Ethanol augments GABAergic transmission in the central amygdala via CRF1 receptors.
paper
Cited
Public
Unavailable
- Authors
- Nie, Zhiguo; Schweitzer, Paul; Roberts, Amanda J; Madamba, Samuel G; Moore, Scott D; Siggins, George Robert
- Year
- 2004
- Journal
- Science (New York, N.Y.)
- PMID
- 15001778
- DOI
- 10.1126/science.1092550
The central amygdala (CeA) plays a role in the relationship among stress, corticotropin-releasing factor (CRF), and alcohol abuse. In whole-cell recordings, both CRF and ethanol enhanced gamma-aminobutyric acid-mediated (GABAergic) neurotransmission in CeA neurons from wild-type and CRF2 receptor knockout mice, but not CRF1 receptor knockout mice. CRF1 (but not CRF2) receptor antagonists blocked both CRF and ethanol effects in wild-type mice. These data indicate that CRF1 receptors mediate ethanol enhancement of GABAergic synaptic transmission in the CeA, and they suggest a cellular mechanism underlying involvement of CRF in ethanol's behavioral and motivational effects.
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