evaluate motor function in genetically engineered mutant mice, only a small portion of the domain will be assessed and results may be misleading. This caveat likely extends to many behavioral domains (e.g. learning and memory, anxiety).
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| Motor impairment: a new ethanol withdrawal phenotype in mice. | Philibin SD et al. | β | 2008 | β |
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| Three murine anxiety models: results from multiple inbred strain comparisons. | Milner LC et al. | β | 2008 | β |
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| An investigation of the behavioral actions of ethanol across adolescence in mice. | Hefner K et al. | β | 2007 | β |
| Mouse inbred strain differences in ethanol drinking to intoxication. | Rhodes JS et al. | β | 2007 | β |
| The parallel rod floor test: a measure of ataxia in mice. | Kamens HM et al. | β | 2007 | β |
| Assessment of the aversive and rewarding effects of alcohol in Fischer and Lewis rats. | Roma PG et al. | β | 2006 | β |
| Comparison between multiple behavioral effects of peripheral ethanol administration in rats: sedation, ataxia, and bradykinesia. | Chuck TL et al. | β | 2006 | β |
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| Increased ethanol resistance and consumption in Eps8 knockout mice correlates with altered actin dynamics. | OffenhΓ€user N et al. | β | 2006 | β |
| Quantitative PCR assays for mouse enteric flora reveal strain-dependent differences in composition that are influenced by the microenvironment. | Deloris Alexander A et al. | β | 2006 | β |
| Alcoholism: the dissection for endophenotypes. | Hines LM et al. | β | 2005 | β |
| Alcohol withdrawal severity in inbred mouse (Mus musculus) strains. | Metten P et al. | β | 2005 | β |
| Genetic dissociation between ethanol sensitivity and rapid tolerance in mouse and rat strains selectively bred for differential ethanol sensitivity. | Radcliffe RA et al. | β | 2005 | β |
| Laboratory models of alcoholism: treatment target identification and insight into mechanisms. | Lovinger DM et al. | β | 2005 | β |
| Scheduled access to ethanol results in motor impairment and tolerance in female C57BL/6J mice. | Cronise K et al. | β | 2005 | β |
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