Genetics of alcoholism: a review of recent studies in human and animal models.
paper
Primary
Public
Unavailable
- Authors
- Foroud, T; Li, T K
- Year
- 1999
- Journal
- The American journal on addictions
- PMID
- 10598210
- DOI
- 10.1080/105504999305677
There is substantial evidence for a significant genetic component to the risk of alcoholism. In searching for genes that contribute to this risk, several approaches may be utilized in order to identify the genetic loci underlying alcoholism susceptibility. Several candidate genes have been evaluated for their role in alcoholism; however, with the exception of the enzymes of alcohol metabolism, results from these studies have been inconsistent. Recently, two large studies have employed a genome screen methodology to identify novel genes contributing to the risk of alcoholism. As an alternative strategy, researchers have utilized mouse and rat models to identify quantitative trait loci influencing alcohol preference. Through the development of congenic lines and transgenic and knock-out animals, candidate genes can be identified and evaluated for their role in alcohol preference.
No figures extracted from this document.
No chunks — full text not yet ingested.
No entities extracted from this document yet.
No uploaded files.
Not in any collection.
No citations found.
In this knowledge base
| Title | Year | PMID |
|---|---|---|
| Genetic influences in emotional dysfunction and alcoholism-related brain damage. | 2005 | 18568071 |
External
| Title | Authors | Journal | Year | Link |
|---|---|---|---|---|
| Mesolimbic transcriptional response to hedonic substitution of voluntary exercise and voluntary ethanol consumption. | Darlington TM et al. | — | 2014 | → |
| Use of the expanded panel of BXD mice narrow QTL regions in ethanol-induced locomotor activation and motor incoordination. | DuBose CS et al. | — | 2013 | → |
| Damage in the dorsal striatum alleviates addictive behavior. | Muskens JB et al. | — | 2012 | → |
| Balancing environmental and genetic factors for alcoholism in the black community: implications for social work practice. | Snell CL et al. | — | 2011 | → |
| Molecular targets of alcohol action: Translational research for pharmacotherapy development and screening. | Gorini G et al. | — | 2011 | → |
| [Genetic factors of alcohol-dependence]. | Pinto E et al. | — | 2009 | → |
| Bone morphometry strongly predicts cortical bone stiffness and strength, but not toughness, in inbred mouse models of high and low bone mass. | Voide R et al. | — | 2008 | → |
| Analysis of behavior using genetical genomics in mice as a model: from alcohol preferences to gene expression differences. | Singh SM et al. | — | 2007 | → |
| Metabolic and genetic factors contributing to alcohol induced effects and fetal alcohol syndrome. | Gemma S et al. | — | 2007 | → |
| Alcoholism: Study boosts evidence on linkage regions associated with alcoholism. | Hopfer C | — | 2006 | → |
| Effect of polymorphism on expression of the neuropeptide Y gene in inbred alcohol-preferring and -nonpreferring rats. | Spence JP et al. | — | 2005 | → |
| Expression profiling and QTL analysis: a powerful complementary strategy in drug abuse research. | Spence J et al. | — | 2005 | → |
| Genetic influences in emotional dysfunction and alcoholism-related brain damage. | Oscar-Berman M et al. | — | 2005 | → |
| Transcriptome analysis of frontal cortex in alcohol-preferring and nonpreferring rats. | Worst TJ et al. | — | 2005 | → |
| Mouse striatal transcriptome analysis: effects of oral self-administration of alcohol. | Saito M et al. | — | 2004 | → |
| Paternal contribution to fetal alcohol syndrome. | Abel E | — | 2004 | → |
| Possible epistatic role of ADH7 in the protection against alcoholism. | Osier MV et al. | — | 2004 | → |
| Recent advances in cyclic-adenosine monophosphate/protein kinase A signaling in ethanol-induced synaptic and behavioral alterations. | Chandler LJ et al. | — | 2004 | → |
| Analyses of quantitative trait loci contributing to alcohol preference in HAD1/LAD1 and HAD2/LAD2 rats. | Carr LG et al. | — | 2003 | → |
| Differences in basal levels of CREB and NPY in nucleus accumbens regions between C57BL/6 and DBA/2 mice differing in inborn alcohol drinking behavior. | Misra K et al. | — | 2003 | → |
| Ethanol disrupts fear conditioning in C57BL/6 mice. | Gould TJ | — | 2003 | → |
| Pleiotropic effect of a locus on chromosome 4 influencing alcohol drinking and emotional reactivity in rats. | Terenina-Rigaldie E et al. | — | 2003 | → |
| Fine mapping of polymorphic alcohol-related quantitative trait loci candidate genes using interval-specific congenic recombinant mice. | Ehringer MA et al. | — | 2002 | → |
| Human alcoholism studies of genes identified through mouse quantitative trait locus analysis. | Ehringer MA et al. | — | 2002 | → |
| Suggestive linkage on chromosome 1 for a quantitative alcohol-related phenotype. | Dick DM et al. | — | 2002 | → |
| Voluntary ethanol consumption by mice: genome-wide analysis of quantitative trait loci and their interactions in a C57BL/6ByJ x 129P3/J F2 intercross. | Bachmanov AA et al. | — | 2002 | → |
| Finding paradigms for the future of alcoholism research: an interdisciplinary perspective. | Meyer RE | — | 2001 | → |
| Neurotoxicity and neurocognitive impairments with alcohol and drug-use disorders: potential roles in addiction and recovery. | Bowden SC et al. | — | 2001 | → |
| The cAMP-protein kinase A signal transduction pathway modulates ethanol consumption and sedative effects of ethanol. | Wand G et al. | — | 2001 | → |
| Variability in skeletal mass, structure, and biomechanical properties among inbred strains of rats. | Turner CH et al. | — | 2001 | → |